Research Article
BibTex RIS Cite

Development of natural rubber latex patch infused with Piper nigrum L. extract

Year 2024, Volume: 28 Issue: 3, 821 - 827, 28.06.2025

Nutlada Nusontra Acharavadee Pansanit Chakree Wattanasiri

Abstract

Piper nigrum L. or black pepper is a well-known spice which is also used in herbal medicine. It has been used as a single herb and in a formula to treat many conditions such as muscle pain. This study develops a transdermal patch using natural rubber latex as a base and infused with P.nigrum extract. The physicochemical properties of the prepared patches were optimized with the addition of plasticizers, which are dibutyl phthalate, polyethylene glycol 400 and glycerin. The efficiency of the transdermal patches was evaluated by measuring the releasing profile of piperine, the main active component of P.nigrum. Other physical characteristics were measured by the tensile strength, moisture uptake, swelling rate and erosion rate. In conclusion, the formulation with the additives of dibutyl phthalate and glycerin showed good piperine release profile and mechanical properties.

Keywords

Transdermal patch Piper nigrum L. black pepper extract natural rubber latex plasticizer

References

  • [1] Liew BXW, Del Vecchio A, Falla D. The influence of musculoskeletal pain disorders on muscle synergies—A systematic review. PLoS One. 2018; 13(11): e0206885. https://doi.org/10.1371/journal.pone.0206885
  • [2] Geneen LJ, Moore RA, Clarke C, Martin D, Colvin LA, Smith BA. Physical activity and exercise for chronic pain in adults: An overview of Cochrane reviews. Cochrane Database Syst Rev. 2017; 4(4): CD011279. https://doi.org/10.1002/14651858.CD011279.pub3
  • [3] Takooree H, Aumeeruddy MZ, Rengasamy KRR, Venugopala KN, Jeewon R, Zengin G, Mahomoodally MF. A systematic review on black pepper ( Piper nigrum L .): From folk uses to pharmacological applications. Crit Rev Food Sci Nutr. 2019; 59: 210–243. https://doi.org/10.1080/10408398.2019.1565489
  • [4] Meghwal M, Goswami TK. Piper nigrum and piperine: An update. Phyther Res. 2013;27(8):1121–1130. https://doi.org/10.1002/ptr.4972
  • [5] Heidari-Beni M, Moravejolahkami AR, Gorgian P, Askari G, Tarrahi MJ, Bahreini-Esfahani N. Herbal formulation “turmeric extract, black pepper, and ginger” versus Naproxen for chronic knee osteoarthritis: A randomized, double-blind, controlled clinical trial. Phyther Res. 2020; 34(8): 2067–2073. https://doi.org/10.1002/ptr.6671
  • [6] Ministry of Public Health NDI. National List of Essential Medicine. Government Gazettes. 2018 http://ndi.fda.moph.go.th/uploads/main_drug_file/20180529192247.pdf (accessed on 2 February 2023)
  • [7] Kakatum N, Jaiarree N, Makchucit S, Itharat A. Antioxidant and anti-inflammatory activities of Thai medicinal plants in Sahasthara remedy for muscle pain treatment. J Med Assoc Thai. 2012; 95(1): 120–126.
  • [8] Nootim P, Bunchuailua W, Kapol N. Comparative Efficacy of Sahasthara Capsule vs Diclofenac tablet for the relief of muscle pain. J Thai Tradit Altern Med. 2013; 11(1): 54–65.
  • [9] Yousuf M, Khan HMS, Rasool F, Khan K ur R, Usman F, Ghalloo BA, Umair M, Babalghith AO, Kamran M, Aadil RM, Al Jaouni SK, Selim S, Korma SA, Conte-Junior CA. Chemical profiling, formulation development, ın vitro evaluation and molecular docking of Piper nigrum seeds extract loaded emulgel for anti-aging. Molecules. 2022; 27(18):5990. https://doi.org/10.3390/molecules27185990
  • [10] Eren H, Turkmen AS, Aslan A. Effect of topical application of black pepper essential oil on peripheral intravenous catheter insertion: A randomized controlled study. Explore. 2022; 18(4): 457–462. https://doi.org/10.1016/j.explore.2021.06.001
  • [11] Asasutjarit R, Sookdee P, Veeranondha S, Fuongfuchat A, Itharat A. Application of film-forming solution as a transdermal delivery system of piperine-rich herbal mixture extract for anti-inflammation. Heliyon. 2020; 6(6) :e04139. https://doi.org/10.1016/j.heliyon.2020.e04139
  • [12] Quijia CR, Araujo VH, Chorilli M. Piperine: Chemical, biological and nanotechnological applications. Acta Pharm. 2021; 71(2): 185–213. https://doi.org/10.2478/acph-2021-0015
  • [13] Chien YW. Development of transdermal drug delivery systems. Drug Dev Ind Pharm. 1987; 13(4–5): 589–651. https://doi.org/10.3109/03639048709105212
  • [14] Pastore MN, Kalia YN, Horstmann M, Roberts MS. Transdermal patches: history, development and pharmacology. Br J Pharmacol. 2015; 172(9): 2179–2209. https://doi.org/10.1111/bph.13059
  • [15] Floriano JF, de Barros NR, Cinman JLF, da Silva RG, Loffredo AV, Borges FA, Norberto AMQ, Chagas ALD, Garms BC, de Oliveira Graeff CF, Herculano RD. Ketoprofen loaded in natural rubber latex transdermal patch for tendinitis treatment. J Polym Environ. 2018; 26(6): 2281–2289. https://doi.org/10.1007/s10924-017-1127-x
  • [16] Prodduturi S, Sadrieh N, Wokovich AM, Doub WH, Westenberger BJ, Buhse L. Transdermal delivery of fentanyl from matrix and reservoir systems: Effect of heat and compromised skin. J Pharm Sci. 2010; 99(5): 2357–2366. https://doi.org/10.1002/jps.22004
  • [17] Morise BT, Chagas ALD, Barros NR, Miranda MCR, Borges FA, Gemeinder JLP, Silva RG, Paulino CG, Herculano RD, Norberto AMQ. Scopolamine loaded in natural rubber latex as a future transdermal patch for sialorrhea treatment. Int J Polym Mater Polym Biomater. 2019; 68(13):788–795. https://doi.org/10.1080/00914037.2018.1506984
  • [18] Yonashiro Marcelino M, Azevedo Borges F, Martins Costa AF, De Lacorte Singulani J, Ribeiro NV, Barcelos Costa-Orlandi C, Garms BC, Soares Mendes-Giannini MJ, Herculano RD, Fusco-Almeida AM. Antifungal activity of fluconazole-loaded natural rubber latex against Candida albicans. Future Microbiol. 2018;13(3):359–367. https://doi.org/10.2217/fmb-2017-0154
  • [19] Romeira MK, Drago BC, Murbach HD, Aielo BP,da Silva MGR, Brunello AC, Hercula DR. Evaluation of Stryphnodendron sp. release using natural rubber latex membrane as carrier. J Appl Sci. 2012; 12(7): 693–697. https://doi.org/10.3923/jas.2012.693.697
  • [20] Pichayakorn W, Suksaeree J, Boonme P, Amnuaikit T, Taweepreda W, Ritthidej GC. Deproteinized natural rubber latex/hydroxypropylmethyl cellulose blending polymers for nicotine matrix films. Ind Eng Chem Res. 2012; 51(25): 8442–8452. https://doi.org/10.1021/ie300608j
  • [21] Azevedo Borges F, Cesar Bolognesi LF, Trecco A, de Camargo Drago B, Baldo de Arruda L, Noronha Lisboa Filho P, Gonçalves Pierri E, de Oliveira Graeff CF, Gonzaga dos Santos A, Romeiro Miranda MC, Donizetti Herculano R. Natural rubber latex: Study of a novel carrier for Casearia sylvestris Swartz delivery . ISRN Polym Sci. 2014; Article ID 241297. https://doi.org/10.1155/2014/241297
  • [22] Hamza ZP, Dilfi KFA, Muralidharan MN, Kurian T. Microwave oven for the rapid determination of total solids content of natural rubber latex. Int J Polym Mater Polym Biomater. 2008; 57(9): 918–923. https://doi.org/10.1080/00914030802153066.
  • [23] Pichayakorn W, Suksaeree J, Boonme P, Amnuaikit T, Taweepreda W, Ritthidej GC. Nicotine transdermal patches using polymeric natural rubber as the matrix controlling system: Effect of polymer and plasticizer blends. J Memb Sci. 2012; 411–412: 81–90. https://doi.org/10.1016/j.memsci.2012.04.017
There are 23 citations in total.

Details

Primary Language English
Subjects Pharmaceutical Chemistry
Journal Section Articles
Authors

Nutlada Nusontra 0000-0002-5103-6658

Acharavadee Pansanit 0000-0001-8358-4889

Chakree Wattanasiri 0000-0001-9967-3843

Publication Date June 28, 2025
Published in Issue Year 2024 Volume: 28 Issue: 3

Cite

APA Nusontra, N., Pansanit, A., & Wattanasiri, C. (2025). Development of natural rubber latex patch infused with Piper nigrum L. extract. Journal of Research in Pharmacy, 28(3), 821-827.
AMA Nusontra N, Pansanit A, Wattanasiri C. Development of natural rubber latex patch infused with Piper nigrum L. extract. J. Res. Pharm. June 2025;28(3):821-827.
Chicago Nusontra, Nutlada, Acharavadee Pansanit, and Chakree Wattanasiri. “Development of Natural Rubber Latex Patch Infused With Piper Nigrum L. Extract”. Journal of Research in Pharmacy 28, no. 3 (June 2025): 821-27.
EndNote Nusontra N, Pansanit A, Wattanasiri C (June 1, 2025) Development of natural rubber latex patch infused with Piper nigrum L. extract. Journal of Research in Pharmacy 28 3 821–827.
IEEE N. Nusontra, A. Pansanit, and C. Wattanasiri, “Development of natural rubber latex patch infused with Piper nigrum L. extract”, J. Res. Pharm., vol. 28, no. 3, pp. 821–827, 2025.
ISNAD Nusontra, Nutlada et al. “Development of Natural Rubber Latex Patch Infused With Piper Nigrum L. Extract”. Journal of Research in Pharmacy 28/3 (June 2025), 821-827.
JAMA Nusontra N, Pansanit A, Wattanasiri C. Development of natural rubber latex patch infused with Piper nigrum L. extract. J. Res. Pharm. 2025;28:821–827.
MLA Nusontra, Nutlada et al. “Development of Natural Rubber Latex Patch Infused With Piper Nigrum L. Extract”. Journal of Research in Pharmacy, vol. 28, no. 3, 2025, pp. 821-7.
Vancouver Nusontra N, Pansanit A, Wattanasiri C. Development of natural rubber latex patch infused with Piper nigrum L. extract. J. Res. Pharm. 2025;28(3):821-7.