Clinical Research
Relationship between Erectile Dysfunction and Asymmetric Dimethyl Arginine Levels in Patients with End-Stage Renal Disease
Abstract
Introduction: Asymmetric dimethylarginine is a major inhibitor of nitric oxide synthesis. Erectile dysfunction and chronic kidney disease (CKD) are associated with elevated levels of asymmetric dimethylarginine. This study aimed to examine the effects of ADMA on erectile dysfunction in patients undergoing peritoneal hemodialysis.
Methods: A total of 32 peritoneal, 32 hemodialysis patients, and 32 healthy male volunteers were included in the study. Serum asymmetric dimethylarginine levels were measured, and clinical and laboratory parameters were analyzed. The International Index of Erectile Function-5 was used to evaluate sexual function and the Pittsburgh Sleep Quality Index was used to evaluate sleep quality. Depressive symptoms were assessed using the Beck Depression Inventory Scale.
Results: Asymmetric dimethylarginine levels differed significantly among the three groups (p<0.001). It was higher in patients undergoing hemodialysis than in those undergoing peritoneal dialysis (p <0.002). Erectile dysfunction was detected more frequently in the patient group than in the control group (p<0.001). However, correlation analysis revealed no significant relationship between asymmetric dimethylarginine levels and erectile dysfunction scores. There was a negative correlation between the erectile dysfunction score, sleep quality, and depression scale scores. Asymmetric dimethylarginine showed a significant positive correlation with treatment duration, phosphorus, calcium-phosphorous product, and parathormone. A negative correlation was observed between albumin, cholesterol, low-density lipoprotein (LDL), residual urine, and asymmetric dimethylarginine levels. Residual urine amount in the correlation analysis showed a negative correlation with asymmetric dimethylarginine, phosphorus, and calcium-phosphorus products, and a positive correlation with total cholesterol and low-density lipoprotein.
Keywords
References
- Bode-Böger SM, Scalera F, Ignarro LJ. The l-arginine paradox: Importance of the l-arginine/asymmetrical dimethylarginine ratio. Pharmacol Ther. 2007 Jun;114(3):295–306. doi: 10.1016/j.pharmthera.2007.03.002
- Vallance P, Leiper J. Cardiovascular biology of the asymmetric dimethylarginine:dimethylarginine dimethylaminohydrolase pathway. Arterioscler Thromb Vasc Biol. 2004 Jun;24(6):1023–30. doi: 10.1161/01.ATV.0000128897.54893.26
- Au AYM, Mantik K, Bahadory F, Stathakis P, Guiney H, Erlich J, et al. Plasma arginine metabolites in health and chronic kidney disease. Nephrol Dial Transplant. 2023 Dec;38(12):2767–75. doi: 10.1093/ndt/gfad108
- Ravani P, Tripepi G, Malberti F, Testa S, Mallamaci F, Zoccali C. Asymmetrical dimethylarginine predicts progression to dialysis and death in patients with chronic kidney disease: a competing risks modeling approach. J Am Soc Nephrol. 2005;16(8):2449–55. doi: 10.1681/ASN.2005010076
- Zoccali C, Bode-Böger SM, Mallamaci F, Benedetto FA, Tripepi G, Malatino LS, et al. Plasma concentration of asymmetrical dimethylarginine and mortality in patients with end-stage renal disease: A prospective study. Lancet. 2001 Dec;358(9299):2113–7. doi: 10.1016/s0140-6736(01)07217-8
- Bima C, Parasiliti-Caprino M, Rumbolo F, Ponzetto F, Gesmundo I, Nonnato A, et al. Asymmetric and symmetric dimethylarginine as markers of endothelial dysfunction in cerebrovascular disease: A prospective study. Nutrition, Metabolism and Cardiovascular Diseases. 2024 Jul;34(7):1639–48. doi: 10.1016/j.numecd.2024.03.015.
- Wieczór R, Wieczór AM, Kulwas A, Rość D. ADMA (asymmetric dimethylarginine) and angiogenic potential in patients with type 2 diabetes and prediabetes. Exp Biol Med. 2021 Jan;246(2):153. doi: 10.1177/1535370220959738.
- Gkaliagkousi E, Gavriilaki E, Triantafyllou A, Nikolaidou B, Anyfanti P, Koletsos N, et al. Asymmetric dimethylarginine levels are associated with augmentation index across naïve untreated patients with different hypertension phenotypes. The Journal of Clinical Hypertension. 2018 Apr;20(4):680. doi: 10.1111/jch.13237.
- Braekke K, Ueland PM, Harsem NK, Staff AC. Asymmetric Dimethylarginine in the Maternal and Fetal Circulation in Preeclampsia. Pediatric Research 2009 66:4. 2009;66(4):411–5. doi:10.1203/PDR.0b013e3181b33392.
- Zakrzewicz, Dariusz. Asymmetric dimethylarginine metabolism and its involvement in the pathogenesis of pulmonary arterial hypertension ( PhD Thesis). Poznan, Poland: Faculties of Veterinary Medicine and Medicine of the Justus Liebig University Giessen; 2008.
- Schrauben SJ, Sapa H, Xie D, Zhang X, Anderson AH, Shlipak MG, et al. Association of urine and plasma ADMA with atherosclerotic risk in DKD cardiovascular disease risk in diabetic kidney disease: findings from the Chronic Renal Insufficiency Cohort (CRIC) study. Nephrol Dial Transplant. 2023 Dec;38(12):2809–15. doi: 10.1093/ndt/gfad103.
- Vîlcea A, Borta SM, Popețiu RO, Alexandra RL, Pilat L, Nica DV, et al. High ADMA Is Associated with Worse Health Profile in Heart Failure Patients Hospitalized for Episodes of Acute Decompensation. Medicina 2024, Vol 60, Page 813. 2024 May;60(5):813. doi: 10.3390/medicina60050813.
- Arlt S, Schulze F, Eichenlaub M, Maas R, Wiedemann K, Böger R, et al. Asymmetrical dimethylarginine is increased in plasma and decreased in cerebrospinal fluid of patients with Alzheimer’s disease. Pharmacopsychiatry. 2009 Sep;42(05):A3. doi:10.1159/000144026.
- Shafi T, Hostetter TH, Meyer TW, Hwang S, Hai X, Melamed ML, et al. Serum Asymmetric and Symmetric Dimethylarginine and Morbidity and Mortality in Hemodialysis Patients. Am J Kidney Dis. 2017 Jul;70(1):48–58. doi: 10.1053/j.ajkd.2016.10.033.
- Shafi T, Hostetter TH, Meyer TW, Hwang S, Hai X, Melamed ML, et al. Serum Asymmetric and Symmetric Dimethylarginine and Morbidity and Mortality in Hemodialysis Patients. Am J Kidney Dis. 2017 Jul;70(1):48–58. doi: 10.1053/j.ajkd.2016.10.033.
- Navaneethan SD, Vecchio M, Johnson DW, Saglimbene V, Graziano G, Pellegrini F, et al. Prevalence and correlates of self-reported sexual dysfunction in CKD: A meta-analysis of observational studies. American Journal of Kidney Diseases. 2010 Oct;56(4):670–85. doi: 10.1053/j.ajkd.2010.06.016.
- Moriyama T. Sexual dysfunction in chronic renal failure. J Mens Health. 2011 Apr;8(SUPPL. 1):S29–32. doi: 10.1016/S1875-6867(11)60016-X.
- Zhang DL, Liu J, Liu S, Zhang Y, Liu WH. The differences of asymmetric dimethylarginine removal by different dialysis treatments. Ren Fail. 2010 Sep;32(8):935–40. doi: 10. 3109/0886022X.2010.502281.
- Shafi T, Hostetter TH, Meyer TW, Hwang S, Hai X, Melamed ML, et al. Serum Asymmetric and Symmetric Dimethylarginine and Morbidity and Mortality in Hemodialysis Patients. Am J Kidney Dis. 2017 Jul;70(1):48–58. doi: 10.1053/j.ajkd.2016.10.033.
- Paroni R, Barassi A, Ciociola F, Dozio E, Finati E, Fermo I, et al. Asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA) and L-arginine in patients with arteriogenic and non-arteriogenic erectile dysfunction. Int J Androl. 2012 Oct;35(5):660–7. doi: 10 .1111/j.1365-2605.2012.01272.x.
- Yang G, Muzepper M. Platelet indices and erectile dysfunction: A systematic review and meta‐analysis. Andrologia, 2019, 51.5: e13248. doi: 10.1111/and13248
- Peng J, An J., Chen Y, Zhou J, Xiang B. The associations among platelet count, mean platelet volume, and erectile dysfunction: an observational and Mendelian randomization study. Sexual Medicine, 2024, 12.6: qfae093. doi: 10.1093/sexmed/qfae093
- Tangal S, Ozayar A., Ener K., Gokçe MI, Haliloglu AH.. Does mean platelet volume (MPV) have a role in evaluation of erectile dysfunction and its severity? Revista Internacional de Andrología, 2020, 18.1: 1-6. doi: 10.1016/j.androl.2018.07.007
- Culha MG, Atalay HA, Canat HL, Alkan I,Ozbir S, Can O, et al. The relationship between erectile dysfunction severity, mean platelet volume and vitamin D levels. The Aging Male, 2020. doi: 10.1080/13685538.2018.1459544
- Arslan D, Aslan G, Sifil A, Çavdar C, Çelebi I, Gamsari T, et al. Sexual dysfunction in male patients on hemodialysis: Assessment with the International Index of Erectile Function (IIEF). Int J Impot Res. 2002 Dec;14(6):539–42. doi: 10.1038/sj.ijir.3900937.
- Costa MR, Reis AMB, Pereira BP, Ponciano VC, Oliveira EC de. Associated factors and prevalence of erectile dysfunction in hemodialysis patients. International braz j urol. 2014 Jan;40(1):44–55. doi: 10. 1590/S1677-5538.IBJU.2014.01.07.
- Mesquita JFP, Ramos TF, Mesquita FP, Netto JMB, Bastos MG, de Figueiredo AA. Prevalence of erectile dysfunction in chronic renal disease patients on conservative treatment. Clinics. 2012;67(2):181. doi: 10. 6061/clinics/2012(02)15.
- Papadopoulou E, Varouktsi A, Lazaridis A, Boutari C, Doumas M. Erectile dysfunction in chronic kidney disease: From pathophysiology to management. World J Nephrol. 2015;4(3):379. doi: 10. 5527/wjn.v4.i3.379.
- Alipoor E, Salehi S, Dehghani S, Yaseri M, Hosseinzadeh-Attar MJ. Asymmetric dimethylarginine serum concentration in normal weight and obese CKD patients treated with hemodialysis. BMC Nephrol. 2024 Dec;25(1):1–7. doi: 10.1186/s12882-024-03736-2.
- Lowrie EG, Lew NL. Death risk in hemodialysis patients: the predictive value of commonly measured variables and an evaluation of death rate differences between facilities. Am J Kidney Dis. 1990;15(5):458–82. doi: 10.1016/s0272-6386(12)70364-5.
- Kielstein JT, Bode-Böger SM, Frölich JC, Ritz E, Haller H, Fliser D. Asymmetric dimethylarginine, blood pressure, and renal perfusion in elderly subjects. Circulation. 2003 Apr;107(14):1891–5. doi: 10.1161/01.CIR.0000060496.23144.A7.
- Nanayakkara PWB, Teerlink T, Stehouwer CDA, Allajar D, Spijkerman A, Schalkwijk C, et al. Plasma asymmetric dimethylarginine (ADMA) concentration is independently associated with carotid intima-media thickness and plasma soluble vascular cell adhesion molecule-1 (sVCAM-1) concentration in patients with mild-to-moderate renal failure. Kidney Int. 2005 Nov;68(5):2230–6. doi: 10.1111/j.1523-1755.2005.00680.x.
- Iseki K, Yamazato M, Tozawa M, Takishita S. Hypocholesterolemia is a significant predictor of death in a cohort of chronic hemodialysis patients. Kidney Int. 2002;61(5):1887–93. doi: 10.1046/j.1523-1755.2002.00324.x.
- Oliva-Damaso E, Oliva-Damaso N, Rodriguez-Esparragon F, Payan J, Marañes A, Parodis Y, et al. Asymmetric Dimethylarginine (ADMA) Levels Are Lower in Hemodialysis Patients Treated With Paricalcitol. Kidney Int Rep. 2016;2(2):165. doi: 10.1016/j.ekir.2016.10.002.
- Gohda T, Shou I, Fukui M, Funabiki K, Horikoshi S, Shirato I, et al. Parathyroid hormone gene polymorphism and secondary hyperparathyroidism in hemodialysis patients. American Journal of Kidney Diseases. 2002;39(6):1255–60. doi: 10.1053/ajkd.2002.33399.
- Perl J, Bargman JM. The importance of residual kidney function for patients on dialysis: a critical review. Am J Kidney Dis. 2009 Jun;53(6):1068–81. doi: 10.1053/j.ajkd.2009.02.012.
- Okazaki M, Obi Y, Shafi T, Rhee CM, Kovesdy CP, Kalantar-Zadeh K. Residual Kidney Function and Cause-Specific Mortality Among Incident Hemodialysis Patients. Kidney Int Rep. 2023 Oct;8(10):1989–2000. doi: 10.1016/j.ekir.2023.07.020.
- Shafi T, Jaar BG, Plantinga LC, Fink NE, Sadler JH, Parekh RS, et al. Association of residual urine output with mortality, quality of life, and inflammation in incident hemodialysis patients: the Choices for Healthy Outcomes in Caring for End-Stage Renal Disease (CHOICE) Study. Am J Kidney Dis. 2010;56(2):348–58. doi: 0.1053/j.ajkd.2010.03.020.
- Suda T, Hiroshige K, Ohta T, Watanabe Y, Iwamoto M, Kanegae K, et al. The contribution of residual renal function to overall nutritional status in chronic haemodialysis patients. Nephrol Dial Transplant. 2000;15(3):396–401. doi: 10.1093/ndt/15.3.396.
- Merkus MP, Jager KJ, Dekker FW, Boeschoten EW, Stevens P, Krediet RT, et al. Quality of life in patients on chronic dialysis: self-assessment 3 months after the start of treatment. The Necosad Study Group. Am J Kidney Dis. 1997;29(4):584–92. doi: 0.1016/s0272-6386(97)90342-5.
Son Dönem Böbrek Hastalığı Olan Hastalarda Erektil Disfonksiyon ve Asimetrik Dimetil Arginin Düzeyleri Arasındaki İlişki
Abstract
Giriş: Asimetrik dimetilarginin, nitrik oksit sentezinin majör inhibitörüdür. Erektil disfonksiyon ve kronik böbrek hastalığı (KBH), yüksek asimetrik dimetilarginin seviyeleriyle ilişkili bulunmuştur. Bu çalışma, ADMA'nın peritoneal hemodiyaliz geçiren hastalarda erektil disfonksiyon üzerindeki etkilerini incelemeyi amaçlamıştır.
Yöntemler: Çalışmaya toplam 32 peritoneal, 32 hemodiyaliz hastası ve 32 sağlıklı erkek gönüllü dahil edildi. Serum asimetrik dimetilarginin seviyeleri ölçüldü ve klinik ve laboratuvar parametreleri analiz edildi. Cinsel fonksiyonu değerlendirmek için Uluslararası Erektil Fonksiyon İndeksi-5 ve uyku kalitesini değerlendirmek için Pittsburgh Uyku Kalitesi İndeksi kullanıldı. Depresif semptomlar Beck Depresyon Envanteri Ölçeği kullanılarak değerlendirildi.
Sonuçlar: Asimetrik dimetilarginin seviyeleri üç grup arasında önemli ölçüde farklılık gösterdi (p<0,001). Hemodiyalize giren hastalarda peritoneal diyalizi yapanlara göre daha yüksekti (p <0,002). Hasta grubunda erektil disfonksiyon kontrol grubuna göre daha sık tespit edildi (p<0,001). Ancak korelasyon analizi asimetrik dimetilarginin düzeyleri ile erektil disfonksiyon skorları arasında anlamlı bir ilişki olmadığını ortaya koydu. Erektil disfonksiyon skoru, uyku kalitesi ve depresyon ölçeği skorları arasında negatif korelasyon gösterdi. Asimetrik dimetilarginin tedavi süresi, fosfor, kalsiyum-fosfor ürünü ve parathormon ile anlamlı pozitif korelasyon gösterdi. Albümin, kolesterol, düşük yoğunluklu lipoprotein (LDL), rezidüel idrar ve asimetrik dimetilarginin düzeyleri arasında negatif korelasyon gözlendi. Korelasyon analizindeki rezidüel idrar miktarı asimetrik dimetilarginin, fosfor ve kalsiyum-fosfor ürünleri ile negatif korelasyon, toplam kolesterol ve düşük yoğunluklu lipoprotein ile pozitif korelasyon gösterdi.
Keywords
References
- Bode-Böger SM, Scalera F, Ignarro LJ. The l-arginine paradox: Importance of the l-arginine/asymmetrical dimethylarginine ratio. Pharmacol Ther. 2007 Jun;114(3):295–306. doi: 10.1016/j.pharmthera.2007.03.002
- Vallance P, Leiper J. Cardiovascular biology of the asymmetric dimethylarginine:dimethylarginine dimethylaminohydrolase pathway. Arterioscler Thromb Vasc Biol. 2004 Jun;24(6):1023–30. doi: 10.1161/01.ATV.0000128897.54893.26
- Au AYM, Mantik K, Bahadory F, Stathakis P, Guiney H, Erlich J, et al. Plasma arginine metabolites in health and chronic kidney disease. Nephrol Dial Transplant. 2023 Dec;38(12):2767–75. doi: 10.1093/ndt/gfad108
- Ravani P, Tripepi G, Malberti F, Testa S, Mallamaci F, Zoccali C. Asymmetrical dimethylarginine predicts progression to dialysis and death in patients with chronic kidney disease: a competing risks modeling approach. J Am Soc Nephrol. 2005;16(8):2449–55. doi: 10.1681/ASN.2005010076
- Zoccali C, Bode-Böger SM, Mallamaci F, Benedetto FA, Tripepi G, Malatino LS, et al. Plasma concentration of asymmetrical dimethylarginine and mortality in patients with end-stage renal disease: A prospective study. Lancet. 2001 Dec;358(9299):2113–7. doi: 10.1016/s0140-6736(01)07217-8
- Bima C, Parasiliti-Caprino M, Rumbolo F, Ponzetto F, Gesmundo I, Nonnato A, et al. Asymmetric and symmetric dimethylarginine as markers of endothelial dysfunction in cerebrovascular disease: A prospective study. Nutrition, Metabolism and Cardiovascular Diseases. 2024 Jul;34(7):1639–48. doi: 10.1016/j.numecd.2024.03.015.
- Wieczór R, Wieczór AM, Kulwas A, Rość D. ADMA (asymmetric dimethylarginine) and angiogenic potential in patients with type 2 diabetes and prediabetes. Exp Biol Med. 2021 Jan;246(2):153. doi: 10.1177/1535370220959738.
- Gkaliagkousi E, Gavriilaki E, Triantafyllou A, Nikolaidou B, Anyfanti P, Koletsos N, et al. Asymmetric dimethylarginine levels are associated with augmentation index across naïve untreated patients with different hypertension phenotypes. The Journal of Clinical Hypertension. 2018 Apr;20(4):680. doi: 10.1111/jch.13237.
- Braekke K, Ueland PM, Harsem NK, Staff AC. Asymmetric Dimethylarginine in the Maternal and Fetal Circulation in Preeclampsia. Pediatric Research 2009 66:4. 2009;66(4):411–5. doi:10.1203/PDR.0b013e3181b33392.
- Zakrzewicz, Dariusz. Asymmetric dimethylarginine metabolism and its involvement in the pathogenesis of pulmonary arterial hypertension ( PhD Thesis). Poznan, Poland: Faculties of Veterinary Medicine and Medicine of the Justus Liebig University Giessen; 2008.
- Schrauben SJ, Sapa H, Xie D, Zhang X, Anderson AH, Shlipak MG, et al. Association of urine and plasma ADMA with atherosclerotic risk in DKD cardiovascular disease risk in diabetic kidney disease: findings from the Chronic Renal Insufficiency Cohort (CRIC) study. Nephrol Dial Transplant. 2023 Dec;38(12):2809–15. doi: 10.1093/ndt/gfad103.
- Vîlcea A, Borta SM, Popețiu RO, Alexandra RL, Pilat L, Nica DV, et al. High ADMA Is Associated with Worse Health Profile in Heart Failure Patients Hospitalized for Episodes of Acute Decompensation. Medicina 2024, Vol 60, Page 813. 2024 May;60(5):813. doi: 10.3390/medicina60050813.
- Arlt S, Schulze F, Eichenlaub M, Maas R, Wiedemann K, Böger R, et al. Asymmetrical dimethylarginine is increased in plasma and decreased in cerebrospinal fluid of patients with Alzheimer’s disease. Pharmacopsychiatry. 2009 Sep;42(05):A3. doi:10.1159/000144026.
- Shafi T, Hostetter TH, Meyer TW, Hwang S, Hai X, Melamed ML, et al. Serum Asymmetric and Symmetric Dimethylarginine and Morbidity and Mortality in Hemodialysis Patients. Am J Kidney Dis. 2017 Jul;70(1):48–58. doi: 10.1053/j.ajkd.2016.10.033.
- Shafi T, Hostetter TH, Meyer TW, Hwang S, Hai X, Melamed ML, et al. Serum Asymmetric and Symmetric Dimethylarginine and Morbidity and Mortality in Hemodialysis Patients. Am J Kidney Dis. 2017 Jul;70(1):48–58. doi: 10.1053/j.ajkd.2016.10.033.
- Navaneethan SD, Vecchio M, Johnson DW, Saglimbene V, Graziano G, Pellegrini F, et al. Prevalence and correlates of self-reported sexual dysfunction in CKD: A meta-analysis of observational studies. American Journal of Kidney Diseases. 2010 Oct;56(4):670–85. doi: 10.1053/j.ajkd.2010.06.016.
- Moriyama T. Sexual dysfunction in chronic renal failure. J Mens Health. 2011 Apr;8(SUPPL. 1):S29–32. doi: 10.1016/S1875-6867(11)60016-X.
- Zhang DL, Liu J, Liu S, Zhang Y, Liu WH. The differences of asymmetric dimethylarginine removal by different dialysis treatments. Ren Fail. 2010 Sep;32(8):935–40. doi: 10. 3109/0886022X.2010.502281.
- Shafi T, Hostetter TH, Meyer TW, Hwang S, Hai X, Melamed ML, et al. Serum Asymmetric and Symmetric Dimethylarginine and Morbidity and Mortality in Hemodialysis Patients. Am J Kidney Dis. 2017 Jul;70(1):48–58. doi: 10.1053/j.ajkd.2016.10.033.
- Paroni R, Barassi A, Ciociola F, Dozio E, Finati E, Fermo I, et al. Asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA) and L-arginine in patients with arteriogenic and non-arteriogenic erectile dysfunction. Int J Androl. 2012 Oct;35(5):660–7. doi: 10 .1111/j.1365-2605.2012.01272.x.
- Yang G, Muzepper M. Platelet indices and erectile dysfunction: A systematic review and meta‐analysis. Andrologia, 2019, 51.5: e13248. doi: 10.1111/and13248
- Peng J, An J., Chen Y, Zhou J, Xiang B. The associations among platelet count, mean platelet volume, and erectile dysfunction: an observational and Mendelian randomization study. Sexual Medicine, 2024, 12.6: qfae093. doi: 10.1093/sexmed/qfae093
- Tangal S, Ozayar A., Ener K., Gokçe MI, Haliloglu AH.. Does mean platelet volume (MPV) have a role in evaluation of erectile dysfunction and its severity? Revista Internacional de Andrología, 2020, 18.1: 1-6. doi: 10.1016/j.androl.2018.07.007
- Culha MG, Atalay HA, Canat HL, Alkan I,Ozbir S, Can O, et al. The relationship between erectile dysfunction severity, mean platelet volume and vitamin D levels. The Aging Male, 2020. doi: 10.1080/13685538.2018.1459544
- Arslan D, Aslan G, Sifil A, Çavdar C, Çelebi I, Gamsari T, et al. Sexual dysfunction in male patients on hemodialysis: Assessment with the International Index of Erectile Function (IIEF). Int J Impot Res. 2002 Dec;14(6):539–42. doi: 10.1038/sj.ijir.3900937.
- Costa MR, Reis AMB, Pereira BP, Ponciano VC, Oliveira EC de. Associated factors and prevalence of erectile dysfunction in hemodialysis patients. International braz j urol. 2014 Jan;40(1):44–55. doi: 10. 1590/S1677-5538.IBJU.2014.01.07.
- Mesquita JFP, Ramos TF, Mesquita FP, Netto JMB, Bastos MG, de Figueiredo AA. Prevalence of erectile dysfunction in chronic renal disease patients on conservative treatment. Clinics. 2012;67(2):181. doi: 10. 6061/clinics/2012(02)15.
- Papadopoulou E, Varouktsi A, Lazaridis A, Boutari C, Doumas M. Erectile dysfunction in chronic kidney disease: From pathophysiology to management. World J Nephrol. 2015;4(3):379. doi: 10. 5527/wjn.v4.i3.379.
- Alipoor E, Salehi S, Dehghani S, Yaseri M, Hosseinzadeh-Attar MJ. Asymmetric dimethylarginine serum concentration in normal weight and obese CKD patients treated with hemodialysis. BMC Nephrol. 2024 Dec;25(1):1–7. doi: 10.1186/s12882-024-03736-2.
- Lowrie EG, Lew NL. Death risk in hemodialysis patients: the predictive value of commonly measured variables and an evaluation of death rate differences between facilities. Am J Kidney Dis. 1990;15(5):458–82. doi: 10.1016/s0272-6386(12)70364-5.
- Kielstein JT, Bode-Böger SM, Frölich JC, Ritz E, Haller H, Fliser D. Asymmetric dimethylarginine, blood pressure, and renal perfusion in elderly subjects. Circulation. 2003 Apr;107(14):1891–5. doi: 10.1161/01.CIR.0000060496.23144.A7.
- Nanayakkara PWB, Teerlink T, Stehouwer CDA, Allajar D, Spijkerman A, Schalkwijk C, et al. Plasma asymmetric dimethylarginine (ADMA) concentration is independently associated with carotid intima-media thickness and plasma soluble vascular cell adhesion molecule-1 (sVCAM-1) concentration in patients with mild-to-moderate renal failure. Kidney Int. 2005 Nov;68(5):2230–6. doi: 10.1111/j.1523-1755.2005.00680.x.
- Iseki K, Yamazato M, Tozawa M, Takishita S. Hypocholesterolemia is a significant predictor of death in a cohort of chronic hemodialysis patients. Kidney Int. 2002;61(5):1887–93. doi: 10.1046/j.1523-1755.2002.00324.x.
- Oliva-Damaso E, Oliva-Damaso N, Rodriguez-Esparragon F, Payan J, Marañes A, Parodis Y, et al. Asymmetric Dimethylarginine (ADMA) Levels Are Lower in Hemodialysis Patients Treated With Paricalcitol. Kidney Int Rep. 2016;2(2):165. doi: 10.1016/j.ekir.2016.10.002.
- Gohda T, Shou I, Fukui M, Funabiki K, Horikoshi S, Shirato I, et al. Parathyroid hormone gene polymorphism and secondary hyperparathyroidism in hemodialysis patients. American Journal of Kidney Diseases. 2002;39(6):1255–60. doi: 10.1053/ajkd.2002.33399.
- Perl J, Bargman JM. The importance of residual kidney function for patients on dialysis: a critical review. Am J Kidney Dis. 2009 Jun;53(6):1068–81. doi: 10.1053/j.ajkd.2009.02.012.
- Okazaki M, Obi Y, Shafi T, Rhee CM, Kovesdy CP, Kalantar-Zadeh K. Residual Kidney Function and Cause-Specific Mortality Among Incident Hemodialysis Patients. Kidney Int Rep. 2023 Oct;8(10):1989–2000. doi: 10.1016/j.ekir.2023.07.020.
- Shafi T, Jaar BG, Plantinga LC, Fink NE, Sadler JH, Parekh RS, et al. Association of residual urine output with mortality, quality of life, and inflammation in incident hemodialysis patients: the Choices for Healthy Outcomes in Caring for End-Stage Renal Disease (CHOICE) Study. Am J Kidney Dis. 2010;56(2):348–58. doi: 0.1053/j.ajkd.2010.03.020.
- Suda T, Hiroshige K, Ohta T, Watanabe Y, Iwamoto M, Kanegae K, et al. The contribution of residual renal function to overall nutritional status in chronic haemodialysis patients. Nephrol Dial Transplant. 2000;15(3):396–401. doi: 10.1093/ndt/15.3.396.
- Merkus MP, Jager KJ, Dekker FW, Boeschoten EW, Stevens P, Krediet RT, et al. Quality of life in patients on chronic dialysis: self-assessment 3 months after the start of treatment. The Necosad Study Group. Am J Kidney Dis. 1997;29(4):584–92. doi: 0.1016/s0272-6386(97)90342-5.
There are 40 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Internal Diseases, Urology |
| Journal Section | Research Articles |
| Authors | |
| Publication Date | June 30, 2025 |
| Submission Date | November 25, 2024 |
| Acceptance Date | June 11, 2025 |
| Published in Issue | Year 2025 Volume: 8 Issue: 2 |
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