CHEMICAL COMPOSITION AND BIOLOGICAL ACTIVITY OF PHOLIOTA AURIVELLA (BATSCH) P. KUMM.

Cenker Yaman; Gizem Gül; Atakan Benek; Dilay Turu; Selime Deniz Bozkurt; Ilgaz Akata; Kerem Canlı

doi:10.33483/jfpau.1607129

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PHOLIOTA AURIVELLA (BATSCH) P. KUMM.’NİN KİMYASAL BİLEŞİMİ VE BİYOLOJİK AKTİVİTELERİ

Year 2025, Volume: 49 Issue: 2, 10 - 10

Cenker Yaman , Gizem Gül , Atakan Benek , Dilay Turu , Selime Deniz Bozkurt , Ilgaz Akata , Kerem Canlı

https://doi.org/10.33483/jfpau.1607129

Abstract

Amaç: Bu çalışma, Pholiota aurivella mantarının antimikrobiyal, antibiyofilm ve antioksidan aktivitelerini araştırarak kimyasal kompozisyonunu belirlemeyi amaçlamaktadır. Çalışmada, mantarın etanol ekstraktının, çoklu ilaç direncine sahip suşlar da dahil olmak üzere toplam 27 farklı mikroorganizma üzerindeki potansiyel etkisi incelenmiştir. Ayrıca, mantar ekstraktının biyofilm inhibisyon kapasitesi ve serbest radikal süpürme aktiviteleri test edilmiştir.
Gereç ve Yöntem: P. aurivella örneğinden etanol ile elde edilen ekstrakt, biyolojik aktivitelerini değerlendirmek amacıyla çeşitli testlere tabi tutulmuştur. Antimikrobiyal etkinlik, disk difüzyon ve Minimum İnhibitör Konsantrasyon (MİK) testleri ile analiz edilmiştir. Antibiyofilm aktivitesi, biyofilm oluşumunu inhibe etme kapasitesiyle değerlendirilirken, antioksidan aktivite DPPH yöntemi ile test edilmiştir. Kimyasal kompozisyon ise Gaz Kromatografisi-Kütle Spektrometrisi (GC-MS) analiziyle belirlenmiştir.
Sonuç ve Tartışma: Çalışmamız, P. aurivella'nın özellikle antimikrobiyal ve antibiyofilm aktiviteleri açısından umut verici bir doğal ajan olduğunu ortaya koymaktadır. Ekstrakt, 16 farklı Gram-pozitif ve Gram-negatif mikroorganizmaya karşı antimikrobiyal etkinlik gösterirken, çoklu ilaç direnci (MDR) gösteren Klebsiella pneumoniae ve Enterobacter aerogenes gibi suşlarda da artan ekstrakt miktarı ile genişleyen inhibisyon alanları gözlemlenmiştir. Biyofilm inhibisyonu testlerinde de en güçlü etkiler, Listeria innocua ve Bacillus subtilis DSMZ 1971 suşlarında gözlemlenmiştir. Öte yandan, DPPH yöntemiyle test edilen antioksidan aktivite oldukça düşüktür; bu durum, ekstraktın kimyasal bileşiminde fenolik bileşiklerin bulunmamasıyla açıklanabilir. GC-MS analizinde, majör bileşenlerin linoleik asit (%59.20) ve etil linoleat (%17.13) olduğu tespit edilmiştir. Bu bulgular, P. aurivella'nın antibiyofilm ve antimikrobiyal özellikleriyle farmasötik uygulamalar açısından potansiyele sahip olduğunu ve MDR patojenlere karşı dahi tedavi seçenekleri geliştirilmesinde önemli bir doğal kaynak sunabileceğini göstermektedir.

Keywords

Antibyiofilm aktivite, antimikrobiyal aktivite, antioksidan aktivite, GC-MS, Pholiota aurivella

Thanks

Bu makale, Kerem Canlı, Ilgaz Akata, Ali Yetgin, Özcan Şimşek ve Ergin Murat Altuner tarafından "In Vitro Antimicrobial Activity Screening of Pholiota aurivella and Determination of the Ethanol Extract Composition by Gas Chromatography/Mass Spectrometry" başlığıyla 2017 yılında Trabzon'da düzenlenen The Second Japan – Turkey International Symposium on Pharmaceutical and Biomedical Sciences adlı sempozyumda bildiri olarak sunulan çalışmaya dayanmaktadır.

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CHEMICAL COMPOSITION AND BIOLOGICAL ACTIVITY OF PHOLIOTA AURIVELLA (BATSCH) P. KUMM.

Year 2025, Volume: 49 Issue: 2, 10 - 10

Cenker Yaman , Gizem Gül , Atakan Benek , Dilay Turu , Selime Deniz Bozkurt , Ilgaz Akata , Kerem Canlı

https://doi.org/10.33483/jfpau.1607129

Abstract

Objective: This study aims to determine the chemical composition of the mushroom Pholiota aurivella by investigating its antimicrobial, antibiofilm, and antioxidant activities. The potential effects of the ethanol extract of the mushroom on a total of 27 different microorganisms, including strains with multidrug resistance (MDR), were examined. Additionally, the biofilm inhibition capacity and free radical scavenging activities of the mushroom extract were tested.
Material and Method: The ethanol extract obtained from the P. aurivella sample was subjected to various tests to evaluate its biological activities. Antimicrobial activity was analyzed using disk diffusion and Minimum Inhibitory Concentration (MIC) tests. Antibiofilm activity was assessed based on its capacity to inhibit biofilm formation, while antioxidant activity was tested using the DPPH method. The chemical composition was determined by Gas Chromatography-Mass Spectrometry (GC-MS) analysis.
Result and Discussion: Our study reveals that P. aurivella is a promising natural agent, especially in terms of its antimicrobial and antibiofilm activities. The extract exhibited antimicrobial activity against 16 different Gram-positive and Gram-negative microorganisms. Expanding zones of inhibition were observed with increasing extract amounts in strains such as Klebsiella pneumoniae and Enterobacter aerogenes, which show multidrug resistance (MDR). In biofilm inhibition tests, the strongest effects were observed in strains of Listeria innocua and Bacillus subtilis DSMZ 1971. On the other hand, the antioxidant activity tested by the DPPH method was quite low; this can be explained by the absence of phenolic compounds in the chemical composition of the extract. GC-MS analysis identified the major components as linoleic acid (59.20%) and ethyl linoleate (17.13%). These findings indicate that P. aurivella, with its antibiofilm and antimicrobial properties, has potential for pharmaceutical applications and may offer an important natural resource for developing treatment options even against MDR pathogens.

Keywords

Antibiofilm activity, antimicrobial activities, antioxidant activity, GC-MS, Pholiota aurivella

Thanks

This manuscript is based on the study previously presented as a conference abstract under the title "In Vitro Antimicrobial Activity Screening of Pholiota aurivella and Determination of the Ethanol Extract Composition by Gas Chromatography/Mass Spectrometry" by Kerem Canlı, Ilgaz Akata, Ali Yetgin, Özcan Şimşek, and Ergin Murat Altuner at The Second Japan – Turkey International Symposium on Pharmaceutical and Biomedical Sciences, held in 2017 in Trabzon.

References

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9. Altuner, E.M., Akata, I. (2000). Antimicrobial activity of some macrofungi extracts. Sakarya Üniversitesi Fen Bilimleri Enstitüsü Dergisi, 14, 1(2010).
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11. Ahmadi, M., Vahabzadeh, F., Bonakdarpour, B., Mehranian, M. (2006). Empirical modeling of olive oil mill wastewater treatment using loofa-immobilized Phanerochaete chrysosporium. Process Biochemistry, 41(5), 1148-1154. [CrossRef]
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17. Solak M.H., Gücin F. (1992). New records of macrofungi for Turkey from Bursa District and other macrofungi found in the district. Turkish Journal of Botany, 16 (1): 335-346.
18. Canlı, K., Akata, I., Altuner, E. (2016). In vitro antimicrobial activity screening of Xylaria hypoxylon. African Journal of Traditional, Complementary, and Alternative Medicines. 13, 42-46. [CrossRef]
19. Canlı, K., Altuner, E., Akata, I. (2015). Antimicrobial screening of Mnium stellare. Bangladesh Journal of Pharmacology, 10, 321-325. [CrossRef]
20. Andrews, J.M. (2003). BSAC standardized disk susceptibility testing method (version 6). Journal of Antimicrobial Chemotherapy, 60, 20-41.
21. Benek, A., Canlı, K., Altuner, E.M. (2022). Antimicrobial and antioxidant activities of some mosses. Anatolian Bryology, 9(1), 42-49.
22. Baldas, B., Altuner, E.M. (2018). The antimicrobial activity of apple cider vinegar and grape vinegar, which are used as a traditional surface disinfectant for fruits and vegetables. Communications Faculty of Sciences University of Ankara Series C Biology, 27(1), 1-10. [CrossRef]
23. Tunca-Pinarli, Y., Benek, A., Turu, D., Bozyel, M.E., Canli, K., Altuner, E.M. (2023). Biological activities and biochemical composition of endemic Achillea fraasii. Microorganisms, 11(4), 978.
24. Benek, A., Turu, D., Canli, K. (2024). Determination of biological activity and biochemical content of ethanol extract from fruiting body of Tricholoma bufonium (Pers.) Gillet. Journal of Fungi, 10(11), 761. [CrossRef]
25. Turu, D., Bozkurt, S.D., Yaman, C., Gül, G., Benek, A., Canlı, K. (2024). Determination of biochemical content and antioxidant activity of Calliergonella cuspidata (Hedw.) Loeske. Anatolian Bryology, 10(1), 25-33. [CrossRef]
26. Silge, J., Robinson, D. (2016). Tidytext: Text mining and analysis using tidy data principles in R. Journal of OpenSource Software, 1(3), 37. [CrossRef]
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There are 62 citations in total.

Details

Primary Language	English
Subjects	Pharmaceutical Microbiology
Journal Section	Research Article
Authors	Cenker Yaman 0000-0002-3559-9098 Gizem Gül 0000-0003-3928-2917 Atakan Benek 0000-0001-6726-5968 Dilay Turu 0000-0002-8485-0488 Selime Deniz Bozkurt 0009-0003-4782-8884 Ilgaz Akata 0000-0002-1731-1302 Kerem Canlı 0000-0001-6061-6948
Early Pub Date	May 4, 2025
Publication Date
Submission Date	December 27, 2024
Acceptance Date	January 28, 2025
Published in Issue	Year 2025 Volume: 49 Issue: 2

Cite

APA	Yaman, C., Gül, G., Benek, A., Turu, D., et al. (2025). CHEMICAL COMPOSITION AND BIOLOGICAL ACTIVITY OF PHOLIOTA AURIVELLA (BATSCH) P. KUMM. Journal of Faculty of Pharmacy of Ankara University, 49(2), 10-10. https://doi.org/10.33483/jfpau.1607129
AMA	Yaman C, Gül G, Benek A, Turu D, Bozkurt SD, Akata I, Canlı K. CHEMICAL COMPOSITION AND BIOLOGICAL ACTIVITY OF PHOLIOTA AURIVELLA (BATSCH) P. KUMM. J. Fac. Pharm. Ankara. May 2025;49(2):10-10. doi:10.33483/jfpau.1607129
Chicago	Yaman, Cenker, Gizem Gül, Atakan Benek, Dilay Turu, Selime Deniz Bozkurt, Ilgaz Akata, and Kerem Canlı. “ KUMM”. Journal of Faculty of Pharmacy of Ankara University 49, no. 2 (May 2025): 10-10. https://doi.org/10.33483/jfpau.1607129.
EndNote	Yaman C, Gül G, Benek A, Turu D, Bozkurt SD, Akata I, Canlı K (May 1, 2025) CHEMICAL COMPOSITION AND BIOLOGICAL ACTIVITY OF PHOLIOTA AURIVELLA (BATSCH) P. KUMM. Journal of Faculty of Pharmacy of Ankara University 49 2 10–10.
IEEE	C. Yaman, G. Gül, A. Benek, D. Turu, S. D. Bozkurt, I. Akata, and K. Canlı, “ KUMM”., J. Fac. Pharm. Ankara, vol. 49, no. 2, pp. 10–10, 2025, doi: 10.33483/jfpau.1607129.
ISNAD	Yaman, Cenker et al. “ KUMM”. Journal of Faculty of Pharmacy of Ankara University 49/2 (May 2025), 10-10. https://doi.org/10.33483/jfpau.1607129.
JAMA	Yaman C, Gül G, Benek A, Turu D, Bozkurt SD, Akata I, Canlı K. CHEMICAL COMPOSITION AND BIOLOGICAL ACTIVITY OF PHOLIOTA AURIVELLA (BATSCH) P. KUMM. J. Fac. Pharm. Ankara. 2025;49:10–10.
MLA	Yaman, Cenker et al. “ KUMM”. Journal of Faculty of Pharmacy of Ankara University, vol. 49, no. 2, 2025, pp. 10-10, doi:10.33483/jfpau.1607129.
Vancouver	Yaman C, Gül G, Benek A, Turu D, Bozkurt SD, Akata I, Canlı K. CHEMICAL COMPOSITION AND BIOLOGICAL ACTIVITY OF PHOLIOTA AURIVELLA (BATSCH) P. KUMM. J. Fac. Pharm. Ankara. 2025;49(2):10-.

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The Journal of Faculty of Pharmacy of Ankara University is an international medium, an open access, peer-reviewed journal for the publication of original research reports, reviews and short communications in English or Turkish on relevant developments in pharmaceutical sciences., Proceeding of scientific meetings may be published as special issues of supplements to the journal. Additionally, it contains previous and forthcoming national and international scientific meetings with social activities in pharmaceutical areas.