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In situ gels loaded with naringin as ocular drug delivery carriers; development and preliminary characterization

Year 2024, Volume: 28 Issue: 3, 762 - 769, 28.06.2025

Panoraia Siafaka Ayşe Pınar Yağcilar Yağcılar Gökçe Karaotmarli Güven Ayşegül Yoltaş Neslihan Üstündağ Okur

Abstract

Ocular drug delivery of any molecule is quite complex and challenging due to the ophthalmic anatomy. The current ocular formulations such as drops, gels or ointments cannot deliver the active molecules efficiently, therefore newer dosage forms are being developed. In situ gels which are in the liquid state in room temperature or in certain pH but transform to gels when instilled onto the eye belongs to such innovative dosage forms. Herein, the fabrication of in situ gels for naringin ocular delivery is presented since there are very few studies examining the use of naringin as an active molecule for eye delivery. Naringin which is hydrolyzed in naringenin, is a flavonoid glucoside found on citrus fruits and has been studied as antioxidant and anti-inflammatory agent or potent antimicrobial agent. The naringin loaded in situ gels developed via cold method using Poloxamer 407, sodium alginate and hydroxypropyl methylcellulose E5. The temperature-responsive in situ gels were characterized for clarity, sol-gel transition temperature, gelling capacity, pH and viscosity. All the results were of desirable limits. Furthermore, in vitro drug release demonstrated that the in situ gels showed sustained pattern Antimicrobial studies indicated specific antimicrobial potency against Enterococcus faecalis. Future studies will involve in vivo studies and ocular irritation analysis.

Keywords

Naringin ocular in situ gels eye antimicrobial gelation

References

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There are 38 citations in total.

Details

Primary Language English
Subjects Pharmaceutical Delivery Technologies
Journal Section Articles
Authors

Panoraia Siafaka

Ayşe Pınar Yağcilar Yağcılar 0000-0001-5546-4601

Gökçe Karaotmarli Güven

Ayşegül Yoltaş 0000-0003-3115-0346

Neslihan Üstündağ Okur 0000-0002-3210-3747

Publication Date June 28, 2025
Published in Issue Year 2024 Volume: 28 Issue: 3

Cite

APA Siafaka, P., Yağcılar, A. P. Y., Karaotmarli Güven, G., Yoltaş, A., et al. (2025). In situ gels loaded with naringin as ocular drug delivery carriers; development and preliminary characterization. Journal of Research in Pharmacy, 28(3), 762-769.
AMA Siafaka P, Yağcılar APY, Karaotmarli Güven G, Yoltaş A, Üstündağ Okur N. In situ gels loaded with naringin as ocular drug delivery carriers; development and preliminary characterization. J. Res. Pharm. June 2025;28(3):762-769.
Chicago Siafaka, Panoraia, Ayşe Pınar Yağcilar Yağcılar, Gökçe Karaotmarli Güven, Ayşegül Yoltaş, and Neslihan Üstündağ Okur. “In Situ Gels Loaded With Naringin As Ocular Drug Delivery Carriers; Development and Preliminary Characterization”. Journal of Research in Pharmacy 28, no. 3 (June 2025): 762-69.
EndNote Siafaka P, Yağcılar APY, Karaotmarli Güven G, Yoltaş A, Üstündağ Okur N (June 1, 2025) In situ gels loaded with naringin as ocular drug delivery carriers; development and preliminary characterization. Journal of Research in Pharmacy 28 3 762–769.
IEEE P. Siafaka, A. P. Y. Yağcılar, G. Karaotmarli Güven, A. Yoltaş, and N. Üstündağ Okur, “In situ gels loaded with naringin as ocular drug delivery carriers; development and preliminary characterization”, J. Res. Pharm., vol. 28, no. 3, pp. 762–769, 2025.
ISNAD Siafaka, Panoraia et al. “In Situ Gels Loaded With Naringin As Ocular Drug Delivery Carriers; Development and Preliminary Characterization”. Journal of Research in Pharmacy 28/3 (June 2025), 762-769.
JAMA Siafaka P, Yağcılar APY, Karaotmarli Güven G, Yoltaş A, Üstündağ Okur N. In situ gels loaded with naringin as ocular drug delivery carriers; development and preliminary characterization. J. Res. Pharm. 2025;28:762–769.
MLA Siafaka, Panoraia et al. “In Situ Gels Loaded With Naringin As Ocular Drug Delivery Carriers; Development and Preliminary Characterization”. Journal of Research in Pharmacy, vol. 28, no. 3, 2025, pp. 762-9.
Vancouver Siafaka P, Yağcılar APY, Karaotmarli Güven G, Yoltaş A, Üstündağ Okur N. In situ gels loaded with naringin as ocular drug delivery carriers; development and preliminary characterization. J. Res. Pharm. 2025;28(3):762-9.