Abstract
Amiloidoz suda çözünmeyen proteinöz yapıların hücre dışında birikimi ile karakterize nadir görülen bir hastalıktır. Amiloid A (AA) ve amiloid hafif zincir (AL) olmak üzere iki yaygın amiloidoz tipi mevcuttur. AA tipi amiloidoz tüberküloz ve romatoid artrit gibi kronik inflamatuar süreçlere sekonder olarak ortaya çıkar ve pulmoner tutulum nadir bir bulgudur. Öte yandan, AL tipi amiloidoz ise sıklıkla multiple miyelom, gamopatiler ve idiyopatik olarak ortaya çıkan primer amiloidoz gibi durumlarla ilişkilidir. Böbrek tutulumu yaygın olmakla birlikte pulmoner tutulum sistemik amiloidozun bir parçası olarak veya daha nadiren izole bir formda da ortaya çıkabilir. Pulmoner amiloidoz nodüler, diffüz ve trakeobronşiyal olmak üzere üç formda ortaya çıkabilir. Bu çalışmada, 69 yaşında bir kadın hastada saptanan nodüler formdaki primer pulmoner amiloidoz vakası sunulmuştur.
Keywords
References
- Canbakan SÖ, Soylu B, Pelit A, Demirağ F, Başer Y. Primary pulmonary amyloidosis: Case report. Ankara Patoloji Bülteni. 1998;15(2):34-6. Turkish.
- Şenol T, Günay Ş, Eser İ, Erkilet E. A case of tracheobronchial amyloidosis. Dicle Med J. 2014;41(3):581-4. Turkish.
- Engineer DP, Kute VB, Patel HV, Shah PR. Clinical and laboratory profile of renal amyloidosis: a single center experience. Saudi J Kidney Dis Transpl. 2018;29(5):1065-72.
- Al-Umairi RS, Al-Lawati F, Al-Busaidi FM. Nodular pulmonary amyloidosis mimicking metastatic pulmonary nodules: A case report and review of the literature. Sultan Qaboos Univ Med J. 2018;18(3):e393-6.
- Baumgart JV, Stuhlmann-Laeisz C, Hegenbart U, Nattenmüller J, Schönland S, Krüger S, et al. Local vs. systemic pulmonary amyloidosis-impact on diagnostics and clinical management. Virchows Arch. 2018;473(5):627-37.
- Hui AN, Koss MN, Hochholzer L, Wehunt WD. Amyloidosis presenting in the lower respiratory tract. Clinicopathologic, radiologic, immunohistochemical, and histochemical studies on 48 cases. Arch Pathol Lab Med. 1986;110(3):212-8.
- Peng X, Wang X, Luo D, Zuo W, Yao H, Zhang W. Atypical primary pulmonary amyloidosis: A rare case report. Medicine (Baltimore). 2020;99(26):e20828.
- Oki T, Izuka S, Otsuki Y, Katayama M, Nakamura T. Localized nodular pulmonary amyloidosis mimicking primary lung cancer associated with cystic airspaces: A case report. Radiol Case Rep. 2024;19(9):3719-23.
Abstract
Amyloidosis is a rare disorder characterized by the extracellular deposition of insoluble protein aggregates. There are two common types of amyloidosis: Amyloid A (AA) and amyloid light chain (AL). AA amyloidosis typically occurs secondary to chronic inflammatory processes such as tuberculosis and rheumatoid arthritis, with pulmonary involvement being a rare manifestation. AL amyloidosis, on the other hand, is often associated with conditions like multiple myeloma, gammopathies, and idiopathic primary amyloidosis. While kidney involvement is common, pulmonary involvement can also occur as part of systemic amyloidosis or, more rarely, in an isolated form. Pulmonary amyloidosis can present in three forms: nodular, diffuse, and tracheobronchial. This study presented a case of primary pulmonary amyloidosis in the nodular form, identified in a 69-year-old female patient.
Keywords
References
- Canbakan SÖ, Soylu B, Pelit A, Demirağ F, Başer Y. Primary pulmonary amyloidosis: Case report. Ankara Patoloji Bülteni. 1998;15(2):34-6. Turkish.
- Şenol T, Günay Ş, Eser İ, Erkilet E. A case of tracheobronchial amyloidosis. Dicle Med J. 2014;41(3):581-4. Turkish.
- Engineer DP, Kute VB, Patel HV, Shah PR. Clinical and laboratory profile of renal amyloidosis: a single center experience. Saudi J Kidney Dis Transpl. 2018;29(5):1065-72.
- Al-Umairi RS, Al-Lawati F, Al-Busaidi FM. Nodular pulmonary amyloidosis mimicking metastatic pulmonary nodules: A case report and review of the literature. Sultan Qaboos Univ Med J. 2018;18(3):e393-6.
- Baumgart JV, Stuhlmann-Laeisz C, Hegenbart U, Nattenmüller J, Schönland S, Krüger S, et al. Local vs. systemic pulmonary amyloidosis-impact on diagnostics and clinical management. Virchows Arch. 2018;473(5):627-37.
- Hui AN, Koss MN, Hochholzer L, Wehunt WD. Amyloidosis presenting in the lower respiratory tract. Clinicopathologic, radiologic, immunohistochemical, and histochemical studies on 48 cases. Arch Pathol Lab Med. 1986;110(3):212-8.
- Peng X, Wang X, Luo D, Zuo W, Yao H, Zhang W. Atypical primary pulmonary amyloidosis: A rare case report. Medicine (Baltimore). 2020;99(26):e20828.
- Oki T, Izuka S, Otsuki Y, Katayama M, Nakamura T. Localized nodular pulmonary amyloidosis mimicking primary lung cancer associated with cystic airspaces: A case report. Radiol Case Rep. 2024;19(9):3719-23.
Details
| Primary Language | English |
|---|---|
| Subjects | Thoracic Surgery, Chest Diseases, Pathology |
| Journal Section | Case Report |
| Authors | |
| Early Pub Date | April 19, 2025 |
| Publication Date | April 30, 2025 |
| Submission Date | December 26, 2024 |
| Acceptance Date | March 23, 2025 |
| Published in Issue | Year 2025 Volume: 27 Issue: 1 |
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