Review
Year 1993,
Volume: 46 Issue: 2, 213 - 223, 30.06.1993
Abstract
HBV, direk sitopatik bir virus değildir. Karaciğer harabiyeti, ko nağın immun sistem hücrelerince gerçekleştirilmektedir. Kronikleşme nin nedeni kesin olarak bilinmemekle birlikte, bugün için konağın hücresel ve humoral immun sistemleri sorumlu tutulmaktadır.
Keywords
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Project Number
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References
- 1, Alexander GJM : Immunology of Hepatitis B virus infection. British Medical Bulletin 46 : 354-67, 1990.
- 2 Alexander GJM Mondelli M et al : Functional characterization of peripheral blood Iymphocytes in chronic HBsAg carriers. Clin exp immunol 63 ; 498-507, 1986. 3. Barnaba V Levrero M et al : T cell subsets in the hyporesponsiveness to HBsAg and antigen-spesific suppressor lymphocytes in chronic HBV infection. Clinical Immunology and immunopathology 34 : 284-95 1985.
- 4. Barnaba V Musca A et al Relationship between T cell subsets and suppressor cell activity in chronic HBV infection. Clin exp immunol 53 : 281-8, 1983.
- 5. Barnaba V Valesini G et al : Immunoregulation of the in vitro anti-HBs synthesis in chronic HBsAg carriers and recently boosted anti-hepatitis B vaccine recipients. Clin exp immunol 60 ; 259-66, 1985.
- 6. Barnaba V Zaccari C et al : Immunoregulatory T cells in HBV induced chronic liver disease as defined by monoclonal antibodies. Clin immunol immunopathol 26 : 83-90, 1983.
- 7. Bertoletti A Ferrari C et al : I-ILA class 1 restricted human cytotoxic T cells recognize endogenously synthesized HBV nucleocapsid antigen. Proc Natl Acad Sci USA 88 : 10445-9* 1991
- 8. Bowry TR • Immunoregulation, in : Immunology simplified, 2nd ed ,ELBS, Oxford University Press, 1986, pp : 66-73. 9.Burek B Burek V et al : Local xenogeneic greft-versus-host reaction : a measure of T cell function in asymptomatic HBsAg carriesrs. J clin kab immunol 27 69-72, 1988.
- 10. Casini A Alberti A et al : Cell-mediated immunity to HBcAg in chronic HBV infection. Brief scientific reports 88 494-8, 1987.
- Il. Chu Chia-Yung, Liaw Yun-Fa.n : Peripheral T cell subsets in asymptomatic HBV carriers. Cellular immunology 98 • 533-7, 1986.
- 12. Desmet VJ : Immunopathology of chronic viral hepatitis. Hepatogastroenterology 38 : 14-21, 1991.
- 13,.Dienstag JL Wands JR Isselbacher KJ : Acute hepatitis, in : Harrison's Principles of internal medicine (Ed Wilson, Braunwald, Isselbacher, Petersdorf, Martin, Fauci, Root) ,vol : 11,12th ed, McGraw Hill Inc, 1991, pp : 1322-37.
- 14.Ding-Feng Z Bang-yuan L et al : In vitro immunoregulation of anti-HBs synthe sis by peripheral lymphocytes in HBV infections. Chinese medical journal 100 338-40, 1987. 15.Dragosics B Ferenci P et al : Long term follow-up of asymptomatic HBsAg positive voluntary blood donors in Austria : a clinical and histological evaluation of 242 cases. Hepatology 7 : 302-6, 1987.
- 16. Echevarria S Casafot F et al Interleukin-2 and natural killer activity in acute type B hepatitis. Hepatogastroenterology 38 : 307-10, 1991.
- 17. Ehata T Omata M et al : Aminoacid resudues of core region of 1-1B V, asymptomatic carriers versus patients with livre disease. J Gastroenterol Hepatol 6 292-6, 1991
- 18. Ferrari C Penna A. et al : Cellular immune response to hepatitis B virus-encoded antigens in acute and chronic hepatitis B virus infection. J Immunol 145 : 3442-5, 1990.
- 19. Gerber M : Pathology and immunopathology of acute and chronic hepatitis B. Klimik dergisi 1 ; 52-7, 1988.
- 20 Gerken G Kremsdrof D et al : Hepatitis B defective virus with rearrangements in pre-s gene during cnronic HBV infection. Virology 183 : 555-65 1991* 21. Gupta H Tandon BN : Detection of HBsAg in circulating immune complexes in asymptomatic carriers and various hepatic disorders due to HBV. Indian Med Res 88 . 111-7, 1988.
- 22. Hoofnag.le JH Shafritz DA et al : Chronic type B hepatitis and the healthy carrier state. Hepatology 7 : 758-63, 1987.
- 23., Iraburu M Civeire MP et al : Suppressor T cell activity in chronic HBV infection : Relationship with the presence of HBV-DNA in serum. J of medical virology 27 : 39-43, 1989.
- 24.Klhçturgay Kaya : Major histokompatibilite kompleksi ve cloku gruplarl. immuno)ojiye giri§, Yarglçožlu Matbaasl, Bursa, 1987, s : 13-6.
- 25.Lever AML • Treatment of the chronic 1-1B V carrier state. Journal of infection 16 221-9, 1988.
- 26. Li XM Jeffers LJ et al : Immunophenotyping of lymphocytes in liver tissue of patients with chronic liver disease by flow cytometry. HepatQ!ogy 14 0: 121-7, 1991*
- 27.Marmion BP Hepatitis viruses, in Mackie and McCartney Medical microbiology, vol : 1 • Microbial infections (Ed : Duguid JP Marmion BP, Swain RHA), 13th ed, ELBS, Churchill Livingstone Hong Kong, pp : 475-82+
- 28. Milich DR Chisari FV Genetic regul ation of the immune response to HBsAg. The Journal of immunology 129 : 320-5, 1982.
- 29. Onul Melahat Gül Giray ve ark : Hepatit B infeksiyonlannda lenfosit subpopü lasyonu degjsiklikleri. Ankara Hastanesi Dergisi 24 : 87-90, 1989.
- 30. Popper A Shafrits DA et al Relation of the HBV carrier state to hepatocellular carcinoma. Hepato!ogy 7 ; 764-72, 1987.
- 31. Raptopoulu-Gigi M Orphanou-Koumerkeridou H et al • Possible mechanisms underlying peripheral lymphocyte activation in chronic liver disease and asymptomatic HBsAg carrier's. Allergol e timmunopathol 17 : 145 8, 1989.
- 32. Robinson WS : Hepatitis B virus and hepatitis delta virus, in : Principlers and practice of infectious diseases (Ed : Mandell, GL Douglas GR, Bennett JE), 3rd ed, Churchi!l Livingstone, 1990, pp : 1204-31.
- 33.Sherlock S : The natural history of Hepatitis B. Postgraduate medical journal 63 (suppl 2) 7-11, 1987.
- 34. Stanevicha VA Veksler KhM • Immunogenetic indicators in protracted hepatitis and their dynamics during the treatment with T-activin. Pediatriia 10 : 4-8, 1991.
- 35.Sylvan SPE Hellström UB et al : Detection of cellular and humoral immunity to HBsAg in asymptomatic HBsAg carriers, Clin exp immunol 62 : 288-95, 1985,
- 36, Thomas HC Brown D et a.] : Inducer and suppressor T cell in HBV-induced liver disease. Hepatology 2 202-4, 1982.
- 37. Thomas HC Jacyna M etal : Virus-host interaction in chronic HBV infection. Seminars in liver disease 8 342-9, 1988.
- 38. Thomas HC Pignatelli M et al ,Homology between HBV-DNA and a sequence regulating the interferon induced anti-viral system : Possible mechanisms of persistent infection. Journal of decial virology 19 : 63-9* 1986.
- 39. Vento S Chen SH et al : Cellu lar immunity to nucleocapsid and pre-S determinants in asymptomatic carriers of hepatitis B. Immunology 67 : 593-8, 1987.
- 40. Yamazuchi K Nakanishi T et al : Suppression of hepatitis B antibody saynthesis by factor made by T cells from chronic hepatitis B carriers. The Lancet 13 324-6, 1988.
Year 1993,
Volume: 46 Issue: 2, 213 - 223, 30.06.1993
Abstract
HBV is not a directly cytopathic virus. Liver damage is mediated by the immune system celis of the hoşt. Although the reason of chronicity is not known, the cellular and humoral immune systems of the host are thought to be responsible,
Keywords
Ethical Statement
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Supporting Institution
-
Project Number
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Thanks
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References
- 1, Alexander GJM : Immunology of Hepatitis B virus infection. British Medical Bulletin 46 : 354-67, 1990.
- 2 Alexander GJM Mondelli M et al : Functional characterization of peripheral blood Iymphocytes in chronic HBsAg carriers. Clin exp immunol 63 ; 498-507, 1986. 3. Barnaba V Levrero M et al : T cell subsets in the hyporesponsiveness to HBsAg and antigen-spesific suppressor lymphocytes in chronic HBV infection. Clinical Immunology and immunopathology 34 : 284-95 1985.
- 4. Barnaba V Musca A et al Relationship between T cell subsets and suppressor cell activity in chronic HBV infection. Clin exp immunol 53 : 281-8, 1983.
- 5. Barnaba V Valesini G et al : Immunoregulation of the in vitro anti-HBs synthesis in chronic HBsAg carriers and recently boosted anti-hepatitis B vaccine recipients. Clin exp immunol 60 ; 259-66, 1985.
- 6. Barnaba V Zaccari C et al : Immunoregulatory T cells in HBV induced chronic liver disease as defined by monoclonal antibodies. Clin immunol immunopathol 26 : 83-90, 1983.
- 7. Bertoletti A Ferrari C et al : I-ILA class 1 restricted human cytotoxic T cells recognize endogenously synthesized HBV nucleocapsid antigen. Proc Natl Acad Sci USA 88 : 10445-9* 1991
- 8. Bowry TR • Immunoregulation, in : Immunology simplified, 2nd ed ,ELBS, Oxford University Press, 1986, pp : 66-73. 9.Burek B Burek V et al : Local xenogeneic greft-versus-host reaction : a measure of T cell function in asymptomatic HBsAg carriesrs. J clin kab immunol 27 69-72, 1988.
- 10. Casini A Alberti A et al : Cell-mediated immunity to HBcAg in chronic HBV infection. Brief scientific reports 88 494-8, 1987.
- Il. Chu Chia-Yung, Liaw Yun-Fa.n : Peripheral T cell subsets in asymptomatic HBV carriers. Cellular immunology 98 • 533-7, 1986.
- 12. Desmet VJ : Immunopathology of chronic viral hepatitis. Hepatogastroenterology 38 : 14-21, 1991.
- 13,.Dienstag JL Wands JR Isselbacher KJ : Acute hepatitis, in : Harrison's Principles of internal medicine (Ed Wilson, Braunwald, Isselbacher, Petersdorf, Martin, Fauci, Root) ,vol : 11,12th ed, McGraw Hill Inc, 1991, pp : 1322-37.
- 14.Ding-Feng Z Bang-yuan L et al : In vitro immunoregulation of anti-HBs synthe sis by peripheral lymphocytes in HBV infections. Chinese medical journal 100 338-40, 1987. 15.Dragosics B Ferenci P et al : Long term follow-up of asymptomatic HBsAg positive voluntary blood donors in Austria : a clinical and histological evaluation of 242 cases. Hepatology 7 : 302-6, 1987.
- 16. Echevarria S Casafot F et al Interleukin-2 and natural killer activity in acute type B hepatitis. Hepatogastroenterology 38 : 307-10, 1991.
- 17. Ehata T Omata M et al : Aminoacid resudues of core region of 1-1B V, asymptomatic carriers versus patients with livre disease. J Gastroenterol Hepatol 6 292-6, 1991
- 18. Ferrari C Penna A. et al : Cellular immune response to hepatitis B virus-encoded antigens in acute and chronic hepatitis B virus infection. J Immunol 145 : 3442-5, 1990.
- 19. Gerber M : Pathology and immunopathology of acute and chronic hepatitis B. Klimik dergisi 1 ; 52-7, 1988.
- 20 Gerken G Kremsdrof D et al : Hepatitis B defective virus with rearrangements in pre-s gene during cnronic HBV infection. Virology 183 : 555-65 1991* 21. Gupta H Tandon BN : Detection of HBsAg in circulating immune complexes in asymptomatic carriers and various hepatic disorders due to HBV. Indian Med Res 88 . 111-7, 1988.
- 22. Hoofnag.le JH Shafritz DA et al : Chronic type B hepatitis and the healthy carrier state. Hepatology 7 : 758-63, 1987.
- 23., Iraburu M Civeire MP et al : Suppressor T cell activity in chronic HBV infection : Relationship with the presence of HBV-DNA in serum. J of medical virology 27 : 39-43, 1989.
- 24.Klhçturgay Kaya : Major histokompatibilite kompleksi ve cloku gruplarl. immuno)ojiye giri§, Yarglçožlu Matbaasl, Bursa, 1987, s : 13-6.
- 25.Lever AML • Treatment of the chronic 1-1B V carrier state. Journal of infection 16 221-9, 1988.
- 26. Li XM Jeffers LJ et al : Immunophenotyping of lymphocytes in liver tissue of patients with chronic liver disease by flow cytometry. HepatQ!ogy 14 0: 121-7, 1991*
- 27.Marmion BP Hepatitis viruses, in Mackie and McCartney Medical microbiology, vol : 1 • Microbial infections (Ed : Duguid JP Marmion BP, Swain RHA), 13th ed, ELBS, Churchill Livingstone Hong Kong, pp : 475-82+
- 28. Milich DR Chisari FV Genetic regul ation of the immune response to HBsAg. The Journal of immunology 129 : 320-5, 1982.
- 29. Onul Melahat Gül Giray ve ark : Hepatit B infeksiyonlannda lenfosit subpopü lasyonu degjsiklikleri. Ankara Hastanesi Dergisi 24 : 87-90, 1989.
- 30. Popper A Shafrits DA et al Relation of the HBV carrier state to hepatocellular carcinoma. Hepato!ogy 7 ; 764-72, 1987.
- 31. Raptopoulu-Gigi M Orphanou-Koumerkeridou H et al • Possible mechanisms underlying peripheral lymphocyte activation in chronic liver disease and asymptomatic HBsAg carrier's. Allergol e timmunopathol 17 : 145 8, 1989.
- 32. Robinson WS : Hepatitis B virus and hepatitis delta virus, in : Principlers and practice of infectious diseases (Ed : Mandell, GL Douglas GR, Bennett JE), 3rd ed, Churchi!l Livingstone, 1990, pp : 1204-31.
- 33.Sherlock S : The natural history of Hepatitis B. Postgraduate medical journal 63 (suppl 2) 7-11, 1987.
- 34. Stanevicha VA Veksler KhM • Immunogenetic indicators in protracted hepatitis and their dynamics during the treatment with T-activin. Pediatriia 10 : 4-8, 1991.
- 35.Sylvan SPE Hellström UB et al : Detection of cellular and humoral immunity to HBsAg in asymptomatic HBsAg carriers, Clin exp immunol 62 : 288-95, 1985,
- 36, Thomas HC Brown D et a.] : Inducer and suppressor T cell in HBV-induced liver disease. Hepatology 2 202-4, 1982.
- 37. Thomas HC Jacyna M etal : Virus-host interaction in chronic HBV infection. Seminars in liver disease 8 342-9, 1988.
- 38. Thomas HC Pignatelli M et al ,Homology between HBV-DNA and a sequence regulating the interferon induced anti-viral system : Possible mechanisms of persistent infection. Journal of decial virology 19 : 63-9* 1986.
- 39. Vento S Chen SH et al : Cellu lar immunity to nucleocapsid and pre-S determinants in asymptomatic carriers of hepatitis B. Immunology 67 : 593-8, 1987.
- 40. Yamazuchi K Nakanishi T et al : Suppression of hepatitis B antibody saynthesis by factor made by T cells from chronic hepatitis B carriers. The Lancet 13 324-6, 1988.
There are 36 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Medical Bacteriology |
| Journal Section | Articles |
| Authors | |
| Project Number | - |
| Publication Date | June 30, 1993 |
| Published in Issue | Year 1993 Volume: 46 Issue: 2 |
