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Synthesis and antimicrobial effects of cyclotriphosphazenes containing monocarbonyl curcumin analogs

Year 2018, Volume: 22 Issue: 4, 536 - 546, 27.06.2025

Mine Gül Şeker Tuğçe Akbal Devrim Atilla , Neslihan Avşar Hanife İbişoğlu

Abstract

Six novel bridged structure cyclotriphosphazenes (4a-f) were synthesized from the reactions of aryloxycyclotriphosphazenes [aryloxy= phenoxy (2a) and (2-naphthoxy) (2b)] with monocarbonyl curcumin derivatives [acetone (3a), cyclopentanone (3b) and cyclohexanone (3c)] for the first time. The structures of the compounds (4a-f) were defined by elemental analysis, FT-IR, mass and NMR (1H and 31P) spectroscopies. The antimicrobial properties of the compounds (2a, 2b, 3a-c and 4a-f) were screened in vitro against Escherichia coli ATCC 8739, Staphylococcus aureus ATCC 29213, Bacillus subtilis ATCC 6633, Bacillus cereus DSMZ 4312 and Candida albicans ATCC 10231. In addition, effective substance of 3b and 4c were evaluated Minimal Inhibition Concentration.

Keywords

Antimicrobial activity minimal inhibiton concentration phosphazene curcumin

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There are 51 citations in total.

Details

Primary Language English
Subjects Pharmaceutical Chemistry
Journal Section Articles
Authors

Mine Gül Şeker 0009-0007-4176-6191

Tuğçe Akbal

Devrim Atilla 0000-0001-8992-0070

Neslihan Avşar 0000-0002-7315-5674

Hanife İbişoğlu

Publication Date June 27, 2025
Published in Issue Year 2018 Volume: 22 Issue: 4

Cite

APA Gül Şeker, M., Akbal, T., Atilla, D., Avşar, N., et al. (2025). Synthesis and antimicrobial effects of cyclotriphosphazenes containing monocarbonyl curcumin analogs. Journal of Research in Pharmacy, 22(4), 536-546.
AMA Gül Şeker M, Akbal T, Atilla D, Avşar N, İbişoğlu H. Synthesis and antimicrobial effects of cyclotriphosphazenes containing monocarbonyl curcumin analogs. J. Res. Pharm. June 2025;22(4):536-546.
Chicago Gül Şeker, Mine, Tuğçe Akbal, Devrim Atilla, Neslihan Avşar, and Hanife İbişoğlu. “Synthesis and Antimicrobial Effects of Cyclotriphosphazenes Containing Monocarbonyl Curcumin Analogs”. Journal of Research in Pharmacy 22, no. 4 (June 2025): 536-46.
EndNote Gül Şeker M, Akbal T, Atilla D, Avşar N, İbişoğlu H (June 1, 2025) Synthesis and antimicrobial effects of cyclotriphosphazenes containing monocarbonyl curcumin analogs. Journal of Research in Pharmacy 22 4 536–546.
IEEE M. Gül Şeker, T. Akbal, D. Atilla, N. Avşar, and H. İbişoğlu, “Synthesis and antimicrobial effects of cyclotriphosphazenes containing monocarbonyl curcumin analogs”, J. Res. Pharm., vol. 22, no. 4, pp. 536–546, 2025.
ISNAD Gül Şeker, Mine et al. “Synthesis and Antimicrobial Effects of Cyclotriphosphazenes Containing Monocarbonyl Curcumin Analogs”. Journal of Research in Pharmacy 22/4 (June 2025), 536-546.
JAMA Gül Şeker M, Akbal T, Atilla D, Avşar N, İbişoğlu H. Synthesis and antimicrobial effects of cyclotriphosphazenes containing monocarbonyl curcumin analogs. J. Res. Pharm. 2025;22:536–546.
MLA Gül Şeker, Mine et al. “Synthesis and Antimicrobial Effects of Cyclotriphosphazenes Containing Monocarbonyl Curcumin Analogs”. Journal of Research in Pharmacy, vol. 22, no. 4, 2025, pp. 536-4.
Vancouver Gül Şeker M, Akbal T, Atilla D, Avşar N, İbişoğlu H. Synthesis and antimicrobial effects of cyclotriphosphazenes containing monocarbonyl curcumin analogs. J. Res. Pharm. 2025;22(4):536-4.