Use of del Nido Cardioplegia Solution for Different Age Groups (Pediatric/Adult) in Cardiovascular Surgery

Nur Dikmen Yaman

doi:10.4274/atfm.galenos.2024.82574

Review

Kalp ve Damar Cerrahisinde Farklı Yaş Gruplarında (Pediatrik/Erişkin) del Nido Kardiyopleji Solüsyonunun Kullanımı

Year 2024, Volume: 77 Issue: 1, 7 - 12, 28.03.2024

Nur Dikmen Yaman

Abstract

Project Number

References

1. Tschaut Rudolf J, Dreher M, Walczak A, et al. Extracorporeal circulation in theory and practice. Pabst Science Publishers. Lengerich, Germany, 2020.
2. Durandy Y. Pediatric myocardial protection. Curr Opin Cardiol. 2008;23:85- 90.
3. Whittaker A, Aboughdir M, Mahbub S, et al. Myocardial protection in cardiac surgery: how limited are the options? A comprehensive literature review. Perfusion. 2021;36:338-351.
4. Chatrath R, Kaul T, Walker D. Myocardial protection during cardioplegia in open-heart surgery: a review. Can Anaesth Soc J. 1980;27:381-388.
5. Cohn LH. Cardiac Surgery in the Adult. Fourth Edition. McGraw Hill Professional, 2012.
6. Sanetra K, Pawlak I, Cisowski M. Del Nido cardioplegia - what is the current evidence? Kardiochir Torakochirurgia Pol. 2018;15:114-118.
7. Jonas RA, Di Nardo J, Laussen RC, et al. Why early primary repair? In Comprehensive Surgical Management of Congenital Heart Disease. London, 2004, pp 3-6.
8. Gravlee GP, Davis RF, Hammon J, et al. Cardiopulmonary Bypass and Mechanical Support: Principles and Practice. Lippincott Williams & Wilkins, 2015.
9. Bretschneider HJ, Hübner G, Knoll D, et al. Myocardial resistance and tolerance to ischemia: physiological and biochemical basis. J Cardiovasc Surg. 1975;16:241-260.
10. Hearse DJ, Stewart DA, Braimbridge MV. Cellular protection during myocardial ischemia: the development and characterization of a procedure for the induction of reversible ischemic arrest. Circulation. 1976;54:193- 202.
11. Braimbridge Mv, Chayen J, Bitensky L, et al. Cold cardioplegia or continuous coronary perfusion? Report on preliminary clinical experience as assessed cytochemically. J Thorac Cardiovasc Surg. 1977;74:900-906.
12. Follette DM, Mulder DG, Maloney JV, et al. Advantages of blood cardioplegia over continuous coro- nary perfusion and intermittent ischemia. Experimental and clinical study. J Thorac Cardiovasc Surg. 1978;76:604- 619.
13. Matte GS, del Nido PJ. History and use of del Nido cardioplegia solution at Boston Children’s Hospital. J Extra Corpor Technol. 2012;44:98-103.
14. Melrose DG, Dreyer B, Bentall HH, et al. Elective cardiac arrest. The Lancet 1955;266:21-23.
15. Rosenkranz ER, Vinten-Johansen J, Buckberg GD, et al. Benefits of normothermic induction of blood cardioplegia in energy-depleted hearts, with maintenance of arrest by multidose cold blood cardioplegic infusions. J Thorac Cardiovasc Surg. 1982;84:667-677.
16. Bolling K, Kronon M, Allen BS, et al. Myocardial protection in normal and hypoxically stressed neonatal hearts: the superiority of hypocalcemic versus normocalcemic blood cardioplegia. J Thorac Cardiovasc Surg. 1996;112:1193-1201.
17. Morita K, Ihnken K, Buckberg GD, et al. Studies of hypoxemic/reoxygenation injury: Without aortic clamping:: VII. Counteraction of oxidant damage by exogenous antioxidants: Coenzyme Q10. J Thorac Cardiovasc Surg. 1995;110:1221-1227.
18. Jennings RB, Reimer KA. Lethal myocardial ischemic injury. Am J Pathol. 1981;102:241-255.
19. Swanson DK, Pasaoglu I, Berkoff HA, et al. Improved heart preservation with UW preservation solution. J Heart Transplant. 1988;7:456-467.
20. Rebeyka IM, Axford-Gatley RA, Bush BG. Calcium paradox in an in vivo model of multidose cardioplegia and moderate hypothermia. J Thorac Cardiovasc Surg. 1990;99:475-483.
21. O’Blenes SB, Friesen CH, Ali A, et al. Protecting the aged heart during cardiac surgery: The potential benefits of del Nido cardioplegia. J Thorac Cardiovasc Surg. 2011;141:762-769.
22. Valooran GJ, Nair SK, Chandrasekharan K, et al. Del Nido cardioplegia in adult cardiac surgery scopes and concerns. Perfusion. 2016;31:6-14.
23. O’brien JD, Howlett SE, Burton HJ, et al. Pediatric cardioplegia strategy results in enhanced calcium metabolism and lower serum troponin T. Ann Thorac Surg. 2009;87:1517-1524.
24. Kotani Y, Tweddell J, Gruber P, et al. Current cardioplegia practice in pediatric cardiac surgery: a North American multiinstitutional survey. Ann Thorac Surg. 2013;96:923-929.
25. Charette K, Gerrah R, Quaegebeur J, et al. Single dose myocardial protection technique utilizing del Nido cardioplegia solution during congenital heart surgery procedures. Perfusion. 2012;27:98-103.
26. Buel ST, Striker CW, O’Brien JE. del Nido versus St. Thomas cardioplegia solutions: a single-center retrospective analysis of post cross-clamp defibrillation rates. J Extra Corpor Technol. 2016;48:67-70.
27. Talwar S, Bhoje A, Sreenivas V, et al. Comparison of del Nido and St Thomas cardioplegia solutions in pediatric patients: a prospective randomized clinical trial. Semin Thorac Cardiovasc Surg. 2017;29:366-374.
28. Gorjipour F, Dehaki MG, Totonchi Z, et al. Inflammatory cytokine response and cardiac troponin I changes in cardiopulmonary bypass using two cardioplegia solutions; del Nido and modified St. Thomas’: a randomized controlled trial. Perfusion. 2017;32:394-402.
29. Ota T, Yerebakan H, Neely RC, et al. Short-term outcomes in adult cardiac surgery in the use of del Nido cardioplegia solution. Perfusion. 2016;31:27- 33.
30. Kim K, Ball C, Grady P, et al. Use of del Nido cardioplegia for adult cardiac surgery at the Cleveland Clinic: perfusion implications. J Extra Corpor Technol 2014;46:317-323.
31. Mick SL, Robich MP, Houghtaling PL, et al. del Nido versus Buckberg cardioplegia in adult isolated valve surgery. J Thorac Cardiovasc Surg. 2015;149:626-636.
32. Govindapillai A, Hua R, Rose R, et al. Protecting the aged heart during cardiac surgery: use of del Nido cardioplegia provides superior functional recovery in isolated hearts. J Thorac Cardiovasc Surg. 2013;146:940-948.
33. Mishra P, Jadhav RB, Mohapatra CK, et al. Comparison of del Nido cardioplegia and St. Thomas Hospital solution - two types of cardioplegia in adult cardiac surgery. Kardiochir torakochirurgia Pol. 2016;13:295-299.
34. Sorabella RA, Akashi H, Yerebakan H, et al. Myocardial protection using del Nido cardioplegia solution in adult reoperative aortic valve surgery. J Card Surg. 2014;29:445-449.
35. Loberman D, Neely RC, Fitzgerald D, et al. Modified del Nido cardioplegia in adult cardiac surgery; safety and efficacy. J Cardiol Curr Res. 2014;1:00042.
36. Ziazadeh D, Mater R, Himelhoch B, et al. Single-dose del Nido cardioplegia in minimally invasive aortic Valve Surgery. Semin Thorac Cardiovasc Surg. 2017;29:471-476.
37. Guajardo Salinas GE, Nutt R, Rodriguez-Araujo G. Del Nido cardioplegia in low risk adults undergoing first time coronary artery bypass surgery. Perfusion. 2017;32:68-73.
38. Timek T, Willekes C, Hulme O, et al. Propensity matched analysis of del Nido cardioplegia in adult coronary artery bypass grafting: initial experience with 100 consecutive patients. Ann Thorac Surg. 2016;101:2237-2241.
39. Ramanathan R, Parrish DW, Armour TK, et al. Use of del Nido cardioplegia in adult cardiac surgery. Thorac Cardiovasc Surg. 2015;63:624-627.

Use of del Nido Cardioplegia Solution for Different Age Groups (Pediatric/Adult) in Cardiovascular Surgery

Year 2024, Volume: 77 Issue: 1, 7 - 12, 28.03.2024

Nur Dikmen Yaman

Abstract

The use of cardioplegia is an indispensable method of myocardial protection in surgical procedures with cardiac arrest in both pediatric and adult patients. In cardiac surgery, pharmacological arrest with cardioplegia solutions is the most prevalent and valid method for myocardial protection. Although in pediatric cardiac surgery, del Nido cardioplegia solution has been used for decades, it’s use in adult cardiac surgery is a relatively new phenomenon. More data are available due to its widespread use for many years in pediatric and infant patients; however, data on its use in adult
patients are more limited. del Nido cardioplegia solution has been reported to be superior in several aspects in pediatric cardiac surgery. More evidence-based studies are needed to ensure optimal use of this myocardial protection technique for different age groups in a safer way. In this review, studies on the use of del Nido cardioplegia solution in different age groups are discussed

Keywords

del Nido adult, del Nido pediatric, cardioplegia, myocardial protection

Ethical Statement

Concept: O.D., N.D., E.Ö., E.İ., Design: O.D., N.D., E.Ö., E.İ., Analysis or Interpretation: O.D., N.D., E.Ö., E.İ., Literature Search: O.D., N.D., E.Ö., E.İ., Writing: O.D., N.D., E.Ö., E.İ.

Supporting Institution

Project Number

Thanks

References

1. Tschaut Rudolf J, Dreher M, Walczak A, et al. Extracorporeal circulation in theory and practice. Pabst Science Publishers. Lengerich, Germany, 2020.
2. Durandy Y. Pediatric myocardial protection. Curr Opin Cardiol. 2008;23:85- 90.
3. Whittaker A, Aboughdir M, Mahbub S, et al. Myocardial protection in cardiac surgery: how limited are the options? A comprehensive literature review. Perfusion. 2021;36:338-351.
4. Chatrath R, Kaul T, Walker D. Myocardial protection during cardioplegia in open-heart surgery: a review. Can Anaesth Soc J. 1980;27:381-388.
5. Cohn LH. Cardiac Surgery in the Adult. Fourth Edition. McGraw Hill Professional, 2012.
6. Sanetra K, Pawlak I, Cisowski M. Del Nido cardioplegia - what is the current evidence? Kardiochir Torakochirurgia Pol. 2018;15:114-118.
7. Jonas RA, Di Nardo J, Laussen RC, et al. Why early primary repair? In Comprehensive Surgical Management of Congenital Heart Disease. London, 2004, pp 3-6.
8. Gravlee GP, Davis RF, Hammon J, et al. Cardiopulmonary Bypass and Mechanical Support: Principles and Practice. Lippincott Williams & Wilkins, 2015.
9. Bretschneider HJ, Hübner G, Knoll D, et al. Myocardial resistance and tolerance to ischemia: physiological and biochemical basis. J Cardiovasc Surg. 1975;16:241-260.
10. Hearse DJ, Stewart DA, Braimbridge MV. Cellular protection during myocardial ischemia: the development and characterization of a procedure for the induction of reversible ischemic arrest. Circulation. 1976;54:193- 202.
11. Braimbridge Mv, Chayen J, Bitensky L, et al. Cold cardioplegia or continuous coronary perfusion? Report on preliminary clinical experience as assessed cytochemically. J Thorac Cardiovasc Surg. 1977;74:900-906.
12. Follette DM, Mulder DG, Maloney JV, et al. Advantages of blood cardioplegia over continuous coro- nary perfusion and intermittent ischemia. Experimental and clinical study. J Thorac Cardiovasc Surg. 1978;76:604- 619.
13. Matte GS, del Nido PJ. History and use of del Nido cardioplegia solution at Boston Children’s Hospital. J Extra Corpor Technol. 2012;44:98-103.
14. Melrose DG, Dreyer B, Bentall HH, et al. Elective cardiac arrest. The Lancet 1955;266:21-23.
15. Rosenkranz ER, Vinten-Johansen J, Buckberg GD, et al. Benefits of normothermic induction of blood cardioplegia in energy-depleted hearts, with maintenance of arrest by multidose cold blood cardioplegic infusions. J Thorac Cardiovasc Surg. 1982;84:667-677.
16. Bolling K, Kronon M, Allen BS, et al. Myocardial protection in normal and hypoxically stressed neonatal hearts: the superiority of hypocalcemic versus normocalcemic blood cardioplegia. J Thorac Cardiovasc Surg. 1996;112:1193-1201.
17. Morita K, Ihnken K, Buckberg GD, et al. Studies of hypoxemic/reoxygenation injury: Without aortic clamping:: VII. Counteraction of oxidant damage by exogenous antioxidants: Coenzyme Q10. J Thorac Cardiovasc Surg. 1995;110:1221-1227.
18. Jennings RB, Reimer KA. Lethal myocardial ischemic injury. Am J Pathol. 1981;102:241-255.
19. Swanson DK, Pasaoglu I, Berkoff HA, et al. Improved heart preservation with UW preservation solution. J Heart Transplant. 1988;7:456-467.
20. Rebeyka IM, Axford-Gatley RA, Bush BG. Calcium paradox in an in vivo model of multidose cardioplegia and moderate hypothermia. J Thorac Cardiovasc Surg. 1990;99:475-483.
21. O’Blenes SB, Friesen CH, Ali A, et al. Protecting the aged heart during cardiac surgery: The potential benefits of del Nido cardioplegia. J Thorac Cardiovasc Surg. 2011;141:762-769.
22. Valooran GJ, Nair SK, Chandrasekharan K, et al. Del Nido cardioplegia in adult cardiac surgery scopes and concerns. Perfusion. 2016;31:6-14.
23. O’brien JD, Howlett SE, Burton HJ, et al. Pediatric cardioplegia strategy results in enhanced calcium metabolism and lower serum troponin T. Ann Thorac Surg. 2009;87:1517-1524.
24. Kotani Y, Tweddell J, Gruber P, et al. Current cardioplegia practice in pediatric cardiac surgery: a North American multiinstitutional survey. Ann Thorac Surg. 2013;96:923-929.
25. Charette K, Gerrah R, Quaegebeur J, et al. Single dose myocardial protection technique utilizing del Nido cardioplegia solution during congenital heart surgery procedures. Perfusion. 2012;27:98-103.
26. Buel ST, Striker CW, O’Brien JE. del Nido versus St. Thomas cardioplegia solutions: a single-center retrospective analysis of post cross-clamp defibrillation rates. J Extra Corpor Technol. 2016;48:67-70.
27. Talwar S, Bhoje A, Sreenivas V, et al. Comparison of del Nido and St Thomas cardioplegia solutions in pediatric patients: a prospective randomized clinical trial. Semin Thorac Cardiovasc Surg. 2017;29:366-374.
28. Gorjipour F, Dehaki MG, Totonchi Z, et al. Inflammatory cytokine response and cardiac troponin I changes in cardiopulmonary bypass using two cardioplegia solutions; del Nido and modified St. Thomas’: a randomized controlled trial. Perfusion. 2017;32:394-402.
29. Ota T, Yerebakan H, Neely RC, et al. Short-term outcomes in adult cardiac surgery in the use of del Nido cardioplegia solution. Perfusion. 2016;31:27- 33.
30. Kim K, Ball C, Grady P, et al. Use of del Nido cardioplegia for adult cardiac surgery at the Cleveland Clinic: perfusion implications. J Extra Corpor Technol 2014;46:317-323.
31. Mick SL, Robich MP, Houghtaling PL, et al. del Nido versus Buckberg cardioplegia in adult isolated valve surgery. J Thorac Cardiovasc Surg. 2015;149:626-636.
32. Govindapillai A, Hua R, Rose R, et al. Protecting the aged heart during cardiac surgery: use of del Nido cardioplegia provides superior functional recovery in isolated hearts. J Thorac Cardiovasc Surg. 2013;146:940-948.
33. Mishra P, Jadhav RB, Mohapatra CK, et al. Comparison of del Nido cardioplegia and St. Thomas Hospital solution - two types of cardioplegia in adult cardiac surgery. Kardiochir torakochirurgia Pol. 2016;13:295-299.
34. Sorabella RA, Akashi H, Yerebakan H, et al. Myocardial protection using del Nido cardioplegia solution in adult reoperative aortic valve surgery. J Card Surg. 2014;29:445-449.
35. Loberman D, Neely RC, Fitzgerald D, et al. Modified del Nido cardioplegia in adult cardiac surgery; safety and efficacy. J Cardiol Curr Res. 2014;1:00042.
36. Ziazadeh D, Mater R, Himelhoch B, et al. Single-dose del Nido cardioplegia in minimally invasive aortic Valve Surgery. Semin Thorac Cardiovasc Surg. 2017;29:471-476.
37. Guajardo Salinas GE, Nutt R, Rodriguez-Araujo G. Del Nido cardioplegia in low risk adults undergoing first time coronary artery bypass surgery. Perfusion. 2017;32:68-73.
38. Timek T, Willekes C, Hulme O, et al. Propensity matched analysis of del Nido cardioplegia in adult coronary artery bypass grafting: initial experience with 100 consecutive patients. Ann Thorac Surg. 2016;101:2237-2241.
39. Ramanathan R, Parrish DW, Armour TK, et al. Use of del Nido cardioplegia in adult cardiac surgery. Thorac Cardiovasc Surg. 2015;63:624-627.

There are 39 citations in total.

Details

Primary Language	English
Subjects	Cardiovascular Surgery
Journal Section	Articles
Authors	Nur Dikmen Yaman 0000-0002-7515-8465
Project Number	-
Publication Date	March 28, 2024
Submission Date	January 22, 2024
Acceptance Date	February 27, 2024
Published in Issue	Year 2024 Volume: 77 Issue: 1

Cite

APA	Dikmen Yaman, N. (2024). Use of del Nido Cardioplegia Solution for Different Age Groups (Pediatric/Adult) in Cardiovascular Surgery. Ankara Üniversitesi Tıp Fakültesi Mecmuası, 77(1), 7-12. https://doi.org/10.4274/atfm.galenos.2024.82574
AMA	Dikmen Yaman N. Use of del Nido Cardioplegia Solution for Different Age Groups (Pediatric/Adult) in Cardiovascular Surgery. Ankara Üniversitesi Tıp Fakültesi Mecmuası. March 2024;77(1):7-12. doi:10.4274/atfm.galenos.2024.82574
Chicago	Dikmen Yaman, Nur. “Use of Del Nido Cardioplegia Solution for Different Age Groups (Pediatric/Adult) in Cardiovascular Surgery”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 77, no. 1 (March 2024): 7-12. https://doi.org/10.4274/atfm.galenos.2024.82574.
EndNote	Dikmen Yaman N (March 1, 2024) Use of del Nido Cardioplegia Solution for Different Age Groups (Pediatric/Adult) in Cardiovascular Surgery. Ankara Üniversitesi Tıp Fakültesi Mecmuası 77 1 7–12.
IEEE	N. Dikmen Yaman, “Use of del Nido Cardioplegia Solution for Different Age Groups (Pediatric/Adult) in Cardiovascular Surgery”, Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 77, no. 1, pp. 7–12, 2024, doi: 10.4274/atfm.galenos.2024.82574.
ISNAD	Dikmen Yaman, Nur. “Use of Del Nido Cardioplegia Solution for Different Age Groups (Pediatric/Adult) in Cardiovascular Surgery”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 77/1 (March 2024), 7-12. https://doi.org/10.4274/atfm.galenos.2024.82574.
JAMA	Dikmen Yaman N. Use of del Nido Cardioplegia Solution for Different Age Groups (Pediatric/Adult) in Cardiovascular Surgery. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2024;77:7–12.
MLA	Dikmen Yaman, Nur. “Use of Del Nido Cardioplegia Solution for Different Age Groups (Pediatric/Adult) in Cardiovascular Surgery”. Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 77, no. 1, 2024, pp. 7-12, doi:10.4274/atfm.galenos.2024.82574.
Vancouver	Dikmen Yaman N. Use of del Nido Cardioplegia Solution for Different Age Groups (Pediatric/Adult) in Cardiovascular Surgery. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2024;77(1):7-12.

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