Abstract
Kobay timpanik membranının travmatik perforasyonları üzerinde %1 Hyaluronik asit (HA) solüsyonunun ve kendiliğinden iyileşmenin etkisi, perforasyonun kapanma süresi ve histolojik yapısal kriterler açısından incelendi. Topikal olarak uygulanan HA solüsyonu iyileşme oranını artırdı ve timpanik membran perforasyonlarının daha iyi yapısal iyileşme modeliyle sonuçlandı. HA özellikle lifli bağ dokusunun proliferasyonunu iyileştirdi. Bu deneysel bulgular, HA solüsyonunun insanda timpanik membran perforasyonlarının tedavisinde de dikkate alınması gerektiğini düşündürmektedir.
References
- 1. Hellstrom S Laurent C : Hyaluronan and healing of tympanic membrane perforations, An experimental study, ACTA Otolaryngol (Stockh) Suppl. 442 : 54-61, 1987.
- 2. LaCarte MPR Casasin T Pumarola F Alonso A ; An alternative treatment for the reduction of tympanic membrane perforations. Sodium Hyaluronate, ACTA Otolaryngol (Stockh) 110 ; 110-114, 1990.
- 3. Laurent C : Biochemistry of Hyaluronan, ACTA Otolaryngol (Stockh) Suppl.442 . 7-24, 1087.
- 4. Laurent C Hellstrom S$ Fellenius E : Hyaluronan improves the healing of experimental tympanic membrane perforations, Arch Otolaryngol Head Neck Surg 114 ; 1435-1441, 1988.
- 5. Stenfors LE : Treatment of tympanic membrane perforations with Hyaluronan in an open pilot study of unselected patients, ACTA Otolaryngol (Stockh) Suppl. 442 : 81-87, 1987.
- 6. Stenfors LE : Repair of traumatically ruptured tympanic membrane using Hyaluronan, ACTA Otolaryngol (Stockh) Suppl. 442 : 88-91. 1987.
- 7. Stenfors LE : Repair of tympanic membrane perforations using hyaluronic acid. An alternative to myringoplasty, J Laryngol Otol 103 : 39-40, 1989.
Abstract
The effect of 1 % Hyaluronic acid (HA) solution and spontaneous healing on traumatic perforations of the guinea pig tympanic membrane are examined, regarding closure time of the perforation and histological structural criteriae. Topically applied HA solution enhanced the healing rate and resulted in better structural healing pattern of the tympanic membrane perforations. HA particularly improved the proliferation of fibrous connective tissue. These experimental findings suggested that HA solution should also be considered in the treatment of tympanic membrane perforations in man.
References
- 1. Hellstrom S Laurent C : Hyaluronan and healing of tympanic membrane perforations, An experimental study, ACTA Otolaryngol (Stockh) Suppl. 442 : 54-61, 1987.
- 2. LaCarte MPR Casasin T Pumarola F Alonso A ; An alternative treatment for the reduction of tympanic membrane perforations. Sodium Hyaluronate, ACTA Otolaryngol (Stockh) 110 ; 110-114, 1990.
- 3. Laurent C : Biochemistry of Hyaluronan, ACTA Otolaryngol (Stockh) Suppl.442 . 7-24, 1087.
- 4. Laurent C Hellstrom S$ Fellenius E : Hyaluronan improves the healing of experimental tympanic membrane perforations, Arch Otolaryngol Head Neck Surg 114 ; 1435-1441, 1988.
- 5. Stenfors LE : Treatment of tympanic membrane perforations with Hyaluronan in an open pilot study of unselected patients, ACTA Otolaryngol (Stockh) Suppl. 442 : 81-87, 1987.
- 6. Stenfors LE : Repair of traumatically ruptured tympanic membrane using Hyaluronan, ACTA Otolaryngol (Stockh) Suppl. 442 : 88-91. 1987.
- 7. Stenfors LE : Repair of tympanic membrane perforations using hyaluronic acid. An alternative to myringoplasty, J Laryngol Otol 103 : 39-40, 1989.
Details
| Primary Language | Turkish |
|---|---|
| Subjects | Histology and Embryology |
| Journal Section | Articles |
| Authors | |
| Publication Date | March 31, 1992 |
| Published in Issue | Year 1992 Volume: 45 Issue: 1 |
