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Year 2021, Volume: 25 Issue: 1, 1 - 12, 27.06.2025

Seda Rençber , Ece Özcan Bülbül Neslihan Üstündağ , Zeynep Senyiğit

https://doi.org/10.35333/jrp.2021.291
Cited By: 4

Abstract

References

  • Üstündağ Okur N, Yozgatlı V, Okur ME, Yoltaş A, Siafaka PI. Improving Therapeutic Efficacy of Voriconazole Against Fungal Keratitis: Thermo-Sensitive In Situ Gels as Ophthalmic Drug Carriers. J Drug Deliv Sci Technol. 2019; 49: 323–333. [CrossRef]
  • Üstündaǧ Okur N, Yoltas A, Yozgatli V. Development and Characterization of Voriconazole Loaded In Situ Gel Formulations for Ophthalmic Application. Turkish J Pharm Sci. 2016; 13: 311–317. [CrossRef]
  • Okur ME, Ayla Ş, Batur Ş, Yoltaş A, Genç E, Pertek S, et al. Evaluation of In Situ Gel Containing Pycnogenol for Cutaneous Wound Healing. Medeniyet Med J. 2019; 34: 67–75.[CrossRef]
  • Aksu NB, Yozgatlı V, Okur ME, Ayla Ş, Yoltaş A, Üstündağ Okur N. Preparation and Evaluation of QbD Based Fusidic Acid Loaded In Situ Gel Formulations for Burn Wound Treatment. J Drug Deliv Sci Technol. 2019; 52: 110– 121.[CrossRef]
  • The International Pharmacopoeia - Ninth Edition - Ophthalmic Preparations. 2019. Sandle T. Sterile Ophthalmic Preparations and Contamination Control. J GXP Compliance. 2014; 18(3). Brun-Graeppi AKAS, Richard C, Bessodes M, Scherman D, Narita T, Ducouret G, et al. The Effect of Sterilization Methods on the Thermo-Gelation Properties of Xyloglucan Hydrogels. Polym Degrad Stab. 2010; 95(2): 254–259. [CrossRef]
  • Cooper RC, Yang H. Hydrogel-Based Ocular Drug Delivery Systems: Emerging Fabrication Strategies,Applications, and Bench-to-Bedside Manufacturing Considerations. J Control Release. 2019; 306: 29–39. [CrossRef]
  • Aldrich DS, Bach CM, Brown W, Chambers W, Fleitman J, Hunt D, et al. Ophthalmic Preparations. Stimuli to Revis Process. 2013; 39(5): 1–21. Imperiale JC, Acosta GB, Sosnik A. Polymer-Based Carriers for Ophthalmic Drug Delivery. J Control Release. 2018; 285: 106–141. [CrossRef]
  • Galante R, Pinto TJA, Colaço R, Serro AP. Sterilization of Hydrogels for Biomedical Applications: A Review. J Biomed Res. 2018; 106(6): 2472–2492. [12] Soliman KA, Ullah K, Shah A, Jones DS, Singh TRR. Poloxamer-Based In Situ Gelling Thermoresponsive Systems for Ocular Drug Delivery Applications. Drug Discov Today. 2019; 24(8): 1575–1586. [CrossRef]
  • Lihong W, Xin C, Yongxue G, Yiying B, Gang C. Thermoresponsive Ophthalmic Poloxamer/Tween/Carbopol In Situ Gels of a Poorly Water-Soluble Drug Fluconazole: Preparation and In Vitro – In Vivo Evaluation. Drug Dev Ind Pharm. 2014; 40: 1402–1410.[CrossRef
  • Asasutjarit R, Thanasanchokpibull S, Fuongfuchat A, Veeranondha S. Optimization and Evaluation of Thermoresponsive Diclofenac Sodium Ophthalmic In Situ Gels. Int J Pharm. 2011; 411(1-2): 128–135. [CrossRef]
  • Tayel SA, El-Nabarawi MA, Tadros MI, Abd-Elsalam WH. Promising Ion-Sensitive In Situ Ocular Nanoemulsion Gels of Terbinafine Hydrochloride: Design, In Vitro Characterization and In Vivo Estimation of the Ocular Irritation and Drug Pharmacokinetics in the Aqueous Humor of Rabbits. Int J Pharm. 2013; 443(1-2): 293–305. [CrossRef]
  • Burak J, Grela KP, Pluta J, Karolewicz B, Marciniak DM. Impact of Sterilisation Conditions the Rheological Properties of Thermoresponsive Pluronic F-127-Based Gels for the Ophthalmic Use. Acta Pol Pharm - Drug Res 2018; 75(2): 471–481. [17] Ni J, Guo M, Cao Y, Lei L, Liu K, Wang B, et al. Discovery, Synthesis of Novel Fusidic Acid Derivatives Possessed Amino-Terminal Groups at the 3-Hydroxyl Position with Anticancer Activity. Eur J Med Chem. 2019; 162: 122–131. [CrossRef]
  • Akinpelu OI, Lawal MM, Kumalo HM, Mhlongo NN. Drug Repurposing : Fusidic Acid as a Potential Inhibitor of M . Tuberculosis FtsZ Polymerization – Insight from DFT Calculations , Molecular Docking and Molecular Dynamics Simulations. Tuberculosis. 2020; 121: 101920. [CrossRef]
  • Okur ME, Ayla Ş, Yozgatlı V, Aksu NB, Yoltaş A, Orak D, et al. Evaluation of Burn Wound Healing Activity of Novel Fusidic Acid Loaded Microemulsion Based Gel in Male Wistar Albino Rats. Saudi Pharm J. 2020; 28: 338–348. [CrossRef]
  • Biedenbach DJ, Rhomberg PR, Mendes RE, Jones RN. Spectrum of Activity, Mutation Rates, Synergistic Interactions, and the Effects of pH and Serum Proteins for Fusidic Acid (CEM-102). Diagn Microbiol Infect Dis. 2010; 66(3): 301–307. [CrossRef]
  • Bochot A, Fattal E, Grossiord JL, Puisieux F, Couvreur P. Characterization of a New Ocular Delivery System Based on a Dispersion of Liposomes in a Thermosensitive Gel. Int J Pharm. 1998; 162: 119–127. [CrossRef]
  • Youssef NAHA, Kassem AA, Farid RM, Ismail FA, EL-Massik MAE, Boraie NA. A Novel Nasal Almotriptan Loaded Solid Lipid Nanoparticles in Mucoadhesive In Situ Gel Formulation for Brain Targeting: Preparation, Characterization and In Vivo Evaluation. Int J Pharm. 2018; 548: 609–624. [CrossRef]
  • Pagano C, Giovagnoli S, Perioli L, Tiralti MC, Ricci M. Development and Characterization of Mucoadhesive- Thermoresponsive Gels for The Treatment of Oral Mucosa Diseases. Eur J Pharm Sci. 2020; 142: 105125. [CrossRef]
  • Makwana SB, Patel VA, Parmar SJ. Development and Characterization of In-Situ Gel for Ophthalmic Formulation Containing Ciprofloxacin Hydrochloride. Results Pharma Sci. 2016; 6: 1–6. [CrossRef]
  • Pawar SD, Pawar RG, Gadhave M V., Jadhav SL, Gaikwad DD. Controlled Release In Situ Forming Gatifloxacin HCL Hydrogel for Ophthalmic Drug Delivery. Int Res J Pharm. 2012; 3: 86–89.
  • Patel N, Thakkar V, Metalia V, Baldaniya L, Gandhi T, Gohel M. Formulation and Development of Ophthalmic In Situ Gel for the Treatment Ocular Inflammation and Infection Using Application of Quality by Design Concept. Drug Dev Ind Pharm. 2016; 42: 1406–1423.[CrossRef]
  • Güven UM, Berkman MS, Şenel B, Yazan Y. Development and In Vitro/In Vivo Evaluation of Thermo-Sensitive In Situ Gelling Systems for Ocular Allergy. Brazilian J Pharm Sci. 2019; 55: 1–11. [CrossRef]
  • Karatas A, Boluk A, Hilal Algan A. Poloxamer/Chitosan In Situ Gelling System for Ocular Delivery of Ofloxacin. Curr Drug Ther. 2014; 9(4): 219–225. [CrossRef]
  • Yu ZG, Geng ZX, Liu TF, Jiang F. In Vitro and In Vivo Evaluation of an In Situ Forming Gel System for Sustained Delivery of Florfenicol. J Vet Pharmacol Ther. 2015; 38: 271–277.
  • Li L, Guo D, Guo J, Song J, Wu Q, Liu D, et al. Thermosensitive In-Situ Forming Gels for Ophthalmic Delivery of Tea Polyphenols. J Drug Deliv Sci Technol. 2018; 46: 243–250.[CrossRef].
  • Rençber S, Karavana SY, Şenyiğit ZA, Eraç B, Limoncu MH, Baloğlu E. Mucoadhesive In Situ Gel Formulation for Vaginal Delivery of Clotrimazole: Formulation, Preparation, and In Vitro/In Vivo Evaluation. Pharm Dev Technol. 2017; 22(4): 551–561. [CrossRef]
  • Chang JY, Oh YK, Choi H gon, Kim YB, Kim CK. Rheological Evaluation of Thermosensitive and Mucoadhesive Vaginal Gels in Physiological Conditions. Int J Pharm. 2002; 241(1): 155–163. [CrossRef]
  • Kaur H, Loyee S, Garg R. Formulation and Evaluation of In-Situ Ocular Gel of Gatifloxacin. Int J Pharma Res Heal Sci. 2016;4(5):1365–1370. [CrossRef]
  • Mandal S, Thimmasetty MK, Prabhushankar G, MS G. Formulation and Evaluation of an In Situ Gel-Forming Ophthalmic Formulation of Moxifloxacin Hydrochloride. Int J Pharm Investig. 2012; 2(2): 78–82. [CrossRef]
  • Swain GP, Patel S, Gandhi J, Shah P. Development of Moxifloxacin Hydrochloride Loaded In-Situ Gel for the Treatment of Periodontitis: In-Vitro Drug Release Study and Antibacterial Activity. J Oral Biol Craniofacial Res. 2019; 9(3): 190–200. [CrossRef]
  • Baloglu E, Karavana SY, Senyigit ZA, Guneri T. Rheological and Mechanical Properties of Poloxamer Mixtures as a Mucoadhesive Gel Base. Pharm Dev Technol. 2011; 16(6): 627–636. [CrossRef]
  • Baloglu E, Karavana SY, Senyigit ZA, Hilmioglu-Polat S, Metin DY, Zekioglu O, et al. In-Situ Gel Formulations of Econazole Nitrate: Preparation and In-Vitro and In-Vivo Evaluation. J Pharm Pharmacol. 2011; 63: 1274–1282. [CrossRef]
  • Abouhussein DMN, Khattab A, Bayoumi NA, Mahmoud AF, Sakr TM. Brain Targeted Rivastigmine Mucoadhesive Thermosensitive In Situ Gel: Optimization, In Vitro Evaluation, Radiolabeling, In Vivo Pharmacokinetics and Biodistribution. J Drug Deliv Sci Technol. 2018; 43: 129–140. [CrossRef]
  • Siafaka P, Okur ME, Ayla Ş, Er S, Cağlar EŞ, Okur NÜ. Design and Characterization of Nanocarriers Loaded with Levofloxacin for Enhanced Antimicrobial Activity; Physicochemical Properties, In Vitro Release and Oral Acute Toxicity. Brazilian J Pharm Sci. 2019; 55: 1–13. [CrossRef]
  • Bilensoy E, Rouf MA, Vural I, Şen M, Hıncal AA. Mucoadhesive, Thermosensitive, Prolonged-Release Vaginal Gel for Clotrimazole : β-Cyclodextrin Complex. AAPS PharmSciTech. 2006; 7(2): 1–7. [CrossRef]
  • Choi HG, Jung JH, Ryu JM, Yoon SJ, Oh YK, Kim CK. Development of In Situ-Gelling and Mucoadhesive Acetaminophen Liquid Suppository. Int J Pharm .1998; 165(1): 33–44. [CrossRef]
  • Jones DS, Woolfson AD, Djokic J. Texture Profile Analysis of Bioadhesive Polymeric Semisolids: Mechanical Characterization and Investigation of Interactions Between Formulation Components. J Appl Polym Sci. 1996;61(12): 2229–2234. [CrossRef]
  • Üstündaǧ-Okur N, Gökçe EH, Bozbiyik DI, Eǧrilmez S, Özer Ö, Ertan G. Preparation and In Vitro-In Vivo Evaluation of Ofloxacin Loaded Ophthalmic Nano Structured Lipid Carriers Modified with Chitosan Oligosaccharide Lactate for the Treatment of Bacterial Keratitis. Eur J Pharm Sci. 2014; 63: 204–215. [CrossRef]
  • [Özcan Bülbül E, Mesut B, Cevher E, Öztaş E, Özsoy Y. Product Transfer from Lab-Scale to Pilot-Scale of Quetiapine Fumarate Orodispersible Films Using Quality by Design Approach. J Drug Deliv Sci Technol. 2019; 54: 101358. [CrossRef]
  • Dash S, Murthy PN, Nath L, Chowdhury P. Kinetic Modeling on Drug Release from Controlled Drug Delivery Systems. Acta Pol Pharm - Drug Res. 2010; 67: 217–223.
  • Aksu B, Yurdasiper A, Ege MA, Okur NÜ, Karasulu HY. Development and Comparative Evaluation of Extended Release Indomethacin Capsules. African J Pharm Pharmacol. 2013; 7(30): 2201–2209.
  • Costa P, Lobo JMS. Modeling and Comparison of Dissolution Profiles. Eur J Pharm Sci. 2001; 13(2): 123–133. [CrossRef]
  • Üstündağ Okur N, Filippousi M, Okur ME, Ayla Ş, Çağlar EŞ, Yoltaş A, et al. A Novel Approach for Skin Infections: Controlled Release Topical Mats of Poly(Lactic Acid)/Poly(Ethylene Succinate) Blends Containing Voriconazole. J Drug Deliv Sci Technol. 2018; 46: 74–86. [CrossRef]

Preparation and detailed characterization of fusidic acid loaded in situ gel formulations for ophthalmic application

Year 2021, Volume: 25 Issue: 1, 1 - 12, 27.06.2025

Seda Rençber , Ece Özcan Bülbül Neslihan Üstündağ , Zeynep Senyiğit

https://doi.org/10.35333/jrp.2021.291
Cited By: 4

Abstract

This study aimed to assess the potential usage of fusidic acid in situ ocular gels for bacterial conjunctivitis treatment. The in situ gelling systems were applied to improve the bioavailability and residence time of fusidic acid in the ocular mucosa. Temperature-triggered in situ ocular gel formulations were prepared by the cold method with Poloxamer 407 and sodium carboxymethyl cellulose. The in situ gels were evaluated for pH, clarity, gelation temperature, rheological properties, mechanical properties, and in vitro drug release. The gelation temperatures of fusidic acid loaded the formulations were between 29–33°C. All prepared in situ gels showed non- Newtonian pseudoplastic flow (shear thinning system) like tear fluid at 32 ± 0.1ºC. The results of in vitro dissolution studies showed that at least 65% of fusidic acid released in 12 hours. As a result of this study, it was concluded that fusidic acid loaded in situ gels might be offered as a promising ocular tool for the treatment of bacterial conjunctivitis.

Keywords

Fusidic acid in situ gel poloxamer NaCMC ocular

References

  • Üstündağ Okur N, Yozgatlı V, Okur ME, Yoltaş A, Siafaka PI. Improving Therapeutic Efficacy of Voriconazole Against Fungal Keratitis: Thermo-Sensitive In Situ Gels as Ophthalmic Drug Carriers. J Drug Deliv Sci Technol. 2019; 49: 323–333. [CrossRef]
  • Üstündaǧ Okur N, Yoltas A, Yozgatli V. Development and Characterization of Voriconazole Loaded In Situ Gel Formulations for Ophthalmic Application. Turkish J Pharm Sci. 2016; 13: 311–317. [CrossRef]
  • Okur ME, Ayla Ş, Batur Ş, Yoltaş A, Genç E, Pertek S, et al. Evaluation of In Situ Gel Containing Pycnogenol for Cutaneous Wound Healing. Medeniyet Med J. 2019; 34: 67–75.[CrossRef]
  • Aksu NB, Yozgatlı V, Okur ME, Ayla Ş, Yoltaş A, Üstündağ Okur N. Preparation and Evaluation of QbD Based Fusidic Acid Loaded In Situ Gel Formulations for Burn Wound Treatment. J Drug Deliv Sci Technol. 2019; 52: 110– 121.[CrossRef]
  • The International Pharmacopoeia - Ninth Edition - Ophthalmic Preparations. 2019. Sandle T. Sterile Ophthalmic Preparations and Contamination Control. J GXP Compliance. 2014; 18(3). Brun-Graeppi AKAS, Richard C, Bessodes M, Scherman D, Narita T, Ducouret G, et al. The Effect of Sterilization Methods on the Thermo-Gelation Properties of Xyloglucan Hydrogels. Polym Degrad Stab. 2010; 95(2): 254–259. [CrossRef]
  • Cooper RC, Yang H. Hydrogel-Based Ocular Drug Delivery Systems: Emerging Fabrication Strategies,Applications, and Bench-to-Bedside Manufacturing Considerations. J Control Release. 2019; 306: 29–39. [CrossRef]
  • Aldrich DS, Bach CM, Brown W, Chambers W, Fleitman J, Hunt D, et al. Ophthalmic Preparations. Stimuli to Revis Process. 2013; 39(5): 1–21. Imperiale JC, Acosta GB, Sosnik A. Polymer-Based Carriers for Ophthalmic Drug Delivery. J Control Release. 2018; 285: 106–141. [CrossRef]
  • Galante R, Pinto TJA, Colaço R, Serro AP. Sterilization of Hydrogels for Biomedical Applications: A Review. J Biomed Res. 2018; 106(6): 2472–2492. [12] Soliman KA, Ullah K, Shah A, Jones DS, Singh TRR. Poloxamer-Based In Situ Gelling Thermoresponsive Systems for Ocular Drug Delivery Applications. Drug Discov Today. 2019; 24(8): 1575–1586. [CrossRef]
  • Lihong W, Xin C, Yongxue G, Yiying B, Gang C. Thermoresponsive Ophthalmic Poloxamer/Tween/Carbopol In Situ Gels of a Poorly Water-Soluble Drug Fluconazole: Preparation and In Vitro – In Vivo Evaluation. Drug Dev Ind Pharm. 2014; 40: 1402–1410.[CrossRef
  • Asasutjarit R, Thanasanchokpibull S, Fuongfuchat A, Veeranondha S. Optimization and Evaluation of Thermoresponsive Diclofenac Sodium Ophthalmic In Situ Gels. Int J Pharm. 2011; 411(1-2): 128–135. [CrossRef]
  • Tayel SA, El-Nabarawi MA, Tadros MI, Abd-Elsalam WH. Promising Ion-Sensitive In Situ Ocular Nanoemulsion Gels of Terbinafine Hydrochloride: Design, In Vitro Characterization and In Vivo Estimation of the Ocular Irritation and Drug Pharmacokinetics in the Aqueous Humor of Rabbits. Int J Pharm. 2013; 443(1-2): 293–305. [CrossRef]
  • Burak J, Grela KP, Pluta J, Karolewicz B, Marciniak DM. Impact of Sterilisation Conditions the Rheological Properties of Thermoresponsive Pluronic F-127-Based Gels for the Ophthalmic Use. Acta Pol Pharm - Drug Res 2018; 75(2): 471–481. [17] Ni J, Guo M, Cao Y, Lei L, Liu K, Wang B, et al. Discovery, Synthesis of Novel Fusidic Acid Derivatives Possessed Amino-Terminal Groups at the 3-Hydroxyl Position with Anticancer Activity. Eur J Med Chem. 2019; 162: 122–131. [CrossRef]
  • Akinpelu OI, Lawal MM, Kumalo HM, Mhlongo NN. Drug Repurposing : Fusidic Acid as a Potential Inhibitor of M . Tuberculosis FtsZ Polymerization – Insight from DFT Calculations , Molecular Docking and Molecular Dynamics Simulations. Tuberculosis. 2020; 121: 101920. [CrossRef]
  • Okur ME, Ayla Ş, Yozgatlı V, Aksu NB, Yoltaş A, Orak D, et al. Evaluation of Burn Wound Healing Activity of Novel Fusidic Acid Loaded Microemulsion Based Gel in Male Wistar Albino Rats. Saudi Pharm J. 2020; 28: 338–348. [CrossRef]
  • Biedenbach DJ, Rhomberg PR, Mendes RE, Jones RN. Spectrum of Activity, Mutation Rates, Synergistic Interactions, and the Effects of pH and Serum Proteins for Fusidic Acid (CEM-102). Diagn Microbiol Infect Dis. 2010; 66(3): 301–307. [CrossRef]
  • Bochot A, Fattal E, Grossiord JL, Puisieux F, Couvreur P. Characterization of a New Ocular Delivery System Based on a Dispersion of Liposomes in a Thermosensitive Gel. Int J Pharm. 1998; 162: 119–127. [CrossRef]
  • Youssef NAHA, Kassem AA, Farid RM, Ismail FA, EL-Massik MAE, Boraie NA. A Novel Nasal Almotriptan Loaded Solid Lipid Nanoparticles in Mucoadhesive In Situ Gel Formulation for Brain Targeting: Preparation, Characterization and In Vivo Evaluation. Int J Pharm. 2018; 548: 609–624. [CrossRef]
  • Pagano C, Giovagnoli S, Perioli L, Tiralti MC, Ricci M. Development and Characterization of Mucoadhesive- Thermoresponsive Gels for The Treatment of Oral Mucosa Diseases. Eur J Pharm Sci. 2020; 142: 105125. [CrossRef]
  • Makwana SB, Patel VA, Parmar SJ. Development and Characterization of In-Situ Gel for Ophthalmic Formulation Containing Ciprofloxacin Hydrochloride. Results Pharma Sci. 2016; 6: 1–6. [CrossRef]
  • Pawar SD, Pawar RG, Gadhave M V., Jadhav SL, Gaikwad DD. Controlled Release In Situ Forming Gatifloxacin HCL Hydrogel for Ophthalmic Drug Delivery. Int Res J Pharm. 2012; 3: 86–89.
  • Patel N, Thakkar V, Metalia V, Baldaniya L, Gandhi T, Gohel M. Formulation and Development of Ophthalmic In Situ Gel for the Treatment Ocular Inflammation and Infection Using Application of Quality by Design Concept. Drug Dev Ind Pharm. 2016; 42: 1406–1423.[CrossRef]
  • Güven UM, Berkman MS, Şenel B, Yazan Y. Development and In Vitro/In Vivo Evaluation of Thermo-Sensitive In Situ Gelling Systems for Ocular Allergy. Brazilian J Pharm Sci. 2019; 55: 1–11. [CrossRef]
  • Karatas A, Boluk A, Hilal Algan A. Poloxamer/Chitosan In Situ Gelling System for Ocular Delivery of Ofloxacin. Curr Drug Ther. 2014; 9(4): 219–225. [CrossRef]
  • Yu ZG, Geng ZX, Liu TF, Jiang F. In Vitro and In Vivo Evaluation of an In Situ Forming Gel System for Sustained Delivery of Florfenicol. J Vet Pharmacol Ther. 2015; 38: 271–277.
  • Li L, Guo D, Guo J, Song J, Wu Q, Liu D, et al. Thermosensitive In-Situ Forming Gels for Ophthalmic Delivery of Tea Polyphenols. J Drug Deliv Sci Technol. 2018; 46: 243–250.[CrossRef].
  • Rençber S, Karavana SY, Şenyiğit ZA, Eraç B, Limoncu MH, Baloğlu E. Mucoadhesive In Situ Gel Formulation for Vaginal Delivery of Clotrimazole: Formulation, Preparation, and In Vitro/In Vivo Evaluation. Pharm Dev Technol. 2017; 22(4): 551–561. [CrossRef]
  • Chang JY, Oh YK, Choi H gon, Kim YB, Kim CK. Rheological Evaluation of Thermosensitive and Mucoadhesive Vaginal Gels in Physiological Conditions. Int J Pharm. 2002; 241(1): 155–163. [CrossRef]
  • Kaur H, Loyee S, Garg R. Formulation and Evaluation of In-Situ Ocular Gel of Gatifloxacin. Int J Pharma Res Heal Sci. 2016;4(5):1365–1370. [CrossRef]
  • Mandal S, Thimmasetty MK, Prabhushankar G, MS G. Formulation and Evaluation of an In Situ Gel-Forming Ophthalmic Formulation of Moxifloxacin Hydrochloride. Int J Pharm Investig. 2012; 2(2): 78–82. [CrossRef]
  • Swain GP, Patel S, Gandhi J, Shah P. Development of Moxifloxacin Hydrochloride Loaded In-Situ Gel for the Treatment of Periodontitis: In-Vitro Drug Release Study and Antibacterial Activity. J Oral Biol Craniofacial Res. 2019; 9(3): 190–200. [CrossRef]
  • Baloglu E, Karavana SY, Senyigit ZA, Guneri T. Rheological and Mechanical Properties of Poloxamer Mixtures as a Mucoadhesive Gel Base. Pharm Dev Technol. 2011; 16(6): 627–636. [CrossRef]
  • Baloglu E, Karavana SY, Senyigit ZA, Hilmioglu-Polat S, Metin DY, Zekioglu O, et al. In-Situ Gel Formulations of Econazole Nitrate: Preparation and In-Vitro and In-Vivo Evaluation. J Pharm Pharmacol. 2011; 63: 1274–1282. [CrossRef]
  • Abouhussein DMN, Khattab A, Bayoumi NA, Mahmoud AF, Sakr TM. Brain Targeted Rivastigmine Mucoadhesive Thermosensitive In Situ Gel: Optimization, In Vitro Evaluation, Radiolabeling, In Vivo Pharmacokinetics and Biodistribution. J Drug Deliv Sci Technol. 2018; 43: 129–140. [CrossRef]
  • Siafaka P, Okur ME, Ayla Ş, Er S, Cağlar EŞ, Okur NÜ. Design and Characterization of Nanocarriers Loaded with Levofloxacin for Enhanced Antimicrobial Activity; Physicochemical Properties, In Vitro Release and Oral Acute Toxicity. Brazilian J Pharm Sci. 2019; 55: 1–13. [CrossRef]
  • Bilensoy E, Rouf MA, Vural I, Şen M, Hıncal AA. Mucoadhesive, Thermosensitive, Prolonged-Release Vaginal Gel for Clotrimazole : β-Cyclodextrin Complex. AAPS PharmSciTech. 2006; 7(2): 1–7. [CrossRef]
  • Choi HG, Jung JH, Ryu JM, Yoon SJ, Oh YK, Kim CK. Development of In Situ-Gelling and Mucoadhesive Acetaminophen Liquid Suppository. Int J Pharm .1998; 165(1): 33–44. [CrossRef]
  • Jones DS, Woolfson AD, Djokic J. Texture Profile Analysis of Bioadhesive Polymeric Semisolids: Mechanical Characterization and Investigation of Interactions Between Formulation Components. J Appl Polym Sci. 1996;61(12): 2229–2234. [CrossRef]
  • Üstündaǧ-Okur N, Gökçe EH, Bozbiyik DI, Eǧrilmez S, Özer Ö, Ertan G. Preparation and In Vitro-In Vivo Evaluation of Ofloxacin Loaded Ophthalmic Nano Structured Lipid Carriers Modified with Chitosan Oligosaccharide Lactate for the Treatment of Bacterial Keratitis. Eur J Pharm Sci. 2014; 63: 204–215. [CrossRef]
  • [Özcan Bülbül E, Mesut B, Cevher E, Öztaş E, Özsoy Y. Product Transfer from Lab-Scale to Pilot-Scale of Quetiapine Fumarate Orodispersible Films Using Quality by Design Approach. J Drug Deliv Sci Technol. 2019; 54: 101358. [CrossRef]
  • Dash S, Murthy PN, Nath L, Chowdhury P. Kinetic Modeling on Drug Release from Controlled Drug Delivery Systems. Acta Pol Pharm - Drug Res. 2010; 67: 217–223.
  • Aksu B, Yurdasiper A, Ege MA, Okur NÜ, Karasulu HY. Development and Comparative Evaluation of Extended Release Indomethacin Capsules. African J Pharm Pharmacol. 2013; 7(30): 2201–2209.
  • Costa P, Lobo JMS. Modeling and Comparison of Dissolution Profiles. Eur J Pharm Sci. 2001; 13(2): 123–133. [CrossRef]
  • Üstündağ Okur N, Filippousi M, Okur ME, Ayla Ş, Çağlar EŞ, Yoltaş A, et al. A Novel Approach for Skin Infections: Controlled Release Topical Mats of Poly(Lactic Acid)/Poly(Ethylene Succinate) Blends Containing Voriconazole. J Drug Deliv Sci Technol. 2018; 46: 74–86. [CrossRef]
There are 43 citations in total.

Details

Primary Language English
Subjects Pharmaceutical Delivery Technologies
Journal Section Articles
Authors

Seda Rençber

Ece Özcan Bülbül

Neslihan Üstündağ

Zeynep Senyiğit

Publication Date June 27, 2025
Published in Issue Year 2021 Volume: 25 Issue: 1

Cite

APA Rençber, S., Özcan Bülbül, E., Üstündağ, N., Senyiğit, Z. (2025). Preparation and detailed characterization of fusidic acid loaded in situ gel formulations for ophthalmic application. Journal of Research in Pharmacy, 25(1), 1-12. https://doi.org/10.35333/jrp.2021.291
AMA Rençber S, Özcan Bülbül E, Üstündağ N, Senyiğit Z. Preparation and detailed characterization of fusidic acid loaded in situ gel formulations for ophthalmic application. J. Res. Pharm. June 2025;25(1):1-12. doi:10.35333/jrp.2021.291
Chicago Rençber, Seda, Ece Özcan Bülbül, Neslihan Üstündağ, and Zeynep Senyiğit. “Preparation and Detailed Characterization of Fusidic Acid Loaded in Situ Gel Formulations for Ophthalmic Application”. Journal of Research in Pharmacy 25, no. 1 (June 2025): 1-12. https://doi.org/10.35333/jrp.2021.291.
EndNote Rençber S, Özcan Bülbül E, Üstündağ N, Senyiğit Z (June 1, 2025) Preparation and detailed characterization of fusidic acid loaded in situ gel formulations for ophthalmic application. Journal of Research in Pharmacy 25 1 1–12.
IEEE S. Rençber, E. Özcan Bülbül, N. Üstündağ, and Z. Senyiğit, “Preparation and detailed characterization of fusidic acid loaded in situ gel formulations for ophthalmic application”, J. Res. Pharm., vol. 25, no. 1, pp. 1–12, 2025, doi: 10.35333/jrp.2021.291.
ISNAD Rençber, Seda et al. “Preparation and Detailed Characterization of Fusidic Acid Loaded in Situ Gel Formulations for Ophthalmic Application”. Journal of Research in Pharmacy 25/1 (June 2025), 1-12. https://doi.org/10.35333/jrp.2021.291.
JAMA Rençber S, Özcan Bülbül E, Üstündağ N, Senyiğit Z. Preparation and detailed characterization of fusidic acid loaded in situ gel formulations for ophthalmic application. J. Res. Pharm. 2025;25:1–12.
MLA Rençber, Seda et al. “Preparation and Detailed Characterization of Fusidic Acid Loaded in Situ Gel Formulations for Ophthalmic Application”. Journal of Research in Pharmacy, vol. 25, no. 1, 2025, pp. 1-12, doi:10.35333/jrp.2021.291.
Vancouver Rençber S, Özcan Bülbül E, Üstündağ N, Senyiğit Z. Preparation and detailed characterization of fusidic acid loaded in situ gel formulations for ophthalmic application. J. Res. Pharm. 2025;25(1):1-12.

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Bioadhesive Nanoparticles as Potent Drug Delivery Carriers
Current Medicinal Chemistry
https://doi.org/10.2174/0929867329666220613111635
Novel Microemulsion Containing Benzocaine and Fusidic Acid Simultaneously: Formulation, Characterization, and In Vitro Evaluation for Wound Healing
AAPS PharmSciTech
https://doi.org/10.1208/s12249-024-02762-5
Novel Sprayable Thermosensitive Benzydamine Hydrogels for Topical Application: Development, Characterization, and In Vitro Biological Activities
AAPS PharmSciTech
https://doi.org/10.1208/s12249-023-02674-w
A Comprehensive Review of the Evaluation of in Situ Gels
International Journal of Innovative Science and Research Technology (IJISRT)
https://doi.org/10.38124/ijisrt/IJISRT24OCT1075