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YENİ NESİL GÜVENLİK TEHLİKESİ: ELEKTRONİK SİGARALAR

Year 2025, Volume: 14 Issue: 1, 441 - 460, 02.06.2025

Pınar Yılmazcan , Aslı Atasoy Aydın , Nebile Dağlıoğlu

https://doi.org/10.28956/gbd.1534283

Abstract

Tüm dünyada olduğu gibi ülkemizde de elektronik sigaralar (e-sigaralar), geleneksel tütün ürünlerine alternatif olarak oldukça popülerlik kazanmıştır. Ancak bu popülaritesinin yanında, e-sigaraların insan sağlığına etkileri, kullanım amacı ve suiistimali, sosyal etkileri konusundaki tartışmalar da her geçen gün artmaktadır.
E-sigara kullanımı, artan tüketim talebiyle birlikte her geçen gün farklı özellik ve tasarımlarda piyasaya sunulmaktadır. Başlangıçta sigara bırakmada etkin rol oynayacağı iddiasıyla ortaya çıkan, sonrasında ucuz ve kolay ulaşılabilir olması, kısıtlama olmaksızın istenilen her ortamda kullanılması, istenilen aromalarla tatlandırılabilir olması, nikotin oranının kişi tarafından belirlenebilir olması, kötü koku bırakmaması, atık oluşturmaması (kül, izmarit vb.) ve tütüne kıyasla sağlık açısından daha masum olduğu düşünülmesi gibi nedenlerden dolayı birçok kişi tarafından tercih edilmektedir.
E-sigara ile yapılan çalışmalar incelendiğinde, e-sigara sıvılarında birçok yasa dışı madde ve psikoaktif madde tespit edilmiştir. Bu durum e-sigaraların, madde kullanımında yeni bir alternatif yol olduğunu düşündürmekte, hatta e-sigaraların madde kullanımını maskelemek için kullanılabileceğini göstermektedir.
Bu derleme, dünyadaki etkileri de göz önünde bulundurularak ülkemizde yasa dışı madde kullanımında e- sigaraların araç olarak kullanımına dikkat çekmek için yapılmıştır.

Keywords

elektronik sigara elektronik nikotin dağıtım sistemleri (ENDs) yasa dışı madde LC-MS/MS

References

  • Aksakal, A. (2022). Sistematik Bir Literatür İncelemesi: Elektronik Sigaralar. Sağlık bilimlerinde güncel yaklaşımlar 5 (s. 30-38), DOI: 10.1016/j.jpba.2023.115394.
  • Almazrouei, E. S., Bintamim, A. A., Khalil, S. S., Alremeithi, R., Gewily, S., (2022). The identification of drugs of abuse in E-cigarette samples seized in Dubai between 2016 and 2020, Case Report. Forensic Science International, 111233, DOI: 10.1016/j.forsciint.2022.111233.
  • Alver, İ. A. (2021;31(1)). Elektronik Sigara (e-sigara) Likit ve Aerosollerinin Halk Sağlığı Üzerine Etkisi, Tepecik Eğitim ve Araştırma. Hastanesi Dergisi, 9-15, DOI: 10.5222/terh.2021.37268.
  • Angerer, V., Franz, F., Moosmann, B., Bisel, P., Auwärter, V., (2019). 5F-Cumyl-PINACA in ‘e-liquids’ for electronic cigarettes: comprehensive characterization of a new type of synthetic cannabinoid in a trendy product including investigations on the in vitro and in vivo phase I metabolism of 5F-Cumyl-PINACA and its non-fluo. Forensic Toxicology,37, 186-196, DOI: 10.1007/s11419-018-0451-8.
  • Atasoy, A., Daglioglu, N., Gören, İ.E., Girisbay, A., Aslan, R., Anette-Akgür, S., (2021). Determination of synthetic cannabinoids in randomly urine samples collected from probationers in Turkey, Forensic Science International, Volume 322, DOI: 10.1016/j.forsciint.2021.110752.
  • Avrupa Parlamentosu ve Konseyi. Tütün Ürünleri Direktifi (2014/40/AB). (2014). Erişim Tarihi: 14 Mayıs 2024, https://ec. europa. eu/health/sites/health/files/tobacco/docs/dir_201440_en. pdf.
  • Barhdadi, S., Courselle, P., Deconinck, E., Vanhee, C., (2023). The analysis of cannabinoids in e-cigarette liquids using LC-HRAM-MS and LC-UV. Journal of Pharmaceutical and Biomedical Analysis Volume 230, DOI: 10.1016/j.jpba.2023.115394.
  • Blount, B. C., Karwowski, M. P., Shields, P. G., Morel-Espinosa, M., Valentin-Blasini, L., Gardner, M. S., et al., (20 December 2020), Vitamin E Acetate in Bronchoalveolar-Lavage Fluid Associated with EVALI. The New England Journal of Medicine, Volume 382, No. 8: 697-705, DOI: 10.1056/NEJMoa1916433.
  • Blundell, M., Dargan, P., Wood, D., (2018). A cloud on the horizon–a survey into the use of electronic vaping devices for recreational drug and new psychoactive substance (NPS) administration, QJM: An International Journal of Medicine, 9-14, DOI: 10.1093/qjmed/hcx178.
  • Börekçi, Ş., Bilir, N., Karlıkaya, C., Türkiye Solunum Araştırmaları Derneği Tütün Çalışma Grubu, (2015). A New Area to Fight: Electronic Cigarette. Eurasian Pulmonol, DOI: 10.5152/ejp.2015.65375.
  • Canistro, D., Vivarelli, F., Cirillo, S., Marquillas, C. B., Buschini, A., Lazzaretti, M., vd., (2017). E-cigarettes induce toxicological effects that can raise the cancer risk, Scientific Report, DOI: 10.1038/s41598-017-02317-8.
  • Cao DJ, Aldy K, Hsu S, et al., (2020). Review of health consequences of electronic cigarettes and the outbreak of electronic cigarette, or vaping, product use-associated lung injury, Journal of Medical Toxicology, 16(3): 295-310, DOİ:10.1007/s13181-020-00772-w.
  • Chen, G., Rahman, S., Lutfy, K., (2023). E-cigarettes may serve as a gateway to conventional cigarettes and other addictive drugs, Advances in Drug and Alcohol Research, Jun 30:3:11345, DOI: 10.3389/adar.2023.11345.
  • Choi, H., Kim, S., Jang, H., Kim, H. J., Choe, S., (2022). Identification of a novel bromoindazole synthetic cannabinoid analogue in seized e-cigarette liquid: ADB-BRINACA, Forensic Science International, Volume 338, 111385, DOI: 10.1016/j.forsciint.2022.111385.
  • Chun, L. F., Moazed, F., Calfee, C.S., Matthay, M. A., Gotts, J. E., (2017). Pulmonary toxicity of e-cigarettes, American Physiological Society, Volume 313, Issue 2, DOI: 10.1152/ajplung.00071.2017.
  • Cornelius, M. E., Loretan, C. G., Wang, T. W., Jamal, A., Homa, D. M., (2022). Tobacco Product Use Among Adults - United States, 2020. Morbidity and Mortality Weekly Report (MMWR), 397-405, DOI: 10.15585/mmwr.mm7111a1.
  • Etter, J.F., (2015) Electronic cigarettes and cannabis: An exploratory study. European Addiction Research, 21, 124–130, DOI: 10.1159/000369791.
  • Etzel, R. A., Wilson, K. M., Balk, S. J., Farber, H. J., Groner J. A., Moore J. E. (2015). Electronic Nicotine Delivery Systems, Pediatrics, Section on Tobacco Control, 136(5): 1018-1026, DOI: 10.1542/peds.2015-3222.
  • Evans-Polis, R., Chen, B., McCabe, S., West, B., (2024). Longitudinal associations of e-cigarette use with cigarette, marijuana, and other drug use initiation among US adolescents and young adults: Findings from the Population Assessment of Tobacco and Health study (Waves 1-6), Drug and Alcohol Dependence, In Press, DOI: 10.1016/j.drugalcdep.2024.111402.
  • Frinculescu, A., Coombes, G., Shine, T., Ramsey, J., Johnston, A., Couchman, L., (2022). Analysis of illicit drugs in purchased and seized electronic cigarette liquids from the United Kingdom 2014–2021. Drug Testing and AnalysisVolume 15, Issue 1, 1058-1066, DOI: 10.1002/dta.3277.
  • Ghinai, I., Navon, L., Gunn, J. K. L., Duca, L. M., Brister, S., Love, S., et.al, (2020). Characteristics of persons who report using only nicotine-containing products among interviewed patients with e-cigarette, or vaping, product use-associated lung injury - Illinois, August-December 2019, Morbidity and Mortality Weekly Report, Volume 69, Issue 3, 84-89, DOI: 10.15585/mmwr.mm6903e1.
  • Global Tobacco Control. Country Laws Regulating E-cigarettes: Finland. Published online 2019, (2019). Erişim Tarihi: 14 Mayıs 2024, https://www.globaltobaccocontrol.org/e-cigarette/finland.
  • Global Tobacco Control. Country Laws Regulating E-cigarettes: Germany. E-Cigarette Policy Scan. Published 2019, (2019). Erişim Tarihi: 14 Mayıs 2024, https://www.globaltobaccocontrol.org/e-cigarette/germany.
  • Global Tobacco Control. Country Laws Regulating E-cigarettes: Greece. E-Cigarette Policy Scan. Published 2019, (2019). Erişim Tarihi: 14 Mayıs 2024, https://www.globaltobaccocontrol.org/e-cigarette/greece.
  • Goniewicz, M. J., Knysak, J., Gawron, M., Kosmider, L., Sobczak, A., Kurek, J., et.al, (2014), Levels of selected carcinogens and toxicants in vapour from electronic cigarettes, Tobacco Control, Volume 23, Issue 2, p. 133-139, DOI: 10.1136/tobaccocontrol-2012-050859.
  • Gündüz, A. İ. (2022, Kasım 8). ELEKTRONİK SİGARA VE HUKUKİ BOYUTU. Erişim Tarihi: 14 Mayıs 2024, http://ipekbiter.av.tr/blog/elektronik-sigara-ve-hukuki-boyutu/.
  • Hajek, P., Phillips-Waller, A., Przulj, D., Pesola, F., Smith, K. M., Bisal, N., Li, J., Parrot, S., Sasieni, P., Dawkins, L., Ross, L., Goniewicz, M., Wu, Q., McRobbie, H. (2019). A Randomized Trial of E-Cigarettes versus Nicotine-Replacement Therapy. The New England Journal of Medicine, DOI: 10.1056/NEJMoa1808779.
  • Harries, R., Norman, C., Reid, R., et al, (2024). Detection of anabolic-androgenic steroids in e-cigarettes seized from prisons: A case study. Forensic Science Internatiol, Mar:356:111965, DOI: 10.1016/j.forsciint.2024.111965.
  • Hon, L. (2006). Flameless electronic atomizing cigarette. (Patent US20060196518A1)
  • https://tr.wikipedia.org/wiki/Kannabidiol, Erişim Tarihi: 24 Temmuz 2024,
  • https://tr.wikipedia.org/wiki/Nikotin, Erişim Tarihi: 24 Temmuz 2024,
  • https://tr.wikipedia.org/wiki/Tetrahidrokannabinol, Erişim Tarihi: 24 Temmuz 2024,
  • https://www.bbc.com/turkce/articles/cd1rnx9gkeno. (2023, 05 02). BBC NEWS, Erişim Tarihi: 14 Mayıs 2024.
  • https://www.fda.gov/tobacco-products/products-guidance-regulations/rules-regulations-and-guidance. (2019). Erişim Tarihi: 14 Mayıs 2024,
  • https://www.gov.uk/guidance/e-cigarettes-regulations-for-consumer-products#full-publication-update-history. (2022).
  • https://www.publichealthlawcenter.org/commentary/240305/3/5/24-closer-look-23-fda-authorized-e-cigarettes. (2024), Erişim Tarihi: 15 Mayıs 2024.
  • https://www.resmigazete.gov.tr/eskiler/2008/01/20080119-1.htm.(2008), Erişim Tarihi: 14 Mayıs 2024.
  • https://www.resmigazete.gov.tr/eskiler/2020/02/20200225-23.pdf. (2020). Erişim Tarihi: 14 Mayıs 2024.
  • https://www.yesilay.org.tr/tr/makaleler/e-sigara-da-sigara-kadar-zararli., Kasım 2019, Erişim Tarihi: 30 Temmuz 2024.
  • Hutzler, C., Paschke, M., Kruschinski, S., Henkler, F., Hahn, J., Luch, A., (2014), Chemical hazards present in liquids and vapors of electronic cigarettes, Archives of Toxicology, Volume 88, 1295-1308, DOİ: 10.1007/s00204-014-1294-7.
  • Jack, B., Raziaa, Z., et al (2020). How harmless are E-cigarettes? Effects in the pulmonary system, Current Opinion in Pulmonary Medicine 26(1):p 97-102, January,| DOI: 10.1097/MCP.0000000000000645.
  • Jensen, R.P., Luo, W., Pankow, J.F., Strongin, R.M., Peyton, D.H., (2015). Hidden Formaldehyde in E-Cigarette Aerosols, The New England Journal of Medicine, Volume 372, No 4:392-394, DOI: 10.1056/NEJMc1413069.
  • Kandel, E. R., Kandel, D. B., (September 4, 2014), A Molecular Basis for Nicootine as a Gateway Drug, The New England Journal of Medicine, Volume 371, No. 10: 932-943, DOI: 10.1056/NEJMsa1405092.
  • Kemp, A.M., Clark, M.S., Dobbs, T., Galli, R., Sherman, J., Cox, R., (2016). Top 10 Facts You Need to Know About Synthetic Cannabinoids: Not So Nice Spice, The American Journal of Medicine, Volume 129, Issıu 3:240-244, DOI: 10.1016/j.amjmed.2015.10.008.
  • King, B.A., Jones, C.M., Baldwin, G.T., Briss, P. A., (17 January 2020). The EVALI and Youth Vaping Epidemics — Implications for Public Health, The New England Journal of Medicine, Volume 382, No. 8: 689-691, DOI: 10.1056/NEJMp1916171.
  • Köseoğlu, E., Uğur, F., Saraymen, R., Canatan, H., Coşkun, A., Bilgen, M., (2014). Elektronik Sigara Kullanımına Objektif Bakış. Cukurova Medicine Journal, 572-580, DOI: 10.17826/cutf.86547.
  • Krishnasamy V.P., Hallowell B.D., Ko J.Y., et al. Update: characteristics of a nationwide outbreak of e-cigarette, or vaping, product use–associated lung injury—United States, August 2019–January 2020, (24 January 2020). MMWR Morbidity and Mortal Weekly Report, 69(3), 90-94.
  • Krüsemann, E.J.Z., Pennings, J.L.A., Cremers, J.W.J.M, Bakker, F., Boesveldt, S., Talhout, R., (2020). GC-MS analysis of e-cigarette refill solutions: a comparison of flavoring composition between flavor categories. J. Pharm. Biomed. Anal., 188, DOI: 10.1016/j.jpba.2020.113364.
  • Lin, Z., Xiong, J., Yang, J., et al, (2024). A comprehensive analysis of the health effects associated with smoking in the largest population using UK Biobank genotypic and phenotypic data. Heliyon, Volume 10, Issue 16, DOI: 10.1016/j.heliyon.2024.e35649.
  • McConnell, R., Barrington-Trimis, J. L., Wang, K., Urman, R., Hong, H., Unger, J., et.al, (2016). Electronic Cigarette Use and Respiratory Symptoms in Adolescents, American Journal of Respiratory and Critical Care, Volume 195, Issu 8, DOI: 10.1164/rccm.201604-0804OC.
  • Morris, J.D., Pebley, K., Little, M.A., et al, (2023). Vaping Opioids: Should We Be Worried? American Journal of Health Promotion, Volume 37, Issue 8, DOI: 10.1177/08901171231193785.
  • Münster-Müller, S., Matzenbach, I., Knepper, T., Zimmerman, R., Pütz, M., (2020). Profiling of synthesis-related impurities of the synthetic cannabinoid Cumyl-5F-PINACA in seized samples of e-liquids via multivariate analysis of UHPLC−MSn data. Drug Test. Anal., 12, 119-126, DOI: 10.1002/dta.2673.
  • Ogunwale, M. A., Li, M., Raju, M. V. R., Chen, Y., Nantz, M. H., Conklin, D. J., Fu, X.A., (2017). Aldehyde detection in electronic cigarette aerosols, ACS Omega, Volume 2, Issue 3, 1207-1214, DOI: 10.1021/acsomega.6b00489.
  • Peace, M. R., Bjutler, K., Wolf, Poklis, J, L., Poklis, A., (2016). Evaluation of Two Commercially Available Cannabidiol Formulations for Use in Electronic Cigarettes. Frontier in Pharmacology, Sec. Experimental Pharmacology and Drug Discovery, DOI: 10.3389/fphar.2016.00279.
  • Poklis, J. L., Mulder, H., Peace, M: R., (2019). The unexpected identification of the cannabimimetic, 5F-ADB, and dextromethorphan in commercially available cannabidiol e-liquids. Forensic Science International, 25-27, DOI: 10.1016/j.forsciint.2018.10.019.
  • Regulating tobacco and vaping products: Tobacco products regulations. https://www.canada.ca/en/health-canada/services/smoking-tobacco/regulating-tobacco-vaping/tobacco.html.
  • Resmî gazete. (2020, Şubat 24), Erişim Tarihi: 14 Mayıs 2024, https://www.resmigazete.gov.tr/eskiler/2020/02/20200225-23.pdf.
  • Roberts, E., Copeland C., Robson, D., McNeill, A., (10 March 2021), Drug-related deaths associated with vaping product use in the United Kingdom, Addiction, Volume 116, Issue 10, p. 2908-2911, DOI: 10.1111/add.15468.
  • Superintendent of Public Health-Malta. L.N. 67 of 2016: TOBACCO (SMOKING CONTROL) ACT (Cap. 315) Published 2016. (2016). Erişim Tarihi: 14 Mayıs 2024, http://justiceservices.gov.mt/DownloadDocument.aspx?app=lp&itemid=27447&l=1.
  • The Netherlands: Plain packaging decided. Tobacco Journal International. Published 2019. (2019), Erişim Tarihi: 14 Mayıs 2024, http://www.tobaccojournal.com/Plain_packaging_decided.55258.0.html.
  • Trtchounisn, A., Talbot, P. (2011). Electronic nicotine delivery system: is there a need for regulation? Tobacco Control, 47-52, DOI: 10.1136/tc.2010.037259.
  • Varlet, V., (2016). Drug Vaping: From the Dangers of Misuse to New Therapeutic Devices, Toxics, Volume 4, Issue 4, 29, DOI: 10.3390/toxics4040029.
  • Xu, Y., Chen, X., Fan, Y. L., Wu, H., (2023). Structural confirmation of synthetic cannabinoids in seized electronic cigarette oil: a combined mass spectrometric and computational study. Rapid Commun Mass Spectrom.,37, DOI: 10.1002/rcm.9485.
  • Yuan, M., Cross, S.J, Loughlin, S.E., Leslie, F. M., (2015). Nicotine and the adolescent brain, The Journal of Physiology, Volume 593, Issue 16, p. 3397-3412, DOI: 10.1113/JP270492.

NEW GENERATION SAFETY HAZARD: ELECTRONIC CIGARETTES

Year 2025, Volume: 14 Issue: 1, 441 - 460, 02.06.2025

Pınar Yılmazcan , Aslı Atasoy Aydın , Nebile Dağlıoğlu

https://doi.org/10.28956/gbd.1534283

Abstract

As in the rest of the world, electronic cigarettes (e-cigarettes) have gained considerable popularity in our country as an alternative to traditional tobacco products. However, along with this popularity, debates about the health effects of e-cigarettes, their intended use and misuse, and their social impact are growing by the day.
As demand grows, e-cigarettes with different features and designs are being introduced to the market. Initially marketed as an effective smoking cessation tool, they are now preferred by many due to their affordability, ease of access, ability to be used in any environment without restrictions, customizable flavors, adjustable nicotine levels, lack of unpleasant odors, no waste production (such as ash or cigarette butts) and perceived health benefits compared to tobacco.
Studies of e-cigarettes have revealed the presence of many illicit and psychoactive substances in e-cigarette liquids. This suggests that e-cigarettes may serve as a new alternative route for substance use and may even be used to mask substance abuse.
This review aims to highlight the use of e-cigarettes as a tool for illicit substance use in our country, taking into account their impact worldwide.

Keywords

electronic cigarettes electronic nicotine delivery systems (ENDs) illicit substance LC-MS/MS

References

  • Aksakal, A. (2022). Sistematik Bir Literatür İncelemesi: Elektronik Sigaralar. Sağlık bilimlerinde güncel yaklaşımlar 5 (s. 30-38), DOI: 10.1016/j.jpba.2023.115394.
  • Almazrouei, E. S., Bintamim, A. A., Khalil, S. S., Alremeithi, R., Gewily, S., (2022). The identification of drugs of abuse in E-cigarette samples seized in Dubai between 2016 and 2020, Case Report. Forensic Science International, 111233, DOI: 10.1016/j.forsciint.2022.111233.
  • Alver, İ. A. (2021;31(1)). Elektronik Sigara (e-sigara) Likit ve Aerosollerinin Halk Sağlığı Üzerine Etkisi, Tepecik Eğitim ve Araştırma. Hastanesi Dergisi, 9-15, DOI: 10.5222/terh.2021.37268.
  • Angerer, V., Franz, F., Moosmann, B., Bisel, P., Auwärter, V., (2019). 5F-Cumyl-PINACA in ‘e-liquids’ for electronic cigarettes: comprehensive characterization of a new type of synthetic cannabinoid in a trendy product including investigations on the in vitro and in vivo phase I metabolism of 5F-Cumyl-PINACA and its non-fluo. Forensic Toxicology,37, 186-196, DOI: 10.1007/s11419-018-0451-8.
  • Atasoy, A., Daglioglu, N., Gören, İ.E., Girisbay, A., Aslan, R., Anette-Akgür, S., (2021). Determination of synthetic cannabinoids in randomly urine samples collected from probationers in Turkey, Forensic Science International, Volume 322, DOI: 10.1016/j.forsciint.2021.110752.
  • Avrupa Parlamentosu ve Konseyi. Tütün Ürünleri Direktifi (2014/40/AB). (2014). Erişim Tarihi: 14 Mayıs 2024, https://ec. europa. eu/health/sites/health/files/tobacco/docs/dir_201440_en. pdf.
  • Barhdadi, S., Courselle, P., Deconinck, E., Vanhee, C., (2023). The analysis of cannabinoids in e-cigarette liquids using LC-HRAM-MS and LC-UV. Journal of Pharmaceutical and Biomedical Analysis Volume 230, DOI: 10.1016/j.jpba.2023.115394.
  • Blount, B. C., Karwowski, M. P., Shields, P. G., Morel-Espinosa, M., Valentin-Blasini, L., Gardner, M. S., et al., (20 December 2020), Vitamin E Acetate in Bronchoalveolar-Lavage Fluid Associated with EVALI. The New England Journal of Medicine, Volume 382, No. 8: 697-705, DOI: 10.1056/NEJMoa1916433.
  • Blundell, M., Dargan, P., Wood, D., (2018). A cloud on the horizon–a survey into the use of electronic vaping devices for recreational drug and new psychoactive substance (NPS) administration, QJM: An International Journal of Medicine, 9-14, DOI: 10.1093/qjmed/hcx178.
  • Börekçi, Ş., Bilir, N., Karlıkaya, C., Türkiye Solunum Araştırmaları Derneği Tütün Çalışma Grubu, (2015). A New Area to Fight: Electronic Cigarette. Eurasian Pulmonol, DOI: 10.5152/ejp.2015.65375.
  • Canistro, D., Vivarelli, F., Cirillo, S., Marquillas, C. B., Buschini, A., Lazzaretti, M., vd., (2017). E-cigarettes induce toxicological effects that can raise the cancer risk, Scientific Report, DOI: 10.1038/s41598-017-02317-8.
  • Cao DJ, Aldy K, Hsu S, et al., (2020). Review of health consequences of electronic cigarettes and the outbreak of electronic cigarette, or vaping, product use-associated lung injury, Journal of Medical Toxicology, 16(3): 295-310, DOİ:10.1007/s13181-020-00772-w.
  • Chen, G., Rahman, S., Lutfy, K., (2023). E-cigarettes may serve as a gateway to conventional cigarettes and other addictive drugs, Advances in Drug and Alcohol Research, Jun 30:3:11345, DOI: 10.3389/adar.2023.11345.
  • Choi, H., Kim, S., Jang, H., Kim, H. J., Choe, S., (2022). Identification of a novel bromoindazole synthetic cannabinoid analogue in seized e-cigarette liquid: ADB-BRINACA, Forensic Science International, Volume 338, 111385, DOI: 10.1016/j.forsciint.2022.111385.
  • Chun, L. F., Moazed, F., Calfee, C.S., Matthay, M. A., Gotts, J. E., (2017). Pulmonary toxicity of e-cigarettes, American Physiological Society, Volume 313, Issue 2, DOI: 10.1152/ajplung.00071.2017.
  • Cornelius, M. E., Loretan, C. G., Wang, T. W., Jamal, A., Homa, D. M., (2022). Tobacco Product Use Among Adults - United States, 2020. Morbidity and Mortality Weekly Report (MMWR), 397-405, DOI: 10.15585/mmwr.mm7111a1.
  • Etter, J.F., (2015) Electronic cigarettes and cannabis: An exploratory study. European Addiction Research, 21, 124–130, DOI: 10.1159/000369791.
  • Etzel, R. A., Wilson, K. M., Balk, S. J., Farber, H. J., Groner J. A., Moore J. E. (2015). Electronic Nicotine Delivery Systems, Pediatrics, Section on Tobacco Control, 136(5): 1018-1026, DOI: 10.1542/peds.2015-3222.
  • Evans-Polis, R., Chen, B., McCabe, S., West, B., (2024). Longitudinal associations of e-cigarette use with cigarette, marijuana, and other drug use initiation among US adolescents and young adults: Findings from the Population Assessment of Tobacco and Health study (Waves 1-6), Drug and Alcohol Dependence, In Press, DOI: 10.1016/j.drugalcdep.2024.111402.
  • Frinculescu, A., Coombes, G., Shine, T., Ramsey, J., Johnston, A., Couchman, L., (2022). Analysis of illicit drugs in purchased and seized electronic cigarette liquids from the United Kingdom 2014–2021. Drug Testing and AnalysisVolume 15, Issue 1, 1058-1066, DOI: 10.1002/dta.3277.
  • Ghinai, I., Navon, L., Gunn, J. K. L., Duca, L. M., Brister, S., Love, S., et.al, (2020). Characteristics of persons who report using only nicotine-containing products among interviewed patients with e-cigarette, or vaping, product use-associated lung injury - Illinois, August-December 2019, Morbidity and Mortality Weekly Report, Volume 69, Issue 3, 84-89, DOI: 10.15585/mmwr.mm6903e1.
  • Global Tobacco Control. Country Laws Regulating E-cigarettes: Finland. Published online 2019, (2019). Erişim Tarihi: 14 Mayıs 2024, https://www.globaltobaccocontrol.org/e-cigarette/finland.
  • Global Tobacco Control. Country Laws Regulating E-cigarettes: Germany. E-Cigarette Policy Scan. Published 2019, (2019). Erişim Tarihi: 14 Mayıs 2024, https://www.globaltobaccocontrol.org/e-cigarette/germany.
  • Global Tobacco Control. Country Laws Regulating E-cigarettes: Greece. E-Cigarette Policy Scan. Published 2019, (2019). Erişim Tarihi: 14 Mayıs 2024, https://www.globaltobaccocontrol.org/e-cigarette/greece.
  • Goniewicz, M. J., Knysak, J., Gawron, M., Kosmider, L., Sobczak, A., Kurek, J., et.al, (2014), Levels of selected carcinogens and toxicants in vapour from electronic cigarettes, Tobacco Control, Volume 23, Issue 2, p. 133-139, DOI: 10.1136/tobaccocontrol-2012-050859.
  • Gündüz, A. İ. (2022, Kasım 8). ELEKTRONİK SİGARA VE HUKUKİ BOYUTU. Erişim Tarihi: 14 Mayıs 2024, http://ipekbiter.av.tr/blog/elektronik-sigara-ve-hukuki-boyutu/.
  • Hajek, P., Phillips-Waller, A., Przulj, D., Pesola, F., Smith, K. M., Bisal, N., Li, J., Parrot, S., Sasieni, P., Dawkins, L., Ross, L., Goniewicz, M., Wu, Q., McRobbie, H. (2019). A Randomized Trial of E-Cigarettes versus Nicotine-Replacement Therapy. The New England Journal of Medicine, DOI: 10.1056/NEJMoa1808779.
  • Harries, R., Norman, C., Reid, R., et al, (2024). Detection of anabolic-androgenic steroids in e-cigarettes seized from prisons: A case study. Forensic Science Internatiol, Mar:356:111965, DOI: 10.1016/j.forsciint.2024.111965.
  • Hon, L. (2006). Flameless electronic atomizing cigarette. (Patent US20060196518A1)
  • https://tr.wikipedia.org/wiki/Kannabidiol, Erişim Tarihi: 24 Temmuz 2024,
  • https://tr.wikipedia.org/wiki/Nikotin, Erişim Tarihi: 24 Temmuz 2024,
  • https://tr.wikipedia.org/wiki/Tetrahidrokannabinol, Erişim Tarihi: 24 Temmuz 2024,
  • https://www.bbc.com/turkce/articles/cd1rnx9gkeno. (2023, 05 02). BBC NEWS, Erişim Tarihi: 14 Mayıs 2024.
  • https://www.fda.gov/tobacco-products/products-guidance-regulations/rules-regulations-and-guidance. (2019). Erişim Tarihi: 14 Mayıs 2024,
  • https://www.gov.uk/guidance/e-cigarettes-regulations-for-consumer-products#full-publication-update-history. (2022).
  • https://www.publichealthlawcenter.org/commentary/240305/3/5/24-closer-look-23-fda-authorized-e-cigarettes. (2024), Erişim Tarihi: 15 Mayıs 2024.
  • https://www.resmigazete.gov.tr/eskiler/2008/01/20080119-1.htm.(2008), Erişim Tarihi: 14 Mayıs 2024.
  • https://www.resmigazete.gov.tr/eskiler/2020/02/20200225-23.pdf. (2020). Erişim Tarihi: 14 Mayıs 2024.
  • https://www.yesilay.org.tr/tr/makaleler/e-sigara-da-sigara-kadar-zararli., Kasım 2019, Erişim Tarihi: 30 Temmuz 2024.
  • Hutzler, C., Paschke, M., Kruschinski, S., Henkler, F., Hahn, J., Luch, A., (2014), Chemical hazards present in liquids and vapors of electronic cigarettes, Archives of Toxicology, Volume 88, 1295-1308, DOİ: 10.1007/s00204-014-1294-7.
  • Jack, B., Raziaa, Z., et al (2020). How harmless are E-cigarettes? Effects in the pulmonary system, Current Opinion in Pulmonary Medicine 26(1):p 97-102, January,| DOI: 10.1097/MCP.0000000000000645.
  • Jensen, R.P., Luo, W., Pankow, J.F., Strongin, R.M., Peyton, D.H., (2015). Hidden Formaldehyde in E-Cigarette Aerosols, The New England Journal of Medicine, Volume 372, No 4:392-394, DOI: 10.1056/NEJMc1413069.
  • Kandel, E. R., Kandel, D. B., (September 4, 2014), A Molecular Basis for Nicootine as a Gateway Drug, The New England Journal of Medicine, Volume 371, No. 10: 932-943, DOI: 10.1056/NEJMsa1405092.
  • Kemp, A.M., Clark, M.S., Dobbs, T., Galli, R., Sherman, J., Cox, R., (2016). Top 10 Facts You Need to Know About Synthetic Cannabinoids: Not So Nice Spice, The American Journal of Medicine, Volume 129, Issıu 3:240-244, DOI: 10.1016/j.amjmed.2015.10.008.
  • King, B.A., Jones, C.M., Baldwin, G.T., Briss, P. A., (17 January 2020). The EVALI and Youth Vaping Epidemics — Implications for Public Health, The New England Journal of Medicine, Volume 382, No. 8: 689-691, DOI: 10.1056/NEJMp1916171.
  • Köseoğlu, E., Uğur, F., Saraymen, R., Canatan, H., Coşkun, A., Bilgen, M., (2014). Elektronik Sigara Kullanımına Objektif Bakış. Cukurova Medicine Journal, 572-580, DOI: 10.17826/cutf.86547.
  • Krishnasamy V.P., Hallowell B.D., Ko J.Y., et al. Update: characteristics of a nationwide outbreak of e-cigarette, or vaping, product use–associated lung injury—United States, August 2019–January 2020, (24 January 2020). MMWR Morbidity and Mortal Weekly Report, 69(3), 90-94.
  • Krüsemann, E.J.Z., Pennings, J.L.A., Cremers, J.W.J.M, Bakker, F., Boesveldt, S., Talhout, R., (2020). GC-MS analysis of e-cigarette refill solutions: a comparison of flavoring composition between flavor categories. J. Pharm. Biomed. Anal., 188, DOI: 10.1016/j.jpba.2020.113364.
  • Lin, Z., Xiong, J., Yang, J., et al, (2024). A comprehensive analysis of the health effects associated with smoking in the largest population using UK Biobank genotypic and phenotypic data. Heliyon, Volume 10, Issue 16, DOI: 10.1016/j.heliyon.2024.e35649.
  • McConnell, R., Barrington-Trimis, J. L., Wang, K., Urman, R., Hong, H., Unger, J., et.al, (2016). Electronic Cigarette Use and Respiratory Symptoms in Adolescents, American Journal of Respiratory and Critical Care, Volume 195, Issu 8, DOI: 10.1164/rccm.201604-0804OC.
  • Morris, J.D., Pebley, K., Little, M.A., et al, (2023). Vaping Opioids: Should We Be Worried? American Journal of Health Promotion, Volume 37, Issue 8, DOI: 10.1177/08901171231193785.
  • Münster-Müller, S., Matzenbach, I., Knepper, T., Zimmerman, R., Pütz, M., (2020). Profiling of synthesis-related impurities of the synthetic cannabinoid Cumyl-5F-PINACA in seized samples of e-liquids via multivariate analysis of UHPLC−MSn data. Drug Test. Anal., 12, 119-126, DOI: 10.1002/dta.2673.
  • Ogunwale, M. A., Li, M., Raju, M. V. R., Chen, Y., Nantz, M. H., Conklin, D. J., Fu, X.A., (2017). Aldehyde detection in electronic cigarette aerosols, ACS Omega, Volume 2, Issue 3, 1207-1214, DOI: 10.1021/acsomega.6b00489.
  • Peace, M. R., Bjutler, K., Wolf, Poklis, J, L., Poklis, A., (2016). Evaluation of Two Commercially Available Cannabidiol Formulations for Use in Electronic Cigarettes. Frontier in Pharmacology, Sec. Experimental Pharmacology and Drug Discovery, DOI: 10.3389/fphar.2016.00279.
  • Poklis, J. L., Mulder, H., Peace, M: R., (2019). The unexpected identification of the cannabimimetic, 5F-ADB, and dextromethorphan in commercially available cannabidiol e-liquids. Forensic Science International, 25-27, DOI: 10.1016/j.forsciint.2018.10.019.
  • Regulating tobacco and vaping products: Tobacco products regulations. https://www.canada.ca/en/health-canada/services/smoking-tobacco/regulating-tobacco-vaping/tobacco.html.
  • Resmî gazete. (2020, Şubat 24), Erişim Tarihi: 14 Mayıs 2024, https://www.resmigazete.gov.tr/eskiler/2020/02/20200225-23.pdf.
  • Roberts, E., Copeland C., Robson, D., McNeill, A., (10 March 2021), Drug-related deaths associated with vaping product use in the United Kingdom, Addiction, Volume 116, Issue 10, p. 2908-2911, DOI: 10.1111/add.15468.
  • Superintendent of Public Health-Malta. L.N. 67 of 2016: TOBACCO (SMOKING CONTROL) ACT (Cap. 315) Published 2016. (2016). Erişim Tarihi: 14 Mayıs 2024, http://justiceservices.gov.mt/DownloadDocument.aspx?app=lp&itemid=27447&l=1.
  • The Netherlands: Plain packaging decided. Tobacco Journal International. Published 2019. (2019), Erişim Tarihi: 14 Mayıs 2024, http://www.tobaccojournal.com/Plain_packaging_decided.55258.0.html.
  • Trtchounisn, A., Talbot, P. (2011). Electronic nicotine delivery system: is there a need for regulation? Tobacco Control, 47-52, DOI: 10.1136/tc.2010.037259.
  • Varlet, V., (2016). Drug Vaping: From the Dangers of Misuse to New Therapeutic Devices, Toxics, Volume 4, Issue 4, 29, DOI: 10.3390/toxics4040029.
  • Xu, Y., Chen, X., Fan, Y. L., Wu, H., (2023). Structural confirmation of synthetic cannabinoids in seized electronic cigarette oil: a combined mass spectrometric and computational study. Rapid Commun Mass Spectrom.,37, DOI: 10.1002/rcm.9485.
  • Yuan, M., Cross, S.J, Loughlin, S.E., Leslie, F. M., (2015). Nicotine and the adolescent brain, The Journal of Physiology, Volume 593, Issue 16, p. 3397-3412, DOI: 10.1113/JP270492.
There are 64 citations in total.

Details

Primary Language Turkish
Subjects Forensic Medicine
Journal Section Derleme
Authors

Pınar Yılmazcan 0000-0002-2712-6581

Aslı Atasoy Aydın 0000-0001-6901-7511

Nebile Dağlıoğlu 0000-0003-3415-8159

Publication Date June 2, 2025
Submission Date August 16, 2024
Acceptance Date May 30, 2025
Published in Issue Year 2025 Volume: 14 Issue: 1

Cite

APA Yılmazcan, P., Atasoy Aydın, A., & Dağlıoğlu, N. (2025). YENİ NESİL GÜVENLİK TEHLİKESİ: ELEKTRONİK SİGARALAR. Güvenlik Bilimleri Dergisi, 14(1), 441-460. https://doi.org/10.28956/gbd.1534283
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