NEUROPHARMACOLOGICAL EVALUATION OF AQUEOUS EXTRACTS OF FRUIT PEELS AND THEIR POLYHERBAL FORMULATION: ANTIDEPRESSANT AND MUSCLE RELAXANT POTENTIAL

Aruna Kumari Dokkada; Vijay Srinivas Pothula; Gana Manjusha Kondepudi

doi:10.33483/jfpau.1548158

Research Article

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MEYVE KABUKLARININ SULU EKSTRELERİ VE POLİBİTKİSEL FORMÜLASYONUNUN NÖROFARMAKOLOJİK DEĞERLENDİRİLMESİ: ANTİDEPRESAN VE KAS GEVŞETME POTANSİYELİ

Year 2025, Volume: 49 Issue: 2, 8 - 8

Aruna Kumari Dokkada Vijay Srinivas Pothula , Gana Manjusha Kondepudi

https://doi.org/10.33483/jfpau.1548158

Abstract

Amaç: Bu çalışma, Annona squamosa, Cucumis melo, Actinidia deliciosa, Malus pumila gibi belirli meyvelerin kabuklarının nörofarmakolojik özelliklerini değerlendirmeyi amaçlamaktadır. Gereç ve Yöntem: Wistar albino sıçanlar (ağırlıkları 150 g) cinsiyete bakılmaksızın zorunlu yüzme testleri, hareket değerlendirmeleri ve kas koordinasyonu değerlendirmeleri için altı gruba ayrıldı. Referans standartlar olarak diazepam ve imipramin kullanıldı. 200 ve 400 mg/kg dozlarında, tüm kabuk ekstraktları hareketsizlik süresinde azalma, rotarod performansında iyileşme ve lokomotor aktivitede kayda değer bir artış gösterdi.
Sonuç ve Tartışma: Hareketsizlik süresine ilişkin etkinlik sıralaması şu şekildeydi: PHF>APMP>APCM >APAS>APAD. İskelet kası gevşemesi açısından etkinlik sırası şu şekildeydi: PHF>APCM>APMP>APAD>APAS ve tedavi gruplarının lokomotor aktivitesi şu sırayı takip etti: PHF>APMP>APCM>APAD>APAS. Seçilen tüm kabuk özleri hareketsizlik, lokomotor aktivite ve kas üzerinde kayda değer etkiler sergiledi.

Keywords

Meyve kabukları, nörolojik aktivite, polibitkisel karışım

References

1. Alley, M.C., Scudiero, D.A., Monkes, A., Hursey, M.L., Czerwinski, M.J., Fine, D.L., Abbott, B.J., Mayo, J.G., Shoemaker, R.H., Boyd, M.R. (1988). Feasibility of drug screening with panel of human tumor cell lines using a microculture tetrazolium assay. Cancer Research, 48(3), 589-601.
2. Arya, A., Chahal, R., Rao, R., Rahman, M., Kaushik, D., Akhtar, M.F., Mittal, V. (2021). Acetylcholinesterase inhibitory potential of various sesquiterpene analogues for Alzheimer’s disease therapy. Biomolecules, 11(3), 350. [CrossRef]
3. Rahman, M.A., Hannan, M.A., Dash, R., Rahman, M.H., Islam, R., Uddin, M.J., Rhim, H. (2021). Phytochemicals as a complement to cancer chemotherapy: Pharmacological modulation of the autophagy-apoptosis pathway. Frontiers in Pharmacology, 12. [CrossRef]
4. Sindhu, R.K., Kaur, P., Kaur, P., Singh, H., El-Saber Batiha, G., Vermaet I. (2022). Exploring multifunctional antioxidants as potential agents for management of neurological disorders. Environmental Science and Pollution Research, 29, 24458-24477. [CrossRef]
5. Rahman, M.H., Akter, R., Kamal, M.A. (2020). Prospective function of different antioxidant containing natural products in the treatment of neurodegenerative disease. CNS & Neurological Disorders-Drug Targets.
6. Sharma, V.K., Singh, T.G., Garg, N., Dhiman, S., Gupta, S., Rahman, M., Abdel-Daim, M.M. (2021). Dysbiosis and Alzheimer’s disease: A role for chronic stress? Biomolecules, 11(5), 678. [CrossRef]
7. Bhattacharya, T., Dey, P.S., Akter, R., Kabir, M.T., Rahman, M.H., Rauf, A. (2021). Effect of natural leaf extracts as phytomedicine in curing geriatrics. Experimental Gerontology, 150, 111352. [CrossRef]
8. Akter, R., Rahman, H., Behl, T., Chowdhury, M., Rahman, A., Manirujjaman, M., Bungau, S. (2021). Prospective role of polyphenolic compounds in the treatment of neurodegenerative diseases. CNS & Neurological Disorders-Drug Targets, 20(5), 430-450.
9. Fadaka, A.O., Ajiboye, B.O., Adewale, I., Ojo, O.A., Oyinloye, B.E., Okesola, M.A. (2019). Significance of antioxidants in the treatment and prevention of neurodegenerative diseases. Journal of Phytopharmacology, 8(2), 75-83. [CrossRef]
10. Ali Al-Mamary, M., Moussa, Z. (2021). Antioxidant activity: The presence and impact of hydroxyl groups in small molecules of natural and synthetic origin. Antioxidants-Benefits, Sources, Mechanisms of Action. IntechOpen. [CrossRef]
11. Houldsworth, A. (2024). Role of oxidative stress in neurodegenerative disorders: A review of reactive oxygen species and prevention by antioxidants. Brain Communications, 6(1), fcad356. [CrossRef]
12. Kabongo, J.D., Idowu, S.O., Capaldi, N., Zu, L., Das Gupta, A. (2013). Waste Valorization, Springer Berlin Heidelberg, Berlin, Heidelberg, pp2701-2706.
13. Merrington, A. (2017). Recycling of plastics. Applied Plastics Engineering Handbook, Plastics Design Library, M. Kutz, William Andrew Publishing, 167-189.
14. Allwood, J.M. (2014). Squaring the Circular Economy: The Role of Recycling within a Hierarchy of Material Management Strategies. Handbook of Recycling, Boston: Elsevier, pp 445-477.
15. Adıgüzel, F., & Donato, C. (2021). Proud to be sustainable: Upcycled versus recycled luxury products, Journal of Business Research, 130(C), 137-146.
16. Lauria, A., & Lizundia, E. (2020). Luminescent carbon dots obtained from polymeric waste, Journal of Cleaner Production, 262, 121288.
17. Lizundia, E., Luzi, F., Puglia, D. (2022). Organic waste valorisation towards circular and sustainable biocomposites. Green Chemistry: An International Journal and Green Chemistry Resource: GC, 24(14), 5429-5459. [CrossRef]
18. Beetch, M., Harandi-Zadeh, S., Shen, K., Lubecka, K., Kitts, D.D., O'Hagan, H.M., Stefanska, B. (2020). Dietary antioxidants remodel DNA methylation patterns in chronic disease. British Journal of Pharmacology, 177(6), 1382-1408. [CrossRef]
19. El Zawawy, N.A. (2015). Antioxidant, antitumor, antimicrobial studies and quantitative phytochemical estimation of ethanolic extracts of selected fruit peels. International Journal of Current Microbiology and Applied Sciences, 4(5), 298-309.
20. Karmakar, S., De, S. (2019). Pectin Removal and Clarification of Juices. Separation of Functional Molecules in Food by Membrane Technology, Academic Press, 155-194.
21. Wolfe, K., Wu, X., Liu, R.H. (2003). Antioxidant activity of apple peels. Journal of Agricultural and Food Chemistry, 51, 609-614. [CrossRef]
22. Win Min Oo, M., Myat Mon Khine. (2017). Pharmacological activities of Annona squamosa: Updated Review. International Journal of Pharmacy and Chemistry, 3(6), 86-93. [CrossRef]
23. Lydia, D.E., John, S., Swetha, V., & Sivapriya, T. (2017). Investigation on the antimicrobial and antioxidant activity of custard apple (Annona reticulata) peel extracts. Research Journal of Pharmacognosy and Phytochemistry, 9(4), 241-249. [CrossRef]
24. Shastri, K.V., Bhatia, V., Parikh, P.R., & Chaphekar, V.N. (2012). Actinidia deliciosa: A Review. International Journal of Pharmaceutical Sciences and Research, 3(10), 3543-3549. [CrossRef]
25. Alim, A., Li, T., Nisar, T., Ren, D., Zhai, X., Pang, Y., Yang, X. (2019). Evaluation of the effects of pomegranate peel polyphenols on antioxidant activity and inhibition of α-glucosidase, α-amylase and lipase activities. Molecules, 24(24), 4620.
26. Preeti, Raju, P.N. (2017). Comprehensive Overview of Cucumis melo. The Pharma Innovation Journal, 6(10), 181-186.
27. Ismail, H., Chan, K.W., Mariod, A., Ismail, M. (2010). Phenolic content and antioxidant activity of cantaloupe (Cucumis melo) methanolic extracts. Food Chemistry, 119, 643-647. [CrossRef]
28. Dhingra, D., Sharma, A. (2006). Antidepressant-like activity of n-hexane extract of nutmeg (Myristica fragrans) seeds in mice. Journal of Medicinal Food, 9(1), 84-89. [CrossRef]
29. Pandey, A., Tripathi, S. (2014). Concept of standardization, extraction, and pre-phytochemical screening strategies for herbal drug. Pharmacognosy and Phytochemistry, 2, 115-9.
30. Porsolt, R.D., Anton, G., Blavet, N., Jalfre, M. (1978). Behavioral despair in rats: A new model sensitive to antidepressant treatments. European Journal of Pharmacology, 47(4), 379-391. [CrossRef]
31. Yu, L., Jiang, X., Liao, M., Ma, R., Yu, T. (2011). Antidepressant-like effect of tetra methyl pyrazine in mice and rats. Neuroscience and Medicine, 2, 142-148.
32. Gupta, M., Mazumder, U.K., Kumar, T.S., Gomathi, P., Kumar, R.S. (2004). Antioxidant and hepatoprotective effects of Bauhinia racemosa against paracetamol and carbon tetrachloride induced liver damagein rats. Iranian Journal of Pharmacology and Therapeutics, 3, 12-20.

NEUROPHARMACOLOGICAL EVALUATION OF AQUEOUS EXTRACTS OF FRUIT PEELS AND THEIR POLYHERBAL FORMULATION: ANTIDEPRESSANT AND MUSCLE RELAXANT POTENTIAL

Year 2025, Volume: 49 Issue: 2, 8 - 8

Aruna Kumari Dokkada Vijay Srinivas Pothula , Gana Manjusha Kondepudi

https://doi.org/10.33483/jfpau.1548158

Abstract

Objective: This study aims to assess the neuropharmacological properties of peels from specific fruits, namely Annona squamosa, Cucumis melo, Actinidia deliciosa, Malus pumila.
Material and Method: Wistar albino rats (weighing 150 g), regardless of gender, were allocated into six groups for forced swim tests, locomotion assessments, and muscle coordination evaluations. Diazepam and imipramine were employed as reference standards. At doses of 200 and 400 mg/kg, all peel extracts showed a reduction in immobility time, improved rotarod performance, and a notable increase in locomotor activity.
Result and Discussion: The efficacy ranking for immobility time was as follows PHF>APMP>APCM>APAS>APAD. In terms of skeletal muscle relaxation, the order of effectiveness was: PHF>APCM>APMP>APAD>APAS and the treatment groups' locomotor activity followed this sequence: PHF>APMP>APCM>APAD>APAS. All the selected peel extracts exhibited noteworthy effects on immobility, locomotor activity, and muscle relaxation. However, a more comprehensive investigation is required to elucidate the precise mechanisms underlying the antidepressant effects of the selected peel extracts and PHF.

Keywords

Fruit peels, neurological activity, polyherbal mixture

References

1. Alley, M.C., Scudiero, D.A., Monkes, A., Hursey, M.L., Czerwinski, M.J., Fine, D.L., Abbott, B.J., Mayo, J.G., Shoemaker, R.H., Boyd, M.R. (1988). Feasibility of drug screening with panel of human tumor cell lines using a microculture tetrazolium assay. Cancer Research, 48(3), 589-601.
2. Arya, A., Chahal, R., Rao, R., Rahman, M., Kaushik, D., Akhtar, M.F., Mittal, V. (2021). Acetylcholinesterase inhibitory potential of various sesquiterpene analogues for Alzheimer’s disease therapy. Biomolecules, 11(3), 350. [CrossRef]
3. Rahman, M.A., Hannan, M.A., Dash, R., Rahman, M.H., Islam, R., Uddin, M.J., Rhim, H. (2021). Phytochemicals as a complement to cancer chemotherapy: Pharmacological modulation of the autophagy-apoptosis pathway. Frontiers in Pharmacology, 12. [CrossRef]
4. Sindhu, R.K., Kaur, P., Kaur, P., Singh, H., El-Saber Batiha, G., Vermaet I. (2022). Exploring multifunctional antioxidants as potential agents for management of neurological disorders. Environmental Science and Pollution Research, 29, 24458-24477. [CrossRef]
5. Rahman, M.H., Akter, R., Kamal, M.A. (2020). Prospective function of different antioxidant containing natural products in the treatment of neurodegenerative disease. CNS & Neurological Disorders-Drug Targets.
6. Sharma, V.K., Singh, T.G., Garg, N., Dhiman, S., Gupta, S., Rahman, M., Abdel-Daim, M.M. (2021). Dysbiosis and Alzheimer’s disease: A role for chronic stress? Biomolecules, 11(5), 678. [CrossRef]
7. Bhattacharya, T., Dey, P.S., Akter, R., Kabir, M.T., Rahman, M.H., Rauf, A. (2021). Effect of natural leaf extracts as phytomedicine in curing geriatrics. Experimental Gerontology, 150, 111352. [CrossRef]
8. Akter, R., Rahman, H., Behl, T., Chowdhury, M., Rahman, A., Manirujjaman, M., Bungau, S. (2021). Prospective role of polyphenolic compounds in the treatment of neurodegenerative diseases. CNS & Neurological Disorders-Drug Targets, 20(5), 430-450.
9. Fadaka, A.O., Ajiboye, B.O., Adewale, I., Ojo, O.A., Oyinloye, B.E., Okesola, M.A. (2019). Significance of antioxidants in the treatment and prevention of neurodegenerative diseases. Journal of Phytopharmacology, 8(2), 75-83. [CrossRef]
10. Ali Al-Mamary, M., Moussa, Z. (2021). Antioxidant activity: The presence and impact of hydroxyl groups in small molecules of natural and synthetic origin. Antioxidants-Benefits, Sources, Mechanisms of Action. IntechOpen. [CrossRef]
11. Houldsworth, A. (2024). Role of oxidative stress in neurodegenerative disorders: A review of reactive oxygen species and prevention by antioxidants. Brain Communications, 6(1), fcad356. [CrossRef]
12. Kabongo, J.D., Idowu, S.O., Capaldi, N., Zu, L., Das Gupta, A. (2013). Waste Valorization, Springer Berlin Heidelberg, Berlin, Heidelberg, pp2701-2706.
13. Merrington, A. (2017). Recycling of plastics. Applied Plastics Engineering Handbook, Plastics Design Library, M. Kutz, William Andrew Publishing, 167-189.
14. Allwood, J.M. (2014). Squaring the Circular Economy: The Role of Recycling within a Hierarchy of Material Management Strategies. Handbook of Recycling, Boston: Elsevier, pp 445-477.
15. Adıgüzel, F., & Donato, C. (2021). Proud to be sustainable: Upcycled versus recycled luxury products, Journal of Business Research, 130(C), 137-146.
16. Lauria, A., & Lizundia, E. (2020). Luminescent carbon dots obtained from polymeric waste, Journal of Cleaner Production, 262, 121288.
17. Lizundia, E., Luzi, F., Puglia, D. (2022). Organic waste valorisation towards circular and sustainable biocomposites. Green Chemistry: An International Journal and Green Chemistry Resource: GC, 24(14), 5429-5459. [CrossRef]
18. Beetch, M., Harandi-Zadeh, S., Shen, K., Lubecka, K., Kitts, D.D., O'Hagan, H.M., Stefanska, B. (2020). Dietary antioxidants remodel DNA methylation patterns in chronic disease. British Journal of Pharmacology, 177(6), 1382-1408. [CrossRef]
19. El Zawawy, N.A. (2015). Antioxidant, antitumor, antimicrobial studies and quantitative phytochemical estimation of ethanolic extracts of selected fruit peels. International Journal of Current Microbiology and Applied Sciences, 4(5), 298-309.
20. Karmakar, S., De, S. (2019). Pectin Removal and Clarification of Juices. Separation of Functional Molecules in Food by Membrane Technology, Academic Press, 155-194.
21. Wolfe, K., Wu, X., Liu, R.H. (2003). Antioxidant activity of apple peels. Journal of Agricultural and Food Chemistry, 51, 609-614. [CrossRef]
22. Win Min Oo, M., Myat Mon Khine. (2017). Pharmacological activities of Annona squamosa: Updated Review. International Journal of Pharmacy and Chemistry, 3(6), 86-93. [CrossRef]
23. Lydia, D.E., John, S., Swetha, V., & Sivapriya, T. (2017). Investigation on the antimicrobial and antioxidant activity of custard apple (Annona reticulata) peel extracts. Research Journal of Pharmacognosy and Phytochemistry, 9(4), 241-249. [CrossRef]
24. Shastri, K.V., Bhatia, V., Parikh, P.R., & Chaphekar, V.N. (2012). Actinidia deliciosa: A Review. International Journal of Pharmaceutical Sciences and Research, 3(10), 3543-3549. [CrossRef]
25. Alim, A., Li, T., Nisar, T., Ren, D., Zhai, X., Pang, Y., Yang, X. (2019). Evaluation of the effects of pomegranate peel polyphenols on antioxidant activity and inhibition of α-glucosidase, α-amylase and lipase activities. Molecules, 24(24), 4620.
26. Preeti, Raju, P.N. (2017). Comprehensive Overview of Cucumis melo. The Pharma Innovation Journal, 6(10), 181-186.
27. Ismail, H., Chan, K.W., Mariod, A., Ismail, M. (2010). Phenolic content and antioxidant activity of cantaloupe (Cucumis melo) methanolic extracts. Food Chemistry, 119, 643-647. [CrossRef]
28. Dhingra, D., Sharma, A. (2006). Antidepressant-like activity of n-hexane extract of nutmeg (Myristica fragrans) seeds in mice. Journal of Medicinal Food, 9(1), 84-89. [CrossRef]
29. Pandey, A., Tripathi, S. (2014). Concept of standardization, extraction, and pre-phytochemical screening strategies for herbal drug. Pharmacognosy and Phytochemistry, 2, 115-9.
30. Porsolt, R.D., Anton, G., Blavet, N., Jalfre, M. (1978). Behavioral despair in rats: A new model sensitive to antidepressant treatments. European Journal of Pharmacology, 47(4), 379-391. [CrossRef]
31. Yu, L., Jiang, X., Liao, M., Ma, R., Yu, T. (2011). Antidepressant-like effect of tetra methyl pyrazine in mice and rats. Neuroscience and Medicine, 2, 142-148.
32. Gupta, M., Mazumder, U.K., Kumar, T.S., Gomathi, P., Kumar, R.S. (2004). Antioxidant and hepatoprotective effects of Bauhinia racemosa against paracetamol and carbon tetrachloride induced liver damagein rats. Iranian Journal of Pharmacology and Therapeutics, 3, 12-20.

There are 32 citations in total.

Details

Primary Language	English
Subjects	Pharmacognosy
Journal Section	Research Article
Authors	Aruna Kumari Dokkada 0000-0001-8167-6456 Vijay Srinivas Pothula 0000-0003-1496-8226 Gana Manjusha Kondepudi 0000-0002-7982-6934
Early Pub Date	May 4, 2025
Publication Date
Submission Date	September 14, 2024
Acceptance Date	January 28, 2025
Published in Issue	Year 2025 Volume: 49 Issue: 2

Cite

APA	Dokkada, A. K., Pothula, V. S., & Kondepudi, G. M. (2025). NEUROPHARMACOLOGICAL EVALUATION OF AQUEOUS EXTRACTS OF FRUIT PEELS AND THEIR POLYHERBAL FORMULATION: ANTIDEPRESSANT AND MUSCLE RELAXANT POTENTIAL. Journal of Faculty of Pharmacy of Ankara University, 49(2), 8-8. https://doi.org/10.33483/jfpau.1548158
AMA	Dokkada AK, Pothula VS, Kondepudi GM. NEUROPHARMACOLOGICAL EVALUATION OF AQUEOUS EXTRACTS OF FRUIT PEELS AND THEIR POLYHERBAL FORMULATION: ANTIDEPRESSANT AND MUSCLE RELAXANT POTENTIAL. J. Fac. Pharm. Ankara. May 2025;49(2):8-8. doi:10.33483/jfpau.1548158
Chicago	Dokkada, Aruna Kumari, Vijay Srinivas Pothula, and Gana Manjusha Kondepudi. “NEUROPHARMACOLOGICAL EVALUATION OF AQUEOUS EXTRACTS OF FRUIT PEELS AND THEIR POLYHERBAL FORMULATION: ANTIDEPRESSANT AND MUSCLE RELAXANT POTENTIAL”. Journal of Faculty of Pharmacy of Ankara University 49, no. 2 (May 2025): 8-8. https://doi.org/10.33483/jfpau.1548158.
EndNote	Dokkada AK, Pothula VS, Kondepudi GM (May 1, 2025) NEUROPHARMACOLOGICAL EVALUATION OF AQUEOUS EXTRACTS OF FRUIT PEELS AND THEIR POLYHERBAL FORMULATION: ANTIDEPRESSANT AND MUSCLE RELAXANT POTENTIAL. Journal of Faculty of Pharmacy of Ankara University 49 2 8–8.
IEEE	A. K. Dokkada, V. S. Pothula, and G. M. Kondepudi, “NEUROPHARMACOLOGICAL EVALUATION OF AQUEOUS EXTRACTS OF FRUIT PEELS AND THEIR POLYHERBAL FORMULATION: ANTIDEPRESSANT AND MUSCLE RELAXANT POTENTIAL”, J. Fac. Pharm. Ankara, vol. 49, no. 2, pp. 8–8, 2025, doi: 10.33483/jfpau.1548158.
ISNAD	Dokkada, Aruna Kumari et al. “NEUROPHARMACOLOGICAL EVALUATION OF AQUEOUS EXTRACTS OF FRUIT PEELS AND THEIR POLYHERBAL FORMULATION: ANTIDEPRESSANT AND MUSCLE RELAXANT POTENTIAL”. Journal of Faculty of Pharmacy of Ankara University 49/2 (May 2025), 8-8. https://doi.org/10.33483/jfpau.1548158.
JAMA	Dokkada AK, Pothula VS, Kondepudi GM. NEUROPHARMACOLOGICAL EVALUATION OF AQUEOUS EXTRACTS OF FRUIT PEELS AND THEIR POLYHERBAL FORMULATION: ANTIDEPRESSANT AND MUSCLE RELAXANT POTENTIAL. J. Fac. Pharm. Ankara. 2025;49:8–8.
MLA	Dokkada, Aruna Kumari et al. “NEUROPHARMACOLOGICAL EVALUATION OF AQUEOUS EXTRACTS OF FRUIT PEELS AND THEIR POLYHERBAL FORMULATION: ANTIDEPRESSANT AND MUSCLE RELAXANT POTENTIAL”. Journal of Faculty of Pharmacy of Ankara University, vol. 49, no. 2, 2025, pp. 8-8, doi:10.33483/jfpau.1548158.
Vancouver	Dokkada AK, Pothula VS, Kondepudi GM. NEUROPHARMACOLOGICAL EVALUATION OF AQUEOUS EXTRACTS OF FRUIT PEELS AND THEIR POLYHERBAL FORMULATION: ANTIDEPRESSANT AND MUSCLE RELAXANT POTENTIAL. J. Fac. Pharm. Ankara. 2025;49(2):8-.

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The Journal of Faculty of Pharmacy of Ankara University is an international medium, an open access, peer-reviewed journal for the publication of original research reports, reviews and short communications in English or Turkish on relevant developments in pharmaceutical sciences., Proceeding of scientific meetings may be published as special issues of supplements to the journal. Additionally, it contains previous and forthcoming national and international scientific meetings with social activities in pharmaceutical areas.