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Evaluation of conventional karyotyping, lactate dehydrogenase levels, white blood cell count, and bone marrow blast percentage as good prognostic tests in patients with acute lymphoblastic leukemia

Year 2023, Volume: 27 Issue: 6, 2342 - 2352, 28.06.2025

Abdulkader Memeh Abduljalil Ghriwati Ibrahim Kebbe War Khalid Khanji

Abstract

Acute lymphoblastic leukemia is a specific type of hematologic neoplasm in which outcomes may be affected by many variables such as the patient's age, gender, conventional karyotyping reports, lactate dehydrogenase concentration, and white blood cell count at diagnosis. The aim of this study was to assess the prognostic significance of those factors on the overall survival of patients diagnosed with ALL. The current study includes 65 patients diagnosed with ALL who were tested for cytology, conventional karyotyping, and immunophenotyping. The results of the current study have indicated the average patient’s age was 14 years old. In addition, around 47.7% of patients had chromosomal abnormalities. Furthermore, the patients with LDH levels higher than 450 IU/L, and WBC counts over 100 X109 (Cell /L) had a shorter overall survival in month compared to other groups. However, the results suggested that conventional karyotyping, LDH, and WBC count might be used as good prognostic tests in patients with ALL at diagnosis.

Keywords

Acute lymphoblastic Leukemia Conventional Karyotyping LDH WBC.

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There are 45 citations in total.

Details

Primary Language English
Subjects Pharmacology and Pharmaceutical Sciences (Other)
Journal Section Articles
Authors

Abdulkader Memeh 0000-0003-3955-2913

Abduljalil Ghriwati

Ibrahim Kebbe War 0000-0002-3495-5476

Khalid Khanji

Publication Date June 28, 2025
Published in Issue Year 2023 Volume: 27 Issue: 6

Cite

APA Memeh, A., Ghriwati, A., War, I. K., Khanji, K. (2025). Evaluation of conventional karyotyping, lactate dehydrogenase levels, white blood cell count, and bone marrow blast percentage as good prognostic tests in patients with acute lymphoblastic leukemia. Journal of Research in Pharmacy, 27(6), 2342-2352.
AMA Memeh A, Ghriwati A, War IK, Khanji K. Evaluation of conventional karyotyping, lactate dehydrogenase levels, white blood cell count, and bone marrow blast percentage as good prognostic tests in patients with acute lymphoblastic leukemia. J. Res. Pharm. July 2025;27(6):2342-2352.
Chicago Memeh, Abdulkader, Abduljalil Ghriwati, Ibrahim Kebbe War, and Khalid Khanji. “Evaluation of Conventional Karyotyping, Lactate Dehydrogenase Levels, White Blood Cell Count, and Bone Marrow Blast Percentage As Good Prognostic Tests in Patients With Acute Lymphoblastic Leukemia”. Journal of Research in Pharmacy 27, no. 6 (July 2025): 2342-52.
EndNote Memeh A, Ghriwati A, War IK, Khanji K (July 1, 2025) Evaluation of conventional karyotyping, lactate dehydrogenase levels, white blood cell count, and bone marrow blast percentage as good prognostic tests in patients with acute lymphoblastic leukemia. Journal of Research in Pharmacy 27 6 2342–2352.
IEEE A. Memeh, A. Ghriwati, I. K. War, and K. Khanji, “Evaluation of conventional karyotyping, lactate dehydrogenase levels, white blood cell count, and bone marrow blast percentage as good prognostic tests in patients with acute lymphoblastic leukemia”, J. Res. Pharm., vol. 27, no. 6, pp. 2342–2352, 2025.
ISNAD Memeh, Abdulkader et al. “Evaluation of Conventional Karyotyping, Lactate Dehydrogenase Levels, White Blood Cell Count, and Bone Marrow Blast Percentage As Good Prognostic Tests in Patients With Acute Lymphoblastic Leukemia”. Journal of Research in Pharmacy 27/6 (July 2025), 2342-2352.
JAMA Memeh A, Ghriwati A, War IK, Khanji K. Evaluation of conventional karyotyping, lactate dehydrogenase levels, white blood cell count, and bone marrow blast percentage as good prognostic tests in patients with acute lymphoblastic leukemia. J. Res. Pharm. 2025;27:2342–2352.
MLA Memeh, Abdulkader et al. “Evaluation of Conventional Karyotyping, Lactate Dehydrogenase Levels, White Blood Cell Count, and Bone Marrow Blast Percentage As Good Prognostic Tests in Patients With Acute Lymphoblastic Leukemia”. Journal of Research in Pharmacy, vol. 27, no. 6, 2025, pp. 2342-5.
Vancouver Memeh A, Ghriwati A, War IK, Khanji K. Evaluation of conventional karyotyping, lactate dehydrogenase levels, white blood cell count, and bone marrow blast percentage as good prognostic tests in patients with acute lymphoblastic leukemia. J. Res. Pharm. 2025;27(6):2342-5.