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Year 2020, Volume: 24 Issue: 2, 182 - 187, 27.06.2025

Praveen Devanandan Ranadheer Chowdary Puvvada Vijey Aanandhi Muthukumar

https://doi.org/10.35333/jrp.2020.134

Abstract

References

  • [1] Mazloom Z, Hejazi N, Dabbaghmanesh M.H, Tabatabaei H.R, Ahmadi A, Ansar H. Effect of vitamin C supplementation on postprandial oxidative stress and lipid profile in type 2 diabetic patients. Pak J Biol Sci. 2011; 14(19): 900–904. [CrossRef]
  • [2] Prajapat R, Bhattacharya I. Effect of Vitamin E and C Supplementation on Oxidative Stress in Diabetic Patients. Adv Diabet Metabol. 2017; 5(3): 39-42. [CrossRef]
  • [3] Alamdari DH, Paletas K, Pegiou T, Sarigianni M, Befani C, Koliakos GA. A novel assay for the evaluation of the prooxidant-antioxidant balance, before and after antioxidant vitamin administration in type II diabetes patients. Clin Biochem. 2007; 40(3): 248–254. [CrossRef]
  • [4] Das, U. Vitamin C for Type 2 Diabetes Mellitus and Hypertension. Arch Med Res. 2019; 50(2): 11-14. [CrossRef]
  • [5] Bianchi C, Miccoli R, Daniele G, Penno G, Del Prato S. Is there evidence that oral hypoglycemic agents reduce cardiovascular morbidity/mortality? yes. Diabet care. 2009; 32(2): 342–348. [CrossRef]
  • [6] Bishop N, Schorah CJ, Wales JK. The effect of vitamin C supplementation on diabetic hyperlipidaemia: a double blind, crossover study. Diabet Med. 1985; 2(2): 121–124. [CrossRef]
  • [7] Girgis C, Christie-David D, Gunton J. Effects of vitamins C and D in type 2 diabetes mellitus. Nutr Diet Suppl. 2015; 7: 21–28. [CrossRef]
  • [8] Kositsawat J, Freeman VL. Vitamin C and A1c relationship in the National Health and Nutrition Examination Survey (NHANES) 2003–2006. J Am Coll Nutr. 2011; 30: 477–483. [CrossRef]
  • [9] McSorley PT, Bell PM, Young IS, Atkinson AB, Sheridan B, Fee JP, et al. Endothelial function, insulin action and cardiovascular risk factors in young healthy adult offspring of parents with type 2 diabetes: effect of vitamin C in a randomized double-blind, controlled clinical trial. Diabet Med. 2015; 22: 703–710. [CrossRef]
  • [10] Mason SA, Rasmussen B, van Loon L, Salmon J, Wadley G. Ascorbic acid supplementation improves postprandial glycaemic control and blood pressure in individuals with type 2 diabetes: Findings of a randomized cross-over trial. Diab Obes Metab. 2018; 21(3): 674-682. [CrossRef]
  • [11] Zatalia SR, Sanusi H. The role of antioxidants in the pathophysiology, complications, and management of diabetes mellitus. Acta Med. Indones. 2013; 45(2): 141–147.
  • [12] Xu R, Zhang S, Tao A, Chen G, Zhang M. Influence of Vitamin E Supplementation on Glycaemic Control: A Meta-Analysis of Randomised Controlled Trials. PLoS ONE. 2014; 9(4): e95008. [CrossRef]
  • [13] Wilson R, Willis J, Gearry R, Skidmore P, Fleming E, Frampton C et al. Inadequate Vitamin C Status in Prediabetes and Type 2 Diabetes Mellitus: Associations with Glycaemic Control, Obesity, and Smoking. Nutrients. 2017; 9(9): 997. [CrossRef]
  • [14] Srivatsan R, Das S, Gadde R, et al. Antioxidants and lipid peroxidation status in diabetic patients with and without complications. Arch Iran Med. 2009; 12(2): 121–127.
  • [15] Davie SJ, Gould BJ, Yudkin JS. Effect of vitamin C on glycosylation of proteins. Diabetes. 1992; 41(2): 167–173. [CrossRef] [16] Eriksson J, Kohvakka A. Magnesium and ascorbic acid supplementation in diabetes mellitus. Ann Nutr Metab. 1995; 39(4): 217–223. [CrossRef]
  • [17] Sealed Envelope Ltd. 2018. Create a blocked randomisation list. [Online] Available from: https://www.sealedenvelope.com/simple-randomiser/v1/lists [Accessed on 15 Apr 2018].

Effects of vitamin C supplementation on the glycemic control and cardiovascular risk in Type II Diabetes Mellitus

Year 2020, Volume: 24 Issue: 2, 182 - 187, 27.06.2025

Praveen Devanandan Ranadheer Chowdary Puvvada Vijey Aanandhi Muthukumar

https://doi.org/10.35333/jrp.2020.134

Abstract

The oral hypoglycaemic agents as well as injectable insulin does not significantly alter the oxidative stress in the diabetes mellitus patients. Being an antioxidant Vitamin C (ascorbic acid) might help in tackling the adversities of reactive oxygen species. A randomized placebo controlled study was carried out with parallel assignment of both the test group and control group of patients. The intervention model included metformin 500mg twice daily and a placebo once daily for control group. Alternatively, Vitamin C chewable tablets were given for the other group along with metformin 500mg twice daily. Our study postulates that there is a significant reduction in the fasting blood glucose, glycosylated haemoglobin levels, troponin T levels and Framingham risk score in participants who received ascorbic acid supplementation along with regular metformin. The supplementation of Vitamin C along with Metformin was well tolerated and did not cause any serious adverse drug reactions. The cheaper cost adjuvant approach with Vitamin C may be beneficial in patients in reducing the cardiovascular risk as well as to maintain an appropriate glycaemic control

Keywords

Diabetes Mellitus ascorbic acid glycemic control cardiovascular risk

References

  • [1] Mazloom Z, Hejazi N, Dabbaghmanesh M.H, Tabatabaei H.R, Ahmadi A, Ansar H. Effect of vitamin C supplementation on postprandial oxidative stress and lipid profile in type 2 diabetic patients. Pak J Biol Sci. 2011; 14(19): 900–904. [CrossRef]
  • [2] Prajapat R, Bhattacharya I. Effect of Vitamin E and C Supplementation on Oxidative Stress in Diabetic Patients. Adv Diabet Metabol. 2017; 5(3): 39-42. [CrossRef]
  • [3] Alamdari DH, Paletas K, Pegiou T, Sarigianni M, Befani C, Koliakos GA. A novel assay for the evaluation of the prooxidant-antioxidant balance, before and after antioxidant vitamin administration in type II diabetes patients. Clin Biochem. 2007; 40(3): 248–254. [CrossRef]
  • [4] Das, U. Vitamin C for Type 2 Diabetes Mellitus and Hypertension. Arch Med Res. 2019; 50(2): 11-14. [CrossRef]
  • [5] Bianchi C, Miccoli R, Daniele G, Penno G, Del Prato S. Is there evidence that oral hypoglycemic agents reduce cardiovascular morbidity/mortality? yes. Diabet care. 2009; 32(2): 342–348. [CrossRef]
  • [6] Bishop N, Schorah CJ, Wales JK. The effect of vitamin C supplementation on diabetic hyperlipidaemia: a double blind, crossover study. Diabet Med. 1985; 2(2): 121–124. [CrossRef]
  • [7] Girgis C, Christie-David D, Gunton J. Effects of vitamins C and D in type 2 diabetes mellitus. Nutr Diet Suppl. 2015; 7: 21–28. [CrossRef]
  • [8] Kositsawat J, Freeman VL. Vitamin C and A1c relationship in the National Health and Nutrition Examination Survey (NHANES) 2003–2006. J Am Coll Nutr. 2011; 30: 477–483. [CrossRef]
  • [9] McSorley PT, Bell PM, Young IS, Atkinson AB, Sheridan B, Fee JP, et al. Endothelial function, insulin action and cardiovascular risk factors in young healthy adult offspring of parents with type 2 diabetes: effect of vitamin C in a randomized double-blind, controlled clinical trial. Diabet Med. 2015; 22: 703–710. [CrossRef]
  • [10] Mason SA, Rasmussen B, van Loon L, Salmon J, Wadley G. Ascorbic acid supplementation improves postprandial glycaemic control and blood pressure in individuals with type 2 diabetes: Findings of a randomized cross-over trial. Diab Obes Metab. 2018; 21(3): 674-682. [CrossRef]
  • [11] Zatalia SR, Sanusi H. The role of antioxidants in the pathophysiology, complications, and management of diabetes mellitus. Acta Med. Indones. 2013; 45(2): 141–147.
  • [12] Xu R, Zhang S, Tao A, Chen G, Zhang M. Influence of Vitamin E Supplementation on Glycaemic Control: A Meta-Analysis of Randomised Controlled Trials. PLoS ONE. 2014; 9(4): e95008. [CrossRef]
  • [13] Wilson R, Willis J, Gearry R, Skidmore P, Fleming E, Frampton C et al. Inadequate Vitamin C Status in Prediabetes and Type 2 Diabetes Mellitus: Associations with Glycaemic Control, Obesity, and Smoking. Nutrients. 2017; 9(9): 997. [CrossRef]
  • [14] Srivatsan R, Das S, Gadde R, et al. Antioxidants and lipid peroxidation status in diabetic patients with and without complications. Arch Iran Med. 2009; 12(2): 121–127.
  • [15] Davie SJ, Gould BJ, Yudkin JS. Effect of vitamin C on glycosylation of proteins. Diabetes. 1992; 41(2): 167–173. [CrossRef] [16] Eriksson J, Kohvakka A. Magnesium and ascorbic acid supplementation in diabetes mellitus. Ann Nutr Metab. 1995; 39(4): 217–223. [CrossRef]
  • [17] Sealed Envelope Ltd. 2018. Create a blocked randomisation list. [Online] Available from: https://www.sealedenvelope.com/simple-randomiser/v1/lists [Accessed on 15 Apr 2018].
There are 16 citations in total.

Details

Primary Language English
Subjects Pharmacology and Pharmaceutical Sciences (Other)
Journal Section Articles
Authors

Praveen Devanandan

Ranadheer Chowdary Puvvada

Vijey Aanandhi Muthukumar

Publication Date June 27, 2025
Published in Issue Year 2020 Volume: 24 Issue: 2

Cite

APA Devanandan, P., Puvvada, R. C., & Muthukumar, V. A. (2025). Effects of vitamin C supplementation on the glycemic control and cardiovascular risk in Type II Diabetes Mellitus. Journal of Research in Pharmacy, 24(2), 182-187. https://doi.org/10.35333/jrp.2020.134
AMA Devanandan P, Puvvada RC, Muthukumar VA. Effects of vitamin C supplementation on the glycemic control and cardiovascular risk in Type II Diabetes Mellitus. J. Res. Pharm. June 2025;24(2):182-187. doi:10.35333/jrp.2020.134
Chicago Devanandan, Praveen, Ranadheer Chowdary Puvvada, and Vijey Aanandhi Muthukumar. “Effects of Vitamin C Supplementation on the Glycemic Control and Cardiovascular Risk in Type II Diabetes Mellitus”. Journal of Research in Pharmacy 24, no. 2 (June 2025): 182-87. https://doi.org/10.35333/jrp.2020.134.
EndNote Devanandan P, Puvvada RC, Muthukumar VA (June 1, 2025) Effects of vitamin C supplementation on the glycemic control and cardiovascular risk in Type II Diabetes Mellitus. Journal of Research in Pharmacy 24 2 182–187.
IEEE P. Devanandan, R. C. Puvvada, and V. A. Muthukumar, “Effects of vitamin C supplementation on the glycemic control and cardiovascular risk in Type II Diabetes Mellitus”, J. Res. Pharm., vol. 24, no. 2, pp. 182–187, 2025, doi: 10.35333/jrp.2020.134.
ISNAD Devanandan, Praveen et al. “Effects of Vitamin C Supplementation on the Glycemic Control and Cardiovascular Risk in Type II Diabetes Mellitus”. Journal of Research in Pharmacy 24/2 (June 2025), 182-187. https://doi.org/10.35333/jrp.2020.134.
JAMA Devanandan P, Puvvada RC, Muthukumar VA. Effects of vitamin C supplementation on the glycemic control and cardiovascular risk in Type II Diabetes Mellitus. J. Res. Pharm. 2025;24:182–187.
MLA Devanandan, Praveen et al. “Effects of Vitamin C Supplementation on the Glycemic Control and Cardiovascular Risk in Type II Diabetes Mellitus”. Journal of Research in Pharmacy, vol. 24, no. 2, 2025, pp. 182-7, doi:10.35333/jrp.2020.134.
Vancouver Devanandan P, Puvvada RC, Muthukumar VA. Effects of vitamin C supplementation on the glycemic control and cardiovascular risk in Type II Diabetes Mellitus. J. Res. Pharm. 2025;24(2):182-7.