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İlerlemiş Prostat Kanserlerinde Estracyt Tedavisi İle Alınan Sonuçlar

Year 1980, Volume: 33 Issue: 1, 63 - 74, 01.07.1980

Şevket Tuncer

Abstract

Ekserisi «D» evresinde olan prostat kanserli 25 hasta i.v. ve oral Estracyt ile tedavi edildi. Günlük doz olarak i.v. 300 mg. ve oral 700 mg. (2 +3 kapsül) uygulandı: Ortalama tedavi süresi 10 ay, maksimal 18 ay oldu. Kemik ağrılarının süratle gerilemesi ve genel durumun düzelmesi dikkat içekmekteydi. Ayrıca yüksek serum asit fosfataz seviyesi de ekseriya düzeldi. Oral uygulama ambulant tedaviyi kolaylaştırmaktadır. C ve D evresindeki prostat kanserllrinde Estracyt tedavisi metetmeye değer bulunmuştur.

Keywords

prostat kanseri Kemik ağrıları serum asit

References

  • 1. Alfthan, O.S., J. Rusk : Estracyt in aavented prostatic carcinoma. Ann. Chir. Gyn. Fem. 58 : 324-340, 1969
  • 2. Anderes, A. et al. : Die zytostatische Therapie des Prostatakarzinoms. Studie über Estramustinphosphat. Schweiz. Rundshau 'Med. (Praxis) 38 : 1276-1279, 1971
  • 3. Arduinö, L.J. : Chemotherapy in urologic cancer. Surg. Clin.• North Amer. 45 • 1363, 1965
  • 4. Bangshaw, M.A., HIS. Kaplan, R.H. Sagermann : Linear •accelerator supervoltage radiotherapy. VIl Carcinoma of the prostate. Radiology 85 • 121-129. 1965
  • 5 . Belt, E., F.H. Schroeder : Total perineal prostatectomy for carcinoma of the prostate.
  • 6. Blackard, C.E., G.T. Mellinger, D.F. Gleason : Treatment of. stage 1 carcinoma of the prostate J. Urol.• 106 : 729-733, 1971
  • 7. Byar, D.P., F.K. Mostofi : Carcinoma of the prostate : prognostic evaluation of certain pathologic features in 208 radical prostatectomy. Cancer 30 : 5-13, 1972
  • 8. Fergusson, J.D.. W.D .Hendry : Pituitary irradiatoin in advance carcinoma of the prostate. Analysis o f 100 cases. Brit. J. •Urol 4.3 : 514-579 , 1971
  • 9. Flocks, R.H. : International symposium on the treatment of carcinoma of the prostated Berlin Nov. 13-15 (1969). Permagon Press. Oxford (1971)
  • 10. Flocks, R.H., S.F. Cheng : Combination therapy. for prostatic carcinoma with special emposis on the role of chemotherapy. J. Iowa Med. Soc. 58 125-129, 1968
  • 11. Fox, M. : The effect of cyclophosphamide on some urinary tract tumors. Brit. J. Urol. 37 : 399-409, 1965
  • 12. Grout, D.C., J.T. Grayhack, W., Moss, J.M. Hooand : Radiation. theraphy in the treatment of carcinoma of the prostate. J. Urol. 105 (1971) 411
  • 13. Hünig, R; R. Sauer : Die Strahlentherapie des Prostatakarsinoms. Praxis 63 • . 124-127, 1974
  • 14. Jonsson, G. : Cytotoxic agents in the tretament of prostatic carcinoma. International symposium of the treatment of carcinoma of the prostate. Berlin Nov. 13-15 (1969).
  • 15. Jönsson. G., B .Högberg : Treatment of advanced prostatic carcinoma with Estracyt. Scand. J. Urol. Nephrol. 5 : 103-107, 1971
  • 16. Klein, D. : Behandlung mit Estramustinphosphat beim fortgeschrittenem Prostatakarzi nom. Wien. Med: Wschr. 122 : 458-460, 1972
  • 17. Levy, A : Zur Hypophysektomie beim metastasierenden Mammae und Prostatakarzinom. Praxis 63 • 117-119, 1974
  • 18. Lindberg, B. : Treatment of rapidly progressing carcinoma with Eastracyt. J. Urol. 108 : 303-306, 1972
  • 19. Mayer, E.J. : Orale Eastracyt-Behandlung beim Prostatakarzinom. Ther. Umsch. 32 114-119, 1975
  • 20. Morales, A.D., W. Blair, J. Steyn : Yitrium 90 piutitary ablation in advanced carcinoma of the prostate. Brit. J. Urol. 3 : 520-522, 1971
  • 21. Nagel, R., C.P. Kölln : Erfahrungen mit Estracyt beim metastasierenden Prostatakarzinom.• Akt.• Urol. 3 : 241-246, 1972
  • 22 Nilsson, 1., u. JÖnsson : Clinical results with estramustine phosphate : a comparison of the the intravenous and oral preparation. Cancer Chem. Rep. 59 : 229-231, 1975
  • 23. Nilsson T., J. Mi.iñzig : Estracyt in advanced prostatik carcinoma. Scan. J. Urol. Nephr. 11-16. 1972
  • 24 - Nilsson T., J. Münzig : •Histochemical and biochemical investigation of advanced pros tatic carcinoma treated with estramustine phosphate (Estracyt). Scand. J. Urol. J. Urol Nephr. 7 : 18 - 22, 9173
  • 25 - Pavone-Macalusö, M., G. Caramia, M. Vecchioni : La chimiotherapie antiblastique dans le traitement du cancer dc la prostatc. J. d'Urol. Nephrol. 7-8 : 621 - 634, 1972
  • 26 - Persky, L, K. Guerrier, R. Rabin, D.J. Albert : Mitramycin and Metastatic carcinoma of the prostate. J. Urol. 104 : 884 - 887, 1970
  • 27 - Prout, R. Jr., W.R. Brewer Response men with advanced prostatic carcinoma to exogenous administration of testosterone. Cancer 20 : 1878, 1967
  • 28 - Scott, W.W., R.P. Gibson, DE. Johnson, o.R. Prout. J.D. Schmidt, J. Saroff, G.P. Murphy : The continued evalution of the effects of chemotherapy in patents with advanced carCinoma of prostate J. Urol. 116/2 211 - 213, 1976
  • 29 - Straffon, R.A., W.S. Kieser, M. Robitaille, D.F. Dohn. : Yitrium90 hypophysectomy in the management of metastatic carcinoma of the prostate glalnd in 13 patients. J. Urol. 99 : 102 - 105, 1968
  • 30 - Szenröl. Z. : Mit Estracyt erreihte Ergebnisse bei 130 Prostatakarzinom-Patienten. Vortrag 27. Tag. der Dtsch. Gesel. f. Urologie, Düsseldorf. 1-4 Okt. 1975
  • 31 - The Veterans administration co-operative urological; research group. Treatment and survival of patients with cancer of the prostate. Surg. Gyn. Obst. 124 : 1011 - 1017, 1967 32 - Weyrauch. H.M., J.D. Nesbit : Use of triethylene (thio - phosphoramide (thio - TEPA) in treatment of advenced carcinoma of prostate. J. Urol'. 81 • 185 - 193, 1959
  • 33 - Young, J.A., A.W. Bowe : Carcinoma of prostate : Traetment and survival with radical prostatectomy. J. Urol. 107 : 1041 - 1042, 1972

Results of Estracyt Treatment in Advanced Prostate Cancer

Year 1980, Volume: 33 Issue: 1, 63 - 74, 01.07.1980

Şevket Tuncer

Abstract

Twenty-five patients with prostate cancer, mostly in stage «D», were treated with i.v. and oral Estracyt. Daily doses of i.v. 300 mg and oral 700 mg (2 +3 capsules) were administered: Average treatment duration was 10 months, maximum 18 months. Rapid regression of bone pain and improvement of general condition were noted. Also high serum acid phosphatase level was mostly improved. Oral administration facilitates ambulatory treatment. Estracyt treatment was found to be worth considering in C and D stage prostate cancers.

Keywords

prostat kanseri Kemik ağrıları serum asit

References

  • 1. Alfthan, O.S., J. Rusk : Estracyt in aavented prostatic carcinoma. Ann. Chir. Gyn. Fem. 58 : 324-340, 1969
  • 2. Anderes, A. et al. : Die zytostatische Therapie des Prostatakarzinoms. Studie über Estramustinphosphat. Schweiz. Rundshau 'Med. (Praxis) 38 : 1276-1279, 1971
  • 3. Arduinö, L.J. : Chemotherapy in urologic cancer. Surg. Clin.• North Amer. 45 • 1363, 1965
  • 4. Bangshaw, M.A., HIS. Kaplan, R.H. Sagermann : Linear •accelerator supervoltage radiotherapy. VIl Carcinoma of the prostate. Radiology 85 • 121-129. 1965
  • 5 . Belt, E., F.H. Schroeder : Total perineal prostatectomy for carcinoma of the prostate.
  • 6. Blackard, C.E., G.T. Mellinger, D.F. Gleason : Treatment of. stage 1 carcinoma of the prostate J. Urol.• 106 : 729-733, 1971
  • 7. Byar, D.P., F.K. Mostofi : Carcinoma of the prostate : prognostic evaluation of certain pathologic features in 208 radical prostatectomy. Cancer 30 : 5-13, 1972
  • 8. Fergusson, J.D.. W.D .Hendry : Pituitary irradiatoin in advance carcinoma of the prostate. Analysis o f 100 cases. Brit. J. •Urol 4.3 : 514-579 , 1971
  • 9. Flocks, R.H. : International symposium on the treatment of carcinoma of the prostated Berlin Nov. 13-15 (1969). Permagon Press. Oxford (1971)
  • 10. Flocks, R.H., S.F. Cheng : Combination therapy. for prostatic carcinoma with special emposis on the role of chemotherapy. J. Iowa Med. Soc. 58 125-129, 1968
  • 11. Fox, M. : The effect of cyclophosphamide on some urinary tract tumors. Brit. J. Urol. 37 : 399-409, 1965
  • 12. Grout, D.C., J.T. Grayhack, W., Moss, J.M. Hooand : Radiation. theraphy in the treatment of carcinoma of the prostate. J. Urol. 105 (1971) 411
  • 13. Hünig, R; R. Sauer : Die Strahlentherapie des Prostatakarsinoms. Praxis 63 • . 124-127, 1974
  • 14. Jonsson, G. : Cytotoxic agents in the tretament of prostatic carcinoma. International symposium of the treatment of carcinoma of the prostate. Berlin Nov. 13-15 (1969).
  • 15. Jönsson. G., B .Högberg : Treatment of advanced prostatic carcinoma with Estracyt. Scand. J. Urol. Nephrol. 5 : 103-107, 1971
  • 16. Klein, D. : Behandlung mit Estramustinphosphat beim fortgeschrittenem Prostatakarzi nom. Wien. Med: Wschr. 122 : 458-460, 1972
  • 17. Levy, A : Zur Hypophysektomie beim metastasierenden Mammae und Prostatakarzinom. Praxis 63 • 117-119, 1974
  • 18. Lindberg, B. : Treatment of rapidly progressing carcinoma with Eastracyt. J. Urol. 108 : 303-306, 1972
  • 19. Mayer, E.J. : Orale Eastracyt-Behandlung beim Prostatakarzinom. Ther. Umsch. 32 114-119, 1975
  • 20. Morales, A.D., W. Blair, J. Steyn : Yitrium 90 piutitary ablation in advanced carcinoma of the prostate. Brit. J. Urol. 3 : 520-522, 1971
  • 21. Nagel, R., C.P. Kölln : Erfahrungen mit Estracyt beim metastasierenden Prostatakarzinom.• Akt.• Urol. 3 : 241-246, 1972
  • 22 Nilsson, 1., u. JÖnsson : Clinical results with estramustine phosphate : a comparison of the the intravenous and oral preparation. Cancer Chem. Rep. 59 : 229-231, 1975
  • 23. Nilsson T., J. Mi.iñzig : Estracyt in advanced prostatik carcinoma. Scan. J. Urol. Nephr. 11-16. 1972
  • 24 - Nilsson T., J. Münzig : •Histochemical and biochemical investigation of advanced pros tatic carcinoma treated with estramustine phosphate (Estracyt). Scand. J. Urol. J. Urol Nephr. 7 : 18 - 22, 9173
  • 25 - Pavone-Macalusö, M., G. Caramia, M. Vecchioni : La chimiotherapie antiblastique dans le traitement du cancer dc la prostatc. J. d'Urol. Nephrol. 7-8 : 621 - 634, 1972
  • 26 - Persky, L, K. Guerrier, R. Rabin, D.J. Albert : Mitramycin and Metastatic carcinoma of the prostate. J. Urol. 104 : 884 - 887, 1970
  • 27 - Prout, R. Jr., W.R. Brewer Response men with advanced prostatic carcinoma to exogenous administration of testosterone. Cancer 20 : 1878, 1967
  • 28 - Scott, W.W., R.P. Gibson, DE. Johnson, o.R. Prout. J.D. Schmidt, J. Saroff, G.P. Murphy : The continued evalution of the effects of chemotherapy in patents with advanced carCinoma of prostate J. Urol. 116/2 211 - 213, 1976
  • 29 - Straffon, R.A., W.S. Kieser, M. Robitaille, D.F. Dohn. : Yitrium90 hypophysectomy in the management of metastatic carcinoma of the prostate glalnd in 13 patients. J. Urol. 99 : 102 - 105, 1968
  • 30 - Szenröl. Z. : Mit Estracyt erreihte Ergebnisse bei 130 Prostatakarzinom-Patienten. Vortrag 27. Tag. der Dtsch. Gesel. f. Urologie, Düsseldorf. 1-4 Okt. 1975
  • 31 - The Veterans administration co-operative urological; research group. Treatment and survival of patients with cancer of the prostate. Surg. Gyn. Obst. 124 : 1011 - 1017, 1967 32 - Weyrauch. H.M., J.D. Nesbit : Use of triethylene (thio - phosphoramide (thio - TEPA) in treatment of advenced carcinoma of prostate. J. Urol'. 81 • 185 - 193, 1959
  • 33 - Young, J.A., A.W. Bowe : Carcinoma of prostate : Traetment and survival with radical prostatectomy. J. Urol. 107 : 1041 - 1042, 1972
There are 32 citations in total.

Details

Primary Language Turkish
Subjects Urology
Journal Section Articles
Authors

Şevket Tuncer

Publication Date July 1, 1980
Published in Issue Year 1980 Volume: 33 Issue: 1

Cite

APA Tuncer, Ş. (1980). İlerlemiş Prostat Kanserlerinde Estracyt Tedavisi İle Alınan Sonuçlar. Ankara Üniversitesi Tıp Fakültesi Mecmuası, 33(1), 63-74.
AMA Tuncer Ş. İlerlemiş Prostat Kanserlerinde Estracyt Tedavisi İle Alınan Sonuçlar. Ankara Üniversitesi Tıp Fakültesi Mecmuası. July 1980;33(1):63-74.
Chicago Tuncer, Şevket. “İlerlemiş Prostat Kanserlerinde Estracyt Tedavisi İle Alınan Sonuçlar”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 33, no. 1 (July 1980): 63-74.
EndNote Tuncer Ş (July 1, 1980) İlerlemiş Prostat Kanserlerinde Estracyt Tedavisi İle Alınan Sonuçlar. Ankara Üniversitesi Tıp Fakültesi Mecmuası 33 1 63–74.
IEEE Ş. Tuncer, “İlerlemiş Prostat Kanserlerinde Estracyt Tedavisi İle Alınan Sonuçlar”, Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 33, no. 1, pp. 63–74, 1980.
ISNAD Tuncer, Şevket. “İlerlemiş Prostat Kanserlerinde Estracyt Tedavisi İle Alınan Sonuçlar”. Ankara Üniversitesi Tıp Fakültesi Mecmuası 33/1 (July 1980), 63-74.
JAMA Tuncer Ş. İlerlemiş Prostat Kanserlerinde Estracyt Tedavisi İle Alınan Sonuçlar. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 1980;33:63–74.
MLA Tuncer, Şevket. “İlerlemiş Prostat Kanserlerinde Estracyt Tedavisi İle Alınan Sonuçlar”. Ankara Üniversitesi Tıp Fakültesi Mecmuası, vol. 33, no. 1, 1980, pp. 63-74.
Vancouver Tuncer Ş. İlerlemiş Prostat Kanserlerinde Estracyt Tedavisi İle Alınan Sonuçlar. Ankara Üniversitesi Tıp Fakültesi Mecmuası. 1980;33(1):63-74.