A Look into High-Intensity Interval Training for Breast Cancer

Müjde Damla Boyaci; Betül Ergün; Gizem Gül Turan; Fatma Kızılay

doi:10.38079/igusabder.1503998

Review

A Look into High-Intensity Interval Training for Breast Cancer

Year 2025, Issue: 25, 358 - 367, 29.04.2025

Müjde Damla Boyaci , Betül Ergün , Gizem Gül Turan , Fatma Kızılay

https://doi.org/10.38079/igusabder.1503998

Abstract

Breast cancer is a common cancer worldwide. Although breast cancer affects both sexes, the prevalence is higher in women. In Türkiye, breast cancer affects about one in four women. Survival rates from breast cancer treatment are improving every day, and people need help with complications from treatment. Exercise is an effective and safe treatment for people with breast cancer. In recent years, the results on the use of high-intensity interval training (HIIT) in the treatment of breast cancer are remarkable. The purpose of this review was to determine the effect of HIIT in the treatment of breast cancer. The studies included in the review were those conducted between 2014 and 2024. PubMed, Scholar Google and Scopus databases were searched using the search terms “breast cancer and high intensity interval training”. According to the results of the studies included in this review, it was concluded that HIIT is an effective form of training on several health parameters in groups at risk of developing breast cancer, those undergoing breast cancer treatment, and breast cancer survivors. Further studies are needed to contribute to the clinical relevance of HIIT in individuals with breast cancer.

Keywords

Exercise, breast cancer, high intensity interval training

References

1. Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians. 2018;68(6):394-424.
2. International Agency for Research on Cancer. Globocan 2022. https://gco.iarc.who.int/media/globocan/factsheets/populations/792-turkiye-fact-sheet.pdf. 2022. Published 2022. Accessed May 22, 2024.
3. Tripathy S, Mohapatra S, Preethika A. Breast cancer awareness among women of reproductive age-a questionnaire based study. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2024;298:153-157.
4. Chen X, Shi X, Yu Z, Ma X. High‐intensity interval training in breast cancer patients: A systematic review and meta‐analysis. Cancer Medicine. 2023;12(17):17692-17705.
5. Shapiro CL. Cancer survivorship. New England Journal of Medicine. 2018;379(25):2438-50.
6. Isanejad A, Nazari S, Gharib B, Motlagh AG. Comparison of the effects of high-intensity interval and moderate-intensity continuous training on inflammatory markers, cardiorespiratory fitness, and quality of life in breast cancer patients. Journal of Sport and Health Science. 2023;12(6):674-689.
7. Pinto-Carbó M, Vanaclocha-Espí M, Ibañez J, et al. Interaction of sedentary behaviour and educational level in breast cancer risk. Plos One. 2024;19(5):e0300349.
8. Çelikkanat Ş, Güngörmüş Z. Risk factors and the importance of risk assessment in breast cancer. Social Sciences Studies Journal (SSS Journal). 2022;4(22):4022-4026.
9. Prat A, Pineda E, Adamo B, et al. Clinical implications of the intrinsic molecular subtypes of breast cancer. The Breast. 2015;24:S26-S35.
10. Bozkurt KK, Durak Ö, Çiriş İM, Kapucuoğlu N, Devrim T. The relationship between molecular subtypes and clinicopathological features in breast cancer. SDÜ Tıp Fakültesi Dergisi. 2020;27(2):160-165.
11. Hortobagyi GN, Edge SB, Giuliano A. New and important changes in the TNM staging system for breast cancer. American Society of Clinical Oncology Educational Book. 2018;38:457-467.
12. Memişoğlu E. Breast Cancer Diagnosis and Clinical Staging. Akademisyen Publishing House; 2020.
13. Amin MB, Greene FL, Edge SB, et al. The eighth edition AJCC cancer staging manual: continuing to build a bridge from a population‐based to a more “personalized” approach to cancer staging. CA: a Cancer Journal for Clinicians. 2017;67(2):93-99.
14. Turkish Medical Oncology Association. Breast Cancer Staging. Turkish Oncology Association. https://www.kanser.org/saglik/toplum/kanser-turleri-alt-kategori/meme-kanseri-evreleme. Published 2012. Accessed March 20, 2024.
15. Aydıntuğ S. Early diagnosis in breast cancer. STED. 2004;13(6):226-229.
16. Gøtzsche PC. Screening for breast cancer with mammography. The Lancet. 2001;358(9299):2167-2168.
17. Özmen V, Fidaner C, Aksaz E, et al. Preparation of breast cancer early diagnosis and screening programs in Turkey “Report of the Ministry of Health Breast Cancer Early Diagnosis and Screening Subcommittee”. Journal of Breast Health. 2009;5(3):125-134.
18. Birhane K, Alemayehu M, Anawte B, et al. Practices of breast self-examination and associated factors among female Debre Berhan University students. Int J Breast Cancer. 2017;2017:8026297. doi: 10.1155/2017/8026297.19.
19. Özgün H, Soyder A, Tunçyürek P. Factors affecting late presentation in breast cancer. Journal of Breast Health. 2009;5(2):87-91.
20. Republic of Turkey Ministry of Health General Directorate of Public Health Department of Cancer Cancer Screenings. Republic of Turkey Ministry of Health, General Directorate of Public Health, Department of Cancer. https://hsgm.saglik.gov.tr/tr/kanser-taramalari.html. Published 2019. Accessed May 20, 2024.
21. Huang ML, Adrada BE, Candelaria R, Thames D, Dawson D, Yang WT. Stereotactic breast biopsy: pitfalls and pearls. Techniques in Vascular and Interventional Radiology. 2014;17(1):32-39.
22. Republic of Turkey Ministry of Health, General Directorate of Health Services. Breast Cancer Prevention, Screening, Diagnosis, Treatment and Follow-up Clinical Guidelines. Republic of Turkey Ministry of Health. https://www.tmhdf.org.tr/icerik/egitim-modulleri-26.html. Published 2020. Accessed May 22, 2024.
23. Moo TA, Sanford R, Dang C, Morrow M. Overview of breast cancer therapy. PET Clinics. 2018;13(3):339-354.
24. Akyolcu N, Özhanlı Y, Kandemir D. Current developments in breast cancer. Journal of Health Sciences and Professions. 2019;6(3):583-594.
25. American Cancer Society. Breast Cancer Risk and Prevention. American Cancer Society. https://www.cancer.org/cancer/breast-cancer/risk-and-prevention.html. Published 2019. Accessed May 20, 2024.
26. Özlük AA, Oytun MG, Günenç D. Cancer immunotherapy. Istanbul Bilim University Florence Nightingale Journal of Transplantation. 2017;2(1):21-23.
27. Zhang X, Li Y, Liu D. Effects of exercise on the quality of life in breast cancer patients: a systematic review of randomized controlled trials. Supportive Care in Cancer. 2019;27:9-21.
28. Ammitzbøll G, Andersen KG, Bidstrup PE, et al. Effect of progressive resistance training on persistent pain after axillary dissection in breast cancer: a randomized controlled trial. Breast Cancer Research and Treatment. 2020;179:173-183.
29. Kurt B, Kapucu S. The effect of progressive relaxation exercises on chemotherapy symptoms in breast cancer patients: A literature review. Mersin University Journal of Health Sciences. 2018;11(2):235-249.
30. Kocamaz D, Düger T. The effect of calisthenic exercises given with different treatments on physical activity level and depression in women with breast cancer. Physiotherapy Rehabilitation. 2017;28(3):93-99.
31. Kilbreath S, Ward L, Davis G, et al. Reduction of breast lymphoedema secondary to breast cancer: a randomised controlled exercise trial. Breast Cancer Research and Treatment. 2020;184:459-467.
32. He L, Qu H, Wu Q, Song Y. Lymphedema in survivors of breast cancer. Oncology Letters. 2020;19(3):2085-2096.
33. Uzkeser H. Post mastectomy lymphedema and treatment approach. Journal of Surgical Medical Sciences, Atatürk University Faculty of Medicine. 2022;1(1):13-18.
34. Buckley S, Knapp K, Lackie A, et al. Multimodal high-intensity interval training increases muscle function and metabolic performance in females. Applied Physiology, Nutrition, and Metabolism. 2015;40(11):1157-1162.
35. Gist NH, Freese EC, Ryan TE, Cureton KJ. Effects of low-volume, high-intensity whole-body calisthenics on army ROTC cadets. Military Medicine. 2015;180(5):492-498.
36. Wewege M, Van Den Berg R, Ward R, Keech A. The effects of high‐intensity interval training vs. moderate‐intensity continuous training on body composition in overweight and obese adults: a systematic review and meta‐analysis. Obesity Reviews. 2017;18(6):635-646.
37. Akgül MŞ. Comparison of the Effects of Different Training Methods on Endurance Performance in Hypoxic and Normoxic Conditions in Normobaric Environment. [doctoral dissertation]. Abkara, Türkiye: Department of Sport Sciences, Institute of Health Sciences, Department of Sport Sciences; 2016.
38. Duran P. The Effect of High Intensity Interval Training on Physical Fitness in Post-Menopausal and Pre-Menopausal Women. [master's thesis]. İstanbul, Türkiye: Department of Movement and Training, Institute of Health Sciences;2021.
39. Coletta AM, Brewster AM, Chen M, et al. High-intensity interval training is feasible in women at high risk for breast cancer. Medicine and Science in Sports and Exercise. 2019;51(11):2193.
40. Mijwel S, Backman M, Bolam KA, et al. Highly favorable physiological responses to concurrent resistance and high-intensity interval training during chemotherapy: the OptiTrain breast cancer trial. Breast Cancer Research and Treatment. 2018;169:93-103.
41. Wilson R, Kang D-W, Tahbaz M, et al. Improving cognitive function through high-intensity interval training in breast cancer patients undergoing chemotherapy: protocol for a randomized controlled trial. JMIR Research Protocols. 2023;12(1):e39740.
42. Ochi E, Tsuji K, Narisawa T, et al. Cardiorespiratory fitness in breast cancer survivors: a randomised controlled trial of home-based smartphone supported high intensity interval training. BMJ Supportive & Palliative Care. 2022;12(1):33-37.
43. Bettariga F, Taaffe DR, Crespo-Garcia C, Clay TD, Galvão DA, Newton RU. Effects of resistance training vs high intensity interval training on body composition, muscle strength, cardiorespiratory fitness, and quality of life in survivors of breast cancer: a randomized trial. Breast Cancer Res Treat. 2025;210:261–270 doi:10.1007/s10549-024-07559-5.
44. Klavina A, Ceseiko R, Campa M, et al. The effect of high-intensity interval training on quality of life and incidence of chemotherapy side effects in women with breast cancer. Integr Cancer Ther. 2024;23:15347354241297385. doi:10.1177/15347354241297385.

Meme Kanserinde Yüksek Yoğunluklu Aralıklı Antrenmana Bakış

Year 2025, Issue: 25, 358 - 367, 29.04.2025

Müjde Damla Boyaci , Betül Ergün , Gizem Gül Turan , Fatma Kızılay

https://doi.org/10.38079/igusabder.1503998

Abstract

Meme kanseri dünyada yaygın olarak görülen bir kanser türüdür. Her iki cinsiyette de görülmesine rağmen prevelans kadınlarda daha yüksektir. Türkiye'de meme kanseri yaklaşık her dört kadından birini etkilemektedir. Meme kanseri tedavisinde sağkalım oranları her geçen gün artmaktadır ve tedavinin ortaya çıkardığı komplikasyonlardan dolayı kişiler yardıma ihtiyaç duymaktadır. Meme kanseri olan bireylerde egzersiz etkili ve güvenilir bir yöntemdir. Son yıllarda meme kanseri tedavisinde yüksek şiddetli aralıklı antrenman (HIIT) kullanımına dair sonuçlar dikkat çekicidir. Bu derlemenin amacı meme kanseri tedavisinde HIIT’in etkisini ortaya koymaktır. Derlemeye dahil edilen çalışmalar 2014-2024 yılları arasında yapılan çalışmalardır. Pubmed, Scholar Google ve Scopus veri tabanlarında “meme kanseri ve yüksek şiddetli aralıklı antrenman” arama terimleri kullanılarak literatür taranmıştır. Bu derlemede yer alan çalışmalardan elde edilen bulgulara göre HIIT’in meme kanserine yakalanma açısından riskli gruplarda, meme kanseri tedavisi görenlerde ve meme kanserinden kurtulanlarda çeşitli sağlık parametreleri üzerinde etkisi olan bir antrenman biçimi olduğu sonucuna ulaşılmıştır. HIIT’ in meme kanseri olan bireylerdeki klinik önemine katkı sağlamak adına daha geniş çaplı çalışmalara ihtiyaç vardır.

Keywords

Egzersiz, meme kanseri, yüksek yoğunluklu aralıklı antrenman

References

1. Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA: A Cancer Journal for Clinicians. 2018;68(6):394-424.
2. International Agency for Research on Cancer. Globocan 2022. https://gco.iarc.who.int/media/globocan/factsheets/populations/792-turkiye-fact-sheet.pdf. 2022. Published 2022. Accessed May 22, 2024.
3. Tripathy S, Mohapatra S, Preethika A. Breast cancer awareness among women of reproductive age-a questionnaire based study. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2024;298:153-157.
4. Chen X, Shi X, Yu Z, Ma X. High‐intensity interval training in breast cancer patients: A systematic review and meta‐analysis. Cancer Medicine. 2023;12(17):17692-17705.
5. Shapiro CL. Cancer survivorship. New England Journal of Medicine. 2018;379(25):2438-50.
6. Isanejad A, Nazari S, Gharib B, Motlagh AG. Comparison of the effects of high-intensity interval and moderate-intensity continuous training on inflammatory markers, cardiorespiratory fitness, and quality of life in breast cancer patients. Journal of Sport and Health Science. 2023;12(6):674-689.
7. Pinto-Carbó M, Vanaclocha-Espí M, Ibañez J, et al. Interaction of sedentary behaviour and educational level in breast cancer risk. Plos One. 2024;19(5):e0300349.
8. Çelikkanat Ş, Güngörmüş Z. Risk factors and the importance of risk assessment in breast cancer. Social Sciences Studies Journal (SSS Journal). 2022;4(22):4022-4026.
9. Prat A, Pineda E, Adamo B, et al. Clinical implications of the intrinsic molecular subtypes of breast cancer. The Breast. 2015;24:S26-S35.
10. Bozkurt KK, Durak Ö, Çiriş İM, Kapucuoğlu N, Devrim T. The relationship between molecular subtypes and clinicopathological features in breast cancer. SDÜ Tıp Fakültesi Dergisi. 2020;27(2):160-165.
11. Hortobagyi GN, Edge SB, Giuliano A. New and important changes in the TNM staging system for breast cancer. American Society of Clinical Oncology Educational Book. 2018;38:457-467.
12. Memişoğlu E. Breast Cancer Diagnosis and Clinical Staging. Akademisyen Publishing House; 2020.
13. Amin MB, Greene FL, Edge SB, et al. The eighth edition AJCC cancer staging manual: continuing to build a bridge from a population‐based to a more “personalized” approach to cancer staging. CA: a Cancer Journal for Clinicians. 2017;67(2):93-99.
14. Turkish Medical Oncology Association. Breast Cancer Staging. Turkish Oncology Association. https://www.kanser.org/saglik/toplum/kanser-turleri-alt-kategori/meme-kanseri-evreleme. Published 2012. Accessed March 20, 2024.
15. Aydıntuğ S. Early diagnosis in breast cancer. STED. 2004;13(6):226-229.
16. Gøtzsche PC. Screening for breast cancer with mammography. The Lancet. 2001;358(9299):2167-2168.
17. Özmen V, Fidaner C, Aksaz E, et al. Preparation of breast cancer early diagnosis and screening programs in Turkey “Report of the Ministry of Health Breast Cancer Early Diagnosis and Screening Subcommittee”. Journal of Breast Health. 2009;5(3):125-134.
18. Birhane K, Alemayehu M, Anawte B, et al. Practices of breast self-examination and associated factors among female Debre Berhan University students. Int J Breast Cancer. 2017;2017:8026297. doi: 10.1155/2017/8026297.19.
19. Özgün H, Soyder A, Tunçyürek P. Factors affecting late presentation in breast cancer. Journal of Breast Health. 2009;5(2):87-91.
20. Republic of Turkey Ministry of Health General Directorate of Public Health Department of Cancer Cancer Screenings. Republic of Turkey Ministry of Health, General Directorate of Public Health, Department of Cancer. https://hsgm.saglik.gov.tr/tr/kanser-taramalari.html. Published 2019. Accessed May 20, 2024.
21. Huang ML, Adrada BE, Candelaria R, Thames D, Dawson D, Yang WT. Stereotactic breast biopsy: pitfalls and pearls. Techniques in Vascular and Interventional Radiology. 2014;17(1):32-39.
22. Republic of Turkey Ministry of Health, General Directorate of Health Services. Breast Cancer Prevention, Screening, Diagnosis, Treatment and Follow-up Clinical Guidelines. Republic of Turkey Ministry of Health. https://www.tmhdf.org.tr/icerik/egitim-modulleri-26.html. Published 2020. Accessed May 22, 2024.
23. Moo TA, Sanford R, Dang C, Morrow M. Overview of breast cancer therapy. PET Clinics. 2018;13(3):339-354.
24. Akyolcu N, Özhanlı Y, Kandemir D. Current developments in breast cancer. Journal of Health Sciences and Professions. 2019;6(3):583-594.
25. American Cancer Society. Breast Cancer Risk and Prevention. American Cancer Society. https://www.cancer.org/cancer/breast-cancer/risk-and-prevention.html. Published 2019. Accessed May 20, 2024.
26. Özlük AA, Oytun MG, Günenç D. Cancer immunotherapy. Istanbul Bilim University Florence Nightingale Journal of Transplantation. 2017;2(1):21-23.
27. Zhang X, Li Y, Liu D. Effects of exercise on the quality of life in breast cancer patients: a systematic review of randomized controlled trials. Supportive Care in Cancer. 2019;27:9-21.
28. Ammitzbøll G, Andersen KG, Bidstrup PE, et al. Effect of progressive resistance training on persistent pain after axillary dissection in breast cancer: a randomized controlled trial. Breast Cancer Research and Treatment. 2020;179:173-183.
29. Kurt B, Kapucu S. The effect of progressive relaxation exercises on chemotherapy symptoms in breast cancer patients: A literature review. Mersin University Journal of Health Sciences. 2018;11(2):235-249.
30. Kocamaz D, Düger T. The effect of calisthenic exercises given with different treatments on physical activity level and depression in women with breast cancer. Physiotherapy Rehabilitation. 2017;28(3):93-99.
31. Kilbreath S, Ward L, Davis G, et al. Reduction of breast lymphoedema secondary to breast cancer: a randomised controlled exercise trial. Breast Cancer Research and Treatment. 2020;184:459-467.
32. He L, Qu H, Wu Q, Song Y. Lymphedema in survivors of breast cancer. Oncology Letters. 2020;19(3):2085-2096.
33. Uzkeser H. Post mastectomy lymphedema and treatment approach. Journal of Surgical Medical Sciences, Atatürk University Faculty of Medicine. 2022;1(1):13-18.
34. Buckley S, Knapp K, Lackie A, et al. Multimodal high-intensity interval training increases muscle function and metabolic performance in females. Applied Physiology, Nutrition, and Metabolism. 2015;40(11):1157-1162.
35. Gist NH, Freese EC, Ryan TE, Cureton KJ. Effects of low-volume, high-intensity whole-body calisthenics on army ROTC cadets. Military Medicine. 2015;180(5):492-498.
36. Wewege M, Van Den Berg R, Ward R, Keech A. The effects of high‐intensity interval training vs. moderate‐intensity continuous training on body composition in overweight and obese adults: a systematic review and meta‐analysis. Obesity Reviews. 2017;18(6):635-646.
37. Akgül MŞ. Comparison of the Effects of Different Training Methods on Endurance Performance in Hypoxic and Normoxic Conditions in Normobaric Environment. [doctoral dissertation]. Abkara, Türkiye: Department of Sport Sciences, Institute of Health Sciences, Department of Sport Sciences; 2016.
38. Duran P. The Effect of High Intensity Interval Training on Physical Fitness in Post-Menopausal and Pre-Menopausal Women. [master's thesis]. İstanbul, Türkiye: Department of Movement and Training, Institute of Health Sciences;2021.
39. Coletta AM, Brewster AM, Chen M, et al. High-intensity interval training is feasible in women at high risk for breast cancer. Medicine and Science in Sports and Exercise. 2019;51(11):2193.
40. Mijwel S, Backman M, Bolam KA, et al. Highly favorable physiological responses to concurrent resistance and high-intensity interval training during chemotherapy: the OptiTrain breast cancer trial. Breast Cancer Research and Treatment. 2018;169:93-103.
41. Wilson R, Kang D-W, Tahbaz M, et al. Improving cognitive function through high-intensity interval training in breast cancer patients undergoing chemotherapy: protocol for a randomized controlled trial. JMIR Research Protocols. 2023;12(1):e39740.
42. Ochi E, Tsuji K, Narisawa T, et al. Cardiorespiratory fitness in breast cancer survivors: a randomised controlled trial of home-based smartphone supported high intensity interval training. BMJ Supportive & Palliative Care. 2022;12(1):33-37.
43. Bettariga F, Taaffe DR, Crespo-Garcia C, Clay TD, Galvão DA, Newton RU. Effects of resistance training vs high intensity interval training on body composition, muscle strength, cardiorespiratory fitness, and quality of life in survivors of breast cancer: a randomized trial. Breast Cancer Res Treat. 2025;210:261–270 doi:10.1007/s10549-024-07559-5.
44. Klavina A, Ceseiko R, Campa M, et al. The effect of high-intensity interval training on quality of life and incidence of chemotherapy side effects in women with breast cancer. Integr Cancer Ther. 2024;23:15347354241297385. doi:10.1177/15347354241297385.

There are 44 citations in total.

Details

Primary Language	English
Subjects	Physiotherapy
Journal Section	Articles
Authors	Müjde Damla Boyaci 0000-0002-8241-878X Betül Ergün 0000-0001-7212-2937 Gizem Gül Turan 0000-0003-1356-7324 Fatma Kızılay 0000-0001-7216-7959
Early Pub Date	April 29, 2025
Publication Date	April 29, 2025
Submission Date	June 24, 2024
Acceptance Date	February 24, 2025
Published in Issue	Year 2025 Issue: 25

Cite

JAMA	Boyaci MD, Ergün B, Turan GG, Kızılay F. A Look into High-Intensity Interval Training for Breast Cancer. IGUSABDER. 2025;:358–367.

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