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Fabrication a novel ethylenediamine sulfonamide polymer resin and graphene-modified carbon paste electrodes for simultaneous determination of anti-HBV drugs entecavir and tenofovir in dosage form by differential pulse voltammetry

Yıl 2024, Cilt: 28 Sayı: 3, 579 - 602, 28.06.2025

Adel Asfoor Zeynep Aydoğmuş , Bahire Senkal

Öz

The combination of entecavir (ETV) and tenofovir (TEV), nucleos(t)ide analogs (NUCs), is advised as first-line treatment for people suffering from multidrug-resistant hepatitis B due to their favorable safety profile, low side-effect rate, and high genetic barrier. This study reports the fabrication of a novel cross-linked ethylenediamine sulfonamide polymer resin (EDASP) and graphene (Gr)-modified carbon paste electrodes (CPE) for the simultaneous determination of the anti-HBV drugs ETV and TEV in bulk and dosage form by differential pulse voltammetry (DPV). The electrodes were specified through cyclic voltammetry, Fourier transform infrared (FTIR), scanning electron microscopy (SEM), and the analytical parameters were optimized. The findings indicate that both drugs displayed clear oxidation peaks on the Gr-CPE and EDASP-CPE electrodes at pH 4.5 and 4.0, respectively, in the Britton-Robinson buffer. The linear dynamic range of ETV and TEV was determined between 1μM and 250μM on both working electrodes by DPV. The limit of detection (LOD) and limit of quantification (LOQ) for ETV were 0.2μM and 0.6μM, respectively, on Gr-CPE. The LOD and LOQ for TEV were 0.2μM and 0.7μM, respectively. The novel EDASP-CPE exhibited improved sensitivity with LOD and LOQ for ETV of 0.2μM and 0.5μM, respectively. The LOD and LOQ for TEV on EDASP CPE were 0.2μM and 0.7μM, respectively. The proposed method was successfully applied to the simultaneous determination of ETV and TEV in a commercial tablet dosage form, exhibiting good accuracy and precision. The results highlight the potential of the novel cross-linked ethylenediamine sulfonamide polymer resin-modified carbon paste electrode for the simultaneous determination of anti-HBV drugs in dosage form by differential pulse voltammetry.

Anahtar Kelimeler

Tenofovir entecavir ethylenediamine sulfonamide polymer resin graphene modified carbon paste electrode voltammetry pharmaceutical preparation

Kaynakça

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Yıl 2024, Cilt: 28 Sayı: 3, 579 - 602, 28.06.2025

Adel Asfoor Zeynep Aydoğmuş , Bahire Senkal

Öz

Kaynakça

  • [1] Asran AM, Mohamed MA, Ahmed N, Banks CE,Allam NK. An innovative electrochemical platform for the sensitive determination of the hepatitis B inhibitor Entecavir with ionic liquid as a mediator. J Mol Liq. 2020; 302: 112498. https://doi.org/10.1016/j.molliq.2020.112498
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  • [3] Yeh ML, Huang CF, Huang CI, Holmes JA, Hsieh MH, Tsai YS, Liang PC, Tsai PC, Hsieh MY, Lin ZY, Chen SC, Huang JF, Dai CY, Chuang WL, Chung RT, Yu ML. Hepatitis B-related outcomes following direct-acting antiviral therapy in Taiwanese patients with chronic HBV/HCV co-infection. J Hepatol. 2020; 73(1): 62-71. https://doi.org/10.1016/j.jhep.2020.01.027
  • [4] Pawlotsky JM, Negro F, Aghemo A, Berenguer M, Dalgard O, Dusheiko G, Marra F, Puoti M, Wedemeyer H. European Association for the Study of the Liver. EASL recommendations on treatment of hepatitis C: Final update of the series. J Hepatol. 2020; 73(5): 1170-1218. https://doi.org/10.1016/j.jhep.2020.08.018
  • [5] Huang P, Wang Y, Yue M, Ge Z, Xia X, Jeyarajan AJ, Holmes JA, Yu R, Zhu C, Yang S, Lin W, Chung RT. The risk of hepatitis C virus recurrence in hepatitis C virus-infected patients treated with direct-acting antivirals after achieving a sustained virological response: A comprehensive analysis. Liver Int. 2021; 41(10): 2341-2357. https://doi.org/10.1111/liv.14976
  • [6] Chien RN, Liaw YF. Current trend in antiviral therapy for chronic hepatitis B. Viruses. 2022; 14(2):434. https://doi.org/10.3390/v14020434
  • [7] Shiffman ML. Approach to the patient with chronic hepatitis B and decompensated cirrhosis. Liver Int. 2020; 40(S1):22-26. https://doi.org/10.1111/liv.14359
  • [8] Lim YS, Seto WK, Kurosaki M, Fung S, Kao JH, Hou J, Gordon SC, Flaherty JF, Yee LJ, Zhao Y, Agarwal K, Lampertico P. Review article: Switching patients with chronic hepatitis B to tenofovir alafenamide-a review of current data. Aliment Pharmacol Ther. 2022; 55(8): 921-943. https://doi.org/10.3390/v12090998
  • [9] Ma X, Liu S, Wang M, Wang Y, Du S, Xin Y, Xuan S. Tenofovir alafenamide fumarate, tenofovir disoproxil fumarate and entecavir: Which is the most effective drug for chronic hepatitis B? A systematic review and meta-analysis. J Clin Transl Hepatol. 2021; 9(3): 335-344. https://doi.org/10.14218/JCTH.2020.00164
  • [10] Lee IC, Lan KH, Su CW, Li CP, Chao Y, Lin HC, Hou MC, Huang YH. Efficacy and renal safety of prophylactic tenofovir alafenamide for HBV-ınfected cancer patients undergoing chemotherapy. Int J Mol Sci. 2022;23(19):11335. https://doi.org/10.3390/ijms231911335
  • [11] Wang Y, Wang L, Chen X, Sun C, Zhu Y, Kang Y,Zeng S. Chiral detection of entecavir stereoisomeric impurities through coordination with R-besivance and Zn(II) using mass spectrometry. J Mass Spectrom. 2018; 53(3): 247-256. https://doi.org/10.1002/jms.4060
  • [12] Kim YJ. Chapter 27 - Antiviral drugs. In: Ray SD, editor. Side Effects of Drugs Annual, 43th ed., Elsevier, 2021,pp323-328. https://doi.org/10.1016/bs.seda.2021.09.007
  • [13] Marino A, Cosentino F, Ceccarelli M, Moscatt V, Pampaloni A, Scuderi D, D'Andrea F, Rullo EV, Nunnari G, Benanti F, Celesia BM, Cacopardo B. Entecavir resistance in a patient with treatment-naïve HBV: A case report. Mol Clin Oncol. 2021;14(6):113. https://doi.org/10.3892/mco.2021.2275
  • [14] Rizwana BF, Prasana JC, Abraham CS,Muthu S. Spectroscopic investigation, hirshfeld surface analysis and molecular docking studies on anti-viral drug entecavir. J Mol Liq. 2018; 1164:447-458. https://doi.org/10.1016/j.molstruc.2018.03.090
  • [15] Babu NR, Padmavathi Y, Kumar PR, Babu RS, Vijaya DV, Polker A. Development of new spectrometric method for estimation of entecavir monohydrate in formulation using 3-amino phenol as chromogenic reagent. J Pharm Sci Res. 2019; 11(6): 2452-2457.
  • [16] Naz A, Tabish I, Naseer A, Siddiqi AZ, Siddiqui FA,Mirza AZ. Green chemistry approach: Method development and validation for identification and quantification of entecavir using FT-IR in bulk and pharmaceutical dosage form. Futur J Pharm Sci. 2021; 7:75. https://doi.org/10.1186/s43094-021-00211-9
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Toplam 67 adet kaynakça vardır.

Ayrıntılar

Birincil Dil İngilizce
Konular Eczacılıkta Analitik Kimya
Bölüm Articles
Yazarlar

Adel Asfoor 0000-0003-3936-7144

Zeynep Aydoğmuş 0000-0001-7784-0129

Bahire Senkal 0000-0002-1616-6828

Yayımlanma Tarihi 28 Haziran 2025
Yayımlandığı Sayı Yıl 2024 Cilt: 28 Sayı: 3

Kaynak Göster

APA Asfoor, A., Aydoğmuş, Z., & Senkal, B. (2025). Fabrication a novel ethylenediamine sulfonamide polymer resin and graphene-modified carbon paste electrodes for simultaneous determination of anti-HBV drugs entecavir and tenofovir in dosage form by differential pulse voltammetry. Journal of Research in Pharmacy, 28(3), 579-602.
AMA Asfoor A, Aydoğmuş Z, Senkal B. Fabrication a novel ethylenediamine sulfonamide polymer resin and graphene-modified carbon paste electrodes for simultaneous determination of anti-HBV drugs entecavir and tenofovir in dosage form by differential pulse voltammetry. J. Res. Pharm. Haziran 2025;28(3):579-602.
Chicago Asfoor, Adel, Zeynep Aydoğmuş, ve Bahire Senkal. “Fabrication a Novel Ethylenediamine Sulfonamide Polymer Resin and Graphene-Modified Carbon Paste Electrodes for Simultaneous Determination of Anti-HBV Drugs Entecavir and Tenofovir in Dosage Form by Differential Pulse Voltammetry”. Journal of Research in Pharmacy 28, sy. 3 (Haziran 2025): 579-602.
EndNote Asfoor A, Aydoğmuş Z, Senkal B (01 Haziran 2025) Fabrication a novel ethylenediamine sulfonamide polymer resin and graphene-modified carbon paste electrodes for simultaneous determination of anti-HBV drugs entecavir and tenofovir in dosage form by differential pulse voltammetry. Journal of Research in Pharmacy 28 3 579–602.
IEEE A. Asfoor, Z. Aydoğmuş, ve B. Senkal, “Fabrication a novel ethylenediamine sulfonamide polymer resin and graphene-modified carbon paste electrodes for simultaneous determination of anti-HBV drugs entecavir and tenofovir in dosage form by differential pulse voltammetry”, J. Res. Pharm., c. 28, sy. 3, ss. 579–602, 2025.
ISNAD Asfoor, Adel vd. “Fabrication a Novel Ethylenediamine Sulfonamide Polymer Resin and Graphene-Modified Carbon Paste Electrodes for Simultaneous Determination of Anti-HBV Drugs Entecavir and Tenofovir in Dosage Form by Differential Pulse Voltammetry”. Journal of Research in Pharmacy 28/3 (Haziran 2025), 579-602.
JAMA Asfoor A, Aydoğmuş Z, Senkal B. Fabrication a novel ethylenediamine sulfonamide polymer resin and graphene-modified carbon paste electrodes for simultaneous determination of anti-HBV drugs entecavir and tenofovir in dosage form by differential pulse voltammetry. J. Res. Pharm. 2025;28:579–602.
MLA Asfoor, Adel vd. “Fabrication a Novel Ethylenediamine Sulfonamide Polymer Resin and Graphene-Modified Carbon Paste Electrodes for Simultaneous Determination of Anti-HBV Drugs Entecavir and Tenofovir in Dosage Form by Differential Pulse Voltammetry”. Journal of Research in Pharmacy, c. 28, sy. 3, 2025, ss. 579-02.
Vancouver Asfoor A, Aydoğmuş Z, Senkal B. Fabrication a novel ethylenediamine sulfonamide polymer resin and graphene-modified carbon paste electrodes for simultaneous determination of anti-HBV drugs entecavir and tenofovir in dosage form by differential pulse voltammetry. J. Res. Pharm. 2025;28(3):579-602.