Case Report
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Methemoglobineminin nadir bir nedeni; besin proteini ile ilişkili enterokolit sendromu

Year 2025, Volume: 24 Issue: 1, 47 - 50, 29.04.2025
https://doi.org/10.17941/agd.1682561

Abstract

Nadir görülen immünglobulin-E aracılı olmayan bir gıda aşırı duyarlılığı olan besin proteini ile ilişkili enterokolit sendromu, aşırı kusma, ishal ve akut dehidratasyon ile karakterizedir. Spesifik bir laboratuvar bulgusu yoktur, ancak lökositoz, metabolik asidoz ve nadiren methemoglobinemi görülebilir. Birincil tedavi, alerjik reaksiyona neden olan gıdanın ortadan kaldırılmasını içerir. Burada methemoglobineminin eşlik ettiği akut besin proteini ile ilişkili enterokolit sendromu tanısı konulan 45 günlük bir kız infant olgusu sunulmuştur.

References

  • 1. Caubet JC, Bencharitiwong R, Ross A, et al. Humoral and cellular responses to casein in patients with food protein–induced enterocolitis to cow’s milk. J Allergy Clin Immunol. 2017;139(2):572-83.
  • 2. Anvari S, Ruffner MA, Nowak-Wegrzyn A. Current and future perspectives on the consensus guideline for food protein-induced enterocolitis syndrome (FPIES). Allergol Int. 2024;73(2):188-95.
  • 3. Alonso SB, Ezquiaga JG, Berzal PT, et al. Food protein–induced enterocolitis syndrome: Increased prevalence of this great unknown-results of the PREVALE study. J Allergy Clin Immunol. 2019;143(1):430-3.
  • 4. Mehr S, Frith K, Barnes EH, Campbell DE; FPIES Study Group. Food protein-induced enterocolitis syndrome in Australia: A population-based study, 2012-2014. J Allergy Clin Immunol. 2017;140(5):1323-30.
  • 5. Nowak-Węgrzyn A. Food protein-induced enterocolitis syndrome and allergic proctocolitis. Allergy Asthma Proc. 2015;36(3):172-84.
  • 6. Su KW, Patil SU, Stockbridge JL, et al. Food aversion and poor weight gain in food protein-induced enterocolitis syndrome: A retrospective study. J Allergy Clin Immunol. 2020;145(5):1430-7.e11.
  • 7. Özdemi̇r Ö. Food Protein-Induced Enterocolitis Syndrome: Review. Turkiye Klinikleri J Med Sci 2009;29(6):1705-9.
  • 8. Mehr S, Kakakios A, Frith K, et al. Food Protein-Induced Enterocolitis Syndrome: 16-Year Experience. Pediatrics. 2009;123(3):e459-64.
  • 9. Uzuner N, Ölmez D, Babayiğit A. Gıda ile oluşan gastrointestinal sistem aşırı duyarlılık reaksiyonları. Türkiye Klinikleri J Pediatr 2009;18(3):214-21.
  • 10. Özdemir Ö, Sari M. Two Cases of Food Protein Induced Enterocolitis Syndrome. Turkiye Klinikleri J Med Sci 2012;32(5):1480-5.
  • 11. Nowak-Węgrzyn A, Jarocka-Cyrta E, Moschione Castro A. Food Protein-Induced Enterocolitis Syndrome. J Investig Allergol Clin Immunol. 2017;27(1):1-18.
  • 12. NIAID-Sponsored Expert Panel; Boyce JA, Assa'ad A, Burks AW, et al. Guidelines for the diagnosis and management of food allergy in the United States: report of the NIAID-sponsored expert panel. J Allergy Clin Immunol. 2010;126(6 Suppl):S1-58.
  • 13. Caubet JC, Szajewska H, Shamir R, Nowak-Węgrzyn A. Non-IgE-mediated gastrointestinal food allergies in children. Pediatr Allergy Immunol. 2017;28(1):6-17.
  • 14. Leonard SA, Pecora V, Fiocchi AG, Nowak-Wegrzyn A. Food protein-induced enterocolitis syndrome: a review of the new guidelines. World Allergy Organ J. 2018;11(1):4.
  • 15. Lee E, Barnes EH, Mehr S, Campbell DE. Differentiating Acute Food Protein-Induced Enterocolitis Syndrome From Its Mimics: A Comparison of Clinical Features and Routine Laboratory Biomarkers. J Allergy Clin Immunol Pract. 2019;7(2):471-478.e3.
  • 16. Murray KF, Christie DL. Dietary protein intolerance in infants with transient methemoglobinemia and diarrhea. J Pediatr. 1993;122(1):90-2.
  • 17. Baldo F, Bevacqua M, Corrado C, et al. FPIES in exclusively breastfed infants: two case reports and review of the literature. Ital J Pediatr. 2020;46(1):144.
  • 18. Malin SW, Lutfi R, Friedman ML, Teagarden AM. Food Protein-Induced Enterocolitis Syndrome Causing Hypovolemic Shock and Methemoglobinemia. Case Rep Crit Care. 2018;2018:1903787.
  • 19. Ribeiro A, Moreira D, Costa C, Pinto Pais I. Food protein-induced enterocolitis syndrome: a challenging diagnosis. BMJ Case Rep. 2018;2018:bcr2017222822.

A rare cause of methemoglobinemia; food protein-induced enterocolitis syndrome

Year 2025, Volume: 24 Issue: 1, 47 - 50, 29.04.2025
https://doi.org/10.17941/agd.1682561

Abstract

Food protein-induced enterocolitis syndrome, an uncommon non-immunoglobuline-E mediated food hypersensitivity, is characterized by profuse vomiting, diarrhea and acute dehydration. There are no specific laboratory findings, however leukocytosis, metabolic acidosis and rarely methemoglobinemia may be observed. The primary treatment involves elimination of the food that causes the allergic reaction. Here we report the case of a 45-day-old female infant diagnosed acute food protein-induced enterocolitis syndrome co-existing with methemoglobinemia.

References

  • 1. Caubet JC, Bencharitiwong R, Ross A, et al. Humoral and cellular responses to casein in patients with food protein–induced enterocolitis to cow’s milk. J Allergy Clin Immunol. 2017;139(2):572-83.
  • 2. Anvari S, Ruffner MA, Nowak-Wegrzyn A. Current and future perspectives on the consensus guideline for food protein-induced enterocolitis syndrome (FPIES). Allergol Int. 2024;73(2):188-95.
  • 3. Alonso SB, Ezquiaga JG, Berzal PT, et al. Food protein–induced enterocolitis syndrome: Increased prevalence of this great unknown-results of the PREVALE study. J Allergy Clin Immunol. 2019;143(1):430-3.
  • 4. Mehr S, Frith K, Barnes EH, Campbell DE; FPIES Study Group. Food protein-induced enterocolitis syndrome in Australia: A population-based study, 2012-2014. J Allergy Clin Immunol. 2017;140(5):1323-30.
  • 5. Nowak-Węgrzyn A. Food protein-induced enterocolitis syndrome and allergic proctocolitis. Allergy Asthma Proc. 2015;36(3):172-84.
  • 6. Su KW, Patil SU, Stockbridge JL, et al. Food aversion and poor weight gain in food protein-induced enterocolitis syndrome: A retrospective study. J Allergy Clin Immunol. 2020;145(5):1430-7.e11.
  • 7. Özdemi̇r Ö. Food Protein-Induced Enterocolitis Syndrome: Review. Turkiye Klinikleri J Med Sci 2009;29(6):1705-9.
  • 8. Mehr S, Kakakios A, Frith K, et al. Food Protein-Induced Enterocolitis Syndrome: 16-Year Experience. Pediatrics. 2009;123(3):e459-64.
  • 9. Uzuner N, Ölmez D, Babayiğit A. Gıda ile oluşan gastrointestinal sistem aşırı duyarlılık reaksiyonları. Türkiye Klinikleri J Pediatr 2009;18(3):214-21.
  • 10. Özdemir Ö, Sari M. Two Cases of Food Protein Induced Enterocolitis Syndrome. Turkiye Klinikleri J Med Sci 2012;32(5):1480-5.
  • 11. Nowak-Węgrzyn A, Jarocka-Cyrta E, Moschione Castro A. Food Protein-Induced Enterocolitis Syndrome. J Investig Allergol Clin Immunol. 2017;27(1):1-18.
  • 12. NIAID-Sponsored Expert Panel; Boyce JA, Assa'ad A, Burks AW, et al. Guidelines for the diagnosis and management of food allergy in the United States: report of the NIAID-sponsored expert panel. J Allergy Clin Immunol. 2010;126(6 Suppl):S1-58.
  • 13. Caubet JC, Szajewska H, Shamir R, Nowak-Węgrzyn A. Non-IgE-mediated gastrointestinal food allergies in children. Pediatr Allergy Immunol. 2017;28(1):6-17.
  • 14. Leonard SA, Pecora V, Fiocchi AG, Nowak-Wegrzyn A. Food protein-induced enterocolitis syndrome: a review of the new guidelines. World Allergy Organ J. 2018;11(1):4.
  • 15. Lee E, Barnes EH, Mehr S, Campbell DE. Differentiating Acute Food Protein-Induced Enterocolitis Syndrome From Its Mimics: A Comparison of Clinical Features and Routine Laboratory Biomarkers. J Allergy Clin Immunol Pract. 2019;7(2):471-478.e3.
  • 16. Murray KF, Christie DL. Dietary protein intolerance in infants with transient methemoglobinemia and diarrhea. J Pediatr. 1993;122(1):90-2.
  • 17. Baldo F, Bevacqua M, Corrado C, et al. FPIES in exclusively breastfed infants: two case reports and review of the literature. Ital J Pediatr. 2020;46(1):144.
  • 18. Malin SW, Lutfi R, Friedman ML, Teagarden AM. Food Protein-Induced Enterocolitis Syndrome Causing Hypovolemic Shock and Methemoglobinemia. Case Rep Crit Care. 2018;2018:1903787.
  • 19. Ribeiro A, Moreira D, Costa C, Pinto Pais I. Food protein-induced enterocolitis syndrome: a challenging diagnosis. BMJ Case Rep. 2018;2018:bcr2017222822.
There are 19 citations in total.

Details

Primary Language English
Subjects Gastroenterology and Hepatology
Journal Section Articles
Authors

İrem Kuter Emeklioğlu 0000-0002-0167-5451

Hamdi Metin 0000-0003-3110-0410

Sebiha Şükran Gündeşli 0009-0001-8425-3624

Kübra Akan 0000-0003-4138-3194

Eylem Sevinç 0000-0003-1778-6559

Publication Date April 29, 2025
Submission Date June 27, 2024
Acceptance Date September 10, 2024
Published in Issue Year 2025 Volume: 24 Issue: 1

Cite

APA Kuter Emeklioğlu, İ., Metin, H., Gündeşli, S. Ş., Akan, K., et al. (2025). A rare cause of methemoglobinemia; food protein-induced enterocolitis syndrome. Akademik Gastroenteroloji Dergisi, 24(1), 47-50. https://doi.org/10.17941/agd.1682561

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