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PEG 8000 increases solubility and dissolution rate of quercetin in solid dispersion system

Year 2018, Volume: 22 Issue: 2, 259 - 266, 27.06.2025

Setyawan Dwi Setiawardani Febrianti Amrullah Zainul Retno Sari

Abstract

The aim of this study was to examine the physical characteristics, solubility, and in vitro dissolution profile of quercetin-PEG 8000 solid dispersion prepared by melting method. Solid dispersion was prepared by melting method with various ratios of quercetin and PEG 8000 (1:1; 1:2; 1:3). The solid dispersion was characterized using differential thermal analyzer (DTA), powder X-ray diffraction (PXRD), scanning electron microscope (SEM), and fourier transform infrared spectroscopy (FTIR). The solubility and in vitro dissolution of quercetin-PEG 8000 solid dispersion were evaluated and compared to physical mixture and pure quercetin. The solid dispersion of quercetin-PEG 8000 has lower melting point and crystal peak intensity compared to pure quercetin and physical mixture. The infrared spectra of solid dispersions and physical mixtures indicated the occurrence of physical interactions that involved weak bonding forces such as the hydrogen bond between quercetin functional groups and O-H group. The solubility and the dissolution rate enhanced in accordance with increasing of PEG 8000 amount.

Keywords

Quercetin PEG 8000 solid dispersion solubility dissolution rate

References

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There are 19 citations in total.

Details

Primary Language English
Subjects Pharmaceutical Delivery Technologies
Journal Section Articles
Authors

Setyawan Dwi 0000-0001-8009-6054

Setiawardani Febrianti

Amrullah Zainul

Retno Sari 0000-0002-3391-1877

Publication Date June 27, 2025
Published in Issue Year 2018 Volume: 22 Issue: 2

Cite

APA Dwi, S., Febrianti, S., Zainul, A., Sari, R. (2025). PEG 8000 increases solubility and dissolution rate of quercetin in solid dispersion system. Journal of Research in Pharmacy, 22(2), 259-266.
AMA Dwi S, Febrianti S, Zainul A, Sari R. PEG 8000 increases solubility and dissolution rate of quercetin in solid dispersion system. J. Res. Pharm. June 2025;22(2):259-266.
Chicago Dwi, Setyawan, Setiawardani Febrianti, Amrullah Zainul, and Retno Sari. “PEG 8000 Increases Solubility and Dissolution Rate of Quercetin in Solid Dispersion System”. Journal of Research in Pharmacy 22, no. 2 (June 2025): 259-66.
EndNote Dwi S, Febrianti S, Zainul A, Sari R (June 1, 2025) PEG 8000 increases solubility and dissolution rate of quercetin in solid dispersion system. Journal of Research in Pharmacy 22 2 259–266.
IEEE S. Dwi, S. Febrianti, A. Zainul, and R. Sari, “PEG 8000 increases solubility and dissolution rate of quercetin in solid dispersion system”, J. Res. Pharm., vol. 22, no. 2, pp. 259–266, 2025.
ISNAD Dwi, Setyawan et al. “PEG 8000 Increases Solubility and Dissolution Rate of Quercetin in Solid Dispersion System”. Journal of Research in Pharmacy 22/2 (June 2025), 259-266.
JAMA Dwi S, Febrianti S, Zainul A, Sari R. PEG 8000 increases solubility and dissolution rate of quercetin in solid dispersion system. J. Res. Pharm. 2025;22:259–266.
MLA Dwi, Setyawan et al. “PEG 8000 Increases Solubility and Dissolution Rate of Quercetin in Solid Dispersion System”. Journal of Research in Pharmacy, vol. 22, no. 2, 2025, pp. 259-66.
Vancouver Dwi S, Febrianti S, Zainul A, Sari R. PEG 8000 increases solubility and dissolution rate of quercetin in solid dispersion system. J. Res. Pharm. 2025;22(2):259-66.