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Urodynamic Findings of The Patients with Interstitial Cystitis/ Bladder Pain Syndrome: A Single Tertiary Center Results

Year 2025, Volume: 15 Issue: 2, 290 - 294

Mehmet Fatih Şahin , Murat Akgül , Çağrı Doğan , Arzu Malak , Serkan Şeramet , Muhammed Sencer Köroğlu , Onur Orbeği , Cenk Murat Yazıcı

https://doi.org/10.33808/clinexphealthsci.1475656

Abstract

Objective: Patients with interstitial cystitis/bladder pain syndrome (IC/BPS) exhibit a wide range of symptoms. Urodynamics-pressure flow study (UD-PFS) results may show that these patients have urgency, decreased bladder capacity, and pelvic pain worsening as the volume increases. UD-PFS examinations may contribute to analyzing the pathophysiology of lower urinary tract symptoms (LUTS). This study aimed to evaluate the demographic and clinical findings of IC/BPS patients and the results of UD-PFS examinations.
Methods: The data of 132 IC/BPS patients between 2010 and 2020 were examined retrospectively, and UD-PFS was applied to 63 patients whose LUTS did not benefit from medical treatment. The patients' clinical and demographic data and UD-PFS findings were evaluated separately.
Results: Of the patients who underwent UD-PFS, 7 were men, and 56 were women. The first urine sensation in UD was 74.0 ± 32.22 cc, and the maximum cystometric capacity was 288.4 ± 181.2 cc. Seven patients had a hypo-compliant bladder, and 42 had a normo-compliant bladder. In PFS, Qmax and maximum detrusor pressure in the voiding phase were 18.87 ± 8.21 mL/sec and 33.93 ± 14.78 cmH2O, respectively. Stress urinary incontinence was detected in 7 patients. For detrusor function, neurogenic detrusor overactivity was detected in 18 patients, and normal UD-PFS was detected in 45 patients, whereas reflexive detrusor was not observed. Cystoscopy revealed Hunner's ulcer in 7 patients.
Conclusion: Urodynamic variables associated with early sensations, first urge, intense desire, and a reduced maximum cystometric capacity were significantly related to the severity of the IC/BPS symptoms. Urodynamic testing is not often a definitive diagnostic method for IC/BPS, although it may assist in the diagnosis process.

Keywords

Urodynamic examination Pressure Flow Study Bladder Pain Syndrome Interstitial Cystitis

Ethical Statement

This study protocol was reviewed and approved by Tekirdağ Namık Kemal University, Non-interventional Clinical Trials Ethical Committee (Approval date: 26.01.2021; Number: 2021.18.01.18)

References

  • Propert KJ, Schaeffer AJ, Brensinger CM, Kusek KW, Nyberg LM, Landis JR. A prospective study of interstitial cystitis: Results of longitudinal follow-up of the interstitial cystitis data base cohort. J Urol. 2000;163:1434–1439. https://doi.org/10.1016/s0022-5347(05)67637-9
  • Howard FM. Chronic pelvic pain. Obstet Gynecol. 2003;101:594–611. https://doi.org/10.1016/s0029-7844(02)02723-0
  • Sant GR. Etiology, pathogenesis, and diagnosis of interstitial cystitis. Rev Urol. 2002; 4(Suppl 1):9-15.
  • Kim S, Kim T, Kim S, Oh S. Urodynamic findings of the painful bladder syndrome/interstitial cystitis: A comparison with idiopathic overactive bladder. The Journal of Urology. 2009;181(6):2550-2554. https://doi.org/10.1016/j.juro.2009.01.106.
  • Sastry D, Hunter K, Whitmore K. Urodynamic testing and interstitial cystitis/painful bladder syndrome. International Urogynecology Journal. 2010;21:157-161. https://doi.org/10.1007/s00192-009-1015-6.
  • Peng Y, Chiu Y, Feng M, Liang C. The effect of intravesical hyaluronic acid therapy on urodynamic and clinical outcomes among women with interstitial cystitis/bladder pain syndrome. Taiwanese Journal of Obstetrics & Gynecology. 2020;59(6):922-926. https://doi.org/10.1016/j.tjog.2020.09.021.
  • Schäfer W, Abrams P, Liao L, Mattiasson A, Pesce F, Spangberg A, Sterling AM, Zinner NR, Kerrebroeck P, International Continence Society. Good urodynamic practices: Uroflowmetry, filling cystometry, and pressure-flow studies. Neurourol Urodyn. 2002; 21:261-274. https://doi.org/10.1002/nau.10066
  • Teichman JM, Parsons CL. Contemporary clinical presentation of interstitial cystitis. Urology. 2007;69(4), 41-47. https://doi.org/10.1016/j.urology.2006.08.1111
  • Nigro DA, Wein AJ, Foy M. Associations among cystoscopic and urodynamic findings for women enrolled in the Interstitial Cystitis Data Base (ICDB) Study. Urology. 1997;49(suppl 5A):86–92. https://doi.org/10.1016/s0090-4295(99)80337-9
  • Nazif O, Teichman JMH, Gebhart GF. Neural upregulation in interstitial cystitis. Urology. 2007;69(suppl 4A):24–33. https://doi.org/10.1016/j.urology.2006.08.1108
  • Kuo HC, Chang SC, Hsu T. Urodynamic findings in interstitial cystitis. J Fromos Med Assoc. 1992;91:694–698.
  • Steinkohl WB, Leach GE. Urodynamic findings in interstitial cystitis. Urology. 1989;34(6):399–401. https://doi.org/10.1016/0090-4295(89)90453-6
  • Perez-Marrero R, Emerson L, Juma S. Urodynamic studies in interstitial cystitis. Urology. 1987;29(4suppl):27–30.
  • Messing E, Pauk D, Schaeffer A, Nieweglowski M, Nyberg LM, Landis JR, Cook YL, Simon LJ. Associations among cystoscopic findings and symptoms and physical examination findings in women enrolled in the Interstitial Cystitis Data Base (ICDB) study. Urology. 1997;49(5A suppl):81–85. https://doi.org/10.1016/s0090-4295(99)80336-7
  • Simon LJ, Landis JR, Erickson DR. Interstitial cystitis data base study: Concepts and preliminary baseline descriptive statistics. Urology. 1997;49(suppl 5A):64–75. https://doi.org/10.1016/s0090-4295(99)80334-3
  • Cangül CM, Boylu U, Horasanlı K. Nörogenic bladder. Med Bull Sisli Etfal Hosp. 2003;37(4):7-16.
  • Sahin F, Adan R, Emeklioglu CN, Ozdemir S, Mihmanli V. The role of pelvic ultrasound in evaluating the success of tension-free vaginal tape (TVT). Med Bull Sisli Etfal Hosp. 2023; 57(4): 500-505. https://doi.org/10.14744/SEMB.2023.33497
  • Özlülerden Y, Toktaş C, Zümrütbaş AE, Gülten MC, Başer A, Yapıcı O, Aybek Z. Can feeling of incomplete bladder emptying reflect significant postvoid residual urine? Is it reliable as a symptom solely? Investigative and clinical urology. 2018; 59(1):38–43. https://doi.org/10.4111/icu.2018.59.1.38

Year 2025, Volume: 15 Issue: 2, 290 - 294

Mehmet Fatih Şahin , Murat Akgül , Çağrı Doğan , Arzu Malak , Serkan Şeramet , Muhammed Sencer Köroğlu , Onur Orbeği , Cenk Murat Yazıcı

https://doi.org/10.33808/clinexphealthsci.1475656

Abstract

References

  • Propert KJ, Schaeffer AJ, Brensinger CM, Kusek KW, Nyberg LM, Landis JR. A prospective study of interstitial cystitis: Results of longitudinal follow-up of the interstitial cystitis data base cohort. J Urol. 2000;163:1434–1439. https://doi.org/10.1016/s0022-5347(05)67637-9
  • Howard FM. Chronic pelvic pain. Obstet Gynecol. 2003;101:594–611. https://doi.org/10.1016/s0029-7844(02)02723-0
  • Sant GR. Etiology, pathogenesis, and diagnosis of interstitial cystitis. Rev Urol. 2002; 4(Suppl 1):9-15.
  • Kim S, Kim T, Kim S, Oh S. Urodynamic findings of the painful bladder syndrome/interstitial cystitis: A comparison with idiopathic overactive bladder. The Journal of Urology. 2009;181(6):2550-2554. https://doi.org/10.1016/j.juro.2009.01.106.
  • Sastry D, Hunter K, Whitmore K. Urodynamic testing and interstitial cystitis/painful bladder syndrome. International Urogynecology Journal. 2010;21:157-161. https://doi.org/10.1007/s00192-009-1015-6.
  • Peng Y, Chiu Y, Feng M, Liang C. The effect of intravesical hyaluronic acid therapy on urodynamic and clinical outcomes among women with interstitial cystitis/bladder pain syndrome. Taiwanese Journal of Obstetrics & Gynecology. 2020;59(6):922-926. https://doi.org/10.1016/j.tjog.2020.09.021.
  • Schäfer W, Abrams P, Liao L, Mattiasson A, Pesce F, Spangberg A, Sterling AM, Zinner NR, Kerrebroeck P, International Continence Society. Good urodynamic practices: Uroflowmetry, filling cystometry, and pressure-flow studies. Neurourol Urodyn. 2002; 21:261-274. https://doi.org/10.1002/nau.10066
  • Teichman JM, Parsons CL. Contemporary clinical presentation of interstitial cystitis. Urology. 2007;69(4), 41-47. https://doi.org/10.1016/j.urology.2006.08.1111
  • Nigro DA, Wein AJ, Foy M. Associations among cystoscopic and urodynamic findings for women enrolled in the Interstitial Cystitis Data Base (ICDB) Study. Urology. 1997;49(suppl 5A):86–92. https://doi.org/10.1016/s0090-4295(99)80337-9
  • Nazif O, Teichman JMH, Gebhart GF. Neural upregulation in interstitial cystitis. Urology. 2007;69(suppl 4A):24–33. https://doi.org/10.1016/j.urology.2006.08.1108
  • Kuo HC, Chang SC, Hsu T. Urodynamic findings in interstitial cystitis. J Fromos Med Assoc. 1992;91:694–698.
  • Steinkohl WB, Leach GE. Urodynamic findings in interstitial cystitis. Urology. 1989;34(6):399–401. https://doi.org/10.1016/0090-4295(89)90453-6
  • Perez-Marrero R, Emerson L, Juma S. Urodynamic studies in interstitial cystitis. Urology. 1987;29(4suppl):27–30.
  • Messing E, Pauk D, Schaeffer A, Nieweglowski M, Nyberg LM, Landis JR, Cook YL, Simon LJ. Associations among cystoscopic findings and symptoms and physical examination findings in women enrolled in the Interstitial Cystitis Data Base (ICDB) study. Urology. 1997;49(5A suppl):81–85. https://doi.org/10.1016/s0090-4295(99)80336-7
  • Simon LJ, Landis JR, Erickson DR. Interstitial cystitis data base study: Concepts and preliminary baseline descriptive statistics. Urology. 1997;49(suppl 5A):64–75. https://doi.org/10.1016/s0090-4295(99)80334-3
  • Cangül CM, Boylu U, Horasanlı K. Nörogenic bladder. Med Bull Sisli Etfal Hosp. 2003;37(4):7-16.
  • Sahin F, Adan R, Emeklioglu CN, Ozdemir S, Mihmanli V. The role of pelvic ultrasound in evaluating the success of tension-free vaginal tape (TVT). Med Bull Sisli Etfal Hosp. 2023; 57(4): 500-505. https://doi.org/10.14744/SEMB.2023.33497
  • Özlülerden Y, Toktaş C, Zümrütbaş AE, Gülten MC, Başer A, Yapıcı O, Aybek Z. Can feeling of incomplete bladder emptying reflect significant postvoid residual urine? Is it reliable as a symptom solely? Investigative and clinical urology. 2018; 59(1):38–43. https://doi.org/10.4111/icu.2018.59.1.38
There are 18 citations in total.

Details

Primary Language English
Subjects Urology
Journal Section Articles
Authors

Mehmet Fatih Şahin 0000-0002-0926-3005

Murat Akgül 0000-0001-6187-1940

Çağrı Doğan 0000-0001-9681-2473

Arzu Malak 0000-0002-3123-9626

Serkan Şeramet 0000-0003-3774-7979

Muhammed Sencer Köroğlu 0009-0004-1942-0520

Onur Orbeği 0009-0002-0924-5541

Cenk Murat Yazıcı 0000-0001-6140-5181

Early Pub Date June 27, 2025
Publication Date
Submission Date April 29, 2024
Acceptance Date May 15, 2025
Published in Issue Year 2025 Volume: 15 Issue: 2

Cite

APA Şahin, M. F., Akgül, M., Doğan, Ç., Malak, A., et al. (2025). Urodynamic Findings of The Patients with Interstitial Cystitis/ Bladder Pain Syndrome: A Single Tertiary Center Results. Clinical and Experimental Health Sciences, 15(2), 290-294. https://doi.org/10.33808/clinexphealthsci.1475656
AMA Şahin MF, Akgül M, Doğan Ç, Malak A, Şeramet S, Köroğlu MS, Orbeği O, Yazıcı CM. Urodynamic Findings of The Patients with Interstitial Cystitis/ Bladder Pain Syndrome: A Single Tertiary Center Results. Clinical and Experimental Health Sciences. June 2025;15(2):290-294. doi:10.33808/clinexphealthsci.1475656
Chicago Şahin, Mehmet Fatih, Murat Akgül, Çağrı Doğan, Arzu Malak, Serkan Şeramet, Muhammed Sencer Köroğlu, Onur Orbeği, and Cenk Murat Yazıcı. “Urodynamic Findings of The Patients With Interstitial Cystitis/ Bladder Pain Syndrome: A Single Tertiary Center Results”. Clinical and Experimental Health Sciences 15, no. 2 (June 2025): 290-94. https://doi.org/10.33808/clinexphealthsci.1475656.
EndNote Şahin MF, Akgül M, Doğan Ç, Malak A, Şeramet S, Köroğlu MS, Orbeği O, Yazıcı CM (June 1, 2025) Urodynamic Findings of The Patients with Interstitial Cystitis/ Bladder Pain Syndrome: A Single Tertiary Center Results. Clinical and Experimental Health Sciences 15 2 290–294.
IEEE M. F. Şahin, M. Akgül, Ç. Doğan, A. Malak, S. Şeramet, M. S. Köroğlu, O. Orbeği, and C. M. Yazıcı, “Urodynamic Findings of The Patients with Interstitial Cystitis/ Bladder Pain Syndrome: A Single Tertiary Center Results”, Clinical and Experimental Health Sciences, vol. 15, no. 2, pp. 290–294, 2025, doi: 10.33808/clinexphealthsci.1475656.
ISNAD Şahin, Mehmet Fatih et al. “Urodynamic Findings of The Patients With Interstitial Cystitis/ Bladder Pain Syndrome: A Single Tertiary Center Results”. Clinical and Experimental Health Sciences 15/2 (June 2025), 290-294. https://doi.org/10.33808/clinexphealthsci.1475656.
JAMA Şahin MF, Akgül M, Doğan Ç, Malak A, Şeramet S, Köroğlu MS, Orbeği O, Yazıcı CM. Urodynamic Findings of The Patients with Interstitial Cystitis/ Bladder Pain Syndrome: A Single Tertiary Center Results. Clinical and Experimental Health Sciences. 2025;15:290–294.
MLA Şahin, Mehmet Fatih et al. “Urodynamic Findings of The Patients With Interstitial Cystitis/ Bladder Pain Syndrome: A Single Tertiary Center Results”. Clinical and Experimental Health Sciences, vol. 15, no. 2, 2025, pp. 290-4, doi:10.33808/clinexphealthsci.1475656.
Vancouver Şahin MF, Akgül M, Doğan Ç, Malak A, Şeramet S, Köroğlu MS, Orbeği O, Yazıcı CM. Urodynamic Findings of The Patients with Interstitial Cystitis/ Bladder Pain Syndrome: A Single Tertiary Center Results. Clinical and Experimental Health Sciences. 2025;15(2):290-4.
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