Research Article
Year 2025,
Volume: 42 Issue: 2, 75 - 79, 05.05.2025
Abstract
Amaç: Bu çalışmada, zirkonyum oksit (ZrO2) ve hidroksiapatit (HA) nanopartikülleri (NP) ile güçlendirilen otopolimerize polimetilmetakrilatın (PMMA) bükülme dayanımı (BD) ve antifungal özellikleri değerlendirilmiştir.
Gereç ve Yöntem: ZrO2 ve HA-NP'ler otopolimerizan PMMA içerisine %1 oranında ilave edilmiştir. BD için 65×10×3 mm'lik ve Candida albicans (C. Albicans) adhezyon testi için 2×10 mm'lik disk örnekler hazırlanmıştır (n=10). Yüzey pürüzlülüğü her numune için profilometre kullanılarak ölçülmüştür. 3-nokta eğme ve Candida adhezyon testleri uygulanmıştır. Elde edilen veriler ANOVA ve Post-Hoc Bonferroni testleri kullanılarak istatistiksel olarak analiz edilmiştir. Anlamlılık düzeyi p<0,05 olarak kabul edilmiştir.
Bulgular: Bulgulara göre, NP'lerin eklenmesi BD'de bir azalmaya neden olmuştur. Diğer gruplarla karşılaştırıldığında, ZrO2 ilavesi (55,47 ± 9,40) BD'de anlamlı bir azalmaya sebep olmuştur.(p<0,05) Ayrıca, ZrO2 ilavesi (16,5 ± 5,8) kontrol grubuna kıyasla C. albicans adhezyonunu önemli ölçüde azaltmıştır.(p<0,05)
Sonuç: Geçici otopolimerizan akriliğe ilave edilen ZrO2-NP'ler bükülme dayanımını azaltmakta ve Candida adhezyonunu önlemektedir.
References
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- 4. Ahmed MA, El-Shennawy M, Althomali YM, Omar AA. Effect of titanium dioxide nano particles incorporation on mechanical and physical properties on two different types of acrylic resin denture base. World J Nano Sci Eng 2016;6:111-9.
- 5. Aldabib JM, Ishak ZAM. Effect of hydroxyapatite filler concentration on mechanical properties of poly (methyl methacrylate) denture base. SN Appl Sci 2020;2:732.
- 6. Ergun G, Sahin Z, Ataol AS. The effects of adding various ratios of zirconium oxide nanoparticles to poly (methyl methacrylate) on physical and mechanical properties. J Oral Sci 2018;60:304-15.
- 7.. Kul E, Aladağ Lİ, Yesildal R. Evaluation of thermal conductivity and flexural strength properties of poly (methyl methacrylate) denture base material reinforced with different fillers. J Prosthet Dent 2016;116:803-10.
- 8. Takamiya AS, Monteiro DR, Gorup LF, Silva EA, de Camargo ER, Gomes-Filho JE, et al. Biocompatible silver nanoparticles incorporated in acrylic resin for dental application inhibit Candida albicans biofilm. Mater Sci Eng C 2021;118:111341.
- 9. Akay C, Çakmak G, Donmez MB, Abou-Ayash S, Mumcu E, Pat S, Yilmaz B. Flexural Strength and Vickers Microhardness of Graphene-Doped SnO2 Thin-Film-Coated Polymethylmethacrylate after Thermocycling. Coat 2023;13:1106.
- 10. Avukat EN, Akay C, Topcu Ersöz MB, Mumcu E, Pat S, Erdönmez D. Could Helium Plasma Treatment be a Novel Approach to Prevent the Biofilm Formation of Candida albicans? Mycopathologia 2023;188:361- 9.
- 11. Topcu Ersöz MB, Mumcu E, Avukat EN, Akay C, Pat S, Erdönmez D. Anti-adherent activity of nano-coatings deposited by thermionic vacuum arc plasma on C. albicans biofilm formation. Int J Artif Organs 2023;46:520-6.
- 12. Akay C, Karakis D, Doğan A, Rad AY. Effect of chemical disinfectants on Candida albicans biofilm formation on poly (methyl methacrylate) resin surfaces: a scanning electron microscope study. J Adv Oral Res 2016;7:21-6.
- 13. Enax J, Epple M. Synthetic hydroxyapatite as a biomimetic oral care agent. Oral Health Prev Dent 2018;16: 7-19.
- 14. Juntavee N, Juntavee A, Plongniras P. Remineralization potential of nano-hydroxyapatite on enamel and cementum surrounding margin of computer-aided design and computer-aided manufacturing ceramic restoration. Int J Nanomedicine 2018;13:2755-65.
- 15. Khajuria DK, Zahra SF, Razdan R. Effect of locally administered novel biodegradable chitosan based risedronate/zinc-hydroxyapatite intra-pocket dental film on alveolar bone density in rat model of periodontitis. J Biomater Sci Polym Ed 2018;29:74-91.
- 16. Karci M, Demir N, Yazman S. Evaluation of flexural strength of different denture base materials reinforced with different nanoparticles. J Prosthodont 2019;28:572-9.
- 17. Alshahrani FA, Gad MM, Al-Thobity AM, Akhtar S, Kashkari A, Alzoubi F, Yilmaz B. Effect of treated zirconium dioxide nanoparticles on the flexural properties of autopolymerized resin for interim fixed restorations: An in vitro study. J Prosthet Dent 2023;130:257-64.
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- 23. Gad MM, Rahoma A, Al-Thobity AM, ArRejaie AS. Influence of incorporation of ZrO2 nanoparticles on the repair strength of polymethylmethacrylate denture bases. Int J Nanomedicine 2016:5633-43.
- 24. Alhareb AO, Ahmad ZA. Effect of Al2O3/ZrO2 reinforcement on the mechanical properties of PMMA denture base. J Reinf Plast Compos2011;30:86-93.
- 25. Anwander M, Rosentritt M, Schneider-Feyrer S, Hahnel S. Biofilm formation on denture base resin including ZnO, CaO, and TiO2 nanoparticles. J Adv Prosthodont 2017;9:482-5.
- 26. Chen R, Han Z, Huang Z, Karki J, Wang C, Zhu B, Zhang X. Antibacterial activity, cytotoxicity and mechanical behavior of nanoenhanced denture base resin with different kinds of inorganic antibacterial agents. Dent Mater J 2017;36:693-9.
- 27. De Matteis V, Cascione M, Toma CC, Albanese G, De Giorgi ML, Corsalini M, Rinaldi R. Silver nanoparticles addition in poly (methyl methacrylate) dental matrix: Topographic and antimycotic studies. Int J Mol Sci 2019;20:4691.
- 28. Gad MM, Al-Thobity AM, Shahin SY, Alsaqer BT, Ali AA. Inhibitory effect of zirconium oxide nanoparticles on Candida albicans adhesion to repaired polymethyl methacrylate denture bases and interim removable prostheses: a new approach for denture stomatitis prevention. Int J Nanomedicine 2017;12:5409-19.
- 29. Abualsaud R, Aleraky DM, Akhtar S, Khan SQ, Gad MM. Antifungal activity of denture base resin containing nanozirconia: In vitro assessment of candida albicans biofilm. Sci World J 2021;2021:8.
- 30. Elboraey AN, Abo-Almaged HH, El-Ashmawy AAE-R, Abdou AR, Moussa AR, Emara LH, et al. Biological and mechanical properties of denture base material as a vehicle for novel hydroxyapatite nanoparticles loaded with drug. Adv Pharm Bull 2021;11:86.
- 31. Ragab H, Ibrahim F, Abdallah F, Al-Ghamdi AA, El-Tantawy F, Radwan N, Yakuphanoglu F. Synthesis and in vitro antibacterial properties of hydroxyapatite nanoparticles. IOSR J Pharm Biol Sci 2014;9:77-85.
Year 2025,
Volume: 42 Issue: 2, 75 - 79, 05.05.2025
Abstract
Objective: The aim of this study was to evaluate the flexural strength (FS) and antifungal properties of autopolymerised polymethylmethacrylate (PMMA) reinforced with the of zirconium oxide (ZrO2) and hydroxyapatite (HA) nanoparticles (NPs).
Materials and Methods: ZrO2 and HA-NPs were incorporated into cold cured PMMA at a rate of 1%. 65×10×3 mm specimens were prepared for FS and 2×10 mm disc specimens for Candida albicans (C. Albicans) adhesion test (n=10). Surface roughness was recorded for each specimen via a profilometer. 3-point bending, Candida adhesion tests were performed. Statistical analysis was done with One-way analysis of variance and Post-Hoc Bonferroni tests. (p<0.05)
Results: Based on the findings, the addition of NPs resulted in a decrease in FS. In comparison to other groups, ZrO2 (55.47 ± 9.40) showed a significant decrease in FS (p<0.05). In addition, the adhesion of C. albicans was significantly reduced by ZrO2 (16.5 ± 5.8) in comparison to the control group (p<0.05).
Conclusion: ZrO2-NPs incorporated into temporary acrylic reduced FS and prevented Candida adhesion, while the impact of HA-NPs remains elusive.
References
- 1. Pituru SM, Greabu M, Totan A, Imre M, Pantea M, Spinu T, et al. A review on the biocompatibility of PMMA-based dental materials for interim prosthetic restorations with a glimpse into their modern manufacturing techniques. Mater 2020;13:2894.
- 2. Albasarah S, Al Abdulghani H, Alaseef N, Al-Qarni FD, Akhtar S, Khan SQ, et al. Impact of ZrO2 nanoparticles addition on flexural properties of denture base resin with different thickness. J Adv Prosthodont 2021;13:226.
- 3. Alhavaz A, Rezaei Dastjerdi M, Ghasemi A, Ghasemi A, Alizadeh Sahraei A. Effect of untreated zirconium oxide nanofiller on the flexural strength and surface hardness of autopolymerized interim fixed restoration resins. J Esthet Restor Dent 2017;29:264-9.
- 4. Ahmed MA, El-Shennawy M, Althomali YM, Omar AA. Effect of titanium dioxide nano particles incorporation on mechanical and physical properties on two different types of acrylic resin denture base. World J Nano Sci Eng 2016;6:111-9.
- 5. Aldabib JM, Ishak ZAM. Effect of hydroxyapatite filler concentration on mechanical properties of poly (methyl methacrylate) denture base. SN Appl Sci 2020;2:732.
- 6. Ergun G, Sahin Z, Ataol AS. The effects of adding various ratios of zirconium oxide nanoparticles to poly (methyl methacrylate) on physical and mechanical properties. J Oral Sci 2018;60:304-15.
- 7.. Kul E, Aladağ Lİ, Yesildal R. Evaluation of thermal conductivity and flexural strength properties of poly (methyl methacrylate) denture base material reinforced with different fillers. J Prosthet Dent 2016;116:803-10.
- 8. Takamiya AS, Monteiro DR, Gorup LF, Silva EA, de Camargo ER, Gomes-Filho JE, et al. Biocompatible silver nanoparticles incorporated in acrylic resin for dental application inhibit Candida albicans biofilm. Mater Sci Eng C 2021;118:111341.
- 9. Akay C, Çakmak G, Donmez MB, Abou-Ayash S, Mumcu E, Pat S, Yilmaz B. Flexural Strength and Vickers Microhardness of Graphene-Doped SnO2 Thin-Film-Coated Polymethylmethacrylate after Thermocycling. Coat 2023;13:1106.
- 10. Avukat EN, Akay C, Topcu Ersöz MB, Mumcu E, Pat S, Erdönmez D. Could Helium Plasma Treatment be a Novel Approach to Prevent the Biofilm Formation of Candida albicans? Mycopathologia 2023;188:361- 9.
- 11. Topcu Ersöz MB, Mumcu E, Avukat EN, Akay C, Pat S, Erdönmez D. Anti-adherent activity of nano-coatings deposited by thermionic vacuum arc plasma on C. albicans biofilm formation. Int J Artif Organs 2023;46:520-6.
- 12. Akay C, Karakis D, Doğan A, Rad AY. Effect of chemical disinfectants on Candida albicans biofilm formation on poly (methyl methacrylate) resin surfaces: a scanning electron microscope study. J Adv Oral Res 2016;7:21-6.
- 13. Enax J, Epple M. Synthetic hydroxyapatite as a biomimetic oral care agent. Oral Health Prev Dent 2018;16: 7-19.
- 14. Juntavee N, Juntavee A, Plongniras P. Remineralization potential of nano-hydroxyapatite on enamel and cementum surrounding margin of computer-aided design and computer-aided manufacturing ceramic restoration. Int J Nanomedicine 2018;13:2755-65.
- 15. Khajuria DK, Zahra SF, Razdan R. Effect of locally administered novel biodegradable chitosan based risedronate/zinc-hydroxyapatite intra-pocket dental film on alveolar bone density in rat model of periodontitis. J Biomater Sci Polym Ed 2018;29:74-91.
- 16. Karci M, Demir N, Yazman S. Evaluation of flexural strength of different denture base materials reinforced with different nanoparticles. J Prosthodont 2019;28:572-9.
- 17. Alshahrani FA, Gad MM, Al-Thobity AM, Akhtar S, Kashkari A, Alzoubi F, Yilmaz B. Effect of treated zirconium dioxide nanoparticles on the flexural properties of autopolymerized resin for interim fixed restorations: An in vitro study. J Prosthet Dent 2023;130:257-64.
- 18. American National Standards Institute ADA. ANSI/ADA Specification No. 27 Direct filling resins. 1993.
- 19. Zidan S, Silikas N, Haider J, Alhotan A, Jahantigh J, Yates J. Evaluation of equivalent flexural strength for complete removable dentures made of zirconia-impregnated PMMA nanocomposites. Mater 2020;13:2580.
- 20. Gad MM, Abualsaud R, Rahoma A, Al-Thobity AM, Akhtar S, Fouda SM. Double-layered acrylic resin denture base with nanoparticle additions: An in vitro study. J Prosthet Dent 2022;127:174-83.
- 21. Zebarjad SM, Sajjadi SA, Sdrabadi TE, Yaghmaei A, Naderi B. A study on mechanical properties of PMMA/hydroxyapatite nanocomposite. Eng 2011;2011.
- 22. Khongwong W, Keawsupsak K, Daungdaw S, Siridamrong P, Boonruang A. Influence of silane coupling agent and nano-filler on the properties of dental resin composite cements. Key Eng Mater 2016;690:230-5.
- 23. Gad MM, Rahoma A, Al-Thobity AM, ArRejaie AS. Influence of incorporation of ZrO2 nanoparticles on the repair strength of polymethylmethacrylate denture bases. Int J Nanomedicine 2016:5633-43.
- 24. Alhareb AO, Ahmad ZA. Effect of Al2O3/ZrO2 reinforcement on the mechanical properties of PMMA denture base. J Reinf Plast Compos2011;30:86-93.
- 25. Anwander M, Rosentritt M, Schneider-Feyrer S, Hahnel S. Biofilm formation on denture base resin including ZnO, CaO, and TiO2 nanoparticles. J Adv Prosthodont 2017;9:482-5.
- 26. Chen R, Han Z, Huang Z, Karki J, Wang C, Zhu B, Zhang X. Antibacterial activity, cytotoxicity and mechanical behavior of nanoenhanced denture base resin with different kinds of inorganic antibacterial agents. Dent Mater J 2017;36:693-9.
- 27. De Matteis V, Cascione M, Toma CC, Albanese G, De Giorgi ML, Corsalini M, Rinaldi R. Silver nanoparticles addition in poly (methyl methacrylate) dental matrix: Topographic and antimycotic studies. Int J Mol Sci 2019;20:4691.
- 28. Gad MM, Al-Thobity AM, Shahin SY, Alsaqer BT, Ali AA. Inhibitory effect of zirconium oxide nanoparticles on Candida albicans adhesion to repaired polymethyl methacrylate denture bases and interim removable prostheses: a new approach for denture stomatitis prevention. Int J Nanomedicine 2017;12:5409-19.
- 29. Abualsaud R, Aleraky DM, Akhtar S, Khan SQ, Gad MM. Antifungal activity of denture base resin containing nanozirconia: In vitro assessment of candida albicans biofilm. Sci World J 2021;2021:8.
- 30. Elboraey AN, Abo-Almaged HH, El-Ashmawy AAE-R, Abdou AR, Moussa AR, Emara LH, et al. Biological and mechanical properties of denture base material as a vehicle for novel hydroxyapatite nanoparticles loaded with drug. Adv Pharm Bull 2021;11:86.
- 31. Ragab H, Ibrahim F, Abdallah F, Al-Ghamdi AA, El-Tantawy F, Radwan N, Yakuphanoglu F. Synthesis and in vitro antibacterial properties of hydroxyapatite nanoparticles. IOSR J Pharm Biol Sci 2014;9:77-85.
There are 31 citations in total.
Details
| Primary Language | English |
|---|---|
| Subjects | Dental Materials and Equipment, Prosthodontics |
| Journal Section | Original Research Article |
| Authors | |
| Publication Date | May 5, 2025 |
| Submission Date | February 13, 2024 |
| Acceptance Date | July 4, 2024 |
| Published in Issue | Year 2025 Volume: 42 Issue: 2 |
