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Yıl 2025, Cilt: 9 Sayı: 1, 84 - 90, 24.06.2025

Ali Arslantas , Mehmet Salih Ağırtaş

https://doi.org/10.32571/ijct.1642171

Öz

Proje Numarası

KBÜBAP-18-DS-046

Kaynakça

  • 1. Leznoff, C.C.; Lever, A.B.P. Phthalocyanines: Properties and applications. VCH New York, USA, 1993.
  • 2. Hanack, M.; Lang, M. Adv. Mater. 1994, 6, 819–833.
  • 3. McKeown, N.B. Phthalocyanine materials: synthesis, structure, and function. Cambridge, U.K.; New York, Cambridge University Press, 1998.
  • 4. Kudrevich, S.V.; Galpern, M.G.; Van Lier, J.E. Synth. 1994, 8, 779–781.
  • 5. Mitzel, F.; Fitzgerald, S.; Beeby, A.; Faust, R. Chem. Commun. 2001, 24, 596–2597.
  • 6. Baran, A.; Çol, S.; Karakılıç, E.; Özen, F. Polyhedron 2020, 175, 114205.
  • 7. Maya, E.M.; García Frutos, E.M.; Vázquez, P.; Torres, T.; Martín, G.; Rojo, G.; Zyss, J. J. Phys. Chem. 2003, 107, 2110–2117.
  • 8. Ban, K.; Nishizawa, K.; Ohta, K.; Shirai, H. J. Mater. Chem. 2000, 10, 1083–1090. 9. Wöhrle, D. Adv. Mater. 1993, 5(12), 942–943. 10. Uslan, C.; Sesalan, B.S. Dyes Pigm. 2012, 94, 127–135.
  • 11. Evren, D.; Bura, A.K.; Özçesmeci, I.; Sesalan, B.S. Dyes Pigm. 2013, 96, 475–482.
  • 12. Amitha, G.S.; Vasudevan, S. Polyhedron 2020, 190, 114773.
  • 13. Boucher, L.J. Metal complexes of phthalocyanines. Springer, Boston, MA, 1979.
  • 14. Ağırtaş, M.S.; Öndeş, M.Y.; Cabir, B. Int. J. Chem. Techno. 2018, 2(1), 50-55.
  • 15. Marmur, J. A. J. Mol. Biol. 1961, 3(2), 208–218.
  • 16. Wang, T.; Wang, A.; Zhou, L.; Lu, S.; Jiang, W.; Lin, Y.; Zhou, J.; Wei, S. Spectrochim. Acta A Mol. Biomol. Spectrosc. 2013, 15, 445–451.
  • 17. Arslantas, A; Agirtas, M.S; Gungordu Solgun, D. Gazi Univ. J. Sci. 2025, DOI: 10.35378/gujs.1588595
  • 18. Arslantas, A; Agirtas, M.S. Chemistryselect 2018, 3(1), 3155-3160.
  • 19. Arslantas, A; Agirtas, M.S.; Durmus, C. Hittite j. Sci. Eng., 2020, 7 (2), 81-87.
  • 20. Baguley, B.C.; Le Bret, M. Biochem. 1984, 23, 937–43.
  • 21. Satyanarayana, S.; Dabrowiak, J.C.; Chaires, J.B.; Neither. Biochem. 1992, 31, 9319–9324.
  • 22. Satyanarayana, S.; Dabrowiak, J.C.; Chaires, J.B. Biochem. 1992, 32, 2573–2584.
  • 23. Barton, J.K.; Goldberg, J.M.; Kumar, C.V.; Turro, N.J. J. Am. Chem. Soc. 1993, 108, 2081–2088.
  • 24. Waring, M.J. J. Mol. Biol. 1965, 13, 269-274.
  • 25. Neyhart, G.A.; Grover, N.; Smith, S.R.; Kalsbeck, W.A.; Fairly, T.A.; Cory, M.; Thorp, H.H. J. Am. Chem. Soc. 1993, 115, 4423-4428.
  • 26. Zipper, H.; Brunner, H.; Bernhagen, J.; Vitzthum, F. Nucleic Acids Res. 2004, 32(12), e103.
  • 27. Umemura, K. Nagami, F.; Okada, T.; Kuroda, R. Nucleic Acids Res. 2004, 28, E39.
  • 28. Shoukry, A.A.; Mohamed, M.S. Spectrochim Acta A Mol Biomol Spectrosc. 2012, 96, 586–593.
  • 29. Lopez, Z.N.C.; Gauna, G.A.; Garcia Vior, M.C.; Awruch, J.; Dicelio, L.E. J. Photochem. Photobiol. B Biol. 2014, 136, 29-33.
  • 30. Thamilarasan, V.; Jayamani, A.; Sengottuvelan, N. Eur. J. Med. Chem. 2015, 89, 266-78.
  • 31. Ma, C.; Tian, D.; Hou, X.; Chang, Y.; Cong, F.; Yu, H.; Du, X.; Du, G. Synth. 2005, 5, 741–748.
  • 32. Keleş, K.; Barut, B.; Biyiklioglu, Z.; Özel, A. Dyes Pigm. 2017, 139, 575-586.
  • 33. Arslantas, A.; Agirtas. M.S. Chemistryselect 2018, 3(11), 3155-3160.
  • 34. Arslantas, A; Agirtas, M.S. J. Chem. Soc. Pakistan, 2024, 46(5), 499-507.

Evaluation of DNA Reactivity Properties of Zn(II) Phthalocyanine Complex Carrying Tetrakis(benzhydryloxy) Ligand

Yıl 2025, Cilt: 9 Sayı: 1, 84 - 90, 24.06.2025

Ali Arslantas , Mehmet Salih Ağırtaş

https://doi.org/10.32571/ijct.1642171

Öz

Using a variety of techniques, the interaction pathway of zinc(II) phthalocyanine with tetrakis(benzhydryloxy) ligand with DNA was assessed in this article. Electrophoresis, thermal denaturation, viscosity, absorption, and fluorescence spectra were employed to investigate the binding mechanism of the ZnPc complex with DNA. The DNA binding constant (Kb) of the ZnPc compound and the thermal melting profile values of the DNA showed that the binding of the ZnPc compound to CT-DNA is governed by an intercalative interaction mechanism. The Kb was computed to be 1.392 106 M-1 for the ZnPc compound, which provides very important clues about the binding mechanism. Fluorescence spectroscopy is another important tool for clarifying the ability of ZnPc to interact with DNA. The information obtained from the fluorescence method confirms that ZnPc interacts with DNA by means of intercalative binding. When the findings obtained from electrophoresis experiments were evaluated, the significant decrease in the intensity of CT-DNA bands revealed that ZnPc interacted with DNA through a physical interaction. The data from the viscosity study confirm data previously obtained by other methods. As a result of their findings, they showed that ZnPc interacts with DNA by intercalative binding. All of these informations suggest that ZnP has DNA interaction properties and could be a potential agent that can be used in the treatment of cancer diseases on the basis of its DNA bonding property.

Anahtar Kelimeler

Metallic phthalocyanines DNA binding Zn(II) Thermal melting Intercalative interaction

Proje Numarası

KBÜBAP-18-DS-046

Kaynakça

  • 1. Leznoff, C.C.; Lever, A.B.P. Phthalocyanines: Properties and applications. VCH New York, USA, 1993.
  • 2. Hanack, M.; Lang, M. Adv. Mater. 1994, 6, 819–833.
  • 3. McKeown, N.B. Phthalocyanine materials: synthesis, structure, and function. Cambridge, U.K.; New York, Cambridge University Press, 1998.
  • 4. Kudrevich, S.V.; Galpern, M.G.; Van Lier, J.E. Synth. 1994, 8, 779–781.
  • 5. Mitzel, F.; Fitzgerald, S.; Beeby, A.; Faust, R. Chem. Commun. 2001, 24, 596–2597.
  • 6. Baran, A.; Çol, S.; Karakılıç, E.; Özen, F. Polyhedron 2020, 175, 114205.
  • 7. Maya, E.M.; García Frutos, E.M.; Vázquez, P.; Torres, T.; Martín, G.; Rojo, G.; Zyss, J. J. Phys. Chem. 2003, 107, 2110–2117.
  • 8. Ban, K.; Nishizawa, K.; Ohta, K.; Shirai, H. J. Mater. Chem. 2000, 10, 1083–1090. 9. Wöhrle, D. Adv. Mater. 1993, 5(12), 942–943. 10. Uslan, C.; Sesalan, B.S. Dyes Pigm. 2012, 94, 127–135.
  • 11. Evren, D.; Bura, A.K.; Özçesmeci, I.; Sesalan, B.S. Dyes Pigm. 2013, 96, 475–482.
  • 12. Amitha, G.S.; Vasudevan, S. Polyhedron 2020, 190, 114773.
  • 13. Boucher, L.J. Metal complexes of phthalocyanines. Springer, Boston, MA, 1979.
  • 14. Ağırtaş, M.S.; Öndeş, M.Y.; Cabir, B. Int. J. Chem. Techno. 2018, 2(1), 50-55.
  • 15. Marmur, J. A. J. Mol. Biol. 1961, 3(2), 208–218.
  • 16. Wang, T.; Wang, A.; Zhou, L.; Lu, S.; Jiang, W.; Lin, Y.; Zhou, J.; Wei, S. Spectrochim. Acta A Mol. Biomol. Spectrosc. 2013, 15, 445–451.
  • 17. Arslantas, A; Agirtas, M.S; Gungordu Solgun, D. Gazi Univ. J. Sci. 2025, DOI: 10.35378/gujs.1588595
  • 18. Arslantas, A; Agirtas, M.S. Chemistryselect 2018, 3(1), 3155-3160.
  • 19. Arslantas, A; Agirtas, M.S.; Durmus, C. Hittite j. Sci. Eng., 2020, 7 (2), 81-87.
  • 20. Baguley, B.C.; Le Bret, M. Biochem. 1984, 23, 937–43.
  • 21. Satyanarayana, S.; Dabrowiak, J.C.; Chaires, J.B.; Neither. Biochem. 1992, 31, 9319–9324.
  • 22. Satyanarayana, S.; Dabrowiak, J.C.; Chaires, J.B. Biochem. 1992, 32, 2573–2584.
  • 23. Barton, J.K.; Goldberg, J.M.; Kumar, C.V.; Turro, N.J. J. Am. Chem. Soc. 1993, 108, 2081–2088.
  • 24. Waring, M.J. J. Mol. Biol. 1965, 13, 269-274.
  • 25. Neyhart, G.A.; Grover, N.; Smith, S.R.; Kalsbeck, W.A.; Fairly, T.A.; Cory, M.; Thorp, H.H. J. Am. Chem. Soc. 1993, 115, 4423-4428.
  • 26. Zipper, H.; Brunner, H.; Bernhagen, J.; Vitzthum, F. Nucleic Acids Res. 2004, 32(12), e103.
  • 27. Umemura, K. Nagami, F.; Okada, T.; Kuroda, R. Nucleic Acids Res. 2004, 28, E39.
  • 28. Shoukry, A.A.; Mohamed, M.S. Spectrochim Acta A Mol Biomol Spectrosc. 2012, 96, 586–593.
  • 29. Lopez, Z.N.C.; Gauna, G.A.; Garcia Vior, M.C.; Awruch, J.; Dicelio, L.E. J. Photochem. Photobiol. B Biol. 2014, 136, 29-33.
  • 30. Thamilarasan, V.; Jayamani, A.; Sengottuvelan, N. Eur. J. Med. Chem. 2015, 89, 266-78.
  • 31. Ma, C.; Tian, D.; Hou, X.; Chang, Y.; Cong, F.; Yu, H.; Du, X.; Du, G. Synth. 2005, 5, 741–748.
  • 32. Keleş, K.; Barut, B.; Biyiklioglu, Z.; Özel, A. Dyes Pigm. 2017, 139, 575-586.
  • 33. Arslantas, A.; Agirtas. M.S. Chemistryselect 2018, 3(11), 3155-3160.
  • 34. Arslantas, A; Agirtas, M.S. J. Chem. Soc. Pakistan, 2024, 46(5), 499-507.
Toplam 32 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Biyokimya ve Hücre Biyolojisi (Diğer)
Bölüm Makale
Yazarlar

Ali Arslantas 0000-0002-0847-9015

Mehmet Salih Ağırtaş 0000-0003-1296-2066

Proje Numarası KBÜBAP-18-DS-046
Erken Görünüm Tarihi 2 Haziran 2025
Yayımlanma Tarihi 24 Haziran 2025
Gönderilme Tarihi 20 Şubat 2025
Kabul Tarihi 26 Mayıs 2025
Yayımlandığı Sayı Yıl 2025 Cilt: 9 Sayı: 1

Kaynak Göster

APA Arslantas, A., & Ağırtaş, M. S. (2025). Evaluation of DNA Reactivity Properties of Zn(II) Phthalocyanine Complex Carrying Tetrakis(benzhydryloxy) Ligand. International Journal of Chemistry and Technology, 9(1), 84-90. https://doi.org/10.32571/ijct.1642171
AMA Arslantas A, Ağırtaş MS. Evaluation of DNA Reactivity Properties of Zn(II) Phthalocyanine Complex Carrying Tetrakis(benzhydryloxy) Ligand. Int. J. Chem. Technol. Haziran 2025;9(1):84-90. doi:10.32571/ijct.1642171
Chicago Arslantas, Ali, ve Mehmet Salih Ağırtaş. “Evaluation of DNA Reactivity Properties of Zn(II) Phthalocyanine Complex Carrying Tetrakis(benzhydryloxy) Ligand”. International Journal of Chemistry and Technology 9, sy. 1 (Haziran 2025): 84-90. https://doi.org/10.32571/ijct.1642171.
EndNote Arslantas A, Ağırtaş MS (01 Haziran 2025) Evaluation of DNA Reactivity Properties of Zn(II) Phthalocyanine Complex Carrying Tetrakis(benzhydryloxy) Ligand. International Journal of Chemistry and Technology 9 1 84–90.
IEEE A. Arslantas ve M. S. Ağırtaş, “Evaluation of DNA Reactivity Properties of Zn(II) Phthalocyanine Complex Carrying Tetrakis(benzhydryloxy) Ligand”, Int. J. Chem. Technol., c. 9, sy. 1, ss. 84–90, 2025, doi: 10.32571/ijct.1642171.
ISNAD Arslantas, Ali - Ağırtaş, Mehmet Salih. “Evaluation of DNA Reactivity Properties of Zn(II) Phthalocyanine Complex Carrying Tetrakis(benzhydryloxy) Ligand”. International Journal of Chemistry and Technology 9/1 (Haziran 2025), 84-90. https://doi.org/10.32571/ijct.1642171.
JAMA Arslantas A, Ağırtaş MS. Evaluation of DNA Reactivity Properties of Zn(II) Phthalocyanine Complex Carrying Tetrakis(benzhydryloxy) Ligand. Int. J. Chem. Technol. 2025;9:84–90.
MLA Arslantas, Ali ve Mehmet Salih Ağırtaş. “Evaluation of DNA Reactivity Properties of Zn(II) Phthalocyanine Complex Carrying Tetrakis(benzhydryloxy) Ligand”. International Journal of Chemistry and Technology, c. 9, sy. 1, 2025, ss. 84-90, doi:10.32571/ijct.1642171.
Vancouver Arslantas A, Ağırtaş MS. Evaluation of DNA Reactivity Properties of Zn(II) Phthalocyanine Complex Carrying Tetrakis(benzhydryloxy) Ligand. Int. J. Chem. Technol. 2025;9(1):84-90.
 Kapak Resmi İndir

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