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Synthesis and antimicrobial activity of [1,2,4]triazіno[2,3c]quinazoline – pyrazoline hybrids

Year 2022, Volume: 26 Issue: 1, 28 - 34, 28.06.2025

Inna Nosulenko , Halyna Berest , Dmytro Skoryna , Oleksii Voskoboinik , Sergiy Kovalenko

Abstract

Present manuscript describes the design, synthesis and antimicrobial activity of novel [1,2,4]triazіno[2,3-c]quinazoline – pyrazoline hybrids. The combination of pyrazoline cycle with [1,2,4]triazіno[2,3-c]quinazoline heterocyclic fragment was substantiated as promising approach for development of novel antibacterial and antifungal agents. The simple and effective synthetic procedure for target heterocyclic hybrids was proposed. The structures of obtained compounds were verified by appropriate physicochemical methods, the features of 1H NMR-spectral characteristics were described as well. It was shown that synthesized compounds reveal significant growth inhibitory activity against Candida albicans strain.

Keywords

quinazoline pyrazoline heterocyclic hybrids antimicrobial activity Candida albicans

References

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There are 18 citations in total.

Details

Primary Language English
Subjects Pharmacology and Pharmaceutical Sciences (Other)
Journal Section Articles
Authors

Inna Nosulenko

Halyna Berest

Dmytro Skoryna

Oleksii Voskoboinik

Sergiy Kovalenko

Publication Date June 28, 2025
Published in Issue Year 2022 Volume: 26 Issue: 1

Cite

APA Nosulenko, I., Berest, H., Skoryna, D., Voskoboinik, O., et al. (2025). Synthesis and antimicrobial activity of [1,2,4]triazіno[2,3c]quinazoline – pyrazoline hybrids. Journal of Research in Pharmacy, 26(1), 28-34.
AMA Nosulenko I, Berest H, Skoryna D, Voskoboinik O, Kovalenko S. Synthesis and antimicrobial activity of [1,2,4]triazіno[2,3c]quinazoline – pyrazoline hybrids. J. Res. Pharm. June 2025;26(1):28-34.
Chicago Nosulenko, Inna, Halyna Berest, Dmytro Skoryna, Oleksii Voskoboinik, and Sergiy Kovalenko. “Synthesis and Antimicrobial Activity of [1,2,4]triazіno[2,3c]quinazoline – Pyrazoline Hybrids”. Journal of Research in Pharmacy 26, no. 1 (June 2025): 28-34.
EndNote Nosulenko I, Berest H, Skoryna D, Voskoboinik O, Kovalenko S (June 1, 2025) Synthesis and antimicrobial activity of [1,2,4]triazіno[2,3c]quinazoline – pyrazoline hybrids. Journal of Research in Pharmacy 26 1 28–34.
IEEE I. Nosulenko, H. Berest, D. Skoryna, O. Voskoboinik, and S. Kovalenko, “Synthesis and antimicrobial activity of [1,2,4]triazіno[2,3c]quinazoline – pyrazoline hybrids”, J. Res. Pharm., vol. 26, no. 1, pp. 28–34, 2025.
ISNAD Nosulenko, Inna et al. “Synthesis and Antimicrobial Activity of [1,2,4]triazіno[2,3c]quinazoline – Pyrazoline Hybrids”. Journal of Research in Pharmacy 26/1 (June 2025), 28-34.
JAMA Nosulenko I, Berest H, Skoryna D, Voskoboinik O, Kovalenko S. Synthesis and antimicrobial activity of [1,2,4]triazіno[2,3c]quinazoline – pyrazoline hybrids. J. Res. Pharm. 2025;26:28–34.
MLA Nosulenko, Inna et al. “Synthesis and Antimicrobial Activity of [1,2,4]triazіno[2,3c]quinazoline – Pyrazoline Hybrids”. Journal of Research in Pharmacy, vol. 26, no. 1, 2025, pp. 28-34.
Vancouver Nosulenko I, Berest H, Skoryna D, Voskoboinik O, Kovalenko S. Synthesis and antimicrobial activity of [1,2,4]triazіno[2,3c]quinazoline – pyrazoline hybrids. J. Res. Pharm. 2025;26(1):28-34.