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The Effect of Sevoflurane and Propofol on Pulmonary Oxidative Stress in Patients Undergoing Single Lung Ventilation

Year 2020, Volume: 73 Issue: 2, 139 - 143, 21.07.2020

Onat Bermede

Abstract

Objectives: Collapsing and re-expanding the operated lung during lung resection create the ideal condition for ischemia-reperfusion injury. Anesthetic agents used during these operations may be determinative on oxidative stress. In this study, we aimed to compare propofol with sevoflurane in terms of oxidative stress in patients undergoing lobectomy with single lung ventilation (SLV).

Materials and Methods: Twenty-eight patients undergoing elective lobectomy for lung cancer were included in the study. Anesthesia was maintained with 5-10 mg kg-1 st-1 propofol and 0.1-0.2 μg kg-1 min-1 remifentanil infusion in group P (propofol), while 1-3% sevoflurane was used in group S (sevoflurane). Peripheral venous blood at baseline, pulmonary venous and peripheral venous blood before SLV lung ventilation was terminated and peripheral venous blood samples 20 minutes after SLV were obtained.

Results: In both groups, plasma malondialdehyde levels increased compared to baseline (p<0.001). There was no significant difference between the groups in terms of baseline and pulmonary vein malondialdehyde after SLV. Peripheral venous malondialdehyde level after SLV was significantly lower in group S p=0.008, whereas peripheral venous malondialdehyde value at 20 minutes after reoxygenation was lower in group P (p=0.021).

Conclusion: Due to the anesthetic method, patients with lung cancer may be less affected by oxidative stress. Total intravenous anesthesia using propofol and remifentanil is as safe and effective as sevoflurane in thoracic surgery.

Keywords

Ischemia Reperfusion Injury Oxidative Stress Malondialdehyde Propofol Sevoflurane

Ethical Statement

Etik Kurul Onayı: Araştırmanın 2010 yılı Ocak-Haziran ayları arasında yapıldığı ve o dönemde etik kurul izni almak zorunluluğu olmadığı için etik kurul onayı alınmamıştır.

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References

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There are 14 citations in total.

Details

Primary Language English
Subjects Anaesthesiology
Journal Section Articles
Authors

Onat Bermede 0000-0002-8598-6264

Project Number -
Publication Date July 21, 2020
Published in Issue Year 2020 Volume: 73 Issue: 2

Cite

APA Bermede, O. (2020). The Effect of Sevoflurane and Propofol on Pulmonary Oxidative Stress in Patients Undergoing Single Lung Ventilation. Ankara Üniversitesi Tıp Fakültesi Mecmuası, 73(2), 139-143. https://doi.org/10.4274/atfm.galenos.2020.30092
AMA Bermede O. The Effect of Sevoflurane and Propofol on Pulmonary Oxidative Stress in Patients Undergoing Single Lung Ventilation. Ankara Üniversitesi Tıp Fakültesi Mecmuası. July 2020;73(2):139-143. doi:10.4274/atfm.galenos.2020.30092
Chicago Bermede, Onat. “The Effect of Sevoflurane and Propofol on Pulmonary Oxidative Stress in Patients Undergoing Single Lung Ventilation”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 73, no. 2 (July 2020): 139-43. https://doi.org/10.4274/atfm.galenos.2020.30092.
EndNote Bermede O (July 1, 2020) The Effect of Sevoflurane and Propofol on Pulmonary Oxidative Stress in Patients Undergoing Single Lung Ventilation. Ankara Üniversitesi Tıp Fakültesi Mecmuası 73 2 139–143.
IEEE O. Bermede, “The Effect of Sevoflurane and Propofol on Pulmonary Oxidative Stress in Patients Undergoing Single Lung Ventilation”, Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 73, no. 2, pp. 139–143, 2020, doi: 10.4274/atfm.galenos.2020.30092.
ISNAD Bermede, Onat. “The Effect of Sevoflurane and Propofol on Pulmonary Oxidative Stress in Patients Undergoing Single Lung Ventilation”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 73/2 (July 2020), 139-143. https://doi.org/10.4274/atfm.galenos.2020.30092.
JAMA Bermede O. The Effect of Sevoflurane and Propofol on Pulmonary Oxidative Stress in Patients Undergoing Single Lung Ventilation. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2020;73:139–143.
MLA Bermede, Onat. “The Effect of Sevoflurane and Propofol on Pulmonary Oxidative Stress in Patients Undergoing Single Lung Ventilation”. Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 73, no. 2, 2020, pp. 139-43, doi:10.4274/atfm.galenos.2020.30092.
Vancouver Bermede O. The Effect of Sevoflurane and Propofol on Pulmonary Oxidative Stress in Patients Undergoing Single Lung Ventilation. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 2020;73(2):139-43.
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