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The Production of Curcumin-Loaded PLGA/PEG Nanoparticle for The Treatment of Alzheimer’s Disease

Year 2023, Volume: 27 Issue: 6, 2399 - 2404, 28.06.2025

Ece Guler Muhammet Emin Çam

Abstract

Alzheimer's disease (AD) is the most common type of dementia in the world. This neurodegenerative disease affects 6.5 million people's lives by leading to functional impairments such as memory loss and cognitive regression. In the treatment of AD, there is no drug for radical treatment in the worldwide. Current treatment strategies provide relief to the symptoms. Therefore, curcumin (CUR) was preferred as a promising alternative therapeutic approach in this study. By using the double emulsion solvent evaporation technique, PLGA/PEG nanoparticles were produced and CUR was loaded to these nanoparticles (CNP). After that, the chemical structures and morphologies of CNP and PNP were analyzed by using FTIR and SEM. As a result, it was proven that these nanoparticles were produced by using PLGA and PEG polymers and CUR was loaded to these nanoparticles successfully.

Keywords

Alzheimer’s disease curcumin nanoparticle PLGA PEG

References

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There are 32 citations in total.

Details

Primary Language English
Subjects Pharmacology and Pharmaceutical Sciences (Other)
Journal Section Articles
Authors

Ece Guler 0000-0002-0639-5029

Muhammet Emin Çam 0000-0001-5398-6801

Publication Date June 28, 2025
Published in Issue Year 2023 Volume: 27 Issue: 6

Cite

APA Guler, E., & Çam, M. E. (2025). The Production of Curcumin-Loaded PLGA/PEG Nanoparticle for The Treatment of Alzheimer’s Disease. Journal of Research in Pharmacy, 27(6), 2399-2404.
AMA Guler E, Çam ME. The Production of Curcumin-Loaded PLGA/PEG Nanoparticle for The Treatment of Alzheimer’s Disease. J. Res. Pharm. July 2025;27(6):2399-2404.
Chicago Guler, Ece, and Muhammet Emin Çam. “The Production of Curcumin-Loaded PLGA/PEG Nanoparticle for The Treatment of Alzheimer’s Disease”. Journal of Research in Pharmacy 27, no. 6 (July 2025): 2399-2404.
EndNote Guler E, Çam ME (July 1, 2025) The Production of Curcumin-Loaded PLGA/PEG Nanoparticle for The Treatment of Alzheimer’s Disease. Journal of Research in Pharmacy 27 6 2399–2404.
IEEE E. Guler and M. E. Çam, “The Production of Curcumin-Loaded PLGA/PEG Nanoparticle for The Treatment of Alzheimer’s Disease”, J. Res. Pharm., vol. 27, no. 6, pp. 2399–2404, 2025.
ISNAD Guler, Ece - Çam, Muhammet Emin. “The Production of Curcumin-Loaded PLGA/PEG Nanoparticle for The Treatment of Alzheimer’s Disease”. Journal of Research in Pharmacy 27/6 (July 2025), 2399-2404.
JAMA Guler E, Çam ME. The Production of Curcumin-Loaded PLGA/PEG Nanoparticle for The Treatment of Alzheimer’s Disease. J. Res. Pharm. 2025;27:2399–2404.
MLA Guler, Ece and Muhammet Emin Çam. “The Production of Curcumin-Loaded PLGA/PEG Nanoparticle for The Treatment of Alzheimer’s Disease”. Journal of Research in Pharmacy, vol. 27, no. 6, 2025, pp. 2399-04.
Vancouver Guler E, Çam ME. The Production of Curcumin-Loaded PLGA/PEG Nanoparticle for The Treatment of Alzheimer’s Disease. J. Res. Pharm. 2025;27(6):2399-404.