Research Article
Year 2025,
Volume: 14 Issue: 1, 19 - 27, 30.04.2025
Abstract
References
- Newton JR, Ah-See KW. A review of nasal polyposis. Therapeutics and clinical risk management. 2008;4(2):507. DOI: 10.2147/tcrm.s2379
- Lee SH, Kim WS, Lee SH, et al. Expression and distribution of thioredoxin and thioredoxin reductase in human nasal mucosa and nasal polyp. Acta oto-laryngologica. 2005;125(8):877-82.doi: 10.1080/00016480510029293.
- Jeanson L, Kelly M, Coste A, Guerrera I, Fritsch J, Nguyen‐Khoa T, et al. Oxidative stress induces unfolding protein response and inflammation in nasal polyposis. Allergy. 2012;67(3):403-12.doi: 10.1111/j.1398-9995.2011.02769.x
- Halliwell B. Biochemistry of oxidative stress. Biochemical society transactions. 2007;35(5):1147-50.DOI: 10.1042/BST0351147
- Erel O, Neselioglu S. A novel and automated assay for thiol/disulphide homeostasis. Clinical biochemistry. 2014;47(18):326-32.doi: 10.1016/j.clinbiochem.2014.09.026.
- Turell L, Radi R, Alvarez B. The thiol pool in human plasma: the central contribution of albumin to redox processes. Free Radical Biology and Medicine. 2013;65:244-53.doi: 10.1016/j.freeradbiomed.2013.05.050.
- Garça MF, Turan M, Avşar B, et al. The evaluation of oxidative stress in the serum and tissue specimens of patients with chronic otitis media. Clinical and experimental otorhinolaryngology. 2015;8(2):97-101.doi: 10.3342/ceo.2015.8.2.97.
- CALIRI, Andrew W.; TOMMASI, Stella; BESARATINIA, Ahmad. Relationships among smoking, oxidative stress, inflammation, macromolecular damage, and cancer. Mutation Research/Reviews in Mutation Research, 2021, 787: 108365.
- Addissouky, T.A., El Sayed, I.E.T., Ali, M.M.A. et al. Oxidative stress and inflammation: elucidating mechanisms of smoking-attributable pathology for therapeutic targeting. Bull Natl Res Cent 48, 16 (2024). https://doi.org/10.1186/s42269-024-01174-6
- Dagli M, Eryilmaz A, Besler T,et al. Role of free radicals and antioxidants in nasal polyps. Laryngoscope. 2004;114(7):1200-3.doi: 10.1097/00005537-200407000-00013.
- Bozkus F, San I, Ulas T, et al. Evaluation of total oxidative stress parameters in patients with nasal polyps. Acta Otorhinolaryngologica Italica. 2013;33(4):248. PMCID: PMC3773957
- Bozdemir K, Sezgin A, Akkoz A, et al. Thiol-disulphide homeostasis in chronic sinusitis without polyposis. The Turkish Journal of Ear Nose and Throat. 2018;28(2):66-70. Doi: http://dx.doi.org/10.5606/Tr-ENT.2018.04453
- Sevil E, Gul F, Oguzhan T, et al. Dynamic thiol-disulfide balance in patients with chronic sinusitis with and without nasal polyposis. 2020. DOI: 10.5455/annalsmedres.2020.04.313
- Görgülü O, Ozdemir S, Canbolat EP, et al. Analysis of the roles of smoking and allergy in nasal polyposis. Ann Otol Rhinol Laryngol. 2012;121(9):615-9. DOI: 10.1177/000348941212100909
- Solak I, Cetinkaya CD, Gederet YT, et al. Effects of smoking on thiol/disulfide homeostasis. Eur Rev Med Pharmacol Sci. 2018;22(8):2477-82 DOI: 10.26355/eurrev_201804_14842
Dynamic Thiol / Disulfide Homeostasis In Patients With Nasal Polyps And The Effects Of Smoking On Homeostasis Parameters
Abstract
Abstract
Objective: The study aimed to determine the dynamic thiol/disulfide homeostasis for measuring oxidative stress and the impacts of smoking on these parameters in nasal polyps (NP) patients.
Materials and methods: A total of forty NP patients and 36 healthy volunteers participated in the current study. Participants were categorized into two groups: 20 smokers and 20 non-smokers. Erel and Neşelioğlu developed an automated method to analyze thiol-disulfide homeostasis parameters in samples of serum from the participants. Groups were compared. Each parameter related to thiol/disulfide homeostasis—native thiol (SH), total thiol (ToSH), disulfide (SS), SS/SH (%), SH/ToSH (%), and SS/ToSH (%)—was evaluated separately.
Results: There were notable differences across the groups relating markers associated with thiol-disulfide balance. Total Thiol (ToSH) µmol/L (p=0.005), Native Thiol (SH) µmol/L (p=0.001), and SH/ToSH (%) levels were lower in patients with nasal polyps than the control group, and disulfide (SS) (p=0.001), SS/NT (%) (p=0.001), and SS/ToSH (%) levels were statistically significantly higher than the control group (p=0.001).
Conclusion: In NP patients, thiol/disulfide homeostasis shifts towards disulfide formation because of native thiol oxidation. Also, parameters of Thiol/disulfide homeostasis can serve as new oxidative stress markers in nasal polyps.
References
- Newton JR, Ah-See KW. A review of nasal polyposis. Therapeutics and clinical risk management. 2008;4(2):507. DOI: 10.2147/tcrm.s2379
- Lee SH, Kim WS, Lee SH, et al. Expression and distribution of thioredoxin and thioredoxin reductase in human nasal mucosa and nasal polyp. Acta oto-laryngologica. 2005;125(8):877-82.doi: 10.1080/00016480510029293.
- Jeanson L, Kelly M, Coste A, Guerrera I, Fritsch J, Nguyen‐Khoa T, et al. Oxidative stress induces unfolding protein response and inflammation in nasal polyposis. Allergy. 2012;67(3):403-12.doi: 10.1111/j.1398-9995.2011.02769.x
- Halliwell B. Biochemistry of oxidative stress. Biochemical society transactions. 2007;35(5):1147-50.DOI: 10.1042/BST0351147
- Erel O, Neselioglu S. A novel and automated assay for thiol/disulphide homeostasis. Clinical biochemistry. 2014;47(18):326-32.doi: 10.1016/j.clinbiochem.2014.09.026.
- Turell L, Radi R, Alvarez B. The thiol pool in human plasma: the central contribution of albumin to redox processes. Free Radical Biology and Medicine. 2013;65:244-53.doi: 10.1016/j.freeradbiomed.2013.05.050.
- Garça MF, Turan M, Avşar B, et al. The evaluation of oxidative stress in the serum and tissue specimens of patients with chronic otitis media. Clinical and experimental otorhinolaryngology. 2015;8(2):97-101.doi: 10.3342/ceo.2015.8.2.97.
- CALIRI, Andrew W.; TOMMASI, Stella; BESARATINIA, Ahmad. Relationships among smoking, oxidative stress, inflammation, macromolecular damage, and cancer. Mutation Research/Reviews in Mutation Research, 2021, 787: 108365.
- Addissouky, T.A., El Sayed, I.E.T., Ali, M.M.A. et al. Oxidative stress and inflammation: elucidating mechanisms of smoking-attributable pathology for therapeutic targeting. Bull Natl Res Cent 48, 16 (2024). https://doi.org/10.1186/s42269-024-01174-6
- Dagli M, Eryilmaz A, Besler T,et al. Role of free radicals and antioxidants in nasal polyps. Laryngoscope. 2004;114(7):1200-3.doi: 10.1097/00005537-200407000-00013.
- Bozkus F, San I, Ulas T, et al. Evaluation of total oxidative stress parameters in patients with nasal polyps. Acta Otorhinolaryngologica Italica. 2013;33(4):248. PMCID: PMC3773957
- Bozdemir K, Sezgin A, Akkoz A, et al. Thiol-disulphide homeostasis in chronic sinusitis without polyposis. The Turkish Journal of Ear Nose and Throat. 2018;28(2):66-70. Doi: http://dx.doi.org/10.5606/Tr-ENT.2018.04453
- Sevil E, Gul F, Oguzhan T, et al. Dynamic thiol-disulfide balance in patients with chronic sinusitis with and without nasal polyposis. 2020. DOI: 10.5455/annalsmedres.2020.04.313
- Görgülü O, Ozdemir S, Canbolat EP, et al. Analysis of the roles of smoking and allergy in nasal polyposis. Ann Otol Rhinol Laryngol. 2012;121(9):615-9. DOI: 10.1177/000348941212100909
- Solak I, Cetinkaya CD, Gederet YT, et al. Effects of smoking on thiol/disulfide homeostasis. Eur Rev Med Pharmacol Sci. 2018;22(8):2477-82 DOI: 10.26355/eurrev_201804_14842
There are 15 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Otorhinolaryngology |
| Journal Section | Research Article |
| Authors | |
| Early Pub Date | April 29, 2025 |
| Publication Date | April 30, 2025 |
| Submission Date | December 2, 2024 |
| Acceptance Date | April 13, 2025 |
| Published in Issue | Year 2025 Volume: 14 Issue: 1 |
