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Hücre Dışı Matris ve Mekanotransdüksiyonun Kanser Üzerindeki Etkileri

Year 2025, , 113 - 130, 29.05.2025

Tuğba Topal , İlknur Tosun

https://doi.org/10.63716/guffd.1594101

Abstract

Hücre dışı matris, canlı gelişimini, doku homeostazını ve doku organizasyonu kontrol ederken hücre proliferasyonunu, migrasyonunu ve farklılaşmasını düzenler; bu yüzden bu matrisin bozulması kanserin ilerlemesine yol açar. Tümör gelişimi, metastaz ve terapötik direnç hem biyokimyasal sinyallerden hem de ekstrasellüler matristeki fiziksel sinyallerden etkilenir. İntegrinler, HDM proteinleri ve HDM’i yeniden şekillendirme hücreleri gibi HDM sensörlerini hedefleyen anti-kanser ilaçların keşfi için, tümör mikro çevresini ve HDM sertliği gibi mekanik etkilerin stromal hücreler ile kanser arasındaki karmaşık bağlantıları aydınlatma üzerindeki etkilerini araştırmamıza yardımcı olacaktır. Kanser hücreleri arasındaki geri bildirim ve HDM yeniden şekillemdirme süreçlerini anlamak, kanser hastaları için etkili tedaviler geliştirmek adına tümör mikro çevresininin temel mekanizmalarını derinlemesine anlamak için esastır.

Keywords

Hücre dışı matris Tümör mikro çevresi Kanserde Mekanotransduksiyon

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Year 2025, , 113 - 130, 29.05.2025

Tuğba Topal , İlknur Tosun

https://doi.org/10.63716/guffd.1594101

Abstract

References

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  • Li, C., Teixeira, A.F., Zhu, H.J., and ten Dijke, P. (2021). Cancer associated-fibroblast-derived exosomes in cancer progression. Molecular Cancer, 20. https://doi.org/10.1186/S12943-021-01463-Y.
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  • Yamada, K.M., Collins, J.W., Cruz Walma, D.A., Doyle, A.D., Morales, S.G., Lu, J., Matsumoto, K., Nazari, S.S., Sekiguchi, R., Shinsato, Y., et al. (2019). Extracellular matrix dynamics in cell migration, invasion and tissue morphogenesis. International Journal of Experimental Pathology, 100, 144–152. https://doi.org/10.1111/iep.12329.
  • Afasizheva, A., Devine, A., Tillman, H., Fung, K.L., Vieira, W.D., Blehm, B.H., Kotobuki, Y., Busby, B., Chen, E.I., and Tanner, K. (2016). Mitogen-activated protein kinase signaling causes malignant melanoma cells to differentially alter extracellular matrix biosynthesis to promote cell survival. BMC Cancer, 16. https://doi.org/10.1186/S12885-016-2211-7.
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  • Theocharis, A.D., Skandalis, S.S., Gialeli, C., and Karamanos, N.K. (2016). Extracellular matrix structure. Advanced Drug Delivery Reviews, 97, 4–27. https://doi.org/10.1016/J.ADDR.2015.11.001.
  • Kyriakopoulou, K., Piperigkou, Z., Tzaferi, K., and Karamanos, N.K. (2023). Trends in extracellular matrix biology. Molecular Biology Reports, 50, 853–863. https://doi.org/10.1007/S11033-022-07931-Y/FIGURES/3.
  • Cruz Walma, D.A., and Yamada, K.M. (2020). The extracellular matrix in development. Development, 147. https://doi.org/10.1242/DEV.175596/224217.
  • Doyle, A.D., Nazari, S.S., and Yamada, K.M. (2022). Cell–extracellular matrix dynamics. Physical Biology, 19, 021002. https://doi.org/10.1088/1478-3975/AC4390.
  • Karamanos, N.K., Theocharis, A.D., Piperigkou, Z., Manou, D., Passi, A., Skandalis, S.S., Vynios, D.H., Orian-Rousseau, V., Ricard-Blum, S., Schmelzer, C.E.H., et al. (2021). A guide to the composition and functions of the extracellular matrix. FEBS Journal, 288, 6850–6912. https://doi.org/10.1111/febs.15776.
  • Cruz Walma, D.A., and Yamada, K.M. (2020). The extracellular matrix in development. Development, 147. https://doi.org/10.1242/DEV.175596/224217.
  • Walker, C., Mojares, E., and Del Río Hernández, A. (2018). Role of Extracellular Matrix in Development and Cancer Progression. International Journal of Molecular Sciences, 19. https://doi.org/10.3390/IJMS19103028.
  • Henke, E., Nandigama, R., and Ergün, S. (2020). Extracellular Matrix in the Tumor Microenvironment and Its Impact on Cancer Therapy. Frontiers in Molecular Biosciences, 6, 470149.
  • Winkler, J., Abisoye-Ogunniyan, A., Metcalf, K.J., and Werb, Z. (2020). Concepts of extracellular matrix remodelling in tumour progression and metastasis. Nature Communications, 11, 1–19.
  • Lu, P., Weaver, V.M., and Werb, Z. (2012). The extracellular matrix: A dynamic niche in cancer progression. Journal of Cell Biology, 196, 395–406. https://doi.org/10.1083/JCB.201102147.
  • Yuan, Z., Li, Y., Zhang, S., Wang, X., Dou, H., Yu, X., Zhang, Z., Yang, S., and Xiao, M. (2023). Extracellular matrix remodeling in tumor progression and immune escape: from mechanisms to treatments. Molecular Cancer, 22, 1–42. https://doi.org/10.1186/S12943-023-01744-8.
  • Lu, P., Weaver, V.M., and Werb, Z. (2012). The extracellular matrix: a dynamic niche in cancer progression. Journal of Cell Biology, 196, 395–406. https://doi.org/10.1083/jcb.201102147.
  • Kessenbrock, K., Plaks, V., and Werb, Z. (2010). Matrix metalloproteinases: regulators of the tumor microenvironment. Cell, 141, 52–67. https://doi.org/10.1016/j.cell.2010.03.015.
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There are 72 citations in total.

Details

Primary Language Turkish
Subjects Cell Development, Proliferation and Death, Cellular Interactions, Receptors and Membrane Biology
Journal Section Derlemeler
Authors

Tuğba Topal 0000-0002-8865-9656

İlknur Tosun 0009-0008-8069-5506

Publication Date May 29, 2025
Submission Date December 2, 2024
Acceptance Date April 14, 2025
Published in Issue Year 2025

Cite

APA Topal, T., & Tosun, İ. (2025). Hücre Dışı Matris ve Mekanotransdüksiyonun Kanser Üzerindeki Etkileri. Gazi Üniversitesi Fen Fakültesi Dergisi, 6(1), 113-130. https://doi.org/10.63716/guffd.1594101
AMA Topal T, Tosun İ. Hücre Dışı Matris ve Mekanotransdüksiyonun Kanser Üzerindeki Etkileri. GÜFFD. May 2025;6(1):113-130. doi:10.63716/guffd.1594101
Chicago Topal, Tuğba, and İlknur Tosun. “Hücre Dışı Matris Ve Mekanotransdüksiyonun Kanser Üzerindeki Etkileri”. Gazi Üniversitesi Fen Fakültesi Dergisi 6, no. 1 (May 2025): 113-30. https://doi.org/10.63716/guffd.1594101.
EndNote Topal T, Tosun İ (May 1, 2025) Hücre Dışı Matris ve Mekanotransdüksiyonun Kanser Üzerindeki Etkileri. Gazi Üniversitesi Fen Fakültesi Dergisi 6 1 113–130.
IEEE T. Topal and İ. Tosun, “Hücre Dışı Matris ve Mekanotransdüksiyonun Kanser Üzerindeki Etkileri”, GÜFFD, vol. 6, no. 1, pp. 113–130, 2025, doi: 10.63716/guffd.1594101.
ISNAD Topal, Tuğba - Tosun, İlknur. “Hücre Dışı Matris Ve Mekanotransdüksiyonun Kanser Üzerindeki Etkileri”. Gazi Üniversitesi Fen Fakültesi Dergisi 6/1 (May 2025), 113-130. https://doi.org/10.63716/guffd.1594101.
JAMA Topal T, Tosun İ. Hücre Dışı Matris ve Mekanotransdüksiyonun Kanser Üzerindeki Etkileri. GÜFFD. 2025;6:113–130.
MLA Topal, Tuğba and İlknur Tosun. “Hücre Dışı Matris Ve Mekanotransdüksiyonun Kanser Üzerindeki Etkileri”. Gazi Üniversitesi Fen Fakültesi Dergisi, vol. 6, no. 1, 2025, pp. 113-30, doi:10.63716/guffd.1594101.
Vancouver Topal T, Tosun İ. Hücre Dışı Matris ve Mekanotransdüksiyonun Kanser Üzerindeki Etkileri. GÜFFD. 2025;6(1):113-30.