FRUITFUL REMEDIES: ANALYZING THERAPEUTIC POTENTIALS IN ESSENTIAL AND FATTY OILS, AND AQUEOUS EXTRACTS FROM PRUNUS CERASIFERA, MALUS SYLVESTRIS, AND CORNUS MAS USING LC-MS AND GC-MS

Bilge Aydın; Hafize Yuca; Gözde Öztürk; Enes Tekman; Songül Karakaya; Gamze Göger; Mehmet Önal; Betül Demirci; Zuhal Güvenalp; Oksana Sytar

doi:10.33483/jfpau.1562768

Research Article

MEYVELERDEN ŞİFAYA: PRUNUS CERASIFERA, MALUS SYLVESTRIS VE CORNUS MAS TÜRLERİNDEN ELDE EDİLEN UÇUCU YAĞLAR, YAĞ ASİTLERİ VE SU EKSTRELERİNİN LC-MS VE GC-MS YÖNTEMLERİYLE TERAPÖTİK POTANSİYELLERİNİN ANALİZİ

Year 2025, Volume: 49 Issue: 2, 13 - 13

Bilge Aydın , Hafize Yuca , Gözde Öztürk , Enes Tekman , Songül Karakaya , Gamze Göger , Mehmet Önal , Betül Demirci , Zuhal Güvenalp , Oksana Sytar

https://doi.org/10.33483/jfpau.1562768

Abstract

Amaç: Prunus cerasifera, Malus sylvestris ve Cornus mas'ın uçucu yağları, yağ asitleri ve sulu ekstrelerinin kimyasal bileşimi ve biyoaktif özellikleri araştırılmıştır.
Gereç ve Yöntem: P. cerasifera, M. sylvestris ve C. mas'ın antidiyabetik, antimikrobiyal, antikolinesteraz ve antioksidan aktiviteleri rapor edilmiştir. Ayrıca bazı sekonder metabolitlerin kantitatif tayini LC-MS/MS ile analiz edilmiştir. Uçucu yağların kimyasal bileşimi de GC-MS ile araştırılmıştır.
Sonuç ve Tartışma: Yağların ana bileşikleri P. cerasifera'da oleik asit (%77.1), M. sylvestris meyvelerinde palmitik asit (%32.5) ve C. mas tohumlarında linoleik asit (%43.2) olarak bulunmuştur. Benzaldehit (%70.1), nonakozan (%30.4), (E,E)-2,4-dekadienal (%43.3) sırasıyla P. cerasifera, M. sylvestris meyveleri ve C. mas tohum uçucu yağlarının ana bileşikleri olarak bulunmuştur. Kinik asit, 11262.2996 ila 18179.6260 ng/ml arasında değişen tüm ekstrelerde en çok bulunan bileşik olmuştur. C. mas yağı Candida albicans ve C. parapsilosis türlerine karşı MIC =625-1250 µg/ml ile antimikrobiyal aktivite göstermiştir. P. cerasifera, C. mas ve M. sylvestris, değişen derecelerde etki gücüne sahip α-glukozidaz inhibitörleri olarak potansiyel taşımaktadır. Özellikle <10 ve 399 µg/ml olan C. mas ve M. sylvestris örneklerinde IC50 değerleri sulu ekstrelerinin etkinliğini daha da vurgulamaktadır.

Keywords

Antidiyabetik, antikolinesteraz, Cornus mas, LC-MS/MS, Malus sylvestris, Prunus cerasifera

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FRUITFUL REMEDIES: ANALYZING THERAPEUTIC POTENTIALS IN ESSENTIAL AND FATTY OILS, AND AQUEOUS EXTRACTS FROM PRUNUS CERASIFERA, MALUS SYLVESTRIS, AND CORNUS MAS USING LC-MS AND GC-MS

Year 2025, Volume: 49 Issue: 2, 13 - 13

Bilge Aydın , Hafize Yuca , Gözde Öztürk , Enes Tekman , Songül Karakaya , Gamze Göger , Mehmet Önal , Betül Demirci , Zuhal Güvenalp , Oksana Sytar

https://doi.org/10.33483/jfpau.1562768

Abstract

Objective: The chemical composition and bioactive properties of essential oils, fatty oils and aqueous extracts of Prunus cerasifera, Malus sylvestris and Cornus mas were investigated.
Material and Method: Antidiabetic, antimicrobial, anticholinesterase and antioxidant activities of P. cerasifera, M. sylvestris and C. mas were reported. The quantitative determination of some secondary metabolites was also analysed by LC-MS/MS. The chemical composition of the essential oils was also investigated by GC-MS.
Result and Discussion: Fatty oils’ major compounds were oleic acid (77.1%) in P. cerasifera, palmitic acid (32.5%) in M. sylvestris fruits, and linoleic acid (43.2%) in C. mas seeds. Benzaldehyde (70.1%), nonacosane (30.4%), (E,E)-2,4-Decadienal (43.3%) were found as major compounds of P. cerasifera, M. sylvestris fruits, and C. mas seed essential oils, respectively. Quinic acid was predominant compound in all extracts, ranging from 11262.2996 to 18179.6260 ng/ml. C. mas fatty oil was showed antimicrobial activity against Candida albicans and C. parapsilosis with MIC =625-1250 µg/ml. P. cerasifera, C. mas, and M. sylvestris hold potential as α-glucosidase inhibitors, with varying degrees of potency. IC50 values further underscore effectiveness of aqueous extracts, especially in cases of C. mas and M. sylvestris with <10 and 399 µg/ml.

Keywords

Anticholinesterase, antidiabetic, Cornus mas, LC-MS/MS, Malus sylvestris, Prunus cerasifera

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9. Stojiljković, D., Arsić, I., Tadić, V. (2016). Extracts of wild apple fruit (Malus sylvestris (L.) Mill., Rosaceae) as a source of antioxidant substances for use in production of nutraceuticals and cosmeceuticals. Industrial Crops and Products, 80, 165-176. [CrossRef]
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12. Horvath, A., Christmann, H., Laigret, F. (2008). Genetic diversity and relationships among Prunus cerasifera (cherry plum) clones. Botany, 86(11), 1311-1318. [CrossRef]
13. Szczepaniak, O., Kobus-Cisowska, J., Kusek, W., Przeor, M. (2019). Functional properties of Cornelian cherry (Cornus mas L.): A comprehensive review. European Food Research and Technology, 245(10) 2071-2087. [CrossRef]
14. Pawlowska, A., Braca, A. (2010). Quali-quantitative analysis of flavonoids of Cornus mas L. (Cornaceae) fruits. Food Chemistry, 119(3), 1257-1261. [CrossRef]
15. Tardío, J., Arnal Olivares, A., Lázaro, A. (2020). Ethnobotany of the crab apple tree (Malus sylvestris (L.) Mill., Rosaceae) in Spain. Genetic Resources and Crop Evolution, 68(2), 795-808. [CrossRef]
16. Bhat, R., Mestha, S., Nagesh, S., Shanbhag, P., Veigas, G., Kumar, R. (2022). An investigation of ant-inflammatory activity of aqueous extract of Malus sylvestris fruits in experimental animals. International Journal of Pharmaceutical Sciences Review and Research, 9, 606-610. [CrossRef]
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There are 65 citations in total.

Details

Primary Language	English
Subjects	Pharmacognosy, Pharmaceutical Botany
Journal Section	Research Article
Authors	Bilge Aydın 0000-0002-7712-7259 Hafize Yuca 0000-0002-0857-4776 Gözde Öztürk 0000-0002-3998-8859 Enes Tekman 0000-0002-1226-7218 Songül Karakaya 0000-0002-3268-721X Gamze Göger 0000-0003-2978-5385 Mehmet Önal 0000-0003-1069-1012 Betül Demirci 0000-0003-2343-746X Zuhal Güvenalp 0000-0002-8803-8147 Oksana Sytar 0000-0003-4219-9292
Early Pub Date	May 9, 2025
Publication Date
Submission Date	October 7, 2024
Acceptance Date	February 3, 2025
Published in Issue	Year 2025 Volume: 49 Issue: 2

Cite

APA	Aydın, B., Yuca, H., Öztürk, G., Tekman, E., et al. (2025). FRUITFUL REMEDIES: ANALYZING THERAPEUTIC POTENTIALS IN ESSENTIAL AND FATTY OILS, AND AQUEOUS EXTRACTS FROM PRUNUS CERASIFERA, MALUS SYLVESTRIS, AND CORNUS MAS USING LC-MS AND GC-MS. Journal of Faculty of Pharmacy of Ankara University, 49(2), 13-13. https://doi.org/10.33483/jfpau.1562768
AMA	Aydın B, Yuca H, Öztürk G, Tekman E, Karakaya S, Göger G, Önal M, Demirci B, Güvenalp Z, Sytar O. FRUITFUL REMEDIES: ANALYZING THERAPEUTIC POTENTIALS IN ESSENTIAL AND FATTY OILS, AND AQUEOUS EXTRACTS FROM PRUNUS CERASIFERA, MALUS SYLVESTRIS, AND CORNUS MAS USING LC-MS AND GC-MS. J. Fac. Pharm. Ankara. May 2025;49(2):13-13. doi:10.33483/jfpau.1562768
Chicago	Aydın, Bilge, Hafize Yuca, Gözde Öztürk, Enes Tekman, Songül Karakaya, Gamze Göger, Mehmet Önal, Betül Demirci, Zuhal Güvenalp, and Oksana Sytar. “FRUITFUL REMEDIES: ANALYZING THERAPEUTIC POTENTIALS IN ESSENTIAL AND FATTY OILS, AND AQUEOUS EXTRACTS FROM PRUNUS CERASIFERA, MALUS SYLVESTRIS, AND CORNUS MAS USING LC-MS AND GC-MS”. Journal of Faculty of Pharmacy of Ankara University 49, no. 2 (May 2025): 13-13. https://doi.org/10.33483/jfpau.1562768.
EndNote	Aydın B, Yuca H, Öztürk G, Tekman E, Karakaya S, Göger G, Önal M, Demirci B, Güvenalp Z, Sytar O (May 1, 2025) FRUITFUL REMEDIES: ANALYZING THERAPEUTIC POTENTIALS IN ESSENTIAL AND FATTY OILS, AND AQUEOUS EXTRACTS FROM PRUNUS CERASIFERA, MALUS SYLVESTRIS, AND CORNUS MAS USING LC-MS AND GC-MS. Journal of Faculty of Pharmacy of Ankara University 49 2 13–13.
IEEE	B. Aydın, “FRUITFUL REMEDIES: ANALYZING THERAPEUTIC POTENTIALS IN ESSENTIAL AND FATTY OILS, AND AQUEOUS EXTRACTS FROM PRUNUS CERASIFERA, MALUS SYLVESTRIS, AND CORNUS MAS USING LC-MS AND GC-MS”, J. Fac. Pharm. Ankara, vol. 49, no. 2, pp. 13–13, 2025, doi: 10.33483/jfpau.1562768.
ISNAD	Aydın, Bilge et al. “FRUITFUL REMEDIES: ANALYZING THERAPEUTIC POTENTIALS IN ESSENTIAL AND FATTY OILS, AND AQUEOUS EXTRACTS FROM PRUNUS CERASIFERA, MALUS SYLVESTRIS, AND CORNUS MAS USING LC-MS AND GC-MS”. Journal of Faculty of Pharmacy of Ankara University 49/2 (May 2025), 13-13. https://doi.org/10.33483/jfpau.1562768.
JAMA	Aydın B, Yuca H, Öztürk G, Tekman E, Karakaya S, Göger G, Önal M, Demirci B, Güvenalp Z, Sytar O. FRUITFUL REMEDIES: ANALYZING THERAPEUTIC POTENTIALS IN ESSENTIAL AND FATTY OILS, AND AQUEOUS EXTRACTS FROM PRUNUS CERASIFERA, MALUS SYLVESTRIS, AND CORNUS MAS USING LC-MS AND GC-MS. J. Fac. Pharm. Ankara. 2025;49:13–13.
MLA	Aydın, Bilge et al. “FRUITFUL REMEDIES: ANALYZING THERAPEUTIC POTENTIALS IN ESSENTIAL AND FATTY OILS, AND AQUEOUS EXTRACTS FROM PRUNUS CERASIFERA, MALUS SYLVESTRIS, AND CORNUS MAS USING LC-MS AND GC-MS”. Journal of Faculty of Pharmacy of Ankara University, vol. 49, no. 2, 2025, pp. 13-13, doi:10.33483/jfpau.1562768.
Vancouver	Aydın B, Yuca H, Öztürk G, Tekman E, Karakaya S, Göger G, Önal M, Demirci B, Güvenalp Z, Sytar O. FRUITFUL REMEDIES: ANALYZING THERAPEUTIC POTENTIALS IN ESSENTIAL AND FATTY OILS, AND AQUEOUS EXTRACTS FROM PRUNUS CERASIFERA, MALUS SYLVESTRIS, AND CORNUS MAS USING LC-MS AND GC-MS. J. Fac. Pharm. Ankara. 2025;49(2):13-.

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The Journal of Faculty of Pharmacy of Ankara University is an international medium, an open access, peer-reviewed journal for the publication of original research reports, reviews and short communications in English or Turkish on relevant developments in pharmaceutical sciences., Proceeding of scientific meetings may be published as special issues of supplements to the journal. Additionally, it contains previous and forthcoming national and international scientific meetings with social activities in pharmaceutical areas.