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The Microencapsulation of Oregano Extract by Using Different Techniques: Spray-Drying and Freeze-Drying Techniques and Their In Vitro Characterization

Year 2022, Volume: 26 Issue: 1, 102 - 111, 28.06.2025

Juste Baranauskaıte Ortasöz , Burcu Üner Gülengül Duman , Çetin Taş

Abstract

The potential antimicrobial and antioxidant benefit of high levels of ursolic, rosmarinic acids and carvacrol in oregano extract has been limited until now by poor bioavailability arising from the low aqueous-phase solubility and slow dissolution behavior of the freeze-dried extract. To address this issue, microencapsulation technique had been used to solve above mentioned problems and to protect active substances from deteriorating due to environmental conditions, such as moisture, oxidation. The experimental settings were performed by statistical mixture experimental design. Moreover, microcapsules and freeze-dried extract were compared to ascertain the merit of microcapsules as a carriers for these poorly aqueous-soluble compounds. When the wall material solution contained 1.43 g of maltodextrin, 4.17 g of gum arabic, 14.39 g of modified starch, and 20 g of ethanol oregano extract, the yield of oregano’s active compounds, ursolic, rosmarinic acids and carvacrol, were 0.98 mg/g, 3.38 mg/g and 3.38 mg/g respectively. In particular, the release profile of ursolic, rosmarinic acids and carvacrol had levelled off after 15 minutes, depicting an impressive 2.7- 3.0 fold increase compared to the freeze-dried control extract. The results imply that all actives can be conveniently delivered via oral and mucosal routes by first internalizing oregano extracts into appropriately engineered microcapsules.

Keywords

Microencapsulation spray-drying freeze-drying Oregano in vitro dissolution data

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There are 28 citations in total.

Details

Primary Language English
Subjects Pharmaceutical Sciences
Journal Section Articles
Authors

Juste Baranauskaıte Ortasöz

Burcu Üner

Gülengül Duman

Çetin Taş

Publication Date June 28, 2025
Published in Issue Year 2022 Volume: 26 Issue: 1

Cite

APA Baranauskaıte Ortasöz, J., Üner, B., Duman, G., Taş, Ç. (2025). The Microencapsulation of Oregano Extract by Using Different Techniques: Spray-Drying and Freeze-Drying Techniques and Their In Vitro Characterization. Journal of Research in Pharmacy, 26(1), 102-111.
AMA Baranauskaıte Ortasöz J, Üner B, Duman G, Taş Ç. The Microencapsulation of Oregano Extract by Using Different Techniques: Spray-Drying and Freeze-Drying Techniques and Their In Vitro Characterization. J. Res. Pharm. June 2025;26(1):102-111.
Chicago Baranauskaıte Ortasöz, Juste, Burcu Üner, Gülengül Duman, and Çetin Taş. “The Microencapsulation of Oregano Extract by Using Different Techniques: Spray-Drying and Freeze-Drying Techniques and Their In Vitro Characterization”. Journal of Research in Pharmacy 26, no. 1 (June 2025): 102-11.
EndNote Baranauskaıte Ortasöz J, Üner B, Duman G, Taş Ç (June 1, 2025) The Microencapsulation of Oregano Extract by Using Different Techniques: Spray-Drying and Freeze-Drying Techniques and Their In Vitro Characterization. Journal of Research in Pharmacy 26 1 102–111.
IEEE J. Baranauskaıte Ortasöz, B. Üner, G. Duman, and Ç. Taş, “The Microencapsulation of Oregano Extract by Using Different Techniques: Spray-Drying and Freeze-Drying Techniques and Their In Vitro Characterization”, J. Res. Pharm., vol. 26, no. 1, pp. 102–111, 2025.
ISNAD Baranauskaıte Ortasöz, Juste et al. “The Microencapsulation of Oregano Extract by Using Different Techniques: Spray-Drying and Freeze-Drying Techniques and Their In Vitro Characterization”. Journal of Research in Pharmacy 26/1 (June 2025), 102-111.
JAMA Baranauskaıte Ortasöz J, Üner B, Duman G, Taş Ç. The Microencapsulation of Oregano Extract by Using Different Techniques: Spray-Drying and Freeze-Drying Techniques and Their In Vitro Characterization. J. Res. Pharm. 2025;26:102–111.
MLA Baranauskaıte Ortasöz, Juste et al. “The Microencapsulation of Oregano Extract by Using Different Techniques: Spray-Drying and Freeze-Drying Techniques and Their In Vitro Characterization”. Journal of Research in Pharmacy, vol. 26, no. 1, 2025, pp. 102-11.
Vancouver Baranauskaıte Ortasöz J, Üner B, Duman G, Taş Ç. The Microencapsulation of Oregano Extract by Using Different Techniques: Spray-Drying and Freeze-Drying Techniques and Their In Vitro Characterization. J. Res. Pharm. 2025;26(1):102-11.