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Swelling and mucoadhesive behavior with drug release characteristics of gastoretentive drug delivery system based on a combination of natural gum and semi-synthetic polymers

Year 2018, Volume: 22 Issue: 2, 286 - 298, 27.06.2025

Rita Bhatta Mohammad Salim Hossain Sujan Banik , Md. Mizanur Rahman Moghal , Mamun Or Rashid Mariyam Akter

Abstract

Using ramipril as a model active pharmaceutical ingredient, the focus of the present study was to fabricate low-cost controlled release tablets using combinations of biopolymer and semi-synthetic polymers. Cellulose derivatives are more viscous where biopolymers form gels more easily. Xanthan gum can’t shape a solid gel, result in fragmentation of gel around the tablets so that depend upon high concentration. Therefore, a combination was used to formulate tablet by direct compression. This combination of polymer provides low cost product with higher potentiality. Ingredients as per formulations were mixed in small polybag through hand blending. Then tablets were compressed one by one tablet in a hydraulic press. Prepared tablets were evaluated for hardness, weight variation, content uniformity, friability, surface pH and in-vitro dissolution studies. ANOVA was used to analyze the differences between release data. Swelling index, mucoadhesive strength and in-vitro residence time was studied to show gastroretention of the tablets. Formulated products exhibit sufficient quality and strength to formulate as a mucoadhesive tablet. Significant differences were found in drug release among different formulations (p ˂0.05) in all cases. Among all of formulations, F11, F12 and F13 containing different ratio of xanthan gum and guar gum showed promising mucoadhesive strength and in-vitro residence time.

Keywords

Gastroretentive drug delivery System natural polymer semi-synthetic polymer swelling index mucoadhesive

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There are 25 citations in total.

Details

Primary Language English
Subjects Pharmaceutical Delivery Technologies
Journal Section Articles
Authors

Rita Bhatta 0000-0001-9731-6367

Mohammad Salim Hossain 0000-0002-5710-1115

Sujan Banik 0000-0001-9639-6836

Md. Mizanur Rahman Moghal 0000-0002-0553-1447

Mamun Or Rashid 0000-0002-3555-6354

Mariyam Akter

Publication Date June 27, 2025
Published in Issue Year 2018 Volume: 22 Issue: 2

Cite

APA Bhatta, R., Hossain, M. S., Banik, S., Moghal, M. M. R., et al. (2025). Swelling and mucoadhesive behavior with drug release characteristics of gastoretentive drug delivery system based on a combination of natural gum and semi-synthetic polymers. Journal of Research in Pharmacy, 22(2), 286-298.
AMA Bhatta R, Hossain MS, Banik S, Moghal MMR, Rashid MO, Akter M. Swelling and mucoadhesive behavior with drug release characteristics of gastoretentive drug delivery system based on a combination of natural gum and semi-synthetic polymers. J. Res. Pharm. June 2025;22(2):286-298.
Chicago Bhatta, Rita, Mohammad Salim Hossain, Sujan Banik, Md. Mizanur Rahman Moghal, Mamun Or Rashid, and Mariyam Akter. “Swelling and Mucoadhesive Behavior With Drug Release Characteristics of Gastoretentive Drug Delivery System Based on a Combination of Natural Gum and Semi-Synthetic Polymers”. Journal of Research in Pharmacy 22, no. 2 (June 2025): 286-98.
EndNote Bhatta R, Hossain MS, Banik S, Moghal MMR, Rashid MO, Akter M (June 1, 2025) Swelling and mucoadhesive behavior with drug release characteristics of gastoretentive drug delivery system based on a combination of natural gum and semi-synthetic polymers. Journal of Research in Pharmacy 22 2 286–298.
IEEE R. Bhatta, M. S. Hossain, S. Banik, M. M. R. Moghal, M. O. Rashid, and M. Akter, “Swelling and mucoadhesive behavior with drug release characteristics of gastoretentive drug delivery system based on a combination of natural gum and semi-synthetic polymers”, J. Res. Pharm., vol. 22, no. 2, pp. 286–298, 2025.
ISNAD Bhatta, Rita et al. “Swelling and Mucoadhesive Behavior With Drug Release Characteristics of Gastoretentive Drug Delivery System Based on a Combination of Natural Gum and Semi-Synthetic Polymers”. Journal of Research in Pharmacy 22/2 (June 2025), 286-298.
JAMA Bhatta R, Hossain MS, Banik S, Moghal MMR, Rashid MO, Akter M. Swelling and mucoadhesive behavior with drug release characteristics of gastoretentive drug delivery system based on a combination of natural gum and semi-synthetic polymers. J. Res. Pharm. 2025;22:286–298.
MLA Bhatta, Rita et al. “Swelling and Mucoadhesive Behavior With Drug Release Characteristics of Gastoretentive Drug Delivery System Based on a Combination of Natural Gum and Semi-Synthetic Polymers”. Journal of Research in Pharmacy, vol. 22, no. 2, 2025, pp. 286-98.
Vancouver Bhatta R, Hossain MS, Banik S, Moghal MMR, Rashid MO, Akter M. Swelling and mucoadhesive behavior with drug release characteristics of gastoretentive drug delivery system based on a combination of natural gum and semi-synthetic polymers. J. Res. Pharm. 2025;22(2):286-98.