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The effects of mesenchymal stem cells on asthma

Year 2025, Volume: 6 Issue: 1, 65 - 71, 30.04.2025

Kemal Yuce

https://doi.org/10.51753/flsrt.1567487

Abstract

Asthma is an inflammatory disease of the respiratory system characterized by cough, shortness of breath, wheezing, sputum, obstruction and bronchial hyperactivity. Asthma leads to disruption of epithelial structure, subepithelial fibrosis, inflammation, and ultimately airway reorganization. MSCs migrate into inflammatory tissue and settle there. Once in the tissue, the MSCs suppress inflammation and improve the internal structure of the tissue. These effects are achieved by transforming into tissue cells, producing anti-inflammatory and growth factors, and releasing microRNAs and extracellular vesicles. The effect of MSCs on asthma is based mostly on in vivo experimental animal models and in vitro studies of airway cells. While ovalbumin, cockroach extract and house dust mite are mostly used for in vivo experimental animal models, airway smooth muscle cells are mostly used for in vivo studies. This study aims to objectively present the information obtained from reliable articles about whether MSCs can be used in the treatment of asthma, a chronic inflammatory lung disease.

Keywords

Asthma models identification of MSCs inflammatory disease mesenchymal stem cells

Project Number

Not aplicable

References

  • Ahmadi, M., Rahbarghazi, R., Aslani, M. R., Shahbazfar, A. A., Kazemi, M., & Keyhanmanesh, R. (2017). Bone marrow mesenchymal stem cells and their conditioned media could potentially ameliorate ovalbumin-induced asthmatic changes. Biomedicine & Pharmacotherapy, 85, 28-40. doi:10.1016/j.biopha.2016.11.127
  • Ahmadi, M., Rahbarghazi, R., Shahbazfar, A. A., Baghban, H., & Keyhanmanesh, R. (2018). Bone marrow mesenchymal stem cells modified pathological changes and immunological responses in ovalbumin-induced asthmatic rats possibly by the modulation of miRNA155 and miRNA133. General Physiology and Biophysics, 37(3), 263-74.doi:10.4149/gpb_2017052
  • Banno, A., Reddy, Aravind T., Lakshmi, Sowmya P., & Reddy, Raju C. (2020). Bidirectional interaction of airway epithelial remodeling and inflammation in asthma. Clinical Science, 134(9), 1063-1079. doi:10.1042/cs20191309
  • Bao, X. H., Gao, F., Athari, S. S., & Wang, H. (2023). Immunomodulatory effect of IL‐35 gene‐transfected mesenchymal stem cells on allergic asthma. Fundamental & Clinical Pharmacology, 37(1), 116-124.doi:10.1111/fcp.12823
  • Bonfield, T. L., Koloze, M., Lennon, D. P., Zuchowski, B., Yang, S. E., & Caplan, A. I. (2010). Human mesenchymal stem cells suppress chronic airway inflammation in the murine ovalbumin asthma model. American Journal of Physiology-Lung Cellular and Molecular Physiology, 299(6), L760-L770.doi:10.1152/ajplung.00182.2009
  • Brychtova, M., Thiele, J.-A., Lysak, D., Holubova, M., Kralickova, M., & Vistejnova, L. (2019). Mesenchymal stem cells as the near future of cardiology medicine--truth or wish? Biomedical Papers of the Medical Faculty of Palacky University in Olomouc, 163(1).
  • Castro, L. L., Kitoko, J. Z., Xisto, D. G., Olsen, P. C., Guedes, H. L., Morales, M. M., ... & Rocco, P. R. (2020). Multiple doses of adipose tissue-derived mesenchymal stromal cells induce immunosuppression in experimental asthma. Stem Cells Translational Medicine, 9(2), 250-260. doi:10.1002/sctm.19-0120
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  • Choi, J. Y., Hur, J., Jeon, S., Jung, C. K., & Rhee, C. K. (2022). Effects of human adipose tissue-and bone marrow-derived mesenchymal stem cells on airway inflammation and remodeling in a murine model of chronic asthma. Scientific Reports, 12(1), 12032.doi:10.1038/s41598-022-16165-8
  • Cui, Z., Feng, Y., Li, D., Li, T., Gao, P., & Xu, T. (2020). Activation of aryl hydrocarbon receptor (AhR) in mesenchymal stem cells modulates macrophage polarization in asthma. Journal of Immunotoxicology, 17(1), 21-30. doi:10.1080/1547691X.2019.1706671
  • Di Cicco, M., Ghezzi, M., Kantar, A., Song, W.-J., Bush, A., Peroni, D., & D'Auria, E. (2023). Pediatric obesity and severe asthma: Targeting pathways driving inflammation. Pharmacological Research, 188, 106658.
  • Dong, L., Wang, Y., Zheng, T., Pu, Y., Ma, Y., Qi, X., . . . Mao, C. (2021). Hypoxic hUCMSC-derived extracellular vesicles attenuate allergic airway inflammation and airway remodeling in chronic asthma mice. Stem Cell Research & Therapy, 12(1).
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  • Fang, Q., Wu, W., Xiao, Z., Zeng, D., Liang, R., Wang, J., ... & Zheng, S. G. (2024). Gingival-derived mesenchymal stem cells alleviate allergic asthma inflammation via HGF in animal models. Iscience, 27(5). doi:10.1016/j.isci.2024.109818.
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  • Firouzabadi, S. R., Mohammadi, I., Ghafourian, K., Kiani, A., & Hashemi, S. M. (2024). Mesenchymal Stem Cell-Derived Extracellular Vesicle Therapy for Asthma in Murine Models: A Systematic Review and Meta-analysis. Stem Cell Reviews and Reports, 20(5), 1162-1183. doi:10.1007/s12015-024-10704-8
  • Ge, X., Bai, C., Yang, J., Lou, G., Li, Q., & Chen, R. (2013). Effect of mesenchymal stem cells on inhibiting airway remodeling and airway inflammation in chronic asthma. Journal of Cellular Biochemistry, 114(7), 1595-1605. doi:10.1002/jcb.24501
  • Ghalavand, M., Gouvarchin Ghaleh, H. E., Khafaei, M., Paryan, M., Kondori, B. J., Nodoushan, M. M., ... & Mohammadi-Yeganeh, S. (2023). Effect of calcitriol treated mesenchymal stem cells as an immunomodulation micro-environment on allergic asthma in a mouse model. Endocrine, Metabolic & Immune Disorders-Drug Targets (Formerly Current Drug Targets-Immune, Endocrine & Metabolic Disorders), 23(8), 1096-1103.doi:10.2174/1871530323666230127115847
  • Gu, W., Zheng, T., Li, W., Luo, X., Xu, X., Wang, Y., ... & Dong, L. (2025). Migrasomes derived from human umbilical cord mesenchymal stem cells: a new therapeutic agent for ovalbumin-induced asthma in mice. Stem Cell Research & Therapy, 16(1), 26.doi:10.1186/s13287-025-04145-4
  • He, X. Y., Han, M. M., Zhao, Y. C., Tang, L., Wang, Y., Xing, L., ... & Jiang, H. L. (2024). Surface-engineered mesenchymal stem cell for refractory asthma therapy: Reversing airway remodeling. Journal of Controlled Release, 376, 972-984.doi:10.1016/j.jconrel.2024.10.056
  • Hur, J., Kang, J. Y., Kim, Y. K., Lee, S. Y., Jeon, S., Kim, Y., ... & Rhee, C. K. (2020). Evaluation of human MSCs treatment frequency on airway inflammation in a mouse model of acute asthma. Journal of Korean Medical Science, 35(23). doi:10.3346/jkms.2020.35.e188
  • Kang, S. Y., Park, D. E., Song, W. J., Bae, B. R., Lee, J. W., Sohn, K. H., ... & Cho, S. H. (2017). Immunologic regulatory effects of human umbilical cord blood‐derived mesenchymal stem cells in a murine ovalbumin asthma model. Clinical & Experimental Allergy, 47(7), 937-945.doi:10.1111/cea.12920
  • Kapoor, S., Patel, S. A., Kartan, S., Axelrod, D., Capitle, E., & Rameshwar, P. (2012). Tolerance-like mediated suppression by mesenchymal stem cells in patients with dust mite allergy–induced asthma. Journal of Allergy and Clinical Immunology, 129(4), 1094-1101. doi:10.1016/j.jaci.2011.10.048
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The effects of mesenchymal stem cells on asthma

Year 2025, Volume: 6 Issue: 1, 65 - 71, 30.04.2025

Kemal Yuce

https://doi.org/10.51753/flsrt.1567487

Abstract

Asthma is an inflammatory disease of the respiratory system characterized by cough, shortness of breath, wheezing, sputum, obstruction and bronchial hyperactivity. Asthma leads to disruption of epithelial structure, subepithelial fibrosis, inflammation, and ultimately airway reorganization. MSCs migrate into inflammatory tissue and settle there. Once in the tissue, the MSCs suppress inflammation and improve the internal structure of the tissue. These effects are achieved by transforming into tissue cells, producing anti-inflammatory and growth factors, and releasing microRNAs and extracellular vesicles. The effect of MSCs on asthma is based mostly on in vivo experimental animal models and in vitro studies of airway cells. While ovalbumin, cockroach extract and house dust mite are mostly used for in vivo experimental animal models, airway smooth muscle cells are mostly used for in vivo studies. This study aims to objectively present the information obtained from reliable articles about whether MSCs can be used in the treatment of asthma, a chronic inflammatory lung disease.

Keywords

Asthma models identification of MSCs inflammatory disease mesenchymal stem cells

Project Number

Not aplicable

References

  • Ahmadi, M., Rahbarghazi, R., Aslani, M. R., Shahbazfar, A. A., Kazemi, M., & Keyhanmanesh, R. (2017). Bone marrow mesenchymal stem cells and their conditioned media could potentially ameliorate ovalbumin-induced asthmatic changes. Biomedicine & Pharmacotherapy, 85, 28-40. doi:10.1016/j.biopha.2016.11.127
  • Ahmadi, M., Rahbarghazi, R., Shahbazfar, A. A., Baghban, H., & Keyhanmanesh, R. (2018). Bone marrow mesenchymal stem cells modified pathological changes and immunological responses in ovalbumin-induced asthmatic rats possibly by the modulation of miRNA155 and miRNA133. General Physiology and Biophysics, 37(3), 263-74.doi:10.4149/gpb_2017052
  • Banno, A., Reddy, Aravind T., Lakshmi, Sowmya P., & Reddy, Raju C. (2020). Bidirectional interaction of airway epithelial remodeling and inflammation in asthma. Clinical Science, 134(9), 1063-1079. doi:10.1042/cs20191309
  • Bao, X. H., Gao, F., Athari, S. S., & Wang, H. (2023). Immunomodulatory effect of IL‐35 gene‐transfected mesenchymal stem cells on allergic asthma. Fundamental & Clinical Pharmacology, 37(1), 116-124.doi:10.1111/fcp.12823
  • Bonfield, T. L., Koloze, M., Lennon, D. P., Zuchowski, B., Yang, S. E., & Caplan, A. I. (2010). Human mesenchymal stem cells suppress chronic airway inflammation in the murine ovalbumin asthma model. American Journal of Physiology-Lung Cellular and Molecular Physiology, 299(6), L760-L770.doi:10.1152/ajplung.00182.2009
  • Brychtova, M., Thiele, J.-A., Lysak, D., Holubova, M., Kralickova, M., & Vistejnova, L. (2019). Mesenchymal stem cells as the near future of cardiology medicine--truth or wish? Biomedical Papers of the Medical Faculty of Palacky University in Olomouc, 163(1).
  • Castro, L. L., Kitoko, J. Z., Xisto, D. G., Olsen, P. C., Guedes, H. L., Morales, M. M., ... & Rocco, P. R. (2020). Multiple doses of adipose tissue-derived mesenchymal stromal cells induce immunosuppression in experimental asthma. Stem Cells Translational Medicine, 9(2), 250-260. doi:10.1002/sctm.19-0120
  • Cevhertas, L., Ogulur, I., Maurer, D. J., Burla, D., Ding, M., Jansen, K., . . . Akdis, C. A. (2020). Advances and recent developments in asthma in 2020. Allergy, 75(12), 3124-3146.
  • Choi, J. Y., Hur, J., Jeon, S., Jung, C. K., & Rhee, C. K. (2022). Effects of human adipose tissue-and bone marrow-derived mesenchymal stem cells on airway inflammation and remodeling in a murine model of chronic asthma. Scientific Reports, 12(1), 12032.doi:10.1038/s41598-022-16165-8
  • Cui, Z., Feng, Y., Li, D., Li, T., Gao, P., & Xu, T. (2020). Activation of aryl hydrocarbon receptor (AhR) in mesenchymal stem cells modulates macrophage polarization in asthma. Journal of Immunotoxicology, 17(1), 21-30. doi:10.1080/1547691X.2019.1706671
  • Di Cicco, M., Ghezzi, M., Kantar, A., Song, W.-J., Bush, A., Peroni, D., & D'Auria, E. (2023). Pediatric obesity and severe asthma: Targeting pathways driving inflammation. Pharmacological Research, 188, 106658.
  • Dong, L., Wang, Y., Zheng, T., Pu, Y., Ma, Y., Qi, X., . . . Mao, C. (2021). Hypoxic hUCMSC-derived extracellular vesicles attenuate allergic airway inflammation and airway remodeling in chronic asthma mice. Stem Cell Research & Therapy, 12(1).
  • Dong, L., Wang, Y., Zheng, T., Pu, Y., Ma, Y., Qi, X., ... & Mao, C. (2021). Hypoxic hUCMSC-derived extracellular vesicles attenuate allergic airway inflammation and airway remodeling in chronic asthma mice. Stem Cell Research & Therapy, 12, 1-14.
  • Du, Y. M., Zhuansun, Y. X., Chen, R., Lin, L., Lin, Y., & Li, J. G. (2018). Mesenchymal stem cell exosomes promote immunosuppression of regulatory T cells in asthma. Experimental Cell Research, 363(1), 114-120. doi:10.1016/j.yexcr.2017.12.021
  • Dunbar, H., Hawthorne, I. J., Tunstead, C., Dunlop, M., Volkova, E., Weiss, D. J., ... & English, K. (2025). The VEGF‐Mediated Cytoprotective Ability of MIF‐Licensed Mesenchymal Stromal Cells in House Dust Mite‐Induced Epithelial Damage. European Journal of Immunology, 55(1), e202451205. doi:10.1002/eji.202451205
  • Fang, Q., Wu, W., Xiao, Z., Zeng, D., Liang, R., Wang, J., ... & Zheng, S. G. (2024). Gingival-derived mesenchymal stem cells alleviate allergic asthma inflammation via HGF in animal models. Iscience, 27(5). doi:10.1016/j.isci.2024.109818.
  • Feng, C. Y., Bai, S. Y., Li, M. L., Zhao, J. Y., Sun, J. M., Bao, H. J., . . . Su, X. M. (2022). Adipose-Derived Mesenchymal Stem Cell-Derived Exosomal miR-301a-3p Regulates Airway Smooth Muscle Cells During Asthma by Targeting STAT3. Journal of Asthma and Allergy, 15, 99-110. doi:10.2147/JAA.S335680
  • Firouzabadi, S. R., Mohammadi, I., Ghafourian, K., Kiani, A., & Hashemi, S. M. (2024). Mesenchymal Stem Cell-Derived Extracellular Vesicle Therapy for Asthma in Murine Models: A Systematic Review and Meta-analysis. Stem Cell Reviews and Reports, 20(5), 1162-1183. doi:10.1007/s12015-024-10704-8
  • Ge, X., Bai, C., Yang, J., Lou, G., Li, Q., & Chen, R. (2013). Effect of mesenchymal stem cells on inhibiting airway remodeling and airway inflammation in chronic asthma. Journal of Cellular Biochemistry, 114(7), 1595-1605. doi:10.1002/jcb.24501
  • Ghalavand, M., Gouvarchin Ghaleh, H. E., Khafaei, M., Paryan, M., Kondori, B. J., Nodoushan, M. M., ... & Mohammadi-Yeganeh, S. (2023). Effect of calcitriol treated mesenchymal stem cells as an immunomodulation micro-environment on allergic asthma in a mouse model. Endocrine, Metabolic & Immune Disorders-Drug Targets (Formerly Current Drug Targets-Immune, Endocrine & Metabolic Disorders), 23(8), 1096-1103.doi:10.2174/1871530323666230127115847
  • Gu, W., Zheng, T., Li, W., Luo, X., Xu, X., Wang, Y., ... & Dong, L. (2025). Migrasomes derived from human umbilical cord mesenchymal stem cells: a new therapeutic agent for ovalbumin-induced asthma in mice. Stem Cell Research & Therapy, 16(1), 26.doi:10.1186/s13287-025-04145-4
  • He, X. Y., Han, M. M., Zhao, Y. C., Tang, L., Wang, Y., Xing, L., ... & Jiang, H. L. (2024). Surface-engineered mesenchymal stem cell for refractory asthma therapy: Reversing airway remodeling. Journal of Controlled Release, 376, 972-984.doi:10.1016/j.jconrel.2024.10.056
  • Hur, J., Kang, J. Y., Kim, Y. K., Lee, S. Y., Jeon, S., Kim, Y., ... & Rhee, C. K. (2020). Evaluation of human MSCs treatment frequency on airway inflammation in a mouse model of acute asthma. Journal of Korean Medical Science, 35(23). doi:10.3346/jkms.2020.35.e188
  • Kang, S. Y., Park, D. E., Song, W. J., Bae, B. R., Lee, J. W., Sohn, K. H., ... & Cho, S. H. (2017). Immunologic regulatory effects of human umbilical cord blood‐derived mesenchymal stem cells in a murine ovalbumin asthma model. Clinical & Experimental Allergy, 47(7), 937-945.doi:10.1111/cea.12920
  • Kapoor, S., Patel, S. A., Kartan, S., Axelrod, D., Capitle, E., & Rameshwar, P. (2012). Tolerance-like mediated suppression by mesenchymal stem cells in patients with dust mite allergy–induced asthma. Journal of Allergy and Clinical Immunology, 129(4), 1094-1101. doi:10.1016/j.jaci.2011.10.048
  • Ke, X., Do, D. C., Li, C., Zhao, Y., Kollarik, M., Fu, Q., ... & Gao, P. (2019). Ras homolog family member A/Rho-associated protein kinase 1 signaling modulates lineage commitment of mesenchymal stem cells in asthmatic patients through lymphoid enhancer–binding factor 1. Journal of Allergy and Clinical Immunology, 143(4), 1560-1574. doi:10.1016/j.jaci.2018.08.023
  • Keyhanmanesh, R., Rahbarghazi, R., Aslani, M. R., Hassanpour, M., & Ahmadi, M. (2018). Systemic delivery of mesenchymal stem cells condition media in repeated doses acts as magic bullets in restoring IFN-γ/IL-4 balance in asthmatic rats. Life Sciences, 212, 30-36. doi:10.1016/j.lfs.2018.09.049
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Details

Primary Language English
Subjects Cellular Interactions
Journal Section Review
Authors

Kemal Yuce 0000-0001-8915-4900

Project Number Not aplicable
Publication Date April 30, 2025
Submission Date October 15, 2024
Acceptance Date March 13, 2025
Published in Issue Year 2025 Volume: 6 Issue: 1

Cite

APA Yuce, K. (2025). The effects of mesenchymal stem cells on asthma. Frontiers in Life Sciences and Related Technologies, 6(1), 65-71. https://doi.org/10.51753/flsrt.1567487
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