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Melilotus albus çiçeklerinin fitokimyası: LC-ESI-MS/MS ile biyoaktif bileşiklerin kantitatif analiziyle ve sensor ile antioksidan analizi

Year 2025, Volume: 8 Issue: 1, 17 - 23, 30.06.2025

Ramazan Erenler , İlyas Yıldız , Esma Nur Geçer , İbrahim Hosaflıoğlu

https://doi.org/10.38059/biodiversity.1726816

Abstract

Bitkiler, biyoaktif bileşikler içermeleri nedeniyle ilaç geliştirmede önemli ilgi görmüştür. Bitkilerde bulunan biyoaktif bileşiklere sekonder metabolitler denir ve bunlar ilaç endüstrisinde önemli bir rol oynar. Günümüzde kullanılan ilaçların çoğu biyolojik olarak aktif doğal bileşiklerden ilham alınarak geliştirilmiştir. Fenoliklerin kantitatif analizi LC-MS/MS ile belirlendi ve ana bileşik olarak kumarin bulundu. DPPH antioksidan aktivitesi sensör analiz ile ölçüldü ve M. albus çiçeklerinin iyi orta derecede aktiviteye sahip olduğu belirlendi (40.57). Bu çiçeklerin ayrıca toplam fenolik içeriği 129.22 mg GA/g olarak bulundu. M. albus çiçekleri ana ürün olarak kumarin içerdiğinden, ilgili bitki çiçekleri kumarin ve antioksidan ajanın kaynağı olabilir.

Keywords

Antioksidan aktivite Kantitatif analiz Melilotus albus Doğal ürünler

References

  • Aksit H, Çelik SM, Sen Ö, Erenler R, Demirtas I, Telci I, Elmastas M (2014). Complete isolation and characterization of polar portion of Mentha dumetorum water extract. Records of Natural Products 8:277-280.
  • Atalar MN, Erenler R, Turkan F, Alma MH, Demirtas I, Baran A, Kandemir SI, Kekec AI, Saltan FZ (2023). Phytochemical analysis and biological activity of Corchorus olitorius L.: Quantitative analysis of bioactive compounds by LC–MS/MS, antibacterial, enzyme inhibition, and cytotoxic activities. European Journal of Integrative Medicine 62:102290.
  • Başar Y, Erenler R (2024). Phytochemical analysis of Silybum marianum flowers: Quantitative analysis of natural compounds and molecular docking application. Turkish Journal of Biodiversity 7:20-31.
  • Başar Y, Hosaflıoğlu İ, Erenler R (2024). Phytochemical analysis of Robinia pseudoacacia flowers and leaf: quantitative analysis of natural compounds and molecular docking application. Turkish Journal of Biodiversity 7:1-10.
  • Cragg GM, Newman DJ, Snader KM (1997). Natural products in drug discovery and development. Journal of Natural Products 60:52-60.
  • Demirtas I, Erenler R, Elmastas M, Goktasoglu A (2013). Studies on the antioxidant potential of flavones of Allium vineale isolated from its water-soluble fraction. Food Chemistry 136:34-40.
  • Elmastas M, Ozturk L, Gokce I, Erenler R, Aboul‐Enein HY (2004). Determination of antioxidant activity of marshmallow flower (Althaea officinalis L.). Analytical Letters 37:1859-1869.
  • Elmastaş M, Telci İ, Akşit H, Erenler R (2015). Comparison of total phenolic contents and antioxidant capacities in mint genotypes used as spices/Baharat olarak kullanılan nane genotiplerinin toplam fenolik içerikleri ve antioksidan kapasitelerinin karşılaştırılması. Turkish Journal of Biochemistry 40:456-462.
  • Elmastas M, Erenler R, Isnac B, Aksit H, Sen O, Genc N, Demirtas I (2016). Isolation and identification of a new neo-clerodane diterpenoid from Teucrium chamaedrys L. Natural Product Research 30:299-304.
  • Elmastas M, Celik SM, Genc N, Aksit H, Erenler R, Gulcin İ (2018). Antioxidant activity of an anatolian herbal tea-Origanum minutiflorum: isolation and characterization of its secondary metabolites. International Journal of Food Properties 21:374-384.
  • Erenler R, Yilmaz S, Aksit H, Sen O, Genc N, Elmastas M, Demirtas I (2014). Antioxidant activities of chemical constituents isolated from Echinops orientalis Trauv. Records of Natural Products 8:32-36.
  • Erenler R, Telci I, Ulutas M, Demirtas I, Gul F, Elmastas M, Kayir O (2015). Chemical Constituents, Quantitative Analysis and Antioxidant Activities of Echinacea purpurea (L.) Moench and Echinacea pallida (Nutt.) Nutt. Journal of Food Biochemistry 39:622-630.
  • Erenler R, Pabuccu K, Yaglioglu AS, Demirtas I, Gul F (2016). Chemical constituents and antiproliferative effects of cultured Mougeotia nummuloides and Spirulina major against cancerous cell lines. Zeitschrift fur Naturforschung-Section C. Journal of Biosciences 71:87-92.
  • Erenler R, Sen O, Aksit H, Demirtas I, Yaglioglu AS, Elmastas M, Telci İ (2016). Isolation and identification of chemical constituents from Origanum majorana and investigation of antiproliferative and antioxidant activities. Journal of the Science of Food and Agriculture 96:822-836.
  • Erenler R, Adak T, Karan T, Elmastas M, Yildiz I, Aksit H, Topcu G, Sanda MA (2017). Chemical Constituents isolated from Origanum solymicum with Antioxidant activities. The Eurasia Proceedings of Science, Technology, Engineering & Mathematics 1:139-145.
  • Erenler R, Nusret G, Elmastaş M, Eminağaoğlu Ö (2019). Evaluation of antioxidant capacity with total phenolic content of Galanthus krasnovii (Amaryllidaceae). Turkish Journal of Biodiversity 2:13-17.
  • Erenler R, Atalar MN, Yıldız İ, Geçer EN, Yıldırım A, Demirtas İ, Alma MH (2023). Quantitative analysis of bioactive compounds by LC-MS/MS from Inula graveolens. Bütünleyici ve Anadolu Tıbbı Dergisi 4:3-10.
  • Erenler R, Chaoui R, Yildiz I, Genc N, Gecer EN, Temiz C, Akkal S (2023). Biosynthesis, Characterisation, and Antioxidant Activity of Silver Nanoparticles using Schinus molle L. Trends in Sciences 20:6105-6105.
  • Erenler R, Gecer EN, Hosaflioglu I, Behcet L (2023). Green synthesis of silver nanoparticles using Stachys spectabilis: Identification, catalytic degradation, and antioxidant activity. Biochemical and Biophysical Research Communications 659:91-95.
  • Erenler R, Hosaflioglu I (2023). Green synthesis of silver nanoparticles using Onobrychis sativa L.: Characterization, catalytic degradation of methylene blue, antioxidant activity, and quantitative analysis of bioactive compounds. Materials Today Communications 35:105863.
  • Erenler R, Karan T, Hosaflioglu İ (2023). Phytochemical analysis of Syringa vulgaris: Quantitative analysis of natural compounds by LC-ESI-MS/MS. Turkish Journal of Biodiversity 6:75-78.
  • Erenler R, Ojelade RA, Karan T, Gecer EN, Genc N, Yaman C (2023). Facile, efficient synthesis of silver nanoparticles using Salvia absconditiflora: Assessment of their antioxidant capacity and catalytic activity. Inorganic Chemistry Communications 158:111623.
  • Erenler R, Yaman C, Demirtas I, Alma MH (2023). Phytochemical Investigation of Hypericum heterophyllum Flowers: LC-ESI-MS/MS Analysis, Total Phenolic and Flavonoid Contents, Antioxidant Activity. The Natural Products Journal 13:e120123212672.
  • Erenler R, Hosaflıoğlu İ, Yıldız İ, Atalar MN, Çelik SM, Alma MH (2024). Quantitative analysis of phenolics in Trifolium pratense L. flowers and evaluation of antioxidant activity by sensory. Journal of New Results in Science 13:165-174.
  • Gecer EN (2021). Green Synthesis of Silver Nanoparticles from Salvia aethiopis L. and Their Antioxidant Activity. Journal of Inorganic and Organometallic Polymers and Materials 31:4402-4409.
  • Gecer EN (2023). Synthesis and characterization of silver nanoparticles using Origanum onites leaves: Cytotoxic, apoptotic, and necrotic effects on Capan-1, L929, and Caco-2 cell lines. Green Processing and Synthesis 12:20228126.
  • Gecer EN, Erenler R (2023). Biogenic synthesis of silver nanoparticles using Echium vulgare: Characterisation, quantitative analysis of bioactive compounds, antioxidant activity and catalytic degradation. Journal of the Indian Chemical Society 100:101003.
  • Genç N, Yıldız İ, Karan T, Eminağaoğlu Ö, Erenler R (2019). Antioxidant activity and total phenolic contents of Galanthus woronowii (Amaryllidaceae). Turkish Journal of Biodiversity 2:1-5.
  • Guzel A, Aksit H, Elmastas M, Erenler R (2017). Bioassay-guided isolation and identification of antioxidant flavonoids from Cyclotrichium origanifolium (Labill.) Manden. and Scheng. Pharmacognosy Magazine 13:316.
  • Isildak Ö, Yildiz I, Genc N (2022). A new potentiometric PVC membrane sensor for the determination of DPPH radical scavenging activity of plant extracts. Food Chemistry 373:131420.
  • Işıldak Ö, Yıldız İ (2024). New potentiometric sensor for total phenolic assay of plant extracts. Bulletin of the Chemical Society of Japan 97:uoae043.
  • Karan T, Erenler R, Bozer Moran B (2022). Synthesis and characterization of silver nanoparticles using curcumin: cytotoxic, apoptotic, and necrotic effects on various cell lines. Zeitschrift für Naturforschung C 77:343-350.
  • Karan T, Erenler R, Gonulalan Z, Kolemen U (2024). Biogenic synthesis of silver nanoparticles using Sambucus nigra leaves: elucidation, antimicrobial, antioxidant activities and quantification of phenolics. Chemical Papers 78:473-481.
  • Karan T, Gonulalan Z, Erenler R, Kolemen U, Eminagaoglu O (2024). Green synthesis of silver nanoparticles using Sambucus ebulus leaves extract: Characterization, quantitative analysis of bioactive molecules, antioxidant and antibacterial activities. Journal of Molecular Structure 1296:136836.
  • Karan YB, Erenler R (2024). Synthesis of Silver Nanoparticles Using Potato Cultivars with Their Antioxidant Activity. Communications in Soil Science and Plant Analysis:1-9.
  • Li JW-H, Vederas JC (2009). Drug discovery and natural products: end of an era or an endless frontier? Science 325:161-165.
  • Liu Y-T, Gong P-H, Xiao F-Q, Shao S, Zhao D-Q, Yan M-M, Yang X-W (2018). Chemical constituents and antioxidant, anti-inflammatory and anti-tumor activities of Melilotus officinalis (Linn.) Pall. Molecules 23:271.
  • Macı́as FA, Simonet AM, Galindo JC, Castellano D (1999). Bioactive phenolics and polar compounds from Melilotus messanensis. Phytochemistry 50:35-46.
  • Nayel N, Marah S, Ozen T, Yıldız I, Erenler R, Behcet L (2024). Characterization and Comparative Investigation of In Vitro Bioactivities for Lactuca anatolica Root Aqueous Extract and Their Green-Chemical Synthesized Nanoparticles; Molecular Docking Studies. BioNanoScience.
  • Pleşca‐Manea L, Pârvu AE, Pârvu M, Taaˇmaş M, Buia R, Puia M (2002). Effects of Melilotus officinalis on acute inflammation. Phytotherapy Research 16:316-319.
  • Sahin Yaglioglu A, Akdulum B, Erenler R, Demirtas I, Telci I, Tekin S (2013). Antiproliferative activity of pentadeca-(8E, 13Z) dien-11-yn-2-one and (E)-1,8-pentadecadiene from Echinacea pallida (Nutt.) Nutt. roots. Medicinal Chemistry Research 22:2946-2953.
  • Sahin Yaglioglu A, Erenler R, Gecer EN, Genc N (2022). Biosynthesis of Silver Nanoparticles Using Astragalus flavesces Leaf: Identification, Antioxidant Activity, and Catalytic Degradation of Methylene Blue. Journal of Inorganic and Organometallic Polymers and Materials 32:3700-3707.
  • Seçme A, Bozer BM, Kocaman AY, Erenler R, Calimli MH (2024). Synthesis, characterization, and anticancer properties of Ag nanoparticles derived from walnut leaves tested on cells of L929, MCF-7 and H1299. Journal of Drug Delivery Science and Technology :105478.
  • Topçu G, Erenler R, Çakmak O, Johansson CB, Çelik C, Chai H-B, Pezzuto JM (1999). Diterpenes from the berries of Juniperus excelsa. Phytochemistry 50:1195-1199.
  • Wu F, Duan Z, Xu P, Yan Q, Meng M, Cao M, Jones CS, Zong X, Zhou P, Wang Y (2022). Genome and systems biology of Melilotus albus provides insights into coumarins biosynthesis. Plant Biotechnology Journal 20:592-609.
  • Yaman C, Önlü Ş, Ahmed H, Erenler R (2022). Comparison of phytochemicals and antioxidant capacity of Hypericum perforatum; wild plant parts and in vitro samples. Journal of Animal & Plant Sciences 32:596-603.
  • Yildiz İ, Başar Y, Erenler R, Alma MH, Calimli MH (2024). A phytochemical content analysis, and antioxidant activity evaluation using a novel method on Melilotus officinalis flower. South African Journal of Botany 174:686-693.

Phytochemistry of Melilotus albus flowers: Antioxidant activity by sensory, quantitative analysis of bioactive compounds by LC-ESI-MS/MS

Year 2025, Volume: 8 Issue: 1, 17 - 23, 30.06.2025

Ramazan Erenler , İlyas Yıldız , Esma Nur Geçer , İbrahim Hosaflıoğlu

https://doi.org/10.38059/biodiversity.1726816

Abstract

Plants have gained substantial attention in drug development because of their inclusion of bioactive compounds. The bioactive compounds found in plants are known as secondary metabolites, and they play a crucial role in the pharmaceutical industry. Many of the drugs in use today have been developed by drawing inspiration from biologically active natural compounds. Quantification of phenolics in the methanol extract of Melilotus albus flowers was determined by LC-MS/MS, and coumarin was found as the major compound. DPPH antioxidant activity was measured by sensory analysis, and M. albus flowers were found to have moderate antioxidant activity (40.57%). These flowers were also found to contain totoal phenolic of 129.22 mg GA/g of plant extract. Since M. albus flowers contain coumarin as the main product, related plant flowers may be the source of coumarin and an antioxidant agent.

Keywords

Antioxidant activity Quantitative analysis Melilotus albus Natural products

References

  • Aksit H, Çelik SM, Sen Ö, Erenler R, Demirtas I, Telci I, Elmastas M (2014). Complete isolation and characterization of polar portion of Mentha dumetorum water extract. Records of Natural Products 8:277-280.
  • Atalar MN, Erenler R, Turkan F, Alma MH, Demirtas I, Baran A, Kandemir SI, Kekec AI, Saltan FZ (2023). Phytochemical analysis and biological activity of Corchorus olitorius L.: Quantitative analysis of bioactive compounds by LC–MS/MS, antibacterial, enzyme inhibition, and cytotoxic activities. European Journal of Integrative Medicine 62:102290.
  • Başar Y, Erenler R (2024). Phytochemical analysis of Silybum marianum flowers: Quantitative analysis of natural compounds and molecular docking application. Turkish Journal of Biodiversity 7:20-31.
  • Başar Y, Hosaflıoğlu İ, Erenler R (2024). Phytochemical analysis of Robinia pseudoacacia flowers and leaf: quantitative analysis of natural compounds and molecular docking application. Turkish Journal of Biodiversity 7:1-10.
  • Cragg GM, Newman DJ, Snader KM (1997). Natural products in drug discovery and development. Journal of Natural Products 60:52-60.
  • Demirtas I, Erenler R, Elmastas M, Goktasoglu A (2013). Studies on the antioxidant potential of flavones of Allium vineale isolated from its water-soluble fraction. Food Chemistry 136:34-40.
  • Elmastas M, Ozturk L, Gokce I, Erenler R, Aboul‐Enein HY (2004). Determination of antioxidant activity of marshmallow flower (Althaea officinalis L.). Analytical Letters 37:1859-1869.
  • Elmastaş M, Telci İ, Akşit H, Erenler R (2015). Comparison of total phenolic contents and antioxidant capacities in mint genotypes used as spices/Baharat olarak kullanılan nane genotiplerinin toplam fenolik içerikleri ve antioksidan kapasitelerinin karşılaştırılması. Turkish Journal of Biochemistry 40:456-462.
  • Elmastas M, Erenler R, Isnac B, Aksit H, Sen O, Genc N, Demirtas I (2016). Isolation and identification of a new neo-clerodane diterpenoid from Teucrium chamaedrys L. Natural Product Research 30:299-304.
  • Elmastas M, Celik SM, Genc N, Aksit H, Erenler R, Gulcin İ (2018). Antioxidant activity of an anatolian herbal tea-Origanum minutiflorum: isolation and characterization of its secondary metabolites. International Journal of Food Properties 21:374-384.
  • Erenler R, Yilmaz S, Aksit H, Sen O, Genc N, Elmastas M, Demirtas I (2014). Antioxidant activities of chemical constituents isolated from Echinops orientalis Trauv. Records of Natural Products 8:32-36.
  • Erenler R, Telci I, Ulutas M, Demirtas I, Gul F, Elmastas M, Kayir O (2015). Chemical Constituents, Quantitative Analysis and Antioxidant Activities of Echinacea purpurea (L.) Moench and Echinacea pallida (Nutt.) Nutt. Journal of Food Biochemistry 39:622-630.
  • Erenler R, Pabuccu K, Yaglioglu AS, Demirtas I, Gul F (2016). Chemical constituents and antiproliferative effects of cultured Mougeotia nummuloides and Spirulina major against cancerous cell lines. Zeitschrift fur Naturforschung-Section C. Journal of Biosciences 71:87-92.
  • Erenler R, Sen O, Aksit H, Demirtas I, Yaglioglu AS, Elmastas M, Telci İ (2016). Isolation and identification of chemical constituents from Origanum majorana and investigation of antiproliferative and antioxidant activities. Journal of the Science of Food and Agriculture 96:822-836.
  • Erenler R, Adak T, Karan T, Elmastas M, Yildiz I, Aksit H, Topcu G, Sanda MA (2017). Chemical Constituents isolated from Origanum solymicum with Antioxidant activities. The Eurasia Proceedings of Science, Technology, Engineering & Mathematics 1:139-145.
  • Erenler R, Nusret G, Elmastaş M, Eminağaoğlu Ö (2019). Evaluation of antioxidant capacity with total phenolic content of Galanthus krasnovii (Amaryllidaceae). Turkish Journal of Biodiversity 2:13-17.
  • Erenler R, Atalar MN, Yıldız İ, Geçer EN, Yıldırım A, Demirtas İ, Alma MH (2023). Quantitative analysis of bioactive compounds by LC-MS/MS from Inula graveolens. Bütünleyici ve Anadolu Tıbbı Dergisi 4:3-10.
  • Erenler R, Chaoui R, Yildiz I, Genc N, Gecer EN, Temiz C, Akkal S (2023). Biosynthesis, Characterisation, and Antioxidant Activity of Silver Nanoparticles using Schinus molle L. Trends in Sciences 20:6105-6105.
  • Erenler R, Gecer EN, Hosaflioglu I, Behcet L (2023). Green synthesis of silver nanoparticles using Stachys spectabilis: Identification, catalytic degradation, and antioxidant activity. Biochemical and Biophysical Research Communications 659:91-95.
  • Erenler R, Hosaflioglu I (2023). Green synthesis of silver nanoparticles using Onobrychis sativa L.: Characterization, catalytic degradation of methylene blue, antioxidant activity, and quantitative analysis of bioactive compounds. Materials Today Communications 35:105863.
  • Erenler R, Karan T, Hosaflioglu İ (2023). Phytochemical analysis of Syringa vulgaris: Quantitative analysis of natural compounds by LC-ESI-MS/MS. Turkish Journal of Biodiversity 6:75-78.
  • Erenler R, Ojelade RA, Karan T, Gecer EN, Genc N, Yaman C (2023). Facile, efficient synthesis of silver nanoparticles using Salvia absconditiflora: Assessment of their antioxidant capacity and catalytic activity. Inorganic Chemistry Communications 158:111623.
  • Erenler R, Yaman C, Demirtas I, Alma MH (2023). Phytochemical Investigation of Hypericum heterophyllum Flowers: LC-ESI-MS/MS Analysis, Total Phenolic and Flavonoid Contents, Antioxidant Activity. The Natural Products Journal 13:e120123212672.
  • Erenler R, Hosaflıoğlu İ, Yıldız İ, Atalar MN, Çelik SM, Alma MH (2024). Quantitative analysis of phenolics in Trifolium pratense L. flowers and evaluation of antioxidant activity by sensory. Journal of New Results in Science 13:165-174.
  • Gecer EN (2021). Green Synthesis of Silver Nanoparticles from Salvia aethiopis L. and Their Antioxidant Activity. Journal of Inorganic and Organometallic Polymers and Materials 31:4402-4409.
  • Gecer EN (2023). Synthesis and characterization of silver nanoparticles using Origanum onites leaves: Cytotoxic, apoptotic, and necrotic effects on Capan-1, L929, and Caco-2 cell lines. Green Processing and Synthesis 12:20228126.
  • Gecer EN, Erenler R (2023). Biogenic synthesis of silver nanoparticles using Echium vulgare: Characterisation, quantitative analysis of bioactive compounds, antioxidant activity and catalytic degradation. Journal of the Indian Chemical Society 100:101003.
  • Genç N, Yıldız İ, Karan T, Eminağaoğlu Ö, Erenler R (2019). Antioxidant activity and total phenolic contents of Galanthus woronowii (Amaryllidaceae). Turkish Journal of Biodiversity 2:1-5.
  • Guzel A, Aksit H, Elmastas M, Erenler R (2017). Bioassay-guided isolation and identification of antioxidant flavonoids from Cyclotrichium origanifolium (Labill.) Manden. and Scheng. Pharmacognosy Magazine 13:316.
  • Isildak Ö, Yildiz I, Genc N (2022). A new potentiometric PVC membrane sensor for the determination of DPPH radical scavenging activity of plant extracts. Food Chemistry 373:131420.
  • Işıldak Ö, Yıldız İ (2024). New potentiometric sensor for total phenolic assay of plant extracts. Bulletin of the Chemical Society of Japan 97:uoae043.
  • Karan T, Erenler R, Bozer Moran B (2022). Synthesis and characterization of silver nanoparticles using curcumin: cytotoxic, apoptotic, and necrotic effects on various cell lines. Zeitschrift für Naturforschung C 77:343-350.
  • Karan T, Erenler R, Gonulalan Z, Kolemen U (2024). Biogenic synthesis of silver nanoparticles using Sambucus nigra leaves: elucidation, antimicrobial, antioxidant activities and quantification of phenolics. Chemical Papers 78:473-481.
  • Karan T, Gonulalan Z, Erenler R, Kolemen U, Eminagaoglu O (2024). Green synthesis of silver nanoparticles using Sambucus ebulus leaves extract: Characterization, quantitative analysis of bioactive molecules, antioxidant and antibacterial activities. Journal of Molecular Structure 1296:136836.
  • Karan YB, Erenler R (2024). Synthesis of Silver Nanoparticles Using Potato Cultivars with Their Antioxidant Activity. Communications in Soil Science and Plant Analysis:1-9.
  • Li JW-H, Vederas JC (2009). Drug discovery and natural products: end of an era or an endless frontier? Science 325:161-165.
  • Liu Y-T, Gong P-H, Xiao F-Q, Shao S, Zhao D-Q, Yan M-M, Yang X-W (2018). Chemical constituents and antioxidant, anti-inflammatory and anti-tumor activities of Melilotus officinalis (Linn.) Pall. Molecules 23:271.
  • Macı́as FA, Simonet AM, Galindo JC, Castellano D (1999). Bioactive phenolics and polar compounds from Melilotus messanensis. Phytochemistry 50:35-46.
  • Nayel N, Marah S, Ozen T, Yıldız I, Erenler R, Behcet L (2024). Characterization and Comparative Investigation of In Vitro Bioactivities for Lactuca anatolica Root Aqueous Extract and Their Green-Chemical Synthesized Nanoparticles; Molecular Docking Studies. BioNanoScience.
  • Pleşca‐Manea L, Pârvu AE, Pârvu M, Taaˇmaş M, Buia R, Puia M (2002). Effects of Melilotus officinalis on acute inflammation. Phytotherapy Research 16:316-319.
  • Sahin Yaglioglu A, Akdulum B, Erenler R, Demirtas I, Telci I, Tekin S (2013). Antiproliferative activity of pentadeca-(8E, 13Z) dien-11-yn-2-one and (E)-1,8-pentadecadiene from Echinacea pallida (Nutt.) Nutt. roots. Medicinal Chemistry Research 22:2946-2953.
  • Sahin Yaglioglu A, Erenler R, Gecer EN, Genc N (2022). Biosynthesis of Silver Nanoparticles Using Astragalus flavesces Leaf: Identification, Antioxidant Activity, and Catalytic Degradation of Methylene Blue. Journal of Inorganic and Organometallic Polymers and Materials 32:3700-3707.
  • Seçme A, Bozer BM, Kocaman AY, Erenler R, Calimli MH (2024). Synthesis, characterization, and anticancer properties of Ag nanoparticles derived from walnut leaves tested on cells of L929, MCF-7 and H1299. Journal of Drug Delivery Science and Technology :105478.
  • Topçu G, Erenler R, Çakmak O, Johansson CB, Çelik C, Chai H-B, Pezzuto JM (1999). Diterpenes from the berries of Juniperus excelsa. Phytochemistry 50:1195-1199.
  • Wu F, Duan Z, Xu P, Yan Q, Meng M, Cao M, Jones CS, Zong X, Zhou P, Wang Y (2022). Genome and systems biology of Melilotus albus provides insights into coumarins biosynthesis. Plant Biotechnology Journal 20:592-609.
  • Yaman C, Önlü Ş, Ahmed H, Erenler R (2022). Comparison of phytochemicals and antioxidant capacity of Hypericum perforatum; wild plant parts and in vitro samples. Journal of Animal & Plant Sciences 32:596-603.
  • Yildiz İ, Başar Y, Erenler R, Alma MH, Calimli MH (2024). A phytochemical content analysis, and antioxidant activity evaluation using a novel method on Melilotus officinalis flower. South African Journal of Botany 174:686-693.
There are 47 citations in total.

Details

Primary Language Turkish
Subjects Natural Products and Bioactive Compounds
Journal Section Research Articles
Authors

Ramazan Erenler 0000-0002-0505-3190

İlyas Yıldız 0000-0003-1254-1069

Esma Nur Geçer 0000-0002-0095-079X

İbrahim Hosaflıoğlu 0009-0000-2730-1493

Early Pub Date June 30, 2025
Publication Date June 30, 2025
Submission Date June 25, 2025
Acceptance Date June 29, 2025
Published in Issue Year 2025 Volume: 8 Issue: 1

Cite

APA Erenler, R., Yıldız, İ., Geçer, E. N., Hosaflıoğlu, İ. (2025). Melilotus albus çiçeklerinin fitokimyası: LC-ESI-MS/MS ile biyoaktif bileşiklerin kantitatif analiziyle ve sensor ile antioksidan analizi. Turkish Journal of Biodiversity, 8(1), 17-23. https://doi.org/10.38059/biodiversity.1726816
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