Research Article
Year 1989,
Volume: 42 Issue: 4, 559 - 568, 31.12.1989
Abstract
Yaşları 2 - 1 yıl arasında değişen unilateral ya da bilateral kriptorşitizmli 15 hasta günde 6 kez 200 ug. intranasal LH - RH uygulanması ile 4 hafta tedavi edildi. Retraktil testisi olan çocuklar çalışmaya alınmadı. Olgulardan 4'ünde komplet iniş sağlandı. İki olguda tesüsler fizyolojik yerleşimine indi ve tam yanıt % 26.6, kısmi yanıt ise % 13.3 olarak belirlendi. Tedavi ile ilgili herhangi bir yan etki gözlenmedi. Tedavi öncesi dönemde tüm hastalarda LH, FSH testosteron düzeyleri, hCG'ne testosteron cevabı denetlendi. Hastalarda uyarıya testiktiler yanıt normal düzeylerde bulundu.
Keywords
Ethical Statement
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Supporting Institution
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Project Number
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Thanks
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References
- 1. Annousskis C, Alexiou D, Lizkokg D et al. : hCG stimulationtest in prepurebtal boys with cyptorchidism. J Pediatr 93 : 630, 1978.
- 2. Bartsch G and Frick J : Therapeutic effects of Luteinizing hormone releasing hormone (LH-RH( in cryptorchitism Andrologia, 6 : 197, 1974.
- 3. Elder JS : Cwptorchidism isolated and associated with other genitourinary defects. Ped Clin N Amer 4 : 1031, 1987.
- 4. Forest MG : Aspects of male infertility. From Ed by Williams and Williams Balr timore, 1982, p : 31. 5. Fonkalsrud EW : Testiculer undescent and torsiyon. Ped Clin N Amer 34 : 1305,1987.
- 6. Garagorri JM, Job JC, Canlorbe P, Choussain JL : Results of early treatment of cryptorchidism with hCG. J Pediatr 101 : 923, 1982.
- 7. Gendral D, Roger M, Job JC : Plasma gonadotrophin and testesteron values in infants with cryptorchidism. J Pediatr 37 : 217, 1980.
- 8. Gonzalez R, Michael A : Undercended testes : from Nelson Textbook of Pediatrics Ed by Behrmann RE and Voughan V; WB Soundres Comp London 1987, P ; 1163.
- 9. Glassberg KI : Annual Meeting of the section Pediatric Urology. Pediatrics 81 :588, 1988.
- 10. Hadziselimovic F, Girard J, Hocht B et al. : Effect of IN-RH tfcatment on hypo halamic-putitary-gonadal axis and Leydig cell ultrast,rnat.nre in crypt..nrahid boys. Hormone Res 13 : 358, 1980.
- 11. Happ J, Kollmann F, Krzwehl M et 81. : Intranasal Gn-RF therapy of maldescended testes. Horm Metab Res 7 : 440, 1975.
- 12. Happ J, Kollman F, Krzwehl M et al. : Treatment of cryptorchidism with pernasal Gn-Rh thenapy. Fertility and sterility. 29 : 546, 1978.
- 13. Hedinger CE : Histopathology of unders cended testes. Eur J Pediatr 139 : 266, 1982.
- 14. Illig R, Kollman F, Exner Cu et alÞ : Treatment of cryptorchidism by intranasal synthetic luteinising-Hormonereleasing hormone. Lancet Il : 522, 1977.
- 15. Il-lig R, Bucher H, Prader A : Success, relaps and failure after intnanasal LH-RH treatment of cryptorchidism in 55 prepubertal boys. Eur J Pediatr 133 147, 1980.
- 16. Illig R, Ton-esani T, Bucher H et al. : Effect of intranasal LH-RH therapy to clinical results in prepubertal boy with cryptorchidism. Clin Endocr 12 : 91, 1980.
- 17. Karpe B, Eneroth P, Ritzen EN ; treatment in unileteral cryptorchidism : Effect an testiculer descent and hormonal response. J Pediatr 103 : 892, 1983.
- 18. Keizer-Schrama SMPF de M, Hazebroek FWI, Drop SLS et al. : Double-blind, placebo controlled study of LH-RH nasal spray in treatment of undescended testes. Lancet 1 : 876, 1986.
- 19. Kouman F, Happ J, Neubauer M et al. : Treatment of cryptorchitism with LH-RH nasal spray. Colloguium at Tubingen Feb. 1976.
- 20. Krabbe S, Skakkeback NE, Berthelsen JG et al. : High incidence of undetected neoplasia in meldescended testis. Lancet 1 : 999, 1979.
- 21. Lee PA, Hoffman WH, White JJ et al. : Serum gonadotropins in Am J Dis Child 127 : 530, 1974.
- 22. Mengel W, Zimmerman FA, Hecker Timing of repair for undescended testes. In Fonkalsrud EW, Mengel W (eds) : The undescended. Testis-Chicago, Year Book Medical 1981, p : 170.
- 23. Pirazolli P, Zappula F, Bernardi F : Luteinising hormonereleasing hormone nasal spray as therapy for undescesded testicle. Arch Dis Child 53 : 235, 1978.
Year 1989,
Volume: 42 Issue: 4, 559 - 568, 31.12.1989
Abstract
Fifteen boys between 2-12 years of age with unilateral or bilateral cryptorchidism were treated with 200 lig LH-RH pernasally six times daily for 4 weeks. Boys with retractile testes were not studied. Complete descent occured in four, improved position attained in 2 patients. The complete and incomplete succes-ratios were 26.6 M 70 and 13.3 % in our patients respectively. No adverse side effects have been Radioimmunologic measurement of serum luteinizing hormone (LH), follicule stimulating hormone (FSH) , testesteron and hCG stimulation test were carried out before treatment. We found normal testicular function after stimulation of testes.
Keywords
Ethical Statement
-
Supporting Institution
-
Project Number
-
Thanks
-
References
- 1. Annousskis C, Alexiou D, Lizkokg D et al. : hCG stimulationtest in prepurebtal boys with cyptorchidism. J Pediatr 93 : 630, 1978.
- 2. Bartsch G and Frick J : Therapeutic effects of Luteinizing hormone releasing hormone (LH-RH( in cryptorchitism Andrologia, 6 : 197, 1974.
- 3. Elder JS : Cwptorchidism isolated and associated with other genitourinary defects. Ped Clin N Amer 4 : 1031, 1987.
- 4. Forest MG : Aspects of male infertility. From Ed by Williams and Williams Balr timore, 1982, p : 31. 5. Fonkalsrud EW : Testiculer undescent and torsiyon. Ped Clin N Amer 34 : 1305,1987.
- 6. Garagorri JM, Job JC, Canlorbe P, Choussain JL : Results of early treatment of cryptorchidism with hCG. J Pediatr 101 : 923, 1982.
- 7. Gendral D, Roger M, Job JC : Plasma gonadotrophin and testesteron values in infants with cryptorchidism. J Pediatr 37 : 217, 1980.
- 8. Gonzalez R, Michael A : Undercended testes : from Nelson Textbook of Pediatrics Ed by Behrmann RE and Voughan V; WB Soundres Comp London 1987, P ; 1163.
- 9. Glassberg KI : Annual Meeting of the section Pediatric Urology. Pediatrics 81 :588, 1988.
- 10. Hadziselimovic F, Girard J, Hocht B et al. : Effect of IN-RH tfcatment on hypo halamic-putitary-gonadal axis and Leydig cell ultrast,rnat.nre in crypt..nrahid boys. Hormone Res 13 : 358, 1980.
- 11. Happ J, Kollmann F, Krzwehl M et 81. : Intranasal Gn-RF therapy of maldescended testes. Horm Metab Res 7 : 440, 1975.
- 12. Happ J, Kollman F, Krzwehl M et al. : Treatment of cryptorchidism with pernasal Gn-Rh thenapy. Fertility and sterility. 29 : 546, 1978.
- 13. Hedinger CE : Histopathology of unders cended testes. Eur J Pediatr 139 : 266, 1982.
- 14. Illig R, Kollman F, Exner Cu et alÞ : Treatment of cryptorchidism by intranasal synthetic luteinising-Hormonereleasing hormone. Lancet Il : 522, 1977.
- 15. Il-lig R, Bucher H, Prader A : Success, relaps and failure after intnanasal LH-RH treatment of cryptorchidism in 55 prepubertal boys. Eur J Pediatr 133 147, 1980.
- 16. Illig R, Ton-esani T, Bucher H et al. : Effect of intranasal LH-RH therapy to clinical results in prepubertal boy with cryptorchidism. Clin Endocr 12 : 91, 1980.
- 17. Karpe B, Eneroth P, Ritzen EN ; treatment in unileteral cryptorchidism : Effect an testiculer descent and hormonal response. J Pediatr 103 : 892, 1983.
- 18. Keizer-Schrama SMPF de M, Hazebroek FWI, Drop SLS et al. : Double-blind, placebo controlled study of LH-RH nasal spray in treatment of undescended testes. Lancet 1 : 876, 1986.
- 19. Kouman F, Happ J, Neubauer M et al. : Treatment of cryptorchitism with LH-RH nasal spray. Colloguium at Tubingen Feb. 1976.
- 20. Krabbe S, Skakkeback NE, Berthelsen JG et al. : High incidence of undetected neoplasia in meldescended testis. Lancet 1 : 999, 1979.
- 21. Lee PA, Hoffman WH, White JJ et al. : Serum gonadotropins in Am J Dis Child 127 : 530, 1974.
- 22. Mengel W, Zimmerman FA, Hecker Timing of repair for undescended testes. In Fonkalsrud EW, Mengel W (eds) : The undescended. Testis-Chicago, Year Book Medical 1981, p : 170.
- 23. Pirazolli P, Zappula F, Bernardi F : Luteinising hormonereleasing hormone nasal spray as therapy for undescesded testicle. Arch Dis Child 53 : 235, 1978.
There are 22 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Pediatric Health and Illnesses Nursing |
| Journal Section | Articles |
| Authors | |
| Project Number | - |
| Publication Date | December 31, 1989 |
| Published in Issue | Year 1989 Volume: 42 Issue: 4 |