Case Report
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Year 2025, Volume: 14 Issue: 1, 28 - 31, 30.04.2025

Esranur Ünal , Saadet Nurşah Gedikli , Fatma Şenel , Muhammed Burak Yücel

https://doi.org/10.47493/abantmedj.1577105

Abstract

COVID-19 aşıları inflamatuvar deri hastalıklarının başlamasına veya alevlenmesine neden olabilir. Bununla birlikte, COVID-19 aşıları ile immün aracılı deri hastalıkları arasındaki ilişki hala tam olarak bilinmemektedir.
Liken planus pigmentosus inversus, liken planusun nadir görülen bir varyantı olup liken planus pigmentozusun aksine, bu form beyaz tenli kişileri etkiler. Kasık ve koltuk altı gibi intertriginöz bölgelerde ortaya çıkar ve hastaların %90'ında aksiller tutulum mevcuttur.
COVID-19 aşıları sonrası bildirilen liken planus olguları mevcut olup, bu vaka inaktif COVID-19 aşısı (Sinovac) sonrası ortaya çıkan liken planus pigmentosus inversusu bildiren ilk vakadır. Bu ilişkiyi ortaya koymak için ek çalışmalara ihtiyaç vardır.

References

  • Català A, Muñoz‐Santos C, Galván‐Casas C, et al. Cutaneous reactions after SARS‐CoV‐2 vaccination: a cross‐sectional Spanish nationwide study of 405 cases. Br J Dermatol. 2022;186(1):142‐152.
  • Weston G, Payette M. Update on lichen planus and its clinical variants. Int J Womens Dermatol. 2015 Sep 16;1(3):140-149.
  • Gaertner E, Elstein W. Lichen planus pigmentosus-inversus: case report and review of an unusual entity. Dermatol Online J. 2012 Feb 15;18(2):11. PMID: 22398232.
  • Al-Mutairi N, El-Khalawany M. Clinicopathological characteristics of lichen planus pigmentosus and its response to tacrolimus ointment: an open label, non-randomized, prospective study. J Eur Acad Dermatol Venereol. 2010 May;24(5):535-40. doi: 10.1111/j.1468-3083.2009.03460.x. Epub 2009 Oct 15.
  • Friedman P, Sabban EC, Marcucci C, Peralta R, Cabo H. Dermoscopic findings in different clinical variants of lichen planus. Is dermoscopy useful? Dermatol Pract Concept. 2015 Oct 31;5(4):51-5. doi: 10.5826/dpc.0504a13. PMID: 26693092; PMCID: PMC4667604.
  • Chaima K, Fatma H, Nadine K, Chahir K, Emna B, Khadija S, Mariem A, Sonia B, Abderrahman M, Tahya B, Hamida T. Lichen planus pigmentosus post COVID-19-vaccination: A case report with literature review. Dermatol Ther. 2022 Dec;35(12):e15891. doi: 10.1111/dth.15891. Epub 2022 Oct 17. PMID: 36183151; PMCID: PMC9538344.
  • Sun L, Duarte S, Soares-de-Almeida L. Case of lichen planus pigmentosus-inversus after Oxford-AstraZeneca COVID-19 vaccine: cause or coincidence? J Eur Acad Dermatol Venereol. 2022 Jul;36(7):e514-e516. doi: 10.1111/jdv.18058. Epub 2022 Mar 16. PMID: 35278243.
  • Rai T, Bohara A, Jha PK. A case of lichen planus pigmentosus in blaschkoid pattern in a 10-year-old female. Clin Dermatol Rev. 2021;5(1):104-106.
  • Edek YC, Tamer F, Öğüt B. Lichen planus pigmentosus inversus with nail involvement following COVID-19 vaccination: A case report. Dermatol Ther. 2022 Nov;35(11):e15809.
  • Gil-Quiñones SR, Velandia JA, Velandia F, Barrera MY. Lichen Planus and Lichen Planus Pigmentosus Inversus Following COVID-19 Vaccine in Dark Phototype Patients. Actas Dermosifiliogr. 2024 Jun;115(6):609-611. doi: 10.1016/j.ad.2023.02.005. Epub 2023 Feb 25. PMID: 36842475; PMCID: PMC9957654.

The case of lichen planus pigmentosus inversus associated with SARS‐CoV‐2 vaccine (Sinovac): a rare entity

Year 2025, Volume: 14 Issue: 1, 28 - 31, 30.04.2025

Esranur Ünal , Saadet Nurşah Gedikli , Fatma Şenel , Muhammed Burak Yücel

https://doi.org/10.47493/abantmedj.1577105

Abstract

COVID-19 vaccines may cause the onset or exacerbation of inflammatory skin diseases. However, the relationship between COVID-19 vaccines and immune-mediated skin diseases is still not fully known. Lichen planus pigmentosus inversus is a rare variant of lichen planus and, unlike lichen planus pigmentosus, this form affects people with white skin. It occurs in intertriginous areas such as the groin and axillae and 90% of patients have axillary involvement. There are cases of lichen planus reported after COVID-19 vaccines, and this is the first case of lichen planus pigmentosus inversus after SARS‐CoV‐2 vaccine (Sinovac). Additional studies are needed to demonstrate this relationship.

Keywords

Covid -19 dermoscopy dermatoscopy lichen planus pigmentosus vaccine

References

  • Català A, Muñoz‐Santos C, Galván‐Casas C, et al. Cutaneous reactions after SARS‐CoV‐2 vaccination: a cross‐sectional Spanish nationwide study of 405 cases. Br J Dermatol. 2022;186(1):142‐152.
  • Weston G, Payette M. Update on lichen planus and its clinical variants. Int J Womens Dermatol. 2015 Sep 16;1(3):140-149.
  • Gaertner E, Elstein W. Lichen planus pigmentosus-inversus: case report and review of an unusual entity. Dermatol Online J. 2012 Feb 15;18(2):11. PMID: 22398232.
  • Al-Mutairi N, El-Khalawany M. Clinicopathological characteristics of lichen planus pigmentosus and its response to tacrolimus ointment: an open label, non-randomized, prospective study. J Eur Acad Dermatol Venereol. 2010 May;24(5):535-40. doi: 10.1111/j.1468-3083.2009.03460.x. Epub 2009 Oct 15.
  • Friedman P, Sabban EC, Marcucci C, Peralta R, Cabo H. Dermoscopic findings in different clinical variants of lichen planus. Is dermoscopy useful? Dermatol Pract Concept. 2015 Oct 31;5(4):51-5. doi: 10.5826/dpc.0504a13. PMID: 26693092; PMCID: PMC4667604.
  • Chaima K, Fatma H, Nadine K, Chahir K, Emna B, Khadija S, Mariem A, Sonia B, Abderrahman M, Tahya B, Hamida T. Lichen planus pigmentosus post COVID-19-vaccination: A case report with literature review. Dermatol Ther. 2022 Dec;35(12):e15891. doi: 10.1111/dth.15891. Epub 2022 Oct 17. PMID: 36183151; PMCID: PMC9538344.
  • Sun L, Duarte S, Soares-de-Almeida L. Case of lichen planus pigmentosus-inversus after Oxford-AstraZeneca COVID-19 vaccine: cause or coincidence? J Eur Acad Dermatol Venereol. 2022 Jul;36(7):e514-e516. doi: 10.1111/jdv.18058. Epub 2022 Mar 16. PMID: 35278243.
  • Rai T, Bohara A, Jha PK. A case of lichen planus pigmentosus in blaschkoid pattern in a 10-year-old female. Clin Dermatol Rev. 2021;5(1):104-106.
  • Edek YC, Tamer F, Öğüt B. Lichen planus pigmentosus inversus with nail involvement following COVID-19 vaccination: A case report. Dermatol Ther. 2022 Nov;35(11):e15809.
  • Gil-Quiñones SR, Velandia JA, Velandia F, Barrera MY. Lichen Planus and Lichen Planus Pigmentosus Inversus Following COVID-19 Vaccine in Dark Phototype Patients. Actas Dermosifiliogr. 2024 Jun;115(6):609-611. doi: 10.1016/j.ad.2023.02.005. Epub 2023 Feb 25. PMID: 36842475; PMCID: PMC9957654.
There are 10 citations in total.

Details

Primary Language English
Subjects Dermatology
Journal Section Case Report
Authors

Esranur Ünal 0000-0002-8309-6452

Saadet Nurşah Gedikli 0009-0007-6494-2194

Fatma Şenel 0000-0002-9865-0399

Muhammed Burak Yücel 0000-0003-0130-8229

Early Pub Date April 29, 2025
Publication Date April 30, 2025
Submission Date November 1, 2024
Acceptance Date April 19, 2025
Published in Issue Year 2025 Volume: 14 Issue: 1

Cite

APA Ünal, E., Gedikli, S. N., Şenel, F., Yücel, M. B. (2025). The case of lichen planus pigmentosus inversus associated with SARS‐CoV‐2 vaccine (Sinovac): a rare entity. Abant Medical Journal, 14(1), 28-31. https://doi.org/10.47493/abantmedj.1577105
AMA Ünal E, Gedikli SN, Şenel F, Yücel MB. The case of lichen planus pigmentosus inversus associated with SARS‐CoV‐2 vaccine (Sinovac): a rare entity. Abant Med J. April 2025;14(1):28-31. doi:10.47493/abantmedj.1577105
Chicago Ünal, Esranur, Saadet Nurşah Gedikli, Fatma Şenel, and Muhammed Burak Yücel. “The Case of Lichen Planus Pigmentosus Inversus Associated With SARS‐CoV‐2 Vaccine (Sinovac): A Rare Entity”. Abant Medical Journal 14, no. 1 (April 2025): 28-31. https://doi.org/10.47493/abantmedj.1577105.
EndNote Ünal E, Gedikli SN, Şenel F, Yücel MB (April 1, 2025) The case of lichen planus pigmentosus inversus associated with SARS‐CoV‐2 vaccine (Sinovac): a rare entity. Abant Medical Journal 14 1 28–31.
IEEE E. Ünal, S. N. Gedikli, F. Şenel, and M. B. Yücel, “The case of lichen planus pigmentosus inversus associated with SARS‐CoV‐2 vaccine (Sinovac): a rare entity”, Abant Med J, vol. 14, no. 1, pp. 28–31, 2025, doi: 10.47493/abantmedj.1577105.
ISNAD Ünal, Esranur et al. “The Case of Lichen Planus Pigmentosus Inversus Associated With SARS‐CoV‐2 Vaccine (Sinovac): A Rare Entity”. Abant Medical Journal 14/1 (April 2025), 28-31. https://doi.org/10.47493/abantmedj.1577105.
JAMA Ünal E, Gedikli SN, Şenel F, Yücel MB. The case of lichen planus pigmentosus inversus associated with SARS‐CoV‐2 vaccine (Sinovac): a rare entity. Abant Med J. 2025;14:28–31.
MLA Ünal, Esranur et al. “The Case of Lichen Planus Pigmentosus Inversus Associated With SARS‐CoV‐2 Vaccine (Sinovac): A Rare Entity”. Abant Medical Journal, vol. 14, no. 1, 2025, pp. 28-31, doi:10.47493/abantmedj.1577105.
Vancouver Ünal E, Gedikli SN, Şenel F, Yücel MB. The case of lichen planus pigmentosus inversus associated with SARS‐CoV‐2 vaccine (Sinovac): a rare entity. Abant Med J. 2025;14(1):28-31.
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