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Reduction of salivary tumor necrosis factor alpha levels in response to magic mouthwash with Curcuma xanthorriza in cancer patients undergoing chemotherapy

Year 2019, Volume: 23 Issue: 1, 55 - 61, 27.06.2025

Irna Sufiawati , Indra Gunawan Indra Wijaya Taofik Rusdiana Anas Subarnas

Abstract

Tumor necrosis factor-alpha (TNF-α) is pro-inflammatory cytokine that play a key role in initiating and accelerating the development of oral mucositis in cancer patients undergoing chemotherapy. Mixed medication mouthwash called magic mouthwash has been widely used to prevent and treat oral mucositis. Curcuma xanthorriza is a traditional herbal medicine, which has shown anti-inflammatory, antibacterial, and antifungal effects. The aim of this study was to evaluate the effect of magic mouthwash with Curcuma xanthorriza on salivary TNF-α levels in cancer patients undergoing chemotherapy. The magic mouthwash formulation used in this study contains diphenhydramine, hydrocortisone, nystatin and dry curcuma extract. This study involved 60 cancer patients undergoing 5-Fluorouracil (5 FU)-based chemotherapy who were assigned into two groups, each group consisted of 30 patients. Group 1 instructed for rinsing with magic mouthwash with Curcuma xanthorriza and group 2 rinsed with NaCl 0.9% as control group. Unstimulated whole saliva was collected before and after oral rinsing with mouthwashes. Salivary TNF-α levels were measured with enzyme linked immunosorbent assay (ELISA). Data were analyzed statistically with Wilcoxon and Chi square test. The result of this study showed a significant decrease in salivary TNF-α levels on both groups (p<0.05). In the study group, more patients were found with salivary TNF-α levels decreased (74.2%) compared to control group (53.5%) and showed significant difference statistically (p<0.05). The study concludes that magic mouthwash with Curcuma xanthorriza can reduce Salivary TNF-α levels and can be used as an alternative therapy for oral mucositis induced chemotherapy.

Keywords

Chemotherapy Curcuma xanthorriza magic mouthwash salivary TNF-α

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There are 29 citations in total.

Details

Primary Language English
Subjects Pharmaceutical Sciences
Journal Section Articles
Authors

Irna Sufiawati

Indra Gunawan

Indra Wijaya

Taofik Rusdiana

Anas Subarnas

Publication Date June 27, 2025
Published in Issue Year 2019 Volume: 23 Issue: 1

Cite

APA Sufiawati, I., Gunawan, I., Wijaya, I., Rusdiana, T., et al. (2025). Reduction of salivary tumor necrosis factor alpha levels in response to magic mouthwash with Curcuma xanthorriza in cancer patients undergoing chemotherapy. Journal of Research in Pharmacy, 23(1), 55-61.
AMA Sufiawati I, Gunawan I, Wijaya I, Rusdiana T, Subarnas A. Reduction of salivary tumor necrosis factor alpha levels in response to magic mouthwash with Curcuma xanthorriza in cancer patients undergoing chemotherapy. J. Res. Pharm. June 2025;23(1):55-61.
Chicago Sufiawati, Irna, Indra Gunawan, Indra Wijaya, Taofik Rusdiana, and Anas Subarnas. “Reduction of Salivary Tumor Necrosis Factor Alpha Levels in Response to Magic Mouthwash With Curcuma Xanthorriza in Cancer Patients Undergoing Chemotherapy”. Journal of Research in Pharmacy 23, no. 1 (June 2025): 55-61.
EndNote Sufiawati I, Gunawan I, Wijaya I, Rusdiana T, Subarnas A (June 1, 2025) Reduction of salivary tumor necrosis factor alpha levels in response to magic mouthwash with Curcuma xanthorriza in cancer patients undergoing chemotherapy. Journal of Research in Pharmacy 23 1 55–61.
IEEE I. Sufiawati, I. Gunawan, I. Wijaya, T. Rusdiana, and A. Subarnas, “Reduction of salivary tumor necrosis factor alpha levels in response to magic mouthwash with Curcuma xanthorriza in cancer patients undergoing chemotherapy”, J. Res. Pharm., vol. 23, no. 1, pp. 55–61, 2025.
ISNAD Sufiawati, Irna et al. “Reduction of Salivary Tumor Necrosis Factor Alpha Levels in Response to Magic Mouthwash With Curcuma Xanthorriza in Cancer Patients Undergoing Chemotherapy”. Journal of Research in Pharmacy 23/1 (June 2025), 55-61.
JAMA Sufiawati I, Gunawan I, Wijaya I, Rusdiana T, Subarnas A. Reduction of salivary tumor necrosis factor alpha levels in response to magic mouthwash with Curcuma xanthorriza in cancer patients undergoing chemotherapy. J. Res. Pharm. 2025;23:55–61.
MLA Sufiawati, Irna et al. “Reduction of Salivary Tumor Necrosis Factor Alpha Levels in Response to Magic Mouthwash With Curcuma Xanthorriza in Cancer Patients Undergoing Chemotherapy”. Journal of Research in Pharmacy, vol. 23, no. 1, 2025, pp. 55-61.
Vancouver Sufiawati I, Gunawan I, Wijaya I, Rusdiana T, Subarnas A. Reduction of salivary tumor necrosis factor alpha levels in response to magic mouthwash with Curcuma xanthorriza in cancer patients undergoing chemotherapy. J. Res. Pharm. 2025;23(1):55-61.