Year 2014,
Volume: 19 Issue: 1, 38 - 40, 29.04.2014
W Hamizan Aneeza
,
Rajalingham Sakthiswary
Suria Hayati Md Pauzi
B.s. Gendeh
References
- James PD, Goodeve AC. von Willebrand disease. Genet Medicine 2011; 13: 365-376.
- Scaramuzzi N, Walsh R, Brennan P, Walsh M. Treatment of intractable epistaxis using arterial embolization. Clin Otolaryngol & Allied Sciences 2008; 26: 307-309.
- Bakri K, Haydar AA, Davis J, et al. Waldenström's macroglobulinaemia presenting as isolated epistaxis: a common complaint but a rare cause. Int J clin pract 2004; 58: 81-82.
- Dutta M, Ghatak S, Dutta S, et al. Glanzmann’s Thrombasthenia: A Rare Cause of Recurrent Profuse Epistaxis. Ind J Hemat Blood Transfusion 2011; 27: 113Nichols W, Hultin M, James A, et al. von Willebrand disease (VWD): evidence‐based diagnosis and management guidelines, the National Heart, Lung, and Blood Institute (NHLBI) Expert Panel report (USA) 1. Haemophilia 2008; 14: 171-232.
- Wood AJJ, Mannucci PM. Treatment of von Willebrand's disease. N Eng J Med 2004; 351: 6836
- Tefferi A, Nichols WL. Acquired von Willebrand disease: concise review of occurrence, diagnosis, pathogenesis, and treatment. Am J Med 1997; 103: 5
- Kumar S, Pruthi RK, Nichols WL, Acquired von Willebrand disease. Mayo Clinic Proceedings; 2002: Mayo Foundation.
- Fukutsuji K, Nishiike S, Aihara T, et al. Superselective angiographic embolization for intractable epistaxis. Acta oto-laryngol (stockh) 2008; 128: 556-560.
Von Willebrand Disease type 2B: A diagnostic dilemma
Year 2014,
Volume: 19 Issue: 1, 38 - 40, 29.04.2014
W Hamizan Aneeza
,
Rajalingham Sakthiswary
Suria Hayati Md Pauzi
B.s. Gendeh
Abstract
A young female presented with isolated chronic unilateral intractable epistaxis with non healing granular mass in the left nasal cavity. Histopathological examination was reported as acute and chronic non specific inflammation which did not respond to antibiotics or steroid. After ten years follow up she was finally diagnosed to have Von Willebrand disease type 2B. This is the first case report of von Willebrand disease presenting with intermittent epistaxis as its sole disease manifestation. Although epistaxis is a common complaint in Otorhinolaryngology clinics, this case posed a diagnostic dilemma.
References
- James PD, Goodeve AC. von Willebrand disease. Genet Medicine 2011; 13: 365-376.
- Scaramuzzi N, Walsh R, Brennan P, Walsh M. Treatment of intractable epistaxis using arterial embolization. Clin Otolaryngol & Allied Sciences 2008; 26: 307-309.
- Bakri K, Haydar AA, Davis J, et al. Waldenström's macroglobulinaemia presenting as isolated epistaxis: a common complaint but a rare cause. Int J clin pract 2004; 58: 81-82.
- Dutta M, Ghatak S, Dutta S, et al. Glanzmann’s Thrombasthenia: A Rare Cause of Recurrent Profuse Epistaxis. Ind J Hemat Blood Transfusion 2011; 27: 113Nichols W, Hultin M, James A, et al. von Willebrand disease (VWD): evidence‐based diagnosis and management guidelines, the National Heart, Lung, and Blood Institute (NHLBI) Expert Panel report (USA) 1. Haemophilia 2008; 14: 171-232.
- Wood AJJ, Mannucci PM. Treatment of von Willebrand's disease. N Eng J Med 2004; 351: 6836
- Tefferi A, Nichols WL. Acquired von Willebrand disease: concise review of occurrence, diagnosis, pathogenesis, and treatment. Am J Med 1997; 103: 5
- Kumar S, Pruthi RK, Nichols WL, Acquired von Willebrand disease. Mayo Clinic Proceedings; 2002: Mayo Foundation.
- Fukutsuji K, Nishiike S, Aihara T, et al. Superselective angiographic embolization for intractable epistaxis. Acta oto-laryngol (stockh) 2008; 128: 556-560.