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Year 2024, Volume: 28 Issue: 6, 1911 - 1920, 28.06.2025

Sevda Türk , Didem Akkaya , Burak Kırılmaz Ezgi Merve Önal Burak Barut

https://doi.org/10.29228/jrp.864

Abstract

References

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Synthesis, characterization and biological activity potential of some novel thiourea derivatives

Year 2024, Volume: 28 Issue: 6, 1911 - 1920, 28.06.2025

Sevda Türk , Didem Akkaya , Burak Kırılmaz Ezgi Merve Önal Burak Barut

https://doi.org/10.29228/jrp.864

Abstract

Within the scope of this study, a new series of thiourea derivatives were synthesized by refluxing different anthranilic acid derivatives with various isothiocyanates in dry acetone medium. The synthesized compounds were purified by crystallization and their purity was determined by TLC method. The structures of the obtained compounds were elucidated by using different spectroscopic methods such as IR, 1H-NMR, 13C-NMR, besides elemental analysis. The inhibitory effects of the compounds against DPPH radical scavenging, α-glucosidase and acetylcholinesterase were investigated by using spectrophotometric method. The results showed that the compounds had moderate radical scavenging activity according to gallic acid (92.25 ± 0.14% at 100 µM) which was used as a reference compound. Compound 5 in the presence of trifluoromethyl group demonstrated the highest α-glucosidase inhibitory effect with 52.26 ± 2.35% at 100 µM. On the other hand, the compounds demonstrated low AChE inhibitory effects compared to galantamine (80.33 ± 0.77% at 100 µM) which was used as a reference compound.

Keywords

Thiourea anthranilic acid DPPH radical scavenging α-glucosidase acetylcholinesterase

References

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There are 51 citations in total.

Details

Primary Language English
Subjects Pharmaceutical Chemistry
Journal Section Articles
Authors

Sevda Türk 0000-0002-4567-6739

Didem Akkaya 0000-0002-0711-951X

Burak Kırılmaz 0009-0003-3585-4997

Ezgi Merve Önal 0009-0004-6814-9845

Burak Barut 0000-0002-7441-8771

Publication Date June 28, 2025
Submission Date August 2, 2024
Acceptance Date September 6, 2024
Published in Issue Year 2024 Volume: 28 Issue: 6

Cite

APA Türk, S., Akkaya, D., Kırılmaz, B., Önal, E. M., et al. (2025). Synthesis, characterization and biological activity potential of some novel thiourea derivatives. Journal of Research in Pharmacy, 28(6), 1911-1920. https://doi.org/10.29228/jrp.864
AMA Türk S, Akkaya D, Kırılmaz B, Önal EM, Barut B. Synthesis, characterization and biological activity potential of some novel thiourea derivatives. J. Res. Pharm. July 2025;28(6):1911-1920. doi:10.29228/jrp.864
Chicago Türk, Sevda, Didem Akkaya, Burak Kırılmaz, Ezgi Merve Önal, and Burak Barut. “Synthesis, Characterization and Biological Activity Potential of Some Novel Thiourea Derivatives”. Journal of Research in Pharmacy 28, no. 6 (July 2025): 1911-20. https://doi.org/10.29228/jrp.864.
EndNote Türk S, Akkaya D, Kırılmaz B, Önal EM, Barut B (July 1, 2025) Synthesis, characterization and biological activity potential of some novel thiourea derivatives. Journal of Research in Pharmacy 28 6 1911–1920.
IEEE S. Türk, D. Akkaya, B. Kırılmaz, E. M. Önal, and B. Barut, “Synthesis, characterization and biological activity potential of some novel thiourea derivatives”, J. Res. Pharm., vol. 28, no. 6, pp. 1911–1920, 2025, doi: 10.29228/jrp.864.
ISNAD Türk, Sevda et al. “Synthesis, Characterization and Biological Activity Potential of Some Novel Thiourea Derivatives”. Journal of Research in Pharmacy 28/6 (July 2025), 1911-1920. https://doi.org/10.29228/jrp.864.
JAMA Türk S, Akkaya D, Kırılmaz B, Önal EM, Barut B. Synthesis, characterization and biological activity potential of some novel thiourea derivatives. J. Res. Pharm. 2025;28:1911–1920.
MLA Türk, Sevda et al. “Synthesis, Characterization and Biological Activity Potential of Some Novel Thiourea Derivatives”. Journal of Research in Pharmacy, vol. 28, no. 6, 2025, pp. 1911-20, doi:10.29228/jrp.864.
Vancouver Türk S, Akkaya D, Kırılmaz B, Önal EM, Barut B. Synthesis, characterization and biological activity potential of some novel thiourea derivatives. J. Res. Pharm. 2025;28(6):1911-20.