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Secondary metabolites from Scabiosa atropurpurea and their antioxidant and xanthine oxidase inhibitory activities

Year 2024, Volume: 28 Issue: 1, 79 - 88, 28.06.2025

Ceren Öztürk Nisa Beril Şen Etil Güzelmeriç , Hasan Kırmızıbekmez

Abstract

Two secoiridoid glycosides, lonicejaposide I (1) and secologanin dimethyl acetal (2), six flavonoids, isoorientin (3) hesperidin (4), apigenin 7-O-neohesperidoside (5), luteolin 7-O-b-D-glucopyranoside (6), kaempferol 3- O-(3'',6''-di-(E)-p-coumaroyl)-b-D-glucopyranoside (7), and kaempferol 3-O-(3''-O-acetyl, 6''-O-(E)-p-coumaroyl)-b-Dglycopyranoside (8), two caffeoylquinic acid derivatives, chlorogenic acid (9) and 3,5-dicaffeoylquinic acid (10) were isolated from the EtOAc and H2O subextracts of the crude MeOH extract prepared from the aerial parts of Scabiosa atropurpurea. Their structures were identified by extensive 1D and 2D NMR experiments as well as ESI-MS analysis. Xanthine oxidase (XO) inhibitory and antioxidant activities of the isolated compounds were evaluated by in vitro tests. Compounds, 3, 5, 6, 9 and 10 showed mild-to-moderate inhibitory effects on XO enzyme. The highest antioxidant activity was found for compound 10 according to results of DPPH, FRAP and CUPRAC assays. This is the first study on the XO inhibitory activities for compounds 1, 2, 5, 7 and 8.

Keywords

Scabiosa atropurpurea secoiridoids flavonoids caffeoylquinic acid derivatives xanthine oxidase inhibitory activity; antioxidant activity

References

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There are 54 citations in total.

Details

Primary Language English
Subjects Pharmacognosy
Journal Section Articles
Authors

Ceren Öztürk 0009-0008-5642-1601

Nisa Beril Şen 0000-0001-8422-8835

Etil Güzelmeriç 0000-0001-9696-3271

Hasan Kırmızıbekmez 0000-0002-6118-8225

Publication Date June 28, 2025
Published in Issue Year 2024 Volume: 28 Issue: 1

Cite

APA Öztürk, C., Şen, N. B., Güzelmeriç, E., Kırmızıbekmez, H. (2025). Secondary metabolites from Scabiosa atropurpurea and their antioxidant and xanthine oxidase inhibitory activities. Journal of Research in Pharmacy, 28(1), 79-88.
AMA Öztürk C, Şen NB, Güzelmeriç E, Kırmızıbekmez H. Secondary metabolites from Scabiosa atropurpurea and their antioxidant and xanthine oxidase inhibitory activities. J. Res. Pharm. June 2025;28(1):79-88.
Chicago Öztürk, Ceren, Nisa Beril Şen, Etil Güzelmeriç, and Hasan Kırmızıbekmez. “Secondary Metabolites from Scabiosa Atropurpurea and Their Antioxidant and Xanthine Oxidase Inhibitory Activities”. Journal of Research in Pharmacy 28, no. 1 (June 2025): 79-88.
EndNote Öztürk C, Şen NB, Güzelmeriç E, Kırmızıbekmez H (June 1, 2025) Secondary metabolites from Scabiosa atropurpurea and their antioxidant and xanthine oxidase inhibitory activities. Journal of Research in Pharmacy 28 1 79–88.
IEEE C. Öztürk, N. B. Şen, E. Güzelmeriç, and H. Kırmızıbekmez, “Secondary metabolites from Scabiosa atropurpurea and their antioxidant and xanthine oxidase inhibitory activities”, J. Res. Pharm., vol. 28, no. 1, pp. 79–88, 2025.
ISNAD Öztürk, Ceren et al. “Secondary Metabolites from Scabiosa Atropurpurea and Their Antioxidant and Xanthine Oxidase Inhibitory Activities”. Journal of Research in Pharmacy 28/1 (June 2025), 79-88.
JAMA Öztürk C, Şen NB, Güzelmeriç E, Kırmızıbekmez H. Secondary metabolites from Scabiosa atropurpurea and their antioxidant and xanthine oxidase inhibitory activities. J. Res. Pharm. 2025;28:79–88.
MLA Öztürk, Ceren et al. “Secondary Metabolites from Scabiosa Atropurpurea and Their Antioxidant and Xanthine Oxidase Inhibitory Activities”. Journal of Research in Pharmacy, vol. 28, no. 1, 2025, pp. 79-88.
Vancouver Öztürk C, Şen NB, Güzelmeriç E, Kırmızıbekmez H. Secondary metabolites from Scabiosa atropurpurea and their antioxidant and xanthine oxidase inhibitory activities. J. Res. Pharm. 2025;28(1):79-88.