In Synovial Fluid, İmmun Complex, Beta-2 Microglobulin Rheumatoid Factor And İmmunglobulin Levels İn Rheumatoid Arthritis
Abstract
In this study immune complexes, beta-2 microglobulin, rheuma toid factor and immunglobulin levels (IgG, IgA, IgM) in synoviyal fluids have been detected in 37 patients with rheumatoid arthritis and 9 patients with non rheumatoid arthritis as control.The ratio of positivity of rheumatoid factor in synovial fluids in rheumatoid arthritis was % 67.5, This value was % 66 in non rheumatoid patients.We didn't find any difference in the means of immune complexes and immunglobulin levels in both groups. But a significant difference was observed in the beta-2 microglobulin levels in rheumatoid patients. It is suggested beta-2 microglobulin levels in synovial fluids may be helper criterium in the diagnosis of rheumatoid arthritis.
Keywords
References
- I. Allen J.C., Kunkel H.G. : Hidden rheumatoid factors with specifity for native gamma globülins. Arthritis Rheum. 9 : 758, 1966.
- 2. Becker W., Parp W. ve ark. Z. Klin. Chem. 6 : 113, 1970.
- 3. Birch R.E., Fager M.W., Bernzier G.M. : Beta-2 mikroglobulin enhances human lymphocyte surface receptor expression for IgG. J. immun. 122 : 997, 1979.
- 4. Boyle J.A„ Buchanan W.W. : Clinical Rheumatology. First edition. Blacwell Scientific Publications. Oxford and Edinburg, 1971.
- 5. Cats A, Hazevoet H.M. : Significance of positive tests for rheumatoid factor in the prognosis of rheumatoid arthritis. Ann. Rheum. Dis 29 : 254, 1970. 6. Cracchiolo A., Goldberg Ll., Barnett E.V. : Studied of cryoprecipitates from synovial fluid of rheumatoid patients. Arth. and Rheumatism. 13/6 : 897, 1970.
- 7. Digeon M., Laver M. ve ark. : Detection of circulating immun complexes in human sera by simplified assaays with polyethylene glycol. J. of Immunolo gical methods. 16 : 165, 1977.
- 8. Freedman, G. Clinical Immunology Second. edition. 295. 1976.
- 9. Ghose T., Woodbury J.F.L. : Immünopathological changes, in rheumatoid' arthritis and other joint disease. J. Clin. Path. 28/2 : 109-117, 1975.
- 10. Hasler F., Stojan B. : Immunologische befunda im serum and in der gelenkflussigkeit bei patienten mit Rheumatoider Arthritis. 89/21 : 713-716, 1977. Il. Manicourt D, Brauman Fl., Orloff S. : Synovial fluid beta-2 microglobulin and hydroxproline fractions in rheumatoid arthritis and nonautoimmune arthropathies. Ann. Rheum. Dis. 39 : 207, 1980.
- 12. Roitt I. : Essential Immunology fourth edition, Black well seintific publications. 1978.
- 13. Santamaria A. ve ark. : Immune complexes and polynuclectides in sinovial fluid Rev. Esp. Rheum. Enferm. Ostecard. 18/10-9, 1975.
- 14. Talal N. ve ark. Elevated salivary and synovial fluid beta-2 mikroglobulin in Sjogren syndrome and rheumatoid arthritis. Science 188 : 1196-1198, 1975.
- 15. Veys E.M., Gabriel P.A. and et al. : Rheumatoid factor and serum IgG, IgM anclevels in rheumatoid arthritis with vasculitis Scan. J. Rheumatol 511.1976.
- 16. Wyngaarden, J.B., Smith L.H. Textbook of medicine. 1982.
Romatoid Artritli Hastalarda Sinoviyal Sıvıda Romatoid Faktör, İmmün Kompleks Beta-2 Mikroglobulin Ve İmmünglobulin Seviyeleri
Abstract
Ça11smam1zda ARA kriterlerine göre romatoid artrit tarnsl alan romatoid artritli hastalardan olusan çahsma grubu ile; romatoid artrit dl$lnda kalan hastalarm olusturdugu kontrol grubunda sinoviyal slvl immün kompleks, beta-2 mikroglobulin, IgG, IgA, IgM ve romatoid faktör degerleri belirlenerek karsllastlrlldl.Çahsma grubunda romatoid faktör sinoviyal slvlda % 67.5 oranmda pozitif bulundu. Kontrol grubunu olusturan hastalarda ise bu oran % 66 idi. Ça11srna ve kontrol gruplarmda sinoviyal SIVI ortalama immün kompleks, IgG, IgA ve IgM degerleri arasmda istatistiksel olarak an-Buna karslllk, çahsma grubunda sinoviyal slvl ortalama beta-2 mikroglobulin düzeyleri kontrol grubunun ortalama degerlerinden belirgin olarak yüksek bulundu. Bu fark istatistiksel olarak da anlamhydl (p
Keywords
References
- I. Allen J.C., Kunkel H.G. : Hidden rheumatoid factors with specifity for native gamma globülins. Arthritis Rheum. 9 : 758, 1966.
- 2. Becker W., Parp W. ve ark. Z. Klin. Chem. 6 : 113, 1970.
- 3. Birch R.E., Fager M.W., Bernzier G.M. : Beta-2 mikroglobulin enhances human lymphocyte surface receptor expression for IgG. J. immun. 122 : 997, 1979.
- 4. Boyle J.A„ Buchanan W.W. : Clinical Rheumatology. First edition. Blacwell Scientific Publications. Oxford and Edinburg, 1971.
- 5. Cats A, Hazevoet H.M. : Significance of positive tests for rheumatoid factor in the prognosis of rheumatoid arthritis. Ann. Rheum. Dis 29 : 254, 1970. 6. Cracchiolo A., Goldberg Ll., Barnett E.V. : Studied of cryoprecipitates from synovial fluid of rheumatoid patients. Arth. and Rheumatism. 13/6 : 897, 1970.
- 7. Digeon M., Laver M. ve ark. : Detection of circulating immun complexes in human sera by simplified assaays with polyethylene glycol. J. of Immunolo gical methods. 16 : 165, 1977.
- 8. Freedman, G. Clinical Immunology Second. edition. 295. 1976.
- 9. Ghose T., Woodbury J.F.L. : Immünopathological changes, in rheumatoid' arthritis and other joint disease. J. Clin. Path. 28/2 : 109-117, 1975.
- 10. Hasler F., Stojan B. : Immunologische befunda im serum and in der gelenkflussigkeit bei patienten mit Rheumatoider Arthritis. 89/21 : 713-716, 1977. Il. Manicourt D, Brauman Fl., Orloff S. : Synovial fluid beta-2 microglobulin and hydroxproline fractions in rheumatoid arthritis and nonautoimmune arthropathies. Ann. Rheum. Dis. 39 : 207, 1980.
- 12. Roitt I. : Essential Immunology fourth edition, Black well seintific publications. 1978.
- 13. Santamaria A. ve ark. : Immune complexes and polynuclectides in sinovial fluid Rev. Esp. Rheum. Enferm. Ostecard. 18/10-9, 1975.
- 14. Talal N. ve ark. Elevated salivary and synovial fluid beta-2 mikroglobulin in Sjogren syndrome and rheumatoid arthritis. Science 188 : 1196-1198, 1975.
- 15. Veys E.M., Gabriel P.A. and et al. : Rheumatoid factor and serum IgG, IgM anclevels in rheumatoid arthritis with vasculitis Scan. J. Rheumatol 511.1976.
- 16. Wyngaarden, J.B., Smith L.H. Textbook of medicine. 1982.
Details
| Primary Language | English |
|---|---|
| Subjects | Immunology (Other), Internal Diseases |
| Journal Section | Articles |
| Authors | |
| Publication Date | December 31, 1986 |
| Published in Issue | Year 1986 Volume: 39 Issue: 4 |
