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Developing a New Collagen Peptide Serum Containing Gold Nanoparticles for Cosmetic Purposes

Year 2023, Volume: 27 Issue: 6, 2210 - 2217, 28.06.2025

Abstract

The reducing property of collagen was employed for the synthesis of gold nanoparticles (AuNPs) without the use of any toxic chemicals. The morphology of the resulting AuNPs-collagen particles appeared in spherical and triangular nanoprisms with sizes ranging from 30-60 nm, as observed in TEM results. Increasing the synthesis temperature led to the growth of AuNPs. Surface-enhanced Raman Spectroscopy studies revealed that amide I and carboxylic acid group vibrations indicated collagen binding to the Au surface through these groups. The AuNPs-collagen nanocomposite was tested for its antimicrobial properties against eight different microorganisms and it exhibited antibacterial properties solely against the Gordonia rubripertincta bacterium.

References

  • [1] Liu D, Nikoo M, Boran G, Zhou P, Regenstein JM. Collagen and gelatin. Annual Review of Food Science and Technology. 2015. https://doi.org/10.1146/annurev-food-031414-111800.
  • [2] Demirbas A, Büyükbezirci K, Celik C, Kislakci E, Karaagac Z, Gokturk E, Kati A, Cimen B, Yilmaz V, Ocsoy I. Synthesis of Long-Term Stable Gold Nanoparticles Benefiting from Red Raspberry (Rubus idaeus), Strawberry (Fragaria ananassa), and Blackberry (Rubus fruticosus) Extracts-Gold Ion Complexation and Investigation of Reaction Conditions. ACS Omega. 2019;4. https://doi.org/10.1021/acsomega.9b02469.
  • [3] Shankar SS, Rai A, Ahmad A, Sastry M. Rapid synthesis of Au, Ag, and bimetallic Au core-Ag shell nanoparticles using Neem (Azadirachta indica) leaf broth. J Colloid Interface Sci. 2004;275: 496–502. https://doi.org/10.1016/j.jcis.2004.03.003.
  • [4] Lin C, Tao K, Hua D, Ma Z, Zhou S. Size effect of gold nanoparticles in catalytic reduction of p-nitrophenol with NaBH4. Molecules. 2013;18. https://doi.org/10.3390/molecules181012609.
  • [5] Xie J, Li MX, Du ZZ. Chemical compounds, anti-aging and antibacterial properties of Rosa rugosa Purple branch. Ind Crops Prod. 2022;181. https://doi.org/10.1016/j.indcrop.2022.114814.
  • [6] Afanasyeva L V, Ayushina TA. Features of microelements and low-molecular weigh antioxidants accumulation in plants ofthe genus rosa L. Khimiya Rastit Syr’ya. 2021. https://doi.org/10.14258/JCPRM.2021027440.
  • [7] Uchida VH, de Araújo Padilha CE, Rios NS, dos Santos ES. Enzymatic inhibition of α-amylase and encapsulation of bioactive compounds by nanoemulsion from pulp extract Terminalia catappa Linn fruit. Results Chem. 2023;5. https://doi.org/10.1016/j.rechem.2022.100736.
  • [8] Indrisari M, Sartini S, Miskad UA, Djawad K, Tahir KA, Nurkhairi N, Muslimin L. Photoprotective and inhibitory activity of tyrosinase in extract and fractions of terminalia catappa l. Open Access Maced J Med Sci. 2021;9. https://doi.org/10.3889/oamjms.2021.5940.
  • [9] Smitha SL, Philip D, Gopchandran KG. Green synthesis of gold nanoparticles using Cinnamomum zeylanicum leaf broth. Spectrochim Acta - Part A Mol Biomol Spectrosc. 2009;74. https://doi.org/10.1016/j.saa.2009.08.007.
  • [10] Suriyagoda L, Mohotti AJ, Vidanarachchi JK, Kodithuwakku SP, Chathurika M, Bandaranayake PCG, Hetherington AM, Beneragama CK. “Ceylon cinnamon”: Much more than just a spice. Plants People Planet. 2021. https://doi.org/10.1002/ppp3.10192.
  • [11] Nascimento LD Do, de Moraes AAB, da Costa KS, Galúcio JMP, Taube PS, Costa CML, Cruz JN, de Aguiar Andrade EH, de Faria LJG. Bioactive natural compounds and antioxidant activity of essential oils from spice plants: New findings and potential applications. Biomolecules. 2020. https://doi.org/10.3390/biom10070988.
  • [12] Rodríguez MIA, Barroso LGR, Sánchez ML. Collagen: A review on its sources and potential cosmetic applications. Journal of Cosmetic Dermatology. 2018. https://doi.org/10.1111/jocd.12450.
  • [13] Sionkowska A, Adamiak K, Musial K, Gadomska M. Collagen based materials in cosmetic applications: A review. Materials. 2020. https://doi.org/10.3390/MA13194217.
  • [14] Alves AL, Marques ALP, Martins E, Silva TH, Reis RL. Cosmetic potential of Marine fish skin collagen. Cosmetics. 2017;4. https://doi.org/10.3390/cosmetics4040039.
  • [15] Peng Y, Glattauer V, Werkmeister JA, Ramshaw JAM. Evaluation for collagen products for cosmetic application. J Cosmet Sci. 2004;55. https://doi.org/10.1111/j.1467-2494.2004.00245_2.x.
  • [16] Oslan SNH, Li CX, Shapawi R, Mokhtar RAM, Noordin WNM, Huda N. Extraction and Characterization of Bioactive Fish By-Product Collagen as Promising for Potential Wound Healing Agent in Pharmaceutical Applications: Current Trend and Future Perspective. Int J Food Sci. 2022;2022. https://doi.org/10.1155/2022/9437878.
  • [17] Unser S, Holcomb S, Cary R, Sagle L. Collagen-gold nanoparticle conjugates for versatile biosensing. Sensors (Switzerland). 2017;17. https://doi.org/10.3390/s17020378.
  • [18] Suwa Y, Nam K, Ozeki K, Kimura T, Kishida A, Masuzawa T. Thermal denaturation behavior of collagen fibrils in wet and dry environment. J Biomed Mater Res - Part B Appl Biomater. 2016;104. https://doi.org/10.1002/jbm.b.33418.
  • [19] Noginov MA, Zhu G, Bahoura M, Adegoke J, Small C, Ritzo BA, Drachev VP, Shalaev VM. The effect of gain and absorption on surface plasmons in metal nanoparticles. Appl Phys B Lasers Opt. 2007;86. https://doi.org/10.1007/s00340-006-2401-0.
  • [20] Badilescu S, Raju D, Bathini S, Packirisamy M. Gold nano-island platforms for localized surface plasmon resonance sensing: A short review. Molecules. 2020. https://doi.org/10.3390/molecules25204661.
  • [21] Sharifi M, Hosseinali SH, Alizadeh RH, Hasan A, Attar F, Salihi A, Shekha MS, Amen KM, Aziz FM, Saboury AA, Akhtari K, Taghizadeh A, Hooshmand N, El-Sayed MA, Falahati M. Plasmonic and chiroplasmonic nanobiosensors based on gold nanoparticles. Talanta. 2020. https://doi.org/10.1016/j.talanta.2020.120782.
  • [22] Herizchi R, Abbasi E, Milani M, Akbarzadeh A. Current methods for synthesis of gold nanoparticles. Artif Cells, Nanomedicine Biotechnol. 2016;44. https://doi.org/10.3109/21691401.2014.971807.
  • [23] Marisca OT, Kantner K, Pfeiffer C, Zhang Q, Pelaz B, Leopold N, Parak WJ, Rejman J. Comparison of the in vitro uptake and toxicity of collagen-and synthetic polymer-coated gold nanoparticles. Nanomaterials. 2015;5. https://doi.org/10.3390/nano5031418.
  • [24] Kramer RZ, Bella J, Mayville P, Brodsky B, Berman HM. Sequence dependent conformational variations of collagen triple-helical structure. Nat Struct Biol. 1999;6. https://doi.org/10.1038/8259.
  • [25] Gauza-Włodarczyk M, Kubisz L, Włodarczyk D. Amino acid composition in determination of collagen origin and assessment of physical factors effects. Int J Biol Macromol. 2017;104. https://doi.org/10.1016/j.ijbiomac.2017.07.013.
  • [26] Gullekson C, Lucas L, Hewitt K, Kreplak L. Surface-sensitive Raman spectroscopy of collagen I fibrils. Biophys J. 2011;100. https://doi.org/10.1016/j.bpj.2011.02.026.
  • [27] Andalibi F, Fatahi-Bafghi M. Gordonia: isolation and identification in clinical samples and role in biotechnology. Folia Microbiologica. 2017. https://doi.org/10.1007/s12223-017-0491-1.
There are 27 citations in total.

Details

Primary Language English
Subjects Pharmacology and Pharmaceutical Sciences (Other)
Journal Section Articles
Authors

Şaban Kalay 0000-0002-9363-0073

Publication Date June 28, 2025
Published in Issue Year 2023 Volume: 27 Issue: 6

Cite

APA Kalay, Ş. (2025). Developing a New Collagen Peptide Serum Containing Gold Nanoparticles for Cosmetic Purposes. Journal of Research in Pharmacy, 27(6), 2210-2217.
AMA Kalay Ş. Developing a New Collagen Peptide Serum Containing Gold Nanoparticles for Cosmetic Purposes. J. Res. Pharm. July 2025;27(6):2210-2217.
Chicago Kalay, Şaban. “Developing a New Collagen Peptide Serum Containing Gold Nanoparticles for Cosmetic Purposes”. Journal of Research in Pharmacy 27, no. 6 (July 2025): 2210-17.
EndNote Kalay Ş (July 1, 2025) Developing a New Collagen Peptide Serum Containing Gold Nanoparticles for Cosmetic Purposes. Journal of Research in Pharmacy 27 6 2210–2217.
IEEE Ş. Kalay, “Developing a New Collagen Peptide Serum Containing Gold Nanoparticles for Cosmetic Purposes”, J. Res. Pharm., vol. 27, no. 6, pp. 2210–2217, 2025.
ISNAD Kalay, Şaban. “Developing a New Collagen Peptide Serum Containing Gold Nanoparticles for Cosmetic Purposes”. Journal of Research in Pharmacy 27/6 (July 2025), 2210-2217.
JAMA Kalay Ş. Developing a New Collagen Peptide Serum Containing Gold Nanoparticles for Cosmetic Purposes. J. Res. Pharm. 2025;27:2210–2217.
MLA Kalay, Şaban. “Developing a New Collagen Peptide Serum Containing Gold Nanoparticles for Cosmetic Purposes”. Journal of Research in Pharmacy, vol. 27, no. 6, 2025, pp. 2210-7.
Vancouver Kalay Ş. Developing a New Collagen Peptide Serum Containing Gold Nanoparticles for Cosmetic Purposes. J. Res. Pharm. 2025;27(6):2210-7.