Review
BibTex RIS Cite

Year 2020, Volume: 24 Issue: 1, 1 - 22, 27.06.2025

Nasrin Dehghan-nayeri Mina Darvishi Pargol Mashati Maryam Rezapour-kalkhoran Morteza Rezaiefard Samareh Younesian

https://doi.org/10.35333/jrp.2020.121
Cited By: 2

Abstract

References

  • [1] Riaz M, van Jaarsveld MT, Hollestelle A, Prager-van der Smissen WJ, Heine AA, Boersma AW, et al. miRNA expression profiling of 51 human breast cancer cell lines reveals subtype and driver mutation-specific miRNAs. Breast Cancer Res. 2013; 15(2): R33. [CrossRef]
  • [2] Dai X, Cheng H, Bai Z, Li J. Breast cancer cell line classification and its relevance with breast tumor subtyping. J Cancer. 2017; 8(16): 3131-3141. [CrossRef]
  • [3] Goodspeed A, Heiser LM, Gray JW, Costello JC. Tumor-derived cell lines as molecular models of cancer pharmacogenomics. Mol Cancer Res. 2016; 14(1): 3-13. [CrossRef]
  • [4] Darvishi M, Esmaeili S, Dehghan-Nayeri N, Mashati P, Gharehbaghian A. Anticancer effect and enhancement of therapeutic potential of Vincristine by extract from aerial parts of Juniperus excelsa on pre-B acute lymphoblastic leukemia cell lines. J Appl Biomed. 2017; 15(3): 219- 226. [CrossRef]
  • [5] Barretina J, Caponigro G, Stransky N, Venkatesan K, Margolin A, et al. The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature. 2012; 483(7391): 603–607. [CrossRef]
  • [6] Suffness M. Assays related to cancer drug discovery. Methods in plant biochemistry: assays for bioactivity. 1990; 6: 71-133.
  • [7] Kroll DJ. Natural Compounds in Cancer Therapy: Promising Nontoxic Antitumor Agents from Plants and Other Natural Sources. J Nat Prod. 2001; 64(12): 1605-1606. [CrossRef]
  • [8] Yuenyongsawad S, Bunluepuech K, Wattanapiromsakul C, Tewtrakul S. Anti-cancer activity of compounds from Cassia garrettiana heartwood. Songklanakarin J Sci Technol. 2014; 36(2): 189-194.
  • [9] Bagul M, Kakumanu S, Wilson TA. Crude garlic extract inhibits cell proliferation and induces cell cycle arrest and apoptosis of cancer cells in vitro. J Med Food. 2015; 18(7): 731-737.[CrossRef]
  • [10] Looi CY, Arya A, Cheah FK, Muharram B, Leong KH, Mohamad K, et al. Induction of apoptosis in human breast cancer cells via caspase pathway by vernodalin isolated from Centratherum anthelminticum (L.) seeds. PloS one. 2013; 8(2): e56643. [CrossRef]
  • [11] Autore G, Marzocco S, Formisano C, Bruno M, Rosselli S, Jemia M, Senatore F. Cytotoxic activity and composition of petroleum ether extract from Magydaris tomentosa (Desf.) WDJ Koch (Apiaceae). Molecules. 2015; 20(1): 1571-1578
  • [12] Gudarzi H, Salimi M, Irian S, Amanzadeh A, Mostafapour Kandelous H, Azadmanesh K, et al. Ethanolic extract of Ferula gummosa is cytotoxic against cancer cells by inducing apoptosis and cell cycle arrest. Nat Prod Res. 2015; 29(6): 546-550.[CrossRef]
  • [13] Graidist P, Martla M, Sukpondma Y. Cytotoxic activity of Piper cubeba extract in breast cancer cell lines. Nutrients. 2015; 7(4): 2707-2718. [CrossRef]
  • [14] Choudhury B, Kandimalla R, Elancheran R, Bharali R, Kotoky J. Garcinia morella fruit, a promising source of antioxidant and anti-inflammatory agents induces breast cancer cell death via triggering apoptotic pathway. Biomed Pharmacother. 2018; 103: 562-573. [CrossRef]
  • [15] Yan G, Lanza-Jacoby S, Wang C. Nexrutine inhibits survival and induces G1 cell cycle arrest, which is associated with apoptosis or autophagy depending on the breast cancer cell line. Nutr Cancer. 2014; 66(3): 506-516. [CrossRef]
  • [16] Plastina P, Bonofiglio D, Vizza D, Fazio A, Rovito D, Giordano C, et al. Identification of bioactive constituents of Ziziphus jujube fruit extracts exerting antiproliferative and apoptotic effects in human breast cancer cells. J Ethnopharmacol. 2012; 140(2): 325-332. [CrossRef]
  • [17] Yin SY, Wei WC, Jian FY, Yang NS. Therapeutic applications of herbal medicines for cancer patients. Evid Based Complement Alternat Med. 2013; 2013: 302426. [CrossRef]
  • [18] Yang L, Yang C, Li C, Zhao Q, Liu L, Fang X, et al. Recent advances in biosynthesis of bioactive compounds in traditional Chinese medicinal plants. Sci Bull. 2016; 61(1): 3-17. [CrossRef]
  • [19] Atanasov AG, Waltenberger B, Pferschy-Wenzig E-M, Linder T, Wawrosch C, Uhrin P, et al. Discovery and resupply of pharmacologically active plant-derived natural products: A review. Biotechnol Adv. 2015; 33(8): 1582- 1614. [CrossRef]
  • [20] Subik K, Lee J-F, Baxter L, Strzepek T, Costello D, Crowley P, et al. The expression patterns of ER, PR, HER2, CK5/6, EGFR, Ki-67 and AR by immunohistochemical analysis in breast cancer cell lines. Breast Cancer (Auckl). 2010; 20(4): 35–41.[CrossRef]
  • [21] Holliday DL, Speirs V. Choosing the right cell line for breast cancer research. Breast Cancer Res. 2011; 13(4): 215. [CrossRef]
  • [22] Zhou X, Seto SW, Chang D, Kiat H, Razmovski-Naumovski V, Chan K, et al. Synergistic effects of Chinese herbal medicine: a comprehensive review of methodology and current research. Front Pharmacol. 2016; 7: 201. [CrossRef]
  • [23] Yaacob NS, Kamal NNNM, Norazmi MN. Synergistic anticancer effects of a bioactive subfraction of Strobilanthes crispus and tamoxifen on MCF-7 and MDA-MB-231 human breast cancer cell lines. BMC Complement Altern Med. 2014; 14(1): 252. [CrossRef]
  • [24] Tiwary BK, Bihani S, Kumar A, Chakraborty R, Ghosh R. The in vitro cytotoxic activity of ethno-pharmacological important plants of Darjeeling district of West Bengal against different human cancer cell lines. BMC Complement Altern Med. 2015; 15(1): 22. [CrossRef]
  • [25] Jetawattana S, Boonsirichai K, Charoen S, Martin SM. Radical intermediate generation and cell cycle arrest by an aqueous extract of Thunbergia laurifolia Linn. In human breast cancer cells. Asian Pac J Cancer Prev. 2015; 16(10): 4357-4361.[CrossRef]
  • [26] Sagadevan P, Suresh S, Rathishkumar S, Gayathri S, Eswari DV. Anticancer activity of methanolic leaf extracts of Andrographis paniculata (Nees) and Cardiospermum halicacabum (Linn) against human breast cancer cell line (MCF-7). Int J of Pharm & Life Sci (IJPLS). 2013; 4(9): 2983-2986.
  • [27] Tagne RS, Telefo BP, Nyemb JN, Yemele DM, Njina SN, Goka SMC, et al. Anticancer and antioxidant activities of methanol extracts and fractions of some Cameroonian medicinal plants. Asian Pac J Trop Med. 2014; 7S1: S442- S447. [CrossRef]
  • [28] Venugopal K, Ahmad H, Manikandan E, Arul KT, Kavitha K, Moodley M, et al. The impact of anticancer activity upon Beta vulgaris extract mediated biosynthesized silver nanoparticles (ag-NPs) against human breast (MCF-7), lung (A549) and pharynx (Hep-2) cancer cell lines. J Photochem Photobiol B. 2017; 173: 99-107. [CrossRef]
  • [29] Kapadia GJ, Rao GS, Ramachandran C, Iida A, Suzuki N, Tokuda H. Synergistic cytotoxicity of red beetroot (Beta vulgaris L.) extract with doxorubicin in human pancreatic, breast and prostate cancer cell lines. J Complement Integr Med. 2013; 10(1): 113-122. [CrossRef]
  • [30] Nowacki L, Vigneron P, Rotellini L, Cazzola H, Merlier F, Prost E, et al. Betanin‐enriched red beetroot (Beta vulgaris L.) extract induces apoptosis and autophagic cell death in MCF‐7 cells. Phytother Res. 2015; 29(12): 1964-1973. [CrossRef]
  • [31] Tripathy G, Pradhan D. Evaluation of IN-VITRO anti-proliferative activity and IN-VIVO immunomodulatory activity of beta vulgaris. Asian J Pharm Clin Res. 2013; 6(suppl 1): 127-130.
  • [32] Nile SH, Nile AS, Keum Y-S. Total phenolics, antioxidant, antitumor, and enzyme inhibitory activity of Indian medicinal and aromatic plants extracted with different extraction methods. 3 Biotech. 2017; 7(1): 76. [CrossRef]
  • [33] Khazaei S, Esa NM, Ramachandran V, Hamid RA, Pandurangan AK, Etemad A, et al. In vitro antiproliferative and apoptosis inducing effect of Allium atroviolaceum bulb extract on breast, cervical, and liver cancer cells. Front Pharmacol. 2017; 31(8): 5. [CrossRef]
  • [34] Azadi HG, Ghaffari SM, Riazi GH, Ahmadian S, Vahedi F. Antiproliferative activity of chloroformic extract of Persian Shallot, Allium hirtifolium, on tumor cell lines. Cytotechnology. 2008; 56(3): 179-185. [CrossRef]
  • [35] Isbilen O, Rizaner N, Volkan E. Anti-proliferative and cytotoxic activities of Allium autumnale PH Davis (Amaryllidaceae) on human breast cancer cell lines MCF-7 and MDA-MB-231. BMC Complement Altern Med. 2018; 18(1): 30. [CrossRef]
  • 36] Tanih NF, Ndip RN. The acetone extract of Sclerocarya birrea (Anacardiaceae) possesses antiproliferative and apoptotic potential against human breast cancer cell lines (MCF-7). Sci World J. 2013; 2013: 956206.[CrossRef]
  • [37 Shaban NZ, Hegazy WA, Abdel-Rahman SM, Awed OM, Khalil SA. Potential effect of Olea europea leaves, Sonchus oleraceus leaves and Mangifera indica peel extracts on aromatase activity in human placental microsomes and CYP19A1 expression in MCF-7 cell line: Comparative study. Cell Mol Biol (OMICS). 2016; 62(9): 11-9.
  • [38] Abdullah AS, Mohammed AS, Abdullah R, Mirghani ME, Al-Qubaisi M. Cytotoxic effects of Mangifera indica L. kernel extract on human breast cancer (MCF-7 and MDA-MB-231 cell lines) and bioactive constituents in the crude extract. BMC Complement Altern Med. 2014; 14: 199. [CrossRef]
  • [39] Ediriweera MK, Tennekoon KH, Samarakoon SR, Thabrew I, Dilip DESE. A study of the potential anticancer activity of Mangifera zeylanica bark: Evaluation of cytotoxic and apoptotic effects of the hexane extract and bioassay-guided fractionation to identify phytochemical constituents. Oncol Lett. 2016; 11(2): 1335-1344. [CrossRef]
  • [40] Lee JO, Moon JW, Lee SK, Kim SM, Kim N, Ko SG, et al. Rhus verniciflua extract modulates survival of MCF-7 breast cancer cells through the modulation of AMPK-pathway. Biol Pharm Bull. 2014; 37(5): 794-801. [CrossRef]
  • [41] Rahmat A, Kumar V, Fong LM, Endrini S, Sani HA. Determination of total antioxidant activity in three types of local vegetables shoots and the cytotoxic effect of their ethanolic extracts against different cancer cell lines. Asia Pac J Clin Nutr. 2004;13(3):308-311.
  • [42] Ghoreishi SM, Haghighi R. Chemical catalytic reaction and biological oxidation for treatment of non-biodegradable textile effluent. Chem Eng J. 2003; 95(1-3): 163-169. [CrossRef]
  • [43] Shebaby WN, El-Sibai M, Smith KB, Karam MC, Mroueh M, Daher CF. The antioxidant and anticancer effects of wild carrot oil extract. Phytother Res. 2013; 27(5): 737-744. [CrossRef]
  • [44] Sharopov FS, Wink M, Khalifaev DR, Zhang H, Dosoky NS, Setzer WN. Composition and bioactivity of the essential oil of Melissa officinalis L. growing wild in Tajikistan. Int J Trad Nat Med. 2013; 2(2): 86-96.
  • [45] Lall N, Kishore N, Binneman B, Twilley D, van de Venter M, du Plessis-Stoman D, et al. Cytotoxicity of syringin and 4-methoxycinnamyl alcohol isolated from Foeniculum vulgare on selected human cell lines. Nat Prod Res. 2015; 29(18): 1752-1756. [CrossRef]
  • [46] Farshori NN, Al-Sheddi ES, Al-Oqail MM, Musarrat J, Al-Khedhairy AA, Siddiqui MA. Anticancer activity of Petroselinum sativum seed extracts on MCF-7 human breast cancer cells. Asian Pac J Cancer Prev (APJCP). 2013; 14(10): 5719-5723. [CrossRef]
  • [47] Hamzeloomoghadam M, Esmaeili S, Fotoohi F, Naghibi F, Pirani A, Hajimehdipoor H. In vitro evaluation for cytotoxic activity of three Ferula species. Int J Pharm Sci Res. 2013; 4(7): 2673-2676.
  • [48] Eslami JB, Dehpouri A, Nemati F, Rezaei B. Cytotoxicity effects of the Ferula gummosa extract on the cancer cell line MCF7. J Anim Biol. 2013; 5(4): 1-7.
  • [49] De la Cruz JF, Vergara EJ, Cho Y, Hong HO, Oyungerel B, Hwang SG. Glehnia littoralis Root Extract Induces G0/G1 Phase Cell Cycle Arrest in the MCF-7 Human Breast Cancer Cell Line. Asian Pac J Cancer Prev (APJCP). 2015; 16(18): 8113-8117. [CrossRef]
  • [50] Popović V, Heyerick A, Petrović S, Van Calenbergh S, Karalic I, Niketić M, et al. Cytotoxic activity of Laserpitium latifolium L. extract and its daucane and phenylpropanoid constituents. Rec Nat Prod. 2013; 7(3): 245-249.
  • [51] Badmus JA, Ekpo OE, Hussein AA, Meyer M, Hiss DC. Antiproliferative and Apoptosis Induction Potential of the Methanolic Leaf Extract of Holarrhena floribunda (G. Don). Evid Based Complement Alternat Med. 2015; 2015: 756482. [CrossRef]
  • [52] Ben Jemia M, Kchouk ME, Senatore F, Autore G, Marzocco S, De Feo V, et al. Antiproliferative activity of hexane extract from Tunisian Cistus libanotis, Cistus monspeliensis and Cistus villosus. Chem Cent J. 2013; 7(1): 47. [CrossRef]
  • [53] Engel N, Falodun A, Kuhn J, Kragl U, Langer P, Nebe B. Pro-apoptotic and anti-adhesive effects of four African plant extracts on the breast cancer cell line MCF-7. BMC Complement Altern Med. 2014; 14: 334.
  • [54] Sunil D, Kumar NA, Nayak AS, Raj US, Deepa P. Cytotoxicity studies of microwave assisted natural product extracts in HeLa and MCF-7 cell lines. IJMAP. 2013; 3(1): 27-31.
  • [55] Souza AHP, Correa RCG, Barros L, Calhelha RC, Santos-Buelga C, Peralta RM, et al. Phytochemicals and bioactive properties of Ilex paraguariensis: An in-vitro comparative study between the whole plant, leaves and stems. Food Res Int. 2015; 78: 286-294. [CrossRef]
  • [56] MHM AE-A, El-Mesalamy A, Yassin F, Khalil S. Identification phenolic and biological activities of methanolic extract of date palm pollen (Phoenix dactylifera). J Microb Biochem Technol. 2015; 7: 047-050. [CrossRef]
  • [57] Freitas DDS, Morgado-Diaz JA, Gehren AS, Vidal FCB, Fernandes RMT, Romao W, et al. Cytotoxic analysis and chemical characterization of fractions of the hydroalcoholic extract of the Euterpe oleracea Mart. seed in the MCF7 cell line. J Pharm Pharmacol. 2017; 69(6): 714-721. [CrossRef]
  • [58] Afsal I V.T, Gautam G, Rajasekaran S, Nishad K. M. Development of Herbal Formulation with Ajwa seed (Phoenix dactylifera l.) Extract and Zam Zam Water for Anticancer Activity. World J Pharm Pharm Sci. 2018; 7(7): 781-795.
  • [59] Anajwala CC, Patel RM, Dakhara SL, Jariwala JK. In vitro cytotoxicity study of agave americana, strychnos nuxvomica and areca catechu extracts using mcf-7 cell line. J Adv Pharm Technol Res. 2010; 1(2): 245-252.
  • [60] Sarath VJ, So CS, Won YD, Gollapudi S. Artemisia princeps var orientalis induces apoptosis in human breast cancer MCF-7 cells. Anticancer Res. 2007; 27(6b): 3891-3898.
  • [61] Ghafari F, Rajabi MR, Mazoochi T, Taghizadeh M, Nikzad H, Atlasi MA, et al. Comparing Apoptosis and Necrosis Effects of Arctium Lappa Root Extract and Doxorubicin on MCF7 and MDA-MB-231 Cell Lines. Asian Pac J Cancer Prev (APJCP). 2017; 18(3): 795-802. [CrossRef]
  • [62] Ho WY, Yeap SK, Ho CL, Raha AR, Suraini AA, Alitheen NB. Elephantopus scaber induces cytotoxicity in MCF-7 human breast cancer cells via p53-induced apoptosis. J Med Plants Res. 2011; 5(24): 5741-5749.
  • [63] Mostafapour Kandelous H, Salimi M, Khori V, Rastkari N, Amanzadeh A, Salimi M. Mitochondrial Apoptosis Induced by Chamaemelum Nobile Extract in Breast Cancer Cells. Iran J Pharm Res (IJPR). 2016; 15(Suppl): 197-204.
  • [64] Dias MI, Barros L, Duenas M, Pereira E, Carvalho AM, Alves RC, et al. Chemical composition of wild and commercial Achillea millefolium L. and bioactivity of the methanolic extract, infusion and decoction. Food Chem. 2013; 141(4): 4152-4160. [CrossRef]
  • [65] Mendoza RP, Vidar WS, Oyong GG. In vitro cytotoxic potential of Yacon (Smallanthus sonchifolius) against HT29, MCF-7 and HDFn cell lines. J Med Plant Res. 2017; 11(10): 207-217. [CrossRef]
  • [66] Akter R, Uddin SJ, Tiralongo J, Grice ID, Tiralongo E. A New Cytotoxic Steroidal Glycoalkaloid from the Methanol Extract of Blumea lacera Leaves. J Pharm Pharm Sci. 2015; 18(4): 616-633. [CrossRef]
  • [67] Pitchai D, Roy A, Ignatius C. In vitro evaluation of anticancer potentials of lupeol isolated from Elephantopus scaber L. on MCF-7 cell line. J Adv Pharm Technol Res. 2014; 5(4): 179-184. [CrossRef]
  • [68] Conforti F, Ioele G, Statti GA, Marrelli M, Ragno G, Menichini F. Antiproliferative activity against human tumor cell lines and toxicity test on Mediterranean dietary plants. Food Chem Toxicol. 2008; 46(10): 3325-3332. [CrossRef]
  • [69] Talib WH, Mahasneh AM. Antiproliferative activity of plant extracts used against cancer in traditional medicine. Sci Pharm. 2010; 78(1): 33-45. [CrossRef]
  • [70] Shin SA, Lee HN, Choo GS, Kim HJ, Che JH, Jung JY. Ixeris dentata (Thunb. Ex Thunb.) Nakai Extract Inhibits Proliferation and Induces Apoptosis in Breast Cancer Cells through Akt/NF-kappaB Pathways. Int J Mol Sci. 2017; 18(2): E275. [CrossRef]
  • [71] Hamzeloo-Moghadam M, Khalaj A, Malekmohammadi M, Mosaddegh M. Achillea vermicularis a medicinal plant from Iranian Traditional Medicine induces apoptosis in MCF-7 cells. Res J Pharmacogn (RJP). 2015; 2(1): 1-5.
  • [72] Serasanambati M, Chilakapati SR, Manikonda PK, Kanala JR. Anticancer Activity of Methanolic Extract of Berberis aristata in MCF-7 Human Breast Cancer Cell Lines. Int J Life Sci Biotechnol Pharma Res. 2015; 4(1): 31-35.
  • [73] Zeng YT, Jiang JM, Lao HY, Guo JW, Lun YN, Yang M. Antitumor and apoptotic activities of the chemical constituents from the ethyl acetate extract of Artemisia indica. Mol Med Rep. 2015; 11(3): 2234-2240. [CrossRef]
  • [74] Bachiega P, Salgado JM, de Carvalho JE, Ruiz A, Schwarz K, Tezotto T, et al. Antioxidant and antiproliferative activities in different maturation stages of broccoli (Brassica oleracea Italica) biofortified with selenium. Food Chem. 2016; 190: 771-776. [CrossRef]
  • [75] Yeo SK, Ali AY, Hayward OA, Turnham D, Jackson T, Bowen ID, et al. beta-Bisabolene, a Sesquiterpene from the Essential Oil Extract of Opoponax (Commiphora guidottii), Exhibits Cytotoxicity in Breast Cancer Cell Lines. Phytother Res. 2016; 30(3): 418-425. [CrossRef]
  • [76] Chaudhary S, Chandrashekar KS, Pai KS, Setty MM, Devkar RA, Reddy ND, et al. Evaluation of antioxidant and anticancer activity of extract and fractions of Nardostachys jatamansi DC in breast carcinoma. BMC Complement Altern Med. 2015; 15: 50.
  • [77] Maisarah A, Asmah R, Fauziah O. Proximate analysis, antioxidant and antiproliferative activities of different parts of Carica papaya. J Nutr Food Sci. 2014; 4(2): 1-7. [CrossRef]
  • [78] Pereira JM, Lopes-Rodrigues V, Xavier CP, Lima MJ, Lima RT, Ferreira IC, et al. An Aqueous Extract of Tuberaria lignosa Inhibits Cell Growth, Alters the Cell Cycle Profile, and Induces Apoptosis of NCI-H460 Tumor Cells. Molecules. 2016; 21(5): E595. [CrossRef]
  • [79] El Euch SK, Bouajila J, Bouzouita N. Chemical composition, biological and cytotoxic activities of Cistus salviifolius flower buds and leaves extracts. Ind Crops Prod. 2015; 76: 1100-1105. [CrossRef]
  • [80] Setiawati A. Anticancer activity of mangosteen pericarp dry extract against MCF-7 breast cancer cell line through estrogen receptor-α. Indonesian J Pharm. 2014; 25(3): 119-124. [CrossRef]
  • [81] Chitra S, Krithika M, Pavithra S. Induction of apoptosis by xanthones from Garcinia mangostana in human breast and laryngeal carcinoma cell lines. Int J Pharma Bio Sci. 2010; 1(3): 1-8.
  • [82] Subarnas A, Diantini A, Abdulah R, Zuhrotun A, Yamazaki C, Nakazawa M, et al. Antiproliferative activity of primates-consumed plants against MCF-7 human breast cancer cell lines. E3 J Med Res. 2012; 1(4): 038-043.
  • [83] Diab KA, Guru SK, Bhushan S, Saxena AK. In Vitro Anticancer Activities of Anogeissus latifolia, Terminalia bellerica, Acacia catechu and Moringa oleiferna Indian Plants. Asian Pac J Cancer Prev (APJCP). 2015; 16(15): 6423- 6428. [CrossRef]
  • [84] Rezaei F, Shokrzadeh M, Majd A, Nezhadsattari T. Cytotoxic Effect of Hydroalcoholic Extract of Cornus mas L. fruit on MCF7, HepG2 and CHO cell line by MTTAssay. J Mazandaran Univ Med Sci. 2014; 24(113): 130-138.
  • [85] Qi Y-j, Cui S, Lu D-x, Yang Y-z, Luo Y, Ma L, et al. Effects of the aqueous extract of a Tibetan herb, Rhodiola algida var. tangutica on proliferation and HIF-1α, HIF-2α expression in MCF-7 cells under hypoxic condition in vitro. Cancer Cell Int. 2015; 15(1): 81. [CrossRef]
  • [86] El-Sharkawy ER, Matloub AA, Atta EM. Cytotoxicity of new flavonoid compound isolated from Farsetia aegyptia. Int J Pharm Sci Inv. 2013; 2(1): 23-27.
  • [87] Moghe AS, Gangal SG, Shilkar PR. In vitro cytotoxicity of Bryonia laciniosa (Linn.) Naud. on human cancer cell lines. Indian J Nat Prod Resour. 2011; 2(3): 322-329.
  • [88] Petchsak P, Sripanidkulchai B. Momordica cochinchinensis Aril Extract Induced Apoptosis in Human MCF-7 Breast Cancer Cells. Asian Pac J Cancer Prev (APJCP). 2015; 16(13): 5507-5513. [CrossRef]
  • [89] Medjakovic S, Hobiger S, Ardjomand-Woelkart K, Bucar F, Jungbauer A. Pumpkin seed extract: Cell growth inhibition of hyperplastic and cancer cells, independent of steroid hormone receptors. Fitoterapia. 2016; 110: 150- 156. [CrossRef]
  • [90] Mukherjee A, Patil SD. Effects of alkaloid rich extract of Citrullus colocynthis fruit on Artemia salina and human cancerous (MCF-7 and HEPG-2) cells. J PharmaSciTech. 2012; 1(2): 15-19.
  • [91] Andalib A, Jafarian-Dehkordi A, Shokouhi-Shourmasti R, Abdolah-Kohpayeh-Esfahani S. The effect of Persian Juniperus excelsa extracts on cell-cycle phases of MCF-7 breast cancer cell line. J Isfahan Med Sch. 2016; 33(360): 2004-2012.
  • [92] Foo JB, Yazan LS, Tor YS, Armania N, Ismail N, Imam MU, et al. Induction of cell cycle arrest and apoptosis in caspase-3 deficient MCF-7 cells by Dillenia suffruticosa root extract via multiple signalling pathways. BMC Complement Altern Med. 2014; 14: 197. [CrossRef]
  • [93] Tor YS, Yazan LS, Foo JB, Wibowo A, Ismail N, Cheah YK, et al. Induction of Apoptosis in MCF-7 Cells via Oxidative Stress Generation, Mitochondria-Dependent and Caspase-Independent Pathway by Ethyl Acetate Extract of Dillenia suffruticosa and Its Chemical Profile. PLoS One. 2015; 10(6): e0127441. [CrossRef]
  • [94] Armania N, Yazan LS, Ismail IS, Foo JB, Tor YS, Ishak N, et al. Dillenia Suffruticosa extract inhibits proliferation of human breast cancer cell lines (MCF-7 and MDA-MB-231) via induction of G2/M arrest and apoptosis. Molecules. 2013; 18(11): 13320-13339. [CrossRef]
  • [95] Pilane MC, Bagla VP, Mokgotho MP, Mbazima V, Matsebatlela TM, Ncube I, et al. Free Radical Scavenging Activity: Antiproliferative and Proteomics Analyses of the Differential Expression of Apoptotic Proteins in MCF-7 Cells Treated with Acetone Leaf Extract of Diospyros lycioides (Ebenaceae). Evid Based Complement Alternat Med (eCAM). 2015; 2015: 534808. [CrossRef]
  • [96] Abdul Salam R. Protective effect of erythroxylum cuneatum and mitragyna speciosa leaf extract on RAW 264.7 and MCF-7: Universiti Teknologi Mara; 2010.
  • [97] Ping KY, Darah I, Chen Y, Sasidharan S. Cytotoxicity and genotoxicity assessment of Euphorbia hirta in MCF-7 cell line model using comet assay. Asian Pac J Trop Biomed. 2013; 3(9): 692-696
  • [98] Jose J, Sudhakaran S, Kumar S, Jayaraman S, Variyar EJ. A comparative evaluation of anticancer activities of flavonoids isolated from Mimosa pudica, Aloe vera and Phyllanthus niruri against human breast carcinoma cell line (MCF-7) using MTT assay. Int J Pharm Pharm Sci. 2014; 6(2): 319-322.
  • [99] Niraimathi V, Sundaraganapathy R. In vitro anticancer activity of various fractions of hydro alcoholic extract of Dalbergia latifolia Roxb. International Journal of Phytopharmacology (IJP). 2014; 5(4): 272-283.
  • [100] Yadav NK, Saini KS, Hossain Z, Omer A, Sharma C, Gayen JR, et al. Saraca indica bark extract shows in vitro antioxidant, antibreast cancer activity and does not exhibit toxicological effects. Oxid Med Cell Longev. 2015; 2015: 205360. [CrossRef]
  • [101] Sreeja S, Anju VS, Sreeja S. In vitro estrogenic activities of fenugreek Trigonella foenum graecum seeds. Indian J Med Res. 2010; 131: 814-819.
  • [102] Alshatwi AA, Shafi G, Hasan TN, Syed NA, Khoja KK. Fenugreek induced apoptosis in breast cancer MCF-7 cells mediated independently by fas receptor change. Asian Pac J Cancer Prev (APJCP). 2013; 14(10):5783-5788. [CrossRef]
  • [103] Uifalean A, Schneider S, Gierok P, Ionescu C, Iuga CA, Lalk M. The Impact of Soy Isoflavones on MCF-7 and MDAMB-231 Breast Cancer Cells Using a Global Metabolomic Approach. Int J Mol Sci. 2016; 17(9): E1443. [CrossRef]
  • [104] Zhang SY, Zheng CG, Yan XY, Tian WX. Low concentration of condensed tannins from catechu significantly inhibits fatty acid synthase and growth of MCF-7 cells. Biochemical and biophysical research communications. 2008; 371(4): 654-658. [CrossRef]
  • [105] Nanasombat S, Teckchuen N. Antimicrobial, antioxidant and anticancer activities of Thai local vegetables. J Med Plant Res. 2009; 3(5): 443-449.
  • [106] Tantengco OAG, Jacinto SD. Cytotoxic activity of crude extracts and fractions from Premna odorata (Blanco), Artocarpus camansi (Blanco) and Gliricidia sepium (Jacq.) against selected human cancer cell lines. Asian Pac J Trop Biomed. 2015; 5(12): 1037-1041. [CrossRef]
  • [107] Hu C, Liu H, Du J, Mo B, Qi H, Wang X, et al. Estrogenic activities of extracts of Chinese licorice (Glycyrrhiza uralensis) root in MCF-7 breast cancer cells. J Steroid Biochem Mol Biol. 2009; 113(3-5): 209-216. [CrossRef]
  • [108] Jo EH, Hong HD, Ahn NC, Jung JW, Yang SR, Park JS, et al. Modulations of the Bcl-2/Bax family were involved in the chemopreventive effects of licorice root (Glycyrrhiza uralensis Fisch) in MCF-7 human breast cancer cell. J Agric Food Chem. 2004; 52(6): 1715-1719. [CrossRef]
  • [109] Rungrojtrakool P, Siripong P, Yahuafai J, Chuakul W, Temsiririrkkul R, Chuakul W, et al. Antiproliferative activity against various cancer cells and phytochemical components of Thai herbal formula. Mahidol Univ J Pharm Sci. 2012; 39(2): 7-14.
  • [110] Bahri GG, Lamuki MS, Rezae-Raad MS. Anti-proliferative effects of alcoholic and aqueous extract of Ginkgo biloba green leaves on MCF-7 cell line. Int J Pharm Med Res (IJMPR). 2014; 2(3): 8-11.
  • [111] Narayanan NK, Kunimasa K, Yamori Y, Mori M, Mori H, Nakamura K, et al. Antitumor activity of melinjo (Gnetum gnemon L.) seed extract in human and murine tumor models in vitro and in a colon-26 tumor-bearing mouse model in vivo. Cancer Med. 2015; 4(11): 1767-1780. [CrossRef]
  • [112] Sriraman S, Ramanujam GM, Ramasamy M, Dubey GP. Identification of beta-sitosterol and stigmasterol in Bambusa bambos (L.) Voss leaf extract using HPLC and its estrogenic effect in vitro. J Pharm Biomed Anal. 2015; 115: 55-61. [CrossRef]
  • [113] Mirmalek SA, Azizi MA, Jangholi E, Yadollah-Damavandi S, Javidi MA, Parsa Y, et al. Cytotoxic and apoptogenic effect of hypericin, the bioactive component of Hypericum perforatum on the MCF-7 human breast cancer cell line. Cancer Cell Int. 2015; 16: 3. [CrossRef]
  • [114] Bakshi HA, Hakkim FL, Sam S. Molecular Mechanism of Crocin Induced Caspase Mediated MCF-7 Cell Death: In Vivo Toxicity Profiling and Ex Vivo Macrophage Activation. Asian Pac J Cancer Prev (APJCP). 2016; 17(3): 1499- 1506. [CrossRef]
  • [115] Hilbig J, Policarpi PB, Grinevicius V, Mota N, Toaldo IM, Luiz MTB, et al. Aqueous extract from pecan nut [Carya illinoinensis (Wangenh) C. Koch] shell show activity against breast cancer cell line MCF-7 and Ehrlich ascites tumor in Balb-C mice. J Ethnopharmacol. 2018; 211: 256-266. [CrossRef]
  • [116] Vinayagam A, Sudha PN. In Vitro Cytotoxicity Activity of Acteoside From Leucas Indica Flowers. Indian J Appl Res. 2014; 4(2). [CrossRef]
  • [117] Hamza AA, Ahmed MM, Elwey HM, Amin A. Melissa officinalis Protects against Doxorubicin-Induced Cardiotoxicity in Rats and Potentiates Its Anticancer Activity on MCF-7 Cells. PLoS One. 2016; 11(11): e0167049. [CrossRef]
  • [118] Saravanan R, Pemaiah B, Sridharan S, Narayanan M, Ramalingam S. Enhanced cytotoxic potential of Orthosiphon stamineus extract in MCF-7 cells through suppression of nucleolin and Bcl2. Bangladesh J Pharmacol. 2017; 12(3): 268-275.
  • [119] Geryani MA, Mahdian D, Mousavi SH, Hosseini A. Ctotoxic and apoptogenic effects of Perovskia abrotanoides flower extract on MCF-7 and HeLa cell lines. Avicenna J Phytomed. 2016; 6(4): 410-417.
  • [120] Gonzalez-Vallinas M, Reglero G, Ramirez de Molina A. Rosemary (Rosmarinus officinalis L.) Extract as a Potential Complementary Agent in Anticancer Therapy. Nutr Cancer. 2015; 67(8): 1221-1229. [CrossRef]
  • [121] Moattar FS, Sariri R, Giahi M, Yaghmaee P, Ghafoori H, Jamalzadeh L. Antioxidant and anti-proliferative activity of Calamintha officinalis extract on breast cancer cell line MCF-7. J Biol Sci. 2015; 15(4): 194-198. [CrossRef]
  • [122] Ali MA, Abul Farah M, Al-Hemaid FM, Abou-Tarboush FM. In vitro cytotoxicity screening of wild plant extracts from Saudi Arabia on human breast adenocarcinoma cells. Genet Mol Res (GMR). 2014; 13(2): 3981-3990. [CrossRef]
  • [123] Pal A, Toppo FA, Chaurasiya PK, Singour PK, Pawar RS. In-vitro cytotoxicity study of methanolic fraction from Ajuga Bracteosa wall ex. benth on MCF-7 breast adenocarcinoma and hep-2 larynx carcinoma cell lines. Pharmacognosy Res. 2014; 6(1): 87-91. [CrossRef]
  • [124] Tarhan L, Nakipoglu M, Kavakcioglu B, Tongul B, Nalbantsoy A. The Induction of Growth Inhibition and Apoptosis in HeLa and MCF-7 Cells by Teucrium sandrasicum, Having Effective Antioxidant Properties. Appl Biochem Biotechnol. 2016; 178(5): 1028-1041. [CrossRef]
  • [125] Narrima P, Paydar M. Persea declinata (Bl.) Kosterm Bark Crude Extract Induces Apoptosis in MCF-7 Cells via G0/G1 Cell Cycle Arrest, Bcl-2/Bax/Bcl-xl Signaling Pathways, and ROS Generation. Evid Based Complement Alternat Med (eCAM). 2014; 2014: 248103. [CrossRef]
  • [126] Casacchia T, Sofo A, Casaburi I, Marrelli M, Conforti F, Statti GA. Antioxidant, enzyme-inhibitory and antitumor activity of the wild dietary plant Muscari comosum (L.) Mill. Int J Plant Biol. 2017; 8(1): 31-35. [CrossRef]
  • [127] Guerriero E, Sorice A, Capone F, Storti G, Colonna G, Ciliberto G, et al. Combining doxorubicin with a phenolic extract from flaxseed oil: Evaluation of the effect on two breast cancer cell lines. Int J Oncol. 2017; 50(2): 468-476. [CrossRef]
  • [128] Theil C, Briese V, Richter DU, Jeschke U, Friese K. An ethanolic extract of Linum usitatissimum caused cell lethality and inhibition of cell vitality/ - proliferation of MCF-7 and BT20 mamma carcinoma cells in vitro. Arch Gynecol Obstet. 2013; 288(1): 149-153. [CrossRef]
  • [129] Zainuddin N, Sul'ain MD. Antiproliferative effect of Dendrophthoe pentandra extracts towards human breast adenocarcinoma cells (MCF-7). J Teknol. 2015; 77(2): 35-39. [CrossRef]
  • [130] Dashora N, Sodde V, Prabhu KS, Lobo R. In vitro cytotoxic activity of Dendrophthoe falcata on human breast adenocarcinoma Cells-MCF-7. Int J Cancer Res. 2011; 7(1): 47-54. [CrossRef]
  • [131] Sahin B, Demir E, Aygun A, Gunduz H, Sen F. Investigation of the effect of pomegranate extract and monodisperse silver nanoparticle combination on MCF-7 cell line. J Biotechnol. 2017; 260: 79-83. [CrossRef]
  • [132] Shirode AB, Kovvuru P, Chittur SV, Henning SM, Heber D, Reliene R. Antiproliferative effects of pomegranate extract in MCF-7 breast cancer cells are associated with reduced DNA repair gene expression and induction of double strand breaks. Mol Carcinog. 2014; 53(6): 458-470. [CrossRef]
  • [133] Manasathien J, Indrapichate K. Apoptosis of MCF-7 cancer cell induced by pomegranate (Punica Granatum L.) Peel extract. Suranaree J Sci Technol. 2017; 24(1): 63-74.
  • [134] Sai Saraswathi V, Saravanan D, Santhakumar K. Isolation of quercetin from the methanolic extract of Lagerstroemia speciosa by HPLC technique, its cytotoxicity against MCF-7 cells and photocatalytic activity. J Photochem Photobiol B. 2017; 171: 20-26. [CrossRef]
  • [135] Wong YH, Tan WY, Tan CP, Long K, Nyam KL. Cytotoxic activity of kenaf (Hibiscus cannabinus L.) seed extract and oil against human cancer cell lines. Asian Pac J Trop Biomed. 2014; 4(Suppl 1): S510-515. [CrossRef]
  • [136] Meena SN, Sharma S, Kulshreshtha R, Janarthanam MK, Ghadi SC. Antiproliferative activity and phytochemical analysis of methanol leaf extract of Grewia nervosa. Curr Sci. 2017; 113(10): 1828-1830.
  • [137] Cheung T, Nigam PS-N, Owusu-Apenten R. Antioxidant activity of curcumin and neem (Azadirachta indica) powders: Combination studies with ALA using MCF-7 breast cancer cells. J Appl Life Sci Int. 2016; 4(3): 1-12. [CrossRef
  • [138] Sharma C, Vas AJ, Goala P, Gheewala TM, Rizvi TA, Hussain A. Ethanolic neem (Azadirachta indica) leaf extract prevents growth of MCF-7 and HeLa cells and potentiates the therapeutic index of cisplatin. J oncol. 2014; 2014: 321754. [CrossRef]
  • [139] Chan LL, George S, Ahmad I, Gosangari SL, Abbasi A, Cunningham BT, et al. Cytotoxicity Effects of Amoora rohituka and chittagonga on Breast and Pancreatic Cancer Cells. Evid Based Complement Alternat Med (eCAM). 2011; 2011: 860605. [CrossRef]
  • [140] Khaghani S, Yajloo MM, Paknejad M, Shariftabrizi A, Pasalar P, Razi F. Selective cytotoxicity and apoptogenic activity of Hibiscus sabdariffa aqueous extract against MCF-7 human breast cancer cell line. J Cancer Ther. 2011; 2(3): 394-400. [CrossRef]
  • [141] Yang S, Zhao Q, Xiang H, Liu M, Zhang Q, Xue W, et al. Antiproliferative activity and apoptosis-inducing mechanism of constituents from Toona sinensis on human cancer cells. Cancer Cell Int. 2013; 13(1): 12. [CrossRef]
  • [142] Gopinath P, Vadivel S, Kamatchiammal S, Saroja V. Anticancerous activity of Albizia amara (Roxb.) Bovin using human breast cancer cells (MCF-7) by in vitro methods. Int J Pharma Res Rev. 2013; 2(8): 23-32.
  • [143] Jasmine R, Manikandan K, Karthikeyan K. Evaluating the antioxidant and anticancer property of Ficus carica fruits. Afr J Biotechnol. 2015; 14(7): 634-641. [CrossRef]
  • [144] Yessoufou K, Elansary HO, Mahmoud EA, Skalicka-Woźniak K. Antifungal, antibacterial and anticancer activities of Ficus drupacea L. stem bark extract and biologically active isolated compounds. Ind Crops Prod. 2015; 74: 752- 758. [CrossRef]
  • [145] Pratumvinit B, Srisapoomi T, Worawattananon P, Opartkiattikul N, Jiratchariyakul W, Kummalue T. In vitro antineoplastic effect of Ficus hispida L. plant against breast cancer cell lines. J Med Plants Res. 2009; 3(4): 255-261.
  • [146] Kumar NN, Ramakrishnaiah H, Krishna V, Radhika M. Cytotoxic activity of Broussonetia papyrifera (L.) Vent on MCF-7, HeLa and HepG2 cell lines. Int J Pharm Pharm Sci. 2014; 6(5): 339-342.
  • [147] Deepa M, Sureshkumar T, Satheeshkumar PK, Priya S. Antioxidant rich Morus alba leaf extract induces apoptosis in human colon and breast cancer cells by the downregulation of nitric oxide produced by inducible nitric oxide synthase. Nutr Cancer. 2013; 65(2): 305-310.[CrossRef]
  • [148] Choi YK, Cho SG, Choi HS, Woo SM, Yun YJ, Shin YC, et al. JNK1/2 Activation by an Extract from the Roots of Morus alba L. Reduces the Viability of Multidrug-Resistant MCF-7/Dox Cells by Inhibiting YB-1-Dependent MDR1 Expression. Evid Based Complement Alternat Med (eCAM). 2013; 2013: 741985. [CrossRef]
  • [149] Elsayed EA, Sharaf-Eldin MA, Wadaan M. In vitro Evaluation of Cytotoxic Activities of Essential Oil from Moringa oleifera Seeds on HeLa, HepG2, MCF-7, CACO-2 and L929 Cell Lines. Asian Pac J Cancer Prev (APJCP). 2015; 16(11) 4671-4675. [CrossRef]
  • [150] Dos Santos RC, Ombredane AS, Souza JMT, Vasconcelos AG, Placido A, Amorim A, et al. Lycopene-rich extract from red guava (Psidium guajava L.) displays cytotoxic effect against human breast adenocarcinoma cell line MCF7 via an apoptotic-like pathway. Food Res Int. 2018; 105: 184-196. [CrossRef]
  • [151] Kumar PS, Febriyanti RM, Sofyan FF, Luftimas DE, Abdulah R. Anticancer potential of Syzygium aromaticum L. in MCF-7 human breast cancer cell lines. Pharmacognosy Res. 2014; 6(4): 350-354. [CrossRef]
  • [152] Zhang L, Shamaladevi N, Jayaprakasha GK, Patil BS, Lokeshwar BL. Polyphenol-rich extract of Pimenta dioica berries (Allspice) kills breast cancer cells by autophagy and delays growth of triple negative breast cancer in athymic mice. Oncotarget. 2015; 6(18): 16379. [CrossRef]
  • [153] Kich DM, Bitencourt S, Caye B, Faleiro D, Alves C, Silva J, et al. Lymphocyte genotoxicity and protective effect of Calyptranthes tricona (Myrtaceae) against H2O2-induced cell death in MCF-7 cells. Mol Cell Biochem. 2017; 424(1- 2): 35-43. [CrossRef]
  • [154] Seyed Hassan Tehrani S, Hashemi Sheikh Shabani S, Tahmasebi Enferadi S, Rabiei Z. Growth Inhibitory Impact of Peganum harmala L. on Two Breast Cancer Cell Lines. Iran J Bıotechnol. 2014; 12(1): 8-14. [CrossRef]
  • [155] Shyur LF, Chen CH, Lo CP, Wang SY, Kang PL, Sun SJ, et al. Induction of apoptosis in MCF-7 human breast cancer cells by phytochemicals from Anoectochilus formosanus. J Biomed Sci. 2004; 11(6): 928-939. [CrossRef]
  • [156] Gali K, Ramakrishnan G, Kothai R, Jaykar B. In-vitro anti-cancer activity of methanolic extract of leaves of Argemone mexicana Linn. Int J PharmTech Res. 2011; 3: 1329-1333.
  • [157] Siao AC, Hou CW, Kao YH, Jeng KC. Effect of sesamin on apoptosis and cell cycle arrest in human breast cancer mcf-7 cells. Asian Pac J Cancer Prev (APJCP). 2015; 16(9): 3779-3783. [CrossRef]
  • [158] Venkatesan T, Choi YW, Mun SP, Kim YK. Pinus radiata bark extract induces caspase-independent apoptosis-like cell death in MCF-7 human breast cancer cells. Cell Biol Toxicol. 2016; 32(5): 451-464. [CrossRef]
  • [159] Grinevicius VM, Andrade KS, Ourique F, Micke GA, Ferreira SR, Pedrosa RC. Antitumor activity of conventional and supercritical extracts from Piper nigrum L. cultivar Bragantina through cell cycle arrest and apoptosis induction. J Supercrit Fluids. 2017; 128: 94-101. [CrossRef]
  • [160] Aditya V, Kumar N, Mokkapati A. In vitro anti-cancer activities of few plant extracts against MCF-7 and HT-29 cell lines. Int J Pharma Sci. 2013; 3: 185-188.
  • [161] Hussain A, Gheewala TM, Vas AJ, Shah K, Goala P, Khan S, et al. Growth inhibitory and adjuvant therapeutic potential of aqueous extract of Triticum aestivum on MCF-7 and HeLa cells. Exp Oncol. 2014; 36(1): 9-16.
  • [162] Kaur P, Kaur V, Kumar M, Kaur S. Suppression of SOS response in E. coli PQ 37, antioxidant potential and antiproliferative action of methanolic extract of Pteris vittata L. on human MCF-7 breast cancer cells. Food Chem Toxicol. 2014; 74: 326-333. [CrossRef]
  • [163] Mahmoud SS, Torchilin VP. Hormetic/cytotoxic effects of Nigella sativa seed alcoholic and aqueous extracts on MCF-7 breast cancer cells alone or in combination with doxorubicin. Cell Biochem Biophys. 2013; 66(3): 451-460. [CrossRef]
  • [164] Kang JX, Liu J, Wang J, He C, Li FP. The extract of huanglian, a medicinal herb, induces cell growth arrest and apoptosis by upregulation of interferon-beta and TNF-alpha in human breast cancer cells. Carcinogenesis. 2005; 26(11): 1934-1939. [CrossRef]
  • [165] Abedini MR, Erfanian N, Nazem H, Jamali S, Hoshyar R. Anti-proliferative and apoptotic effects of Ziziphus Jujube on cervical and breast cancer cells. Avicenna J Phytomed. 2016; 6(2): 142-148.
  • [166] Cheshmi F, Kazerouni F, Omrani MD, Rahimipour A, Shanaki M, Dehghan-Nayeri N, et al. Effect of Emodin on Expression of VEGF-A and VEGFR_2 Genes in Human Breast Carcinoma MCF-7 Cell. Int J Cancer Manag. 2017; 10(7). [CrossRef]
  • [167] George BP, Abrahamse H, Hemmaragala NM. Anticancer effects elicited by combination of Rubus extract with phthalocyanine photosensitiser on MCF-7 human breast cancer cells. Photodiagnosis Photodyn Ther. 2017; 19: 266- 273. [CrossRef]
  • [168] Amatori S, Mazzoni L, Alvarez-Suarez JM, Giampieri F, Gasparrini M, Forbes-Hernandez TY, et al. Polyphenolrich strawberry extract (PRSE) shows in vitro and in vivo biological activity against invasive breast cancer cells. Sci Rep. 2016; 6: 30917. [CrossRef]
  • [169] Atmaca H, Bozkurt E, Cittan M, Dilek Tepe H. Effects of Galium aparine extract on the cell viability, cell cycle and cell death in breast cancer cell lines. J Ethnopharmacol. 2016; 186: 305-310. [CrossRef]
  • [170] Arbab IA, Abdul AB, Sukari MA, Abdullah R, Syam S, Kamalidehghan B, et al. Dentatin isolated from Clausena excavata induces apoptosis in MCF-7 cells through the intrinsic pathway with involvement of NF-kappaB signalling and G0/G1 cell cycle arrest: a bioassay-guided approach. J Ethnopharmacol. 2013; 145(1): 343-354. [CrossRef]
  • [171] Shoja MH, Reddy ND, Nayak PG, Srinivasan KK, Rao CM. Glycosmis pentaphylla (Retz.) DC arrests cell cycle and induces apoptosis via caspase-3/7 activation in breast cancer cells. J Ethnopharmacol. 2015; 168: 50-60. [CrossRef]
  • [172] Gitanjali T, Debasish P. In‐vitro anti breast cancer activity of Limonia acidissima against MCF‐7 cell line. World J Pharm Pharm Sci. 2015; 4: 1543-1550.
  • [173] Xuan H, Li Z, Yan H, Sang Q, Wang K. Antitumor Activity of Chinese Propolis in Human Breast Cancer MCF-7 and MDA-MB-231 Cells. Evid Based Complement Alternat Med (eCAM). 2014; 2014: 280120. [CrossRef]
  • [174] A. Y. Ibrahim, S. E. El-gengaihi, and H. M. Motawe, Phytochemical and Cytotoxicity Investigations of Salvadora Persica Bark Extracts. Phytochem Cytotox Investig J. 2011; 6(2) 127–133.
  • [175] Zhai JW, Gao C, Ma WD, Wang W, Yao LP, Xia XX, et al. Geraniin induces apoptosis of human breast cancer cells MCF-7 via ROS-mediated stimulation of p38 MAPK. Toxicol Mech Methods. 2016; 26(5): 311-318. [CrossRef]
  • [176] Valiyari S, Jahanban-Esfahlan R, Shahneh FZ, Yaripour S, Baradaran B, Delazar A. Cytotoxic and apoptotic activity of Scrophularia oxysepala in MCF-7 human breast cancer cells. Toxicol Environ Chem. 2013; 95(7): 1208-1220. [CrossRef]
  • [177] Azadmehr A, Hajiaghaee R, Baradaran B, Haghdoost-Yazdi H. Apoptosis Cell Death Effect of Scrophularia Variegata on Breast Cancer Cells via Mitochondrial Intrinsic Pathway. Adv Pharm Bull. 2015; 5(3): 443-446. [CrossRef]
  • [178] Jayakumar K, Murugan K. Purified Solasodine and Caulophyllumine: A from Solanum mauritianum Scop. against MCF-7 Breast Cancer Cell Lines in Terms of Cell Growth. J Pharmacogn Phytochem. 2017; 6: 472-478.
  • [179] Munari CC, de Oliveira PF, Campos JC, Martins Sde P, Da Costa JC, Bastos JK, et al. Antiproliferative activity of Solanum lycocarpum alkaloidic extract and their constituents, solamargine and solasonine, in tumor cell lines. J Nat Med. 2014; 68(1): 236-241. [CrossRef]
  • [180] Nazeema B, Julie J, Abirami J, Kumareasan R, Muthukumaran T, Rajasree S, et al. Anti-cancer activity of Datura metel on MCF-7 cell line. Asian J Pharmaceutic Clinic Res. 2014; 7(7): 181-183.
  • [181] Alimohammadi M, Lahiani MH, McGehee D, Khodakovskaya M. Polyphenolic extract of InsP 5-ptase expressing tomato plants reduce the proliferation of MCF-7 breast cancer cells. PLoS One. 2017; 12(4): e0175778. [CrossRef]
  • [182] Thenmozhi A, Nagalakshmi A, Mahadeva Rao U. Study of cytotoxic and antimitotic activities of Solanum nigrum by using Allium ceparoot tip assay and cancer chemo preventive activity using MCF-7-human mammary gland breast adenocarcinoma cell lines. Int J Sci Technol. 2011; 1(2): 26-48.
  • [183] Lai YJ, Tai CJ, Wang CW, Choong CY, Lee BH, Shi YC, et al. Anti-Cancer Activity of Solanum nigrum (AESNthrough Suppression of Mitochondrial Function and Epithelial-Mesenchymal Transition (EMT) in Breast Cancer Cells. Molecules. 2016; 21(5). [CrossRef]
  • [184] Osman M, Wafaa A, Nadia E, Amany A, Doaa E. Potential Role of Withania somnifera on Human Breast Cancer. Nat Sci. 2012; 10(11). [185] Demir T, Özen MÖ, Hameş-Kocabaş EE. Antioxidant and cytotoxic activity of Physalis peruviana. Med Plant Res. 2014; 4(4): 30-34. [CrossRef]
  • [186] Han L, Ma YM, An L, Zhang Q, Wang CL, Zhao QC. Non-alkaloids extract from Stemona sessilifolia enhances the activity of chemotherapeutic agents through P-glycoprotein-mediated multidrug-resistant cancer cells. Nat Prod Res. 2016; 30(10): 1186-1189. [CrossRef]
  • [187] Liu Z, Zheng X, Lv J, Zhou X, Wang Q, Wen X, et al. Pharmacokinetic synergy from the taxane extract of Taxus chinensis improves the bioavailability of paclitaxel. Phytomedicine. 2015; 22(5): 573-578. [CrossRef]
  • [188] Li W, He N, Tian L, Shi X, Yang X. Inhibitory effects of polyphenol-enriched extract from Ziyang tea against human breast cancer MCF-7 cells through reactive oxygen species-dependent mitochondria molecular mechanism. J Food Drug Anal. 2016; 24(3): 527-538. [CrossRef]
  • [189] Chen L, Chen J, Xu H. Sasanquasaponin from Camellia oleifera Abel. induces cell cycle arrest and apoptosis in human breast cancer MCF-7 cells. Fitoterapia. 2013; 84: 123-129. [CrossRef]
  • [190] Guler E. Investigation of chemopreventif properties of Urtica dioica L., in MCF-7 and MDA 231 breast cancer cell lines. New J Med. 2013; 231: 50-53.
  • [191] Reddy AS, Abd Malek SN, Ibrahim H, Sim KS. Cytotoxic effect of Alpinia scabra (Blume) Naves extracts on human breast and ovarian cancer cells. BMC Complement Altern Med. 2013; 13: 314. [CrossRef]
  • [192] Chen X, Pei L, Zhong Z, Guo J, Zhang Q, Wang Y. Anti-tumor potential of ethanol extract of Curcuma phaeocaulis Valeton against breast cancer cells. Phytomedicine. 2011; 18(14): 1238-1243. [CrossRef]
  • [193] Samarghandian S, Hadjzadeh MA, Afshari JT, Hosseini M. Antiproliferative activity and induction of apoptotic by ethanolic extract of Alpinia galanga rhizhome in human breast carcinoma cell line. BMC Complement Altern Med. 2014; 14: 192. [CrossRef]
  • [194] Ghil S. Antiproliferative activity of Alpinia officinarum extract in the human breast cancer cell line MCF-7. Mol Med Rep. 2013; 7(4): 1288-1292. [CrossRef]
  • [195] Lam M, Carmichael AR, Griffiths HR. An aqueous extract of Fagonia cretica induces DNA damage, cell cycle arrest and apoptosis in breast cancer cells via FOXO3a and p53 expression. PLoS One. 2012; 7(6): e40152. [CrossRef]
  • [196] Angelova S, Gospodinova Z, Krasteva M, Antov G, Lozanov V, Markov T, et al. Antitumor activity of Bulgarian herb Tribulus terrestris L. on human breast cancer cells. J BioSci Biotech. 2013; 2(1): 25-32.
  • [197] Moongkarndi P, Kosem N, Luanratana O, Jongsomboonkusol S, Pongpan N. Antiproliferative activity of Thai medicinal plant extracts on human breast adenocarcinoma cell line. Fitoterapia. 2004; 75(3-4): 375-377. [CrossRef]
  • [198] Lee H-N, Shin S-A, Choo G-S, Kim H-J, Park Y-S, Kim S-K, et al. Inhibitory effects of spinach, cabbage, and onion extracts on growth of cancer cells. J Korean Soc Food Sci Nutr. 2016; 45(5): 671-679. [CrossRef]
  • [199] Taylor PG, Cesari IM, Arsenak M, Ballen D, Abad MJ, Fernández A, et al. Evaluation of Venezuelan medicinal plant extracts for antitumor and antiprotease activities. Pharm Biol. 2006; 44(5): 349-362. [CrossRef]
  • [200] Gavamukulya Y, Abou-Elella F, Wamunyokoli F, H AE-S. Phytochemical screening, anti-oxidant activity and in vitro anticancer potential of ethanolic and water leaves extracts of Annona muricata (Graviola). Asian Pac J Trop Med. 2014; 7s1: S355-S363. [CrossRef]
  • [201] Raybaudi-Massilia R, Suárez AI, Arvelo F, Sojo F, Mosqueda-Melgar J, Zambrano A, et al. An analysis in-vitro of the cytotoxic, antioxidant and antimicrobial activity of aqueous and alcoholic extracts of Annona muricata L. seed and pulp. Br J Appl Sci Technol. 2015; 5(4): 333. [CrossRef]
  • [202] Sevimli-Gur C, Cetin B, Akay S, Gulce-Iz S, Yesil-Celiktas O. Extracts from black carrot tissue culture as potent anticancer agents. Plant Foods Hum Nutr. 2013; 68(3): 293-298. [CrossRef]
  • [203] Gorantla JN, Vellekkatt J, Nath LR, Anto RJ, Lankalapalli RS. Cytotoxicity studies of semi-synthetic derivatives of theveside derived from the aqueous extract of leaves of 'suicide tree' Cerbera odollam. Nat Prod Res. 2014; 28(18): 1507-1512. [CrossRef]
  • [204] Samarakoon SR, Shanmuganathan C, Ediriweera MK, Tennekoon KH, Piyathilaka P, Thabrew I, et al. In vitro cytotoxic and antioxidant activity of leaf extracts of mangrove plant, Phoenix paludosa Roxb. Trop J Pharm Res. 2016; 15(1): 127-132. [CrossRef]
  • [205] Mahmoodi N, Motamed N, Paylakhi SH, Mahmoodi NO. Comparing the effect of Silybin and Silybin advanced™ on viability and HER2 expression on the human breast cancer SKBR3 cell line by no serum starvation. Iran J Pharm Res. 2015; 14(2): 521. [CrossRef]
  • [206] Younesian O, Kazerouni F, Dehghan-Nayeri N, Omrani D, Rahimipour A, Shanaki M, et al. Effect of curcumin on fatty acid synthase expression and enzyme activity in breast cancer cell line SKBR3. Int J Cancer Manag. 2017; 10(3): e8173. [CrossRef]
  • [207] Yeo SK, Ali AY, Hayward OA, Turnham D, Jackson T, Bowen ID, et al. beta-Bisabolene, a Sesquiterpene from the Essential Oil Extract of Opoponax (Commiphora guidottii), Exhibits Cytotoxicity in Breast Cancer Cell Lines. Phytother Res. 2016; 30(3): 418-425. [CrossRef]
  • [208] Manosroi A, Jantrawut P, Ogihara E, Yamamoto A, Fukatsu M, Yasukawa K, et al. Biological activities of phenolic compounds and triterpenoids from the galls of Terminalia chebula. Chem Biodivers. 2013; 10(8): 1448-1463. [CrossRef]
  • [209] An I-J, Kwon J-K, Lee J-S, Park H-S, Kim D-C, Choi B-J, et al. Induction of apoptosis in human cancer cells with compositae extracts. J Korean Soc Food Sci Nutr. 2012; 41(5): 584-590.
  • [210] Kummalue T, O-charoenrat P, Jiratchariyakul W, Chanchai M, Pattanapanyasat K, Sukapirom K, Iemsri S. Antiproliferative effect of Erycibe elliptilimba on human breast cancer cell lines. J Ethnopharmacol. 2007; 110(3): 439-443. [CrossRef]
  • [211] Chen D, Cao R, He J, Guo Y, Wang L, Ji W, et al. Synergetic effects of aqueous extracts of Fuzi (Radix Aconiti Lateralis Preparata) and Tubeimu (Rhizoma Bolbostemmatis) on MDA-MB-231 and SKBR3 cells. J Tradit Chin Med. 2016; 36(1): 113-124. [CrossRef]
  • [212] Kongtun S, Jiratchariyakul W, Kummalue T, Tan-ariya P, Kunnachak S, Frahm AW. Cytotoxic properties of root extract and fruit juice of Trichosanthes cucumerina. Planta medica. 2009; 75(8): 839-842. [CrossRef]
  • [213] Zhang J, Zhu WF, Zhu WY, Yang PP, Xu J, Manosroi J, et al. Melanogenesis-Inhibitory and Cytotoxic Activities of Chemical Constituents from the Leaves of Sauropus androgynus L. Merr. (Euphorbiaceae). Chem Biodivers. 2018; 15(2): e1700486. [CrossRef]
  • [214] Kummalue T, Suntiparpluacha M, Jiratchariyakul W. Antiproliferative activity of combination of Thai herbal remedy and chemotherapeutic agents on human cancer cell lines. J Med Plant Res. 2012; 6(2): 200-205. [CrossRef]
  • [215] Jung Y, Xu W, Kim H, Ha N, Neckers L. Curcumin-induced degradation of ErbB2: A role for the E3 ubiquitin ligase CHIP and the Michael reaction acceptor activity of curcumin. Biochimica et biophysica acta. 2007; 1773(3): 383-390. [CrossRef]
  • [216] Park S, Cho DH, Andera L, Suh N, Kim I. Curcumin enhances TRAIL-induced apoptosis of breast cancer cells by regulating apoptosis-related proteins. Mol Cell Biochem. 2013; 383(1-2): 39-48. [CrossRef]
  • [217] Moongkarndi P, Kosem N, Kaslungka S, Luanratana O, Pongpan N, Neungton N. Antiproliferation, antioxidation and induction of apoptosis by Garcinia mangostana (mangosteen) on SKBR3 human breast cancer cell line. J Ethnopharmacol. 2004; 90(1): 161-166. [CrossRef]
  • [218] Moongkarndi P, Jaisupa N, Samer J, Kosem N, Konlata J, Rodpai E, et al. Comparison of the biological activity of two different isolates from mangosteen. J Pharm Pharmacol. 2014; 66(8): 1171-1179. [CrossRef]
  • [219] Fong S, Shoemaker M, Cadaoas J, Lo A, Liao W, Tagliaferri M, et al. Molecular mechanisms underlying selective cytotoxic activity of BZL101, an extract of Scutellaria barbata, towards breast cancer cells. Cancer Biol Ther. 2008; 7(4): 577-586. [CrossRef]
  • [220] Cohen I. Process of making purified extract of Scutellaria barbata D. Don. Google Patents; 2012.
  • [221] Cohen I. Scutellaria barbata extract for the treatment of cancer. Google Patents; 2010.
  • [222] Chen V, Staub RE, Baggett S, Chimmani R, Tagliaferri M, Cohen I, et al. Identification and analysis of the active phytochemicals from the anti-cancer botanical extract Bezielle. PLoS One. 2012; 7(1): e30107. [CrossRef]
  • [223] Oleaga C, Garcia M, Sole A, Ciudad CJ, Izquierdo-Pulido M, Noe V. CYP1A1 is overexpressed upon incubation of breast cancer cells with a polyphenolic cocoa extract. Eur J Nutr. 2012; 51(4): 465-476. [CrossRef]
  • [224] Pan X, Matsumoto M, Nakamura Y, Kikuchi T, Zhang J, Ukiya M, et al. Three new and other limonoids from the hexane extract of Melia azedarach fruits and their cytotoxic activities. Chem Biodivers. 2014; 11(7): 987-1000. [CrossRef]
  • [225] Manosroi A, Kitdamrongtham W, Ishii K, Shinozaki T, Tachi Y, Takagi M, et al. Limonoids from Azadirachta indica var. siamensis extracts and their cytotoxic and melanogenesis-inhibitory activities. Chem Biodivers. 2014; 11(4): 505-531. [CrossRef]
  • [226] Zhang J, Zhu W-f, Xu J, Kitdamrongtham W, Manosroi A, Manosroi J, et al. Potential cancer chemopreventive and anticancer constituents from the fruits of Ficus hispida Lf (Moraceae). J Ethnopharmacol. 2018; 214: 37-46. [CrossRef]
  • [227] Zhang L, Shamaladevi N, Lokeshwar BL. An aqueous extract of Allspice (berries of Pimenta dioica) inhibits breast cancer growth through autophagy by targeting the estrogen receptor. AACR; 2011. [CrossRef]
  • [228] Quirantes-Pine R, Zurek G, Barrajon-Catalan E, Bassmann C, Micol V, Segura-Carretero A, et al. A metaboliteprofiling approach to assess the uptake and metabolism of phenolic compounds from olive leaves in SKBR3 cells by HPLC-ESI-QTOF-MS. J Pharm Biomed Anal. 2013; 72: 121-126. [CrossRef]
  • [229] Samara P, Christoforidou N, Lemus C, Argyropoulou A, Ioannou K, Vougogiannopoulou K, et al. New semisynthetic analogs of oleuropein show improved anticancer activity in vitro and in vivo. Eur J Med Chem. 2017; 137: 11-29. [CrossRef]
  • [230] Kalkhoran MR, Kazerouni F, Omrani MD, Rahimipour A, Shanaki M, Dehghan-Nayeri N, et al. Cytotoxic Effect of Emodin on Growth of SKBR3 Breast Cancer Cells. Int J Cancer Manag. 2017; 10(4): e8094. [CrossRef]
  • [231] Ma W-l, Liang H, Liu Y. Effect of aplysin on the proliferation and apoptosis in human breast cancer SK-BR-3. Nat Prod Res Dev. 2012; 24: 1201-1205.
  • [232] Gu G, Barone I, Gelsomino L, Giordano C, Bonofiglio D, Statti G, et al. Oldenlandia diffusa extracts exert antiproliferative and apoptotic effects on human breast cancer cells through ERα/Sp1‐mediated p53 activation. J Cell Physiol. 2012; 227(10): 3363-3372. [CrossRef]
  • [233] Pradhan D, Tripathy G, Patanaik S. Anticancer activity of Limonia acidissima Linn (Rutaceae) fruit extracts on human breast cancer cell lines. Trop J Pharm Res. 2012; 11(3): 413-419. [CrossRef]
  • [234] Lanza-Jacoby S, Yan G, Wang C. Nexrutine, a phellodendron amurense extract protects against breast cancer. AACR; 2010. [CrossRef]
  • [235] Widodo N, Kaur K, Shrestha BG, Takagi Y, Ishii T, Wadhwa R, et al. Selective killing of cancer cells by leaf extract of Ashwagandha: identification of a tumor-inhibitory factor and the first molecular insights to its effect. Clin Cancer Res. 2007; 13(7): 2298-2306. [CrossRef]
  • [236] Amirghofran Z, Miri R, Javidnia K, Davoodi M. Study of cytotoxic activity of Daphne mucronata Royle grown in Iran. Iran J Med Sci. 2001; 26(3-4): 146-151.
  • [237] Pradhan D, Tripathy G. Antiproliferative activity of Trapa acornis shell extracts against human breast cancer cell lines. Int J Pharm Sci Res. 2014; 5: 2238-2243. [CrossRef]
  • [238] Kijima I, Phung S, Hur G, Kwok S-L, Chen S. Grape seed extract is an aromatase inhibitor and a suppressor of aromatase expression. Cancer Res. 2006; 66(11): 5960-5967. [CrossRef]
  • [239] Tallant EA, Holmes CH, Gallagher PE. Inhibition of cancer cell growth by muscadine grape seed and grape skin extracts. AACR; 2011; 71(8): 4220. [CrossRef]

Comparison of cytotoxic activity of herbal extracts on the most commonly used breast cancer cell lines (MCF7 and SKBR3): A systematic review

Year 2020, Volume: 24 Issue: 1, 1 - 22, 27.06.2025

Nasrin Dehghan-nayeri Mina Darvishi Pargol Mashati Maryam Rezapour-kalkhoran Morteza Rezaiefard Samareh Younesian

https://doi.org/10.35333/jrp.2020.121
Cited By: 2

Abstract

Herbal drug development is considered as an imperative part of complementary and alternative medicine.
Bioactive compounds of botanical sources represent potential anti-cancer agents for modern therapeutics. Primary in
vitro data of herb extracts’ effects against cancer cell lines could be considered as indicators of potential toxicity to reduce
the number of in vivo experiments. This study aims to review the findings of published articles concerning the in
vitro efficacy of herbal extracts against breast cancer cell lines (MCF7 and SKBR3). In vitro studies of herbal extracts
published until July 2018 were included in this review. Totally, nine extracts with IC50<4 exhibited the most inhibitory
effect on breast cancer cell lines. This investigation has highlighted the fact that plant extracts have the potential to act
as promising anticancer agents, making them appropriate components to be applied for chemoprevention or cancer
treatment in case the researchers would find the right plant, the right solvent and the right fraction for the right disease.

Keywords

: Plant extraction breast cancer cytotoxicity MCF7 SKBR3

References

  • [1] Riaz M, van Jaarsveld MT, Hollestelle A, Prager-van der Smissen WJ, Heine AA, Boersma AW, et al. miRNA expression profiling of 51 human breast cancer cell lines reveals subtype and driver mutation-specific miRNAs. Breast Cancer Res. 2013; 15(2): R33. [CrossRef]
  • [2] Dai X, Cheng H, Bai Z, Li J. Breast cancer cell line classification and its relevance with breast tumor subtyping. J Cancer. 2017; 8(16): 3131-3141. [CrossRef]
  • [3] Goodspeed A, Heiser LM, Gray JW, Costello JC. Tumor-derived cell lines as molecular models of cancer pharmacogenomics. Mol Cancer Res. 2016; 14(1): 3-13. [CrossRef]
  • [4] Darvishi M, Esmaeili S, Dehghan-Nayeri N, Mashati P, Gharehbaghian A. Anticancer effect and enhancement of therapeutic potential of Vincristine by extract from aerial parts of Juniperus excelsa on pre-B acute lymphoblastic leukemia cell lines. J Appl Biomed. 2017; 15(3): 219- 226. [CrossRef]
  • [5] Barretina J, Caponigro G, Stransky N, Venkatesan K, Margolin A, et al. The Cancer Cell Line Encyclopedia enables predictive modelling of anticancer drug sensitivity. Nature. 2012; 483(7391): 603–607. [CrossRef]
  • [6] Suffness M. Assays related to cancer drug discovery. Methods in plant biochemistry: assays for bioactivity. 1990; 6: 71-133.
  • [7] Kroll DJ. Natural Compounds in Cancer Therapy: Promising Nontoxic Antitumor Agents from Plants and Other Natural Sources. J Nat Prod. 2001; 64(12): 1605-1606. [CrossRef]
  • [8] Yuenyongsawad S, Bunluepuech K, Wattanapiromsakul C, Tewtrakul S. Anti-cancer activity of compounds from Cassia garrettiana heartwood. Songklanakarin J Sci Technol. 2014; 36(2): 189-194.
  • [9] Bagul M, Kakumanu S, Wilson TA. Crude garlic extract inhibits cell proliferation and induces cell cycle arrest and apoptosis of cancer cells in vitro. J Med Food. 2015; 18(7): 731-737.[CrossRef]
  • [10] Looi CY, Arya A, Cheah FK, Muharram B, Leong KH, Mohamad K, et al. Induction of apoptosis in human breast cancer cells via caspase pathway by vernodalin isolated from Centratherum anthelminticum (L.) seeds. PloS one. 2013; 8(2): e56643. [CrossRef]
  • [11] Autore G, Marzocco S, Formisano C, Bruno M, Rosselli S, Jemia M, Senatore F. Cytotoxic activity and composition of petroleum ether extract from Magydaris tomentosa (Desf.) WDJ Koch (Apiaceae). Molecules. 2015; 20(1): 1571-1578
  • [12] Gudarzi H, Salimi M, Irian S, Amanzadeh A, Mostafapour Kandelous H, Azadmanesh K, et al. Ethanolic extract of Ferula gummosa is cytotoxic against cancer cells by inducing apoptosis and cell cycle arrest. Nat Prod Res. 2015; 29(6): 546-550.[CrossRef]
  • [13] Graidist P, Martla M, Sukpondma Y. Cytotoxic activity of Piper cubeba extract in breast cancer cell lines. Nutrients. 2015; 7(4): 2707-2718. [CrossRef]
  • [14] Choudhury B, Kandimalla R, Elancheran R, Bharali R, Kotoky J. Garcinia morella fruit, a promising source of antioxidant and anti-inflammatory agents induces breast cancer cell death via triggering apoptotic pathway. Biomed Pharmacother. 2018; 103: 562-573. [CrossRef]
  • [15] Yan G, Lanza-Jacoby S, Wang C. Nexrutine inhibits survival and induces G1 cell cycle arrest, which is associated with apoptosis or autophagy depending on the breast cancer cell line. Nutr Cancer. 2014; 66(3): 506-516. [CrossRef]
  • [16] Plastina P, Bonofiglio D, Vizza D, Fazio A, Rovito D, Giordano C, et al. Identification of bioactive constituents of Ziziphus jujube fruit extracts exerting antiproliferative and apoptotic effects in human breast cancer cells. J Ethnopharmacol. 2012; 140(2): 325-332. [CrossRef]
  • [17] Yin SY, Wei WC, Jian FY, Yang NS. Therapeutic applications of herbal medicines for cancer patients. Evid Based Complement Alternat Med. 2013; 2013: 302426. [CrossRef]
  • [18] Yang L, Yang C, Li C, Zhao Q, Liu L, Fang X, et al. Recent advances in biosynthesis of bioactive compounds in traditional Chinese medicinal plants. Sci Bull. 2016; 61(1): 3-17. [CrossRef]
  • [19] Atanasov AG, Waltenberger B, Pferschy-Wenzig E-M, Linder T, Wawrosch C, Uhrin P, et al. Discovery and resupply of pharmacologically active plant-derived natural products: A review. Biotechnol Adv. 2015; 33(8): 1582- 1614. [CrossRef]
  • [20] Subik K, Lee J-F, Baxter L, Strzepek T, Costello D, Crowley P, et al. The expression patterns of ER, PR, HER2, CK5/6, EGFR, Ki-67 and AR by immunohistochemical analysis in breast cancer cell lines. Breast Cancer (Auckl). 2010; 20(4): 35–41.[CrossRef]
  • [21] Holliday DL, Speirs V. Choosing the right cell line for breast cancer research. Breast Cancer Res. 2011; 13(4): 215. [CrossRef]
  • [22] Zhou X, Seto SW, Chang D, Kiat H, Razmovski-Naumovski V, Chan K, et al. Synergistic effects of Chinese herbal medicine: a comprehensive review of methodology and current research. Front Pharmacol. 2016; 7: 201. [CrossRef]
  • [23] Yaacob NS, Kamal NNNM, Norazmi MN. Synergistic anticancer effects of a bioactive subfraction of Strobilanthes crispus and tamoxifen on MCF-7 and MDA-MB-231 human breast cancer cell lines. BMC Complement Altern Med. 2014; 14(1): 252. [CrossRef]
  • [24] Tiwary BK, Bihani S, Kumar A, Chakraborty R, Ghosh R. The in vitro cytotoxic activity of ethno-pharmacological important plants of Darjeeling district of West Bengal against different human cancer cell lines. BMC Complement Altern Med. 2015; 15(1): 22. [CrossRef]
  • [25] Jetawattana S, Boonsirichai K, Charoen S, Martin SM. Radical intermediate generation and cell cycle arrest by an aqueous extract of Thunbergia laurifolia Linn. In human breast cancer cells. Asian Pac J Cancer Prev. 2015; 16(10): 4357-4361.[CrossRef]
  • [26] Sagadevan P, Suresh S, Rathishkumar S, Gayathri S, Eswari DV. Anticancer activity of methanolic leaf extracts of Andrographis paniculata (Nees) and Cardiospermum halicacabum (Linn) against human breast cancer cell line (MCF-7). Int J of Pharm & Life Sci (IJPLS). 2013; 4(9): 2983-2986.
  • [27] Tagne RS, Telefo BP, Nyemb JN, Yemele DM, Njina SN, Goka SMC, et al. Anticancer and antioxidant activities of methanol extracts and fractions of some Cameroonian medicinal plants. Asian Pac J Trop Med. 2014; 7S1: S442- S447. [CrossRef]
  • [28] Venugopal K, Ahmad H, Manikandan E, Arul KT, Kavitha K, Moodley M, et al. The impact of anticancer activity upon Beta vulgaris extract mediated biosynthesized silver nanoparticles (ag-NPs) against human breast (MCF-7), lung (A549) and pharynx (Hep-2) cancer cell lines. J Photochem Photobiol B. 2017; 173: 99-107. [CrossRef]
  • [29] Kapadia GJ, Rao GS, Ramachandran C, Iida A, Suzuki N, Tokuda H. Synergistic cytotoxicity of red beetroot (Beta vulgaris L.) extract with doxorubicin in human pancreatic, breast and prostate cancer cell lines. J Complement Integr Med. 2013; 10(1): 113-122. [CrossRef]
  • [30] Nowacki L, Vigneron P, Rotellini L, Cazzola H, Merlier F, Prost E, et al. Betanin‐enriched red beetroot (Beta vulgaris L.) extract induces apoptosis and autophagic cell death in MCF‐7 cells. Phytother Res. 2015; 29(12): 1964-1973. [CrossRef]
  • [31] Tripathy G, Pradhan D. Evaluation of IN-VITRO anti-proliferative activity and IN-VIVO immunomodulatory activity of beta vulgaris. Asian J Pharm Clin Res. 2013; 6(suppl 1): 127-130.
  • [32] Nile SH, Nile AS, Keum Y-S. Total phenolics, antioxidant, antitumor, and enzyme inhibitory activity of Indian medicinal and aromatic plants extracted with different extraction methods. 3 Biotech. 2017; 7(1): 76. [CrossRef]
  • [33] Khazaei S, Esa NM, Ramachandran V, Hamid RA, Pandurangan AK, Etemad A, et al. In vitro antiproliferative and apoptosis inducing effect of Allium atroviolaceum bulb extract on breast, cervical, and liver cancer cells. Front Pharmacol. 2017; 31(8): 5. [CrossRef]
  • [34] Azadi HG, Ghaffari SM, Riazi GH, Ahmadian S, Vahedi F. Antiproliferative activity of chloroformic extract of Persian Shallot, Allium hirtifolium, on tumor cell lines. Cytotechnology. 2008; 56(3): 179-185. [CrossRef]
  • [35] Isbilen O, Rizaner N, Volkan E. Anti-proliferative and cytotoxic activities of Allium autumnale PH Davis (Amaryllidaceae) on human breast cancer cell lines MCF-7 and MDA-MB-231. BMC Complement Altern Med. 2018; 18(1): 30. [CrossRef]
  • 36] Tanih NF, Ndip RN. The acetone extract of Sclerocarya birrea (Anacardiaceae) possesses antiproliferative and apoptotic potential against human breast cancer cell lines (MCF-7). Sci World J. 2013; 2013: 956206.[CrossRef]
  • [37 Shaban NZ, Hegazy WA, Abdel-Rahman SM, Awed OM, Khalil SA. Potential effect of Olea europea leaves, Sonchus oleraceus leaves and Mangifera indica peel extracts on aromatase activity in human placental microsomes and CYP19A1 expression in MCF-7 cell line: Comparative study. Cell Mol Biol (OMICS). 2016; 62(9): 11-9.
  • [38] Abdullah AS, Mohammed AS, Abdullah R, Mirghani ME, Al-Qubaisi M. Cytotoxic effects of Mangifera indica L. kernel extract on human breast cancer (MCF-7 and MDA-MB-231 cell lines) and bioactive constituents in the crude extract. BMC Complement Altern Med. 2014; 14: 199. [CrossRef]
  • [39] Ediriweera MK, Tennekoon KH, Samarakoon SR, Thabrew I, Dilip DESE. A study of the potential anticancer activity of Mangifera zeylanica bark: Evaluation of cytotoxic and apoptotic effects of the hexane extract and bioassay-guided fractionation to identify phytochemical constituents. Oncol Lett. 2016; 11(2): 1335-1344. [CrossRef]
  • [40] Lee JO, Moon JW, Lee SK, Kim SM, Kim N, Ko SG, et al. Rhus verniciflua extract modulates survival of MCF-7 breast cancer cells through the modulation of AMPK-pathway. Biol Pharm Bull. 2014; 37(5): 794-801. [CrossRef]
  • [41] Rahmat A, Kumar V, Fong LM, Endrini S, Sani HA. Determination of total antioxidant activity in three types of local vegetables shoots and the cytotoxic effect of their ethanolic extracts against different cancer cell lines. Asia Pac J Clin Nutr. 2004;13(3):308-311.
  • [42] Ghoreishi SM, Haghighi R. Chemical catalytic reaction and biological oxidation for treatment of non-biodegradable textile effluent. Chem Eng J. 2003; 95(1-3): 163-169. [CrossRef]
  • [43] Shebaby WN, El-Sibai M, Smith KB, Karam MC, Mroueh M, Daher CF. The antioxidant and anticancer effects of wild carrot oil extract. Phytother Res. 2013; 27(5): 737-744. [CrossRef]
  • [44] Sharopov FS, Wink M, Khalifaev DR, Zhang H, Dosoky NS, Setzer WN. Composition and bioactivity of the essential oil of Melissa officinalis L. growing wild in Tajikistan. Int J Trad Nat Med. 2013; 2(2): 86-96.
  • [45] Lall N, Kishore N, Binneman B, Twilley D, van de Venter M, du Plessis-Stoman D, et al. Cytotoxicity of syringin and 4-methoxycinnamyl alcohol isolated from Foeniculum vulgare on selected human cell lines. Nat Prod Res. 2015; 29(18): 1752-1756. [CrossRef]
  • [46] Farshori NN, Al-Sheddi ES, Al-Oqail MM, Musarrat J, Al-Khedhairy AA, Siddiqui MA. Anticancer activity of Petroselinum sativum seed extracts on MCF-7 human breast cancer cells. Asian Pac J Cancer Prev (APJCP). 2013; 14(10): 5719-5723. [CrossRef]
  • [47] Hamzeloomoghadam M, Esmaeili S, Fotoohi F, Naghibi F, Pirani A, Hajimehdipoor H. In vitro evaluation for cytotoxic activity of three Ferula species. Int J Pharm Sci Res. 2013; 4(7): 2673-2676.
  • [48] Eslami JB, Dehpouri A, Nemati F, Rezaei B. Cytotoxicity effects of the Ferula gummosa extract on the cancer cell line MCF7. J Anim Biol. 2013; 5(4): 1-7.
  • [49] De la Cruz JF, Vergara EJ, Cho Y, Hong HO, Oyungerel B, Hwang SG. Glehnia littoralis Root Extract Induces G0/G1 Phase Cell Cycle Arrest in the MCF-7 Human Breast Cancer Cell Line. Asian Pac J Cancer Prev (APJCP). 2015; 16(18): 8113-8117. [CrossRef]
  • [50] Popović V, Heyerick A, Petrović S, Van Calenbergh S, Karalic I, Niketić M, et al. Cytotoxic activity of Laserpitium latifolium L. extract and its daucane and phenylpropanoid constituents. Rec Nat Prod. 2013; 7(3): 245-249.
  • [51] Badmus JA, Ekpo OE, Hussein AA, Meyer M, Hiss DC. Antiproliferative and Apoptosis Induction Potential of the Methanolic Leaf Extract of Holarrhena floribunda (G. Don). Evid Based Complement Alternat Med. 2015; 2015: 756482. [CrossRef]
  • [52] Ben Jemia M, Kchouk ME, Senatore F, Autore G, Marzocco S, De Feo V, et al. Antiproliferative activity of hexane extract from Tunisian Cistus libanotis, Cistus monspeliensis and Cistus villosus. Chem Cent J. 2013; 7(1): 47. [CrossRef]
  • [53] Engel N, Falodun A, Kuhn J, Kragl U, Langer P, Nebe B. Pro-apoptotic and anti-adhesive effects of four African plant extracts on the breast cancer cell line MCF-7. BMC Complement Altern Med. 2014; 14: 334.
  • [54] Sunil D, Kumar NA, Nayak AS, Raj US, Deepa P. Cytotoxicity studies of microwave assisted natural product extracts in HeLa and MCF-7 cell lines. IJMAP. 2013; 3(1): 27-31.
  • [55] Souza AHP, Correa RCG, Barros L, Calhelha RC, Santos-Buelga C, Peralta RM, et al. Phytochemicals and bioactive properties of Ilex paraguariensis: An in-vitro comparative study between the whole plant, leaves and stems. Food Res Int. 2015; 78: 286-294. [CrossRef]
  • [56] MHM AE-A, El-Mesalamy A, Yassin F, Khalil S. Identification phenolic and biological activities of methanolic extract of date palm pollen (Phoenix dactylifera). J Microb Biochem Technol. 2015; 7: 047-050. [CrossRef]
  • [57] Freitas DDS, Morgado-Diaz JA, Gehren AS, Vidal FCB, Fernandes RMT, Romao W, et al. Cytotoxic analysis and chemical characterization of fractions of the hydroalcoholic extract of the Euterpe oleracea Mart. seed in the MCF7 cell line. J Pharm Pharmacol. 2017; 69(6): 714-721. [CrossRef]
  • [58] Afsal I V.T, Gautam G, Rajasekaran S, Nishad K. M. Development of Herbal Formulation with Ajwa seed (Phoenix dactylifera l.) Extract and Zam Zam Water for Anticancer Activity. World J Pharm Pharm Sci. 2018; 7(7): 781-795.
  • [59] Anajwala CC, Patel RM, Dakhara SL, Jariwala JK. In vitro cytotoxicity study of agave americana, strychnos nuxvomica and areca catechu extracts using mcf-7 cell line. J Adv Pharm Technol Res. 2010; 1(2): 245-252.
  • [60] Sarath VJ, So CS, Won YD, Gollapudi S. Artemisia princeps var orientalis induces apoptosis in human breast cancer MCF-7 cells. Anticancer Res. 2007; 27(6b): 3891-3898.
  • [61] Ghafari F, Rajabi MR, Mazoochi T, Taghizadeh M, Nikzad H, Atlasi MA, et al. Comparing Apoptosis and Necrosis Effects of Arctium Lappa Root Extract and Doxorubicin on MCF7 and MDA-MB-231 Cell Lines. Asian Pac J Cancer Prev (APJCP). 2017; 18(3): 795-802. [CrossRef]
  • [62] Ho WY, Yeap SK, Ho CL, Raha AR, Suraini AA, Alitheen NB. Elephantopus scaber induces cytotoxicity in MCF-7 human breast cancer cells via p53-induced apoptosis. J Med Plants Res. 2011; 5(24): 5741-5749.
  • [63] Mostafapour Kandelous H, Salimi M, Khori V, Rastkari N, Amanzadeh A, Salimi M. Mitochondrial Apoptosis Induced by Chamaemelum Nobile Extract in Breast Cancer Cells. Iran J Pharm Res (IJPR). 2016; 15(Suppl): 197-204.
  • [64] Dias MI, Barros L, Duenas M, Pereira E, Carvalho AM, Alves RC, et al. Chemical composition of wild and commercial Achillea millefolium L. and bioactivity of the methanolic extract, infusion and decoction. Food Chem. 2013; 141(4): 4152-4160. [CrossRef]
  • [65] Mendoza RP, Vidar WS, Oyong GG. In vitro cytotoxic potential of Yacon (Smallanthus sonchifolius) against HT29, MCF-7 and HDFn cell lines. J Med Plant Res. 2017; 11(10): 207-217. [CrossRef]
  • [66] Akter R, Uddin SJ, Tiralongo J, Grice ID, Tiralongo E. A New Cytotoxic Steroidal Glycoalkaloid from the Methanol Extract of Blumea lacera Leaves. J Pharm Pharm Sci. 2015; 18(4): 616-633. [CrossRef]
  • [67] Pitchai D, Roy A, Ignatius C. In vitro evaluation of anticancer potentials of lupeol isolated from Elephantopus scaber L. on MCF-7 cell line. J Adv Pharm Technol Res. 2014; 5(4): 179-184. [CrossRef]
  • [68] Conforti F, Ioele G, Statti GA, Marrelli M, Ragno G, Menichini F. Antiproliferative activity against human tumor cell lines and toxicity test on Mediterranean dietary plants. Food Chem Toxicol. 2008; 46(10): 3325-3332. [CrossRef]
  • [69] Talib WH, Mahasneh AM. Antiproliferative activity of plant extracts used against cancer in traditional medicine. Sci Pharm. 2010; 78(1): 33-45. [CrossRef]
  • [70] Shin SA, Lee HN, Choo GS, Kim HJ, Che JH, Jung JY. Ixeris dentata (Thunb. Ex Thunb.) Nakai Extract Inhibits Proliferation and Induces Apoptosis in Breast Cancer Cells through Akt/NF-kappaB Pathways. Int J Mol Sci. 2017; 18(2): E275. [CrossRef]
  • [71] Hamzeloo-Moghadam M, Khalaj A, Malekmohammadi M, Mosaddegh M. Achillea vermicularis a medicinal plant from Iranian Traditional Medicine induces apoptosis in MCF-7 cells. Res J Pharmacogn (RJP). 2015; 2(1): 1-5.
  • [72] Serasanambati M, Chilakapati SR, Manikonda PK, Kanala JR. Anticancer Activity of Methanolic Extract of Berberis aristata in MCF-7 Human Breast Cancer Cell Lines. Int J Life Sci Biotechnol Pharma Res. 2015; 4(1): 31-35.
  • [73] Zeng YT, Jiang JM, Lao HY, Guo JW, Lun YN, Yang M. Antitumor and apoptotic activities of the chemical constituents from the ethyl acetate extract of Artemisia indica. Mol Med Rep. 2015; 11(3): 2234-2240. [CrossRef]
  • [74] Bachiega P, Salgado JM, de Carvalho JE, Ruiz A, Schwarz K, Tezotto T, et al. Antioxidant and antiproliferative activities in different maturation stages of broccoli (Brassica oleracea Italica) biofortified with selenium. Food Chem. 2016; 190: 771-776. [CrossRef]
  • [75] Yeo SK, Ali AY, Hayward OA, Turnham D, Jackson T, Bowen ID, et al. beta-Bisabolene, a Sesquiterpene from the Essential Oil Extract of Opoponax (Commiphora guidottii), Exhibits Cytotoxicity in Breast Cancer Cell Lines. Phytother Res. 2016; 30(3): 418-425. [CrossRef]
  • [76] Chaudhary S, Chandrashekar KS, Pai KS, Setty MM, Devkar RA, Reddy ND, et al. Evaluation of antioxidant and anticancer activity of extract and fractions of Nardostachys jatamansi DC in breast carcinoma. BMC Complement Altern Med. 2015; 15: 50.
  • [77] Maisarah A, Asmah R, Fauziah O. Proximate analysis, antioxidant and antiproliferative activities of different parts of Carica papaya. J Nutr Food Sci. 2014; 4(2): 1-7. [CrossRef]
  • [78] Pereira JM, Lopes-Rodrigues V, Xavier CP, Lima MJ, Lima RT, Ferreira IC, et al. An Aqueous Extract of Tuberaria lignosa Inhibits Cell Growth, Alters the Cell Cycle Profile, and Induces Apoptosis of NCI-H460 Tumor Cells. Molecules. 2016; 21(5): E595. [CrossRef]
  • [79] El Euch SK, Bouajila J, Bouzouita N. Chemical composition, biological and cytotoxic activities of Cistus salviifolius flower buds and leaves extracts. Ind Crops Prod. 2015; 76: 1100-1105. [CrossRef]
  • [80] Setiawati A. Anticancer activity of mangosteen pericarp dry extract against MCF-7 breast cancer cell line through estrogen receptor-α. Indonesian J Pharm. 2014; 25(3): 119-124. [CrossRef]
  • [81] Chitra S, Krithika M, Pavithra S. Induction of apoptosis by xanthones from Garcinia mangostana in human breast and laryngeal carcinoma cell lines. Int J Pharma Bio Sci. 2010; 1(3): 1-8.
  • [82] Subarnas A, Diantini A, Abdulah R, Zuhrotun A, Yamazaki C, Nakazawa M, et al. Antiproliferative activity of primates-consumed plants against MCF-7 human breast cancer cell lines. E3 J Med Res. 2012; 1(4): 038-043.
  • [83] Diab KA, Guru SK, Bhushan S, Saxena AK. In Vitro Anticancer Activities of Anogeissus latifolia, Terminalia bellerica, Acacia catechu and Moringa oleiferna Indian Plants. Asian Pac J Cancer Prev (APJCP). 2015; 16(15): 6423- 6428. [CrossRef]
  • [84] Rezaei F, Shokrzadeh M, Majd A, Nezhadsattari T. Cytotoxic Effect of Hydroalcoholic Extract of Cornus mas L. fruit on MCF7, HepG2 and CHO cell line by MTTAssay. J Mazandaran Univ Med Sci. 2014; 24(113): 130-138.
  • [85] Qi Y-j, Cui S, Lu D-x, Yang Y-z, Luo Y, Ma L, et al. Effects of the aqueous extract of a Tibetan herb, Rhodiola algida var. tangutica on proliferation and HIF-1α, HIF-2α expression in MCF-7 cells under hypoxic condition in vitro. Cancer Cell Int. 2015; 15(1): 81. [CrossRef]
  • [86] El-Sharkawy ER, Matloub AA, Atta EM. Cytotoxicity of new flavonoid compound isolated from Farsetia aegyptia. Int J Pharm Sci Inv. 2013; 2(1): 23-27.
  • [87] Moghe AS, Gangal SG, Shilkar PR. In vitro cytotoxicity of Bryonia laciniosa (Linn.) Naud. on human cancer cell lines. Indian J Nat Prod Resour. 2011; 2(3): 322-329.
  • [88] Petchsak P, Sripanidkulchai B. Momordica cochinchinensis Aril Extract Induced Apoptosis in Human MCF-7 Breast Cancer Cells. Asian Pac J Cancer Prev (APJCP). 2015; 16(13): 5507-5513. [CrossRef]
  • [89] Medjakovic S, Hobiger S, Ardjomand-Woelkart K, Bucar F, Jungbauer A. Pumpkin seed extract: Cell growth inhibition of hyperplastic and cancer cells, independent of steroid hormone receptors. Fitoterapia. 2016; 110: 150- 156. [CrossRef]
  • [90] Mukherjee A, Patil SD. Effects of alkaloid rich extract of Citrullus colocynthis fruit on Artemia salina and human cancerous (MCF-7 and HEPG-2) cells. J PharmaSciTech. 2012; 1(2): 15-19.
  • [91] Andalib A, Jafarian-Dehkordi A, Shokouhi-Shourmasti R, Abdolah-Kohpayeh-Esfahani S. The effect of Persian Juniperus excelsa extracts on cell-cycle phases of MCF-7 breast cancer cell line. J Isfahan Med Sch. 2016; 33(360): 2004-2012.
  • [92] Foo JB, Yazan LS, Tor YS, Armania N, Ismail N, Imam MU, et al. Induction of cell cycle arrest and apoptosis in caspase-3 deficient MCF-7 cells by Dillenia suffruticosa root extract via multiple signalling pathways. BMC Complement Altern Med. 2014; 14: 197. [CrossRef]
  • [93] Tor YS, Yazan LS, Foo JB, Wibowo A, Ismail N, Cheah YK, et al. Induction of Apoptosis in MCF-7 Cells via Oxidative Stress Generation, Mitochondria-Dependent and Caspase-Independent Pathway by Ethyl Acetate Extract of Dillenia suffruticosa and Its Chemical Profile. PLoS One. 2015; 10(6): e0127441. [CrossRef]
  • [94] Armania N, Yazan LS, Ismail IS, Foo JB, Tor YS, Ishak N, et al. Dillenia Suffruticosa extract inhibits proliferation of human breast cancer cell lines (MCF-7 and MDA-MB-231) via induction of G2/M arrest and apoptosis. Molecules. 2013; 18(11): 13320-13339. [CrossRef]
  • [95] Pilane MC, Bagla VP, Mokgotho MP, Mbazima V, Matsebatlela TM, Ncube I, et al. Free Radical Scavenging Activity: Antiproliferative and Proteomics Analyses of the Differential Expression of Apoptotic Proteins in MCF-7 Cells Treated with Acetone Leaf Extract of Diospyros lycioides (Ebenaceae). Evid Based Complement Alternat Med (eCAM). 2015; 2015: 534808. [CrossRef]
  • [96] Abdul Salam R. Protective effect of erythroxylum cuneatum and mitragyna speciosa leaf extract on RAW 264.7 and MCF-7: Universiti Teknologi Mara; 2010.
  • [97] Ping KY, Darah I, Chen Y, Sasidharan S. Cytotoxicity and genotoxicity assessment of Euphorbia hirta in MCF-7 cell line model using comet assay. Asian Pac J Trop Biomed. 2013; 3(9): 692-696
  • [98] Jose J, Sudhakaran S, Kumar S, Jayaraman S, Variyar EJ. A comparative evaluation of anticancer activities of flavonoids isolated from Mimosa pudica, Aloe vera and Phyllanthus niruri against human breast carcinoma cell line (MCF-7) using MTT assay. Int J Pharm Pharm Sci. 2014; 6(2): 319-322.
  • [99] Niraimathi V, Sundaraganapathy R. In vitro anticancer activity of various fractions of hydro alcoholic extract of Dalbergia latifolia Roxb. International Journal of Phytopharmacology (IJP). 2014; 5(4): 272-283.
  • [100] Yadav NK, Saini KS, Hossain Z, Omer A, Sharma C, Gayen JR, et al. Saraca indica bark extract shows in vitro antioxidant, antibreast cancer activity and does not exhibit toxicological effects. Oxid Med Cell Longev. 2015; 2015: 205360. [CrossRef]
  • [101] Sreeja S, Anju VS, Sreeja S. In vitro estrogenic activities of fenugreek Trigonella foenum graecum seeds. Indian J Med Res. 2010; 131: 814-819.
  • [102] Alshatwi AA, Shafi G, Hasan TN, Syed NA, Khoja KK. Fenugreek induced apoptosis in breast cancer MCF-7 cells mediated independently by fas receptor change. Asian Pac J Cancer Prev (APJCP). 2013; 14(10):5783-5788. [CrossRef]
  • [103] Uifalean A, Schneider S, Gierok P, Ionescu C, Iuga CA, Lalk M. The Impact of Soy Isoflavones on MCF-7 and MDAMB-231 Breast Cancer Cells Using a Global Metabolomic Approach. Int J Mol Sci. 2016; 17(9): E1443. [CrossRef]
  • [104] Zhang SY, Zheng CG, Yan XY, Tian WX. Low concentration of condensed tannins from catechu significantly inhibits fatty acid synthase and growth of MCF-7 cells. Biochemical and biophysical research communications. 2008; 371(4): 654-658. [CrossRef]
  • [105] Nanasombat S, Teckchuen N. Antimicrobial, antioxidant and anticancer activities of Thai local vegetables. J Med Plant Res. 2009; 3(5): 443-449.
  • [106] Tantengco OAG, Jacinto SD. Cytotoxic activity of crude extracts and fractions from Premna odorata (Blanco), Artocarpus camansi (Blanco) and Gliricidia sepium (Jacq.) against selected human cancer cell lines. Asian Pac J Trop Biomed. 2015; 5(12): 1037-1041. [CrossRef]
  • [107] Hu C, Liu H, Du J, Mo B, Qi H, Wang X, et al. Estrogenic activities of extracts of Chinese licorice (Glycyrrhiza uralensis) root in MCF-7 breast cancer cells. J Steroid Biochem Mol Biol. 2009; 113(3-5): 209-216. [CrossRef]
  • [108] Jo EH, Hong HD, Ahn NC, Jung JW, Yang SR, Park JS, et al. Modulations of the Bcl-2/Bax family were involved in the chemopreventive effects of licorice root (Glycyrrhiza uralensis Fisch) in MCF-7 human breast cancer cell. J Agric Food Chem. 2004; 52(6): 1715-1719. [CrossRef]
  • [109] Rungrojtrakool P, Siripong P, Yahuafai J, Chuakul W, Temsiririrkkul R, Chuakul W, et al. Antiproliferative activity against various cancer cells and phytochemical components of Thai herbal formula. Mahidol Univ J Pharm Sci. 2012; 39(2): 7-14.
  • [110] Bahri GG, Lamuki MS, Rezae-Raad MS. Anti-proliferative effects of alcoholic and aqueous extract of Ginkgo biloba green leaves on MCF-7 cell line. Int J Pharm Med Res (IJMPR). 2014; 2(3): 8-11.
  • [111] Narayanan NK, Kunimasa K, Yamori Y, Mori M, Mori H, Nakamura K, et al. Antitumor activity of melinjo (Gnetum gnemon L.) seed extract in human and murine tumor models in vitro and in a colon-26 tumor-bearing mouse model in vivo. Cancer Med. 2015; 4(11): 1767-1780. [CrossRef]
  • [112] Sriraman S, Ramanujam GM, Ramasamy M, Dubey GP. Identification of beta-sitosterol and stigmasterol in Bambusa bambos (L.) Voss leaf extract using HPLC and its estrogenic effect in vitro. J Pharm Biomed Anal. 2015; 115: 55-61. [CrossRef]
  • [113] Mirmalek SA, Azizi MA, Jangholi E, Yadollah-Damavandi S, Javidi MA, Parsa Y, et al. Cytotoxic and apoptogenic effect of hypericin, the bioactive component of Hypericum perforatum on the MCF-7 human breast cancer cell line. Cancer Cell Int. 2015; 16: 3. [CrossRef]
  • [114] Bakshi HA, Hakkim FL, Sam S. Molecular Mechanism of Crocin Induced Caspase Mediated MCF-7 Cell Death: In Vivo Toxicity Profiling and Ex Vivo Macrophage Activation. Asian Pac J Cancer Prev (APJCP). 2016; 17(3): 1499- 1506. [CrossRef]
  • [115] Hilbig J, Policarpi PB, Grinevicius V, Mota N, Toaldo IM, Luiz MTB, et al. Aqueous extract from pecan nut [Carya illinoinensis (Wangenh) C. Koch] shell show activity against breast cancer cell line MCF-7 and Ehrlich ascites tumor in Balb-C mice. J Ethnopharmacol. 2018; 211: 256-266. [CrossRef]
  • [116] Vinayagam A, Sudha PN. In Vitro Cytotoxicity Activity of Acteoside From Leucas Indica Flowers. Indian J Appl Res. 2014; 4(2). [CrossRef]
  • [117] Hamza AA, Ahmed MM, Elwey HM, Amin A. Melissa officinalis Protects against Doxorubicin-Induced Cardiotoxicity in Rats and Potentiates Its Anticancer Activity on MCF-7 Cells. PLoS One. 2016; 11(11): e0167049. [CrossRef]
  • [118] Saravanan R, Pemaiah B, Sridharan S, Narayanan M, Ramalingam S. Enhanced cytotoxic potential of Orthosiphon stamineus extract in MCF-7 cells through suppression of nucleolin and Bcl2. Bangladesh J Pharmacol. 2017; 12(3): 268-275.
  • [119] Geryani MA, Mahdian D, Mousavi SH, Hosseini A. Ctotoxic and apoptogenic effects of Perovskia abrotanoides flower extract on MCF-7 and HeLa cell lines. Avicenna J Phytomed. 2016; 6(4): 410-417.
  • [120] Gonzalez-Vallinas M, Reglero G, Ramirez de Molina A. Rosemary (Rosmarinus officinalis L.) Extract as a Potential Complementary Agent in Anticancer Therapy. Nutr Cancer. 2015; 67(8): 1221-1229. [CrossRef]
  • [121] Moattar FS, Sariri R, Giahi M, Yaghmaee P, Ghafoori H, Jamalzadeh L. Antioxidant and anti-proliferative activity of Calamintha officinalis extract on breast cancer cell line MCF-7. J Biol Sci. 2015; 15(4): 194-198. [CrossRef]
  • [122] Ali MA, Abul Farah M, Al-Hemaid FM, Abou-Tarboush FM. In vitro cytotoxicity screening of wild plant extracts from Saudi Arabia on human breast adenocarcinoma cells. Genet Mol Res (GMR). 2014; 13(2): 3981-3990. [CrossRef]
  • [123] Pal A, Toppo FA, Chaurasiya PK, Singour PK, Pawar RS. In-vitro cytotoxicity study of methanolic fraction from Ajuga Bracteosa wall ex. benth on MCF-7 breast adenocarcinoma and hep-2 larynx carcinoma cell lines. Pharmacognosy Res. 2014; 6(1): 87-91. [CrossRef]
  • [124] Tarhan L, Nakipoglu M, Kavakcioglu B, Tongul B, Nalbantsoy A. The Induction of Growth Inhibition and Apoptosis in HeLa and MCF-7 Cells by Teucrium sandrasicum, Having Effective Antioxidant Properties. Appl Biochem Biotechnol. 2016; 178(5): 1028-1041. [CrossRef]
  • [125] Narrima P, Paydar M. Persea declinata (Bl.) Kosterm Bark Crude Extract Induces Apoptosis in MCF-7 Cells via G0/G1 Cell Cycle Arrest, Bcl-2/Bax/Bcl-xl Signaling Pathways, and ROS Generation. Evid Based Complement Alternat Med (eCAM). 2014; 2014: 248103. [CrossRef]
  • [126] Casacchia T, Sofo A, Casaburi I, Marrelli M, Conforti F, Statti GA. Antioxidant, enzyme-inhibitory and antitumor activity of the wild dietary plant Muscari comosum (L.) Mill. Int J Plant Biol. 2017; 8(1): 31-35. [CrossRef]
  • [127] Guerriero E, Sorice A, Capone F, Storti G, Colonna G, Ciliberto G, et al. Combining doxorubicin with a phenolic extract from flaxseed oil: Evaluation of the effect on two breast cancer cell lines. Int J Oncol. 2017; 50(2): 468-476. [CrossRef]
  • [128] Theil C, Briese V, Richter DU, Jeschke U, Friese K. An ethanolic extract of Linum usitatissimum caused cell lethality and inhibition of cell vitality/ - proliferation of MCF-7 and BT20 mamma carcinoma cells in vitro. Arch Gynecol Obstet. 2013; 288(1): 149-153. [CrossRef]
  • [129] Zainuddin N, Sul'ain MD. Antiproliferative effect of Dendrophthoe pentandra extracts towards human breast adenocarcinoma cells (MCF-7). J Teknol. 2015; 77(2): 35-39. [CrossRef]
  • [130] Dashora N, Sodde V, Prabhu KS, Lobo R. In vitro cytotoxic activity of Dendrophthoe falcata on human breast adenocarcinoma Cells-MCF-7. Int J Cancer Res. 2011; 7(1): 47-54. [CrossRef]
  • [131] Sahin B, Demir E, Aygun A, Gunduz H, Sen F. Investigation of the effect of pomegranate extract and monodisperse silver nanoparticle combination on MCF-7 cell line. J Biotechnol. 2017; 260: 79-83. [CrossRef]
  • [132] Shirode AB, Kovvuru P, Chittur SV, Henning SM, Heber D, Reliene R. Antiproliferative effects of pomegranate extract in MCF-7 breast cancer cells are associated with reduced DNA repair gene expression and induction of double strand breaks. Mol Carcinog. 2014; 53(6): 458-470. [CrossRef]
  • [133] Manasathien J, Indrapichate K. Apoptosis of MCF-7 cancer cell induced by pomegranate (Punica Granatum L.) Peel extract. Suranaree J Sci Technol. 2017; 24(1): 63-74.
  • [134] Sai Saraswathi V, Saravanan D, Santhakumar K. Isolation of quercetin from the methanolic extract of Lagerstroemia speciosa by HPLC technique, its cytotoxicity against MCF-7 cells and photocatalytic activity. J Photochem Photobiol B. 2017; 171: 20-26. [CrossRef]
  • [135] Wong YH, Tan WY, Tan CP, Long K, Nyam KL. Cytotoxic activity of kenaf (Hibiscus cannabinus L.) seed extract and oil against human cancer cell lines. Asian Pac J Trop Biomed. 2014; 4(Suppl 1): S510-515. [CrossRef]
  • [136] Meena SN, Sharma S, Kulshreshtha R, Janarthanam MK, Ghadi SC. Antiproliferative activity and phytochemical analysis of methanol leaf extract of Grewia nervosa. Curr Sci. 2017; 113(10): 1828-1830.
  • [137] Cheung T, Nigam PS-N, Owusu-Apenten R. Antioxidant activity of curcumin and neem (Azadirachta indica) powders: Combination studies with ALA using MCF-7 breast cancer cells. J Appl Life Sci Int. 2016; 4(3): 1-12. [CrossRef
  • [138] Sharma C, Vas AJ, Goala P, Gheewala TM, Rizvi TA, Hussain A. Ethanolic neem (Azadirachta indica) leaf extract prevents growth of MCF-7 and HeLa cells and potentiates the therapeutic index of cisplatin. J oncol. 2014; 2014: 321754. [CrossRef]
  • [139] Chan LL, George S, Ahmad I, Gosangari SL, Abbasi A, Cunningham BT, et al. Cytotoxicity Effects of Amoora rohituka and chittagonga on Breast and Pancreatic Cancer Cells. Evid Based Complement Alternat Med (eCAM). 2011; 2011: 860605. [CrossRef]
  • [140] Khaghani S, Yajloo MM, Paknejad M, Shariftabrizi A, Pasalar P, Razi F. Selective cytotoxicity and apoptogenic activity of Hibiscus sabdariffa aqueous extract against MCF-7 human breast cancer cell line. J Cancer Ther. 2011; 2(3): 394-400. [CrossRef]
  • [141] Yang S, Zhao Q, Xiang H, Liu M, Zhang Q, Xue W, et al. Antiproliferative activity and apoptosis-inducing mechanism of constituents from Toona sinensis on human cancer cells. Cancer Cell Int. 2013; 13(1): 12. [CrossRef]
  • [142] Gopinath P, Vadivel S, Kamatchiammal S, Saroja V. Anticancerous activity of Albizia amara (Roxb.) Bovin using human breast cancer cells (MCF-7) by in vitro methods. Int J Pharma Res Rev. 2013; 2(8): 23-32.
  • [143] Jasmine R, Manikandan K, Karthikeyan K. Evaluating the antioxidant and anticancer property of Ficus carica fruits. Afr J Biotechnol. 2015; 14(7): 634-641. [CrossRef]
  • [144] Yessoufou K, Elansary HO, Mahmoud EA, Skalicka-Woźniak K. Antifungal, antibacterial and anticancer activities of Ficus drupacea L. stem bark extract and biologically active isolated compounds. Ind Crops Prod. 2015; 74: 752- 758. [CrossRef]
  • [145] Pratumvinit B, Srisapoomi T, Worawattananon P, Opartkiattikul N, Jiratchariyakul W, Kummalue T. In vitro antineoplastic effect of Ficus hispida L. plant against breast cancer cell lines. J Med Plants Res. 2009; 3(4): 255-261.
  • [146] Kumar NN, Ramakrishnaiah H, Krishna V, Radhika M. Cytotoxic activity of Broussonetia papyrifera (L.) Vent on MCF-7, HeLa and HepG2 cell lines. Int J Pharm Pharm Sci. 2014; 6(5): 339-342.
  • [147] Deepa M, Sureshkumar T, Satheeshkumar PK, Priya S. Antioxidant rich Morus alba leaf extract induces apoptosis in human colon and breast cancer cells by the downregulation of nitric oxide produced by inducible nitric oxide synthase. Nutr Cancer. 2013; 65(2): 305-310.[CrossRef]
  • [148] Choi YK, Cho SG, Choi HS, Woo SM, Yun YJ, Shin YC, et al. JNK1/2 Activation by an Extract from the Roots of Morus alba L. Reduces the Viability of Multidrug-Resistant MCF-7/Dox Cells by Inhibiting YB-1-Dependent MDR1 Expression. Evid Based Complement Alternat Med (eCAM). 2013; 2013: 741985. [CrossRef]
  • [149] Elsayed EA, Sharaf-Eldin MA, Wadaan M. In vitro Evaluation of Cytotoxic Activities of Essential Oil from Moringa oleifera Seeds on HeLa, HepG2, MCF-7, CACO-2 and L929 Cell Lines. Asian Pac J Cancer Prev (APJCP). 2015; 16(11) 4671-4675. [CrossRef]
  • [150] Dos Santos RC, Ombredane AS, Souza JMT, Vasconcelos AG, Placido A, Amorim A, et al. Lycopene-rich extract from red guava (Psidium guajava L.) displays cytotoxic effect against human breast adenocarcinoma cell line MCF7 via an apoptotic-like pathway. Food Res Int. 2018; 105: 184-196. [CrossRef]
  • [151] Kumar PS, Febriyanti RM, Sofyan FF, Luftimas DE, Abdulah R. Anticancer potential of Syzygium aromaticum L. in MCF-7 human breast cancer cell lines. Pharmacognosy Res. 2014; 6(4): 350-354. [CrossRef]
  • [152] Zhang L, Shamaladevi N, Jayaprakasha GK, Patil BS, Lokeshwar BL. Polyphenol-rich extract of Pimenta dioica berries (Allspice) kills breast cancer cells by autophagy and delays growth of triple negative breast cancer in athymic mice. Oncotarget. 2015; 6(18): 16379. [CrossRef]
  • [153] Kich DM, Bitencourt S, Caye B, Faleiro D, Alves C, Silva J, et al. Lymphocyte genotoxicity and protective effect of Calyptranthes tricona (Myrtaceae) against H2O2-induced cell death in MCF-7 cells. Mol Cell Biochem. 2017; 424(1- 2): 35-43. [CrossRef]
  • [154] Seyed Hassan Tehrani S, Hashemi Sheikh Shabani S, Tahmasebi Enferadi S, Rabiei Z. Growth Inhibitory Impact of Peganum harmala L. on Two Breast Cancer Cell Lines. Iran J Bıotechnol. 2014; 12(1): 8-14. [CrossRef]
  • [155] Shyur LF, Chen CH, Lo CP, Wang SY, Kang PL, Sun SJ, et al. Induction of apoptosis in MCF-7 human breast cancer cells by phytochemicals from Anoectochilus formosanus. J Biomed Sci. 2004; 11(6): 928-939. [CrossRef]
  • [156] Gali K, Ramakrishnan G, Kothai R, Jaykar B. In-vitro anti-cancer activity of methanolic extract of leaves of Argemone mexicana Linn. Int J PharmTech Res. 2011; 3: 1329-1333.
  • [157] Siao AC, Hou CW, Kao YH, Jeng KC. Effect of sesamin on apoptosis and cell cycle arrest in human breast cancer mcf-7 cells. Asian Pac J Cancer Prev (APJCP). 2015; 16(9): 3779-3783. [CrossRef]
  • [158] Venkatesan T, Choi YW, Mun SP, Kim YK. Pinus radiata bark extract induces caspase-independent apoptosis-like cell death in MCF-7 human breast cancer cells. Cell Biol Toxicol. 2016; 32(5): 451-464. [CrossRef]
  • [159] Grinevicius VM, Andrade KS, Ourique F, Micke GA, Ferreira SR, Pedrosa RC. Antitumor activity of conventional and supercritical extracts from Piper nigrum L. cultivar Bragantina through cell cycle arrest and apoptosis induction. J Supercrit Fluids. 2017; 128: 94-101. [CrossRef]
  • [160] Aditya V, Kumar N, Mokkapati A. In vitro anti-cancer activities of few plant extracts against MCF-7 and HT-29 cell lines. Int J Pharma Sci. 2013; 3: 185-188.
  • [161] Hussain A, Gheewala TM, Vas AJ, Shah K, Goala P, Khan S, et al. Growth inhibitory and adjuvant therapeutic potential of aqueous extract of Triticum aestivum on MCF-7 and HeLa cells. Exp Oncol. 2014; 36(1): 9-16.
  • [162] Kaur P, Kaur V, Kumar M, Kaur S. Suppression of SOS response in E. coli PQ 37, antioxidant potential and antiproliferative action of methanolic extract of Pteris vittata L. on human MCF-7 breast cancer cells. Food Chem Toxicol. 2014; 74: 326-333. [CrossRef]
  • [163] Mahmoud SS, Torchilin VP. Hormetic/cytotoxic effects of Nigella sativa seed alcoholic and aqueous extracts on MCF-7 breast cancer cells alone or in combination with doxorubicin. Cell Biochem Biophys. 2013; 66(3): 451-460. [CrossRef]
  • [164] Kang JX, Liu J, Wang J, He C, Li FP. The extract of huanglian, a medicinal herb, induces cell growth arrest and apoptosis by upregulation of interferon-beta and TNF-alpha in human breast cancer cells. Carcinogenesis. 2005; 26(11): 1934-1939. [CrossRef]
  • [165] Abedini MR, Erfanian N, Nazem H, Jamali S, Hoshyar R. Anti-proliferative and apoptotic effects of Ziziphus Jujube on cervical and breast cancer cells. Avicenna J Phytomed. 2016; 6(2): 142-148.
  • [166] Cheshmi F, Kazerouni F, Omrani MD, Rahimipour A, Shanaki M, Dehghan-Nayeri N, et al. Effect of Emodin on Expression of VEGF-A and VEGFR_2 Genes in Human Breast Carcinoma MCF-7 Cell. Int J Cancer Manag. 2017; 10(7). [CrossRef]
  • [167] George BP, Abrahamse H, Hemmaragala NM. Anticancer effects elicited by combination of Rubus extract with phthalocyanine photosensitiser on MCF-7 human breast cancer cells. Photodiagnosis Photodyn Ther. 2017; 19: 266- 273. [CrossRef]
  • [168] Amatori S, Mazzoni L, Alvarez-Suarez JM, Giampieri F, Gasparrini M, Forbes-Hernandez TY, et al. Polyphenolrich strawberry extract (PRSE) shows in vitro and in vivo biological activity against invasive breast cancer cells. Sci Rep. 2016; 6: 30917. [CrossRef]
  • [169] Atmaca H, Bozkurt E, Cittan M, Dilek Tepe H. Effects of Galium aparine extract on the cell viability, cell cycle and cell death in breast cancer cell lines. J Ethnopharmacol. 2016; 186: 305-310. [CrossRef]
  • [170] Arbab IA, Abdul AB, Sukari MA, Abdullah R, Syam S, Kamalidehghan B, et al. Dentatin isolated from Clausena excavata induces apoptosis in MCF-7 cells through the intrinsic pathway with involvement of NF-kappaB signalling and G0/G1 cell cycle arrest: a bioassay-guided approach. J Ethnopharmacol. 2013; 145(1): 343-354. [CrossRef]
  • [171] Shoja MH, Reddy ND, Nayak PG, Srinivasan KK, Rao CM. Glycosmis pentaphylla (Retz.) DC arrests cell cycle and induces apoptosis via caspase-3/7 activation in breast cancer cells. J Ethnopharmacol. 2015; 168: 50-60. [CrossRef]
  • [172] Gitanjali T, Debasish P. In‐vitro anti breast cancer activity of Limonia acidissima against MCF‐7 cell line. World J Pharm Pharm Sci. 2015; 4: 1543-1550.
  • [173] Xuan H, Li Z, Yan H, Sang Q, Wang K. Antitumor Activity of Chinese Propolis in Human Breast Cancer MCF-7 and MDA-MB-231 Cells. Evid Based Complement Alternat Med (eCAM). 2014; 2014: 280120. [CrossRef]
  • [174] A. Y. Ibrahim, S. E. El-gengaihi, and H. M. Motawe, Phytochemical and Cytotoxicity Investigations of Salvadora Persica Bark Extracts. Phytochem Cytotox Investig J. 2011; 6(2) 127–133.
  • [175] Zhai JW, Gao C, Ma WD, Wang W, Yao LP, Xia XX, et al. Geraniin induces apoptosis of human breast cancer cells MCF-7 via ROS-mediated stimulation of p38 MAPK. Toxicol Mech Methods. 2016; 26(5): 311-318. [CrossRef]
  • [176] Valiyari S, Jahanban-Esfahlan R, Shahneh FZ, Yaripour S, Baradaran B, Delazar A. Cytotoxic and apoptotic activity of Scrophularia oxysepala in MCF-7 human breast cancer cells. Toxicol Environ Chem. 2013; 95(7): 1208-1220. [CrossRef]
  • [177] Azadmehr A, Hajiaghaee R, Baradaran B, Haghdoost-Yazdi H. Apoptosis Cell Death Effect of Scrophularia Variegata on Breast Cancer Cells via Mitochondrial Intrinsic Pathway. Adv Pharm Bull. 2015; 5(3): 443-446. [CrossRef]
  • [178] Jayakumar K, Murugan K. Purified Solasodine and Caulophyllumine: A from Solanum mauritianum Scop. against MCF-7 Breast Cancer Cell Lines in Terms of Cell Growth. J Pharmacogn Phytochem. 2017; 6: 472-478.
  • [179] Munari CC, de Oliveira PF, Campos JC, Martins Sde P, Da Costa JC, Bastos JK, et al. Antiproliferative activity of Solanum lycocarpum alkaloidic extract and their constituents, solamargine and solasonine, in tumor cell lines. J Nat Med. 2014; 68(1): 236-241. [CrossRef]
  • [180] Nazeema B, Julie J, Abirami J, Kumareasan R, Muthukumaran T, Rajasree S, et al. Anti-cancer activity of Datura metel on MCF-7 cell line. Asian J Pharmaceutic Clinic Res. 2014; 7(7): 181-183.
  • [181] Alimohammadi M, Lahiani MH, McGehee D, Khodakovskaya M. Polyphenolic extract of InsP 5-ptase expressing tomato plants reduce the proliferation of MCF-7 breast cancer cells. PLoS One. 2017; 12(4): e0175778. [CrossRef]
  • [182] Thenmozhi A, Nagalakshmi A, Mahadeva Rao U. Study of cytotoxic and antimitotic activities of Solanum nigrum by using Allium ceparoot tip assay and cancer chemo preventive activity using MCF-7-human mammary gland breast adenocarcinoma cell lines. Int J Sci Technol. 2011; 1(2): 26-48.
  • [183] Lai YJ, Tai CJ, Wang CW, Choong CY, Lee BH, Shi YC, et al. Anti-Cancer Activity of Solanum nigrum (AESNthrough Suppression of Mitochondrial Function and Epithelial-Mesenchymal Transition (EMT) in Breast Cancer Cells. Molecules. 2016; 21(5). [CrossRef]
  • [184] Osman M, Wafaa A, Nadia E, Amany A, Doaa E. Potential Role of Withania somnifera on Human Breast Cancer. Nat Sci. 2012; 10(11). [185] Demir T, Özen MÖ, Hameş-Kocabaş EE. Antioxidant and cytotoxic activity of Physalis peruviana. Med Plant Res. 2014; 4(4): 30-34. [CrossRef]
  • [186] Han L, Ma YM, An L, Zhang Q, Wang CL, Zhao QC. Non-alkaloids extract from Stemona sessilifolia enhances the activity of chemotherapeutic agents through P-glycoprotein-mediated multidrug-resistant cancer cells. Nat Prod Res. 2016; 30(10): 1186-1189. [CrossRef]
  • [187] Liu Z, Zheng X, Lv J, Zhou X, Wang Q, Wen X, et al. Pharmacokinetic synergy from the taxane extract of Taxus chinensis improves the bioavailability of paclitaxel. Phytomedicine. 2015; 22(5): 573-578. [CrossRef]
  • [188] Li W, He N, Tian L, Shi X, Yang X. Inhibitory effects of polyphenol-enriched extract from Ziyang tea against human breast cancer MCF-7 cells through reactive oxygen species-dependent mitochondria molecular mechanism. J Food Drug Anal. 2016; 24(3): 527-538. [CrossRef]
  • [189] Chen L, Chen J, Xu H. Sasanquasaponin from Camellia oleifera Abel. induces cell cycle arrest and apoptosis in human breast cancer MCF-7 cells. Fitoterapia. 2013; 84: 123-129. [CrossRef]
  • [190] Guler E. Investigation of chemopreventif properties of Urtica dioica L., in MCF-7 and MDA 231 breast cancer cell lines. New J Med. 2013; 231: 50-53.
  • [191] Reddy AS, Abd Malek SN, Ibrahim H, Sim KS. Cytotoxic effect of Alpinia scabra (Blume) Naves extracts on human breast and ovarian cancer cells. BMC Complement Altern Med. 2013; 13: 314. [CrossRef]
  • [192] Chen X, Pei L, Zhong Z, Guo J, Zhang Q, Wang Y. Anti-tumor potential of ethanol extract of Curcuma phaeocaulis Valeton against breast cancer cells. Phytomedicine. 2011; 18(14): 1238-1243. [CrossRef]
  • [193] Samarghandian S, Hadjzadeh MA, Afshari JT, Hosseini M. Antiproliferative activity and induction of apoptotic by ethanolic extract of Alpinia galanga rhizhome in human breast carcinoma cell line. BMC Complement Altern Med. 2014; 14: 192. [CrossRef]
  • [194] Ghil S. Antiproliferative activity of Alpinia officinarum extract in the human breast cancer cell line MCF-7. Mol Med Rep. 2013; 7(4): 1288-1292. [CrossRef]
  • [195] Lam M, Carmichael AR, Griffiths HR. An aqueous extract of Fagonia cretica induces DNA damage, cell cycle arrest and apoptosis in breast cancer cells via FOXO3a and p53 expression. PLoS One. 2012; 7(6): e40152. [CrossRef]
  • [196] Angelova S, Gospodinova Z, Krasteva M, Antov G, Lozanov V, Markov T, et al. Antitumor activity of Bulgarian herb Tribulus terrestris L. on human breast cancer cells. J BioSci Biotech. 2013; 2(1): 25-32.
  • [197] Moongkarndi P, Kosem N, Luanratana O, Jongsomboonkusol S, Pongpan N. Antiproliferative activity of Thai medicinal plant extracts on human breast adenocarcinoma cell line. Fitoterapia. 2004; 75(3-4): 375-377. [CrossRef]
  • [198] Lee H-N, Shin S-A, Choo G-S, Kim H-J, Park Y-S, Kim S-K, et al. Inhibitory effects of spinach, cabbage, and onion extracts on growth of cancer cells. J Korean Soc Food Sci Nutr. 2016; 45(5): 671-679. [CrossRef]
  • [199] Taylor PG, Cesari IM, Arsenak M, Ballen D, Abad MJ, Fernández A, et al. Evaluation of Venezuelan medicinal plant extracts for antitumor and antiprotease activities. Pharm Biol. 2006; 44(5): 349-362. [CrossRef]
  • [200] Gavamukulya Y, Abou-Elella F, Wamunyokoli F, H AE-S. Phytochemical screening, anti-oxidant activity and in vitro anticancer potential of ethanolic and water leaves extracts of Annona muricata (Graviola). Asian Pac J Trop Med. 2014; 7s1: S355-S363. [CrossRef]
  • [201] Raybaudi-Massilia R, Suárez AI, Arvelo F, Sojo F, Mosqueda-Melgar J, Zambrano A, et al. An analysis in-vitro of the cytotoxic, antioxidant and antimicrobial activity of aqueous and alcoholic extracts of Annona muricata L. seed and pulp. Br J Appl Sci Technol. 2015; 5(4): 333. [CrossRef]
  • [202] Sevimli-Gur C, Cetin B, Akay S, Gulce-Iz S, Yesil-Celiktas O. Extracts from black carrot tissue culture as potent anticancer agents. Plant Foods Hum Nutr. 2013; 68(3): 293-298. [CrossRef]
  • [203] Gorantla JN, Vellekkatt J, Nath LR, Anto RJ, Lankalapalli RS. Cytotoxicity studies of semi-synthetic derivatives of theveside derived from the aqueous extract of leaves of 'suicide tree' Cerbera odollam. Nat Prod Res. 2014; 28(18): 1507-1512. [CrossRef]
  • [204] Samarakoon SR, Shanmuganathan C, Ediriweera MK, Tennekoon KH, Piyathilaka P, Thabrew I, et al. In vitro cytotoxic and antioxidant activity of leaf extracts of mangrove plant, Phoenix paludosa Roxb. Trop J Pharm Res. 2016; 15(1): 127-132. [CrossRef]
  • [205] Mahmoodi N, Motamed N, Paylakhi SH, Mahmoodi NO. Comparing the effect of Silybin and Silybin advanced™ on viability and HER2 expression on the human breast cancer SKBR3 cell line by no serum starvation. Iran J Pharm Res. 2015; 14(2): 521. [CrossRef]
  • [206] Younesian O, Kazerouni F, Dehghan-Nayeri N, Omrani D, Rahimipour A, Shanaki M, et al. Effect of curcumin on fatty acid synthase expression and enzyme activity in breast cancer cell line SKBR3. Int J Cancer Manag. 2017; 10(3): e8173. [CrossRef]
  • [207] Yeo SK, Ali AY, Hayward OA, Turnham D, Jackson T, Bowen ID, et al. beta-Bisabolene, a Sesquiterpene from the Essential Oil Extract of Opoponax (Commiphora guidottii), Exhibits Cytotoxicity in Breast Cancer Cell Lines. Phytother Res. 2016; 30(3): 418-425. [CrossRef]
  • [208] Manosroi A, Jantrawut P, Ogihara E, Yamamoto A, Fukatsu M, Yasukawa K, et al. Biological activities of phenolic compounds and triterpenoids from the galls of Terminalia chebula. Chem Biodivers. 2013; 10(8): 1448-1463. [CrossRef]
  • [209] An I-J, Kwon J-K, Lee J-S, Park H-S, Kim D-C, Choi B-J, et al. Induction of apoptosis in human cancer cells with compositae extracts. J Korean Soc Food Sci Nutr. 2012; 41(5): 584-590.
  • [210] Kummalue T, O-charoenrat P, Jiratchariyakul W, Chanchai M, Pattanapanyasat K, Sukapirom K, Iemsri S. Antiproliferative effect of Erycibe elliptilimba on human breast cancer cell lines. J Ethnopharmacol. 2007; 110(3): 439-443. [CrossRef]
  • [211] Chen D, Cao R, He J, Guo Y, Wang L, Ji W, et al. Synergetic effects of aqueous extracts of Fuzi (Radix Aconiti Lateralis Preparata) and Tubeimu (Rhizoma Bolbostemmatis) on MDA-MB-231 and SKBR3 cells. J Tradit Chin Med. 2016; 36(1): 113-124. [CrossRef]
  • [212] Kongtun S, Jiratchariyakul W, Kummalue T, Tan-ariya P, Kunnachak S, Frahm AW. Cytotoxic properties of root extract and fruit juice of Trichosanthes cucumerina. Planta medica. 2009; 75(8): 839-842. [CrossRef]
  • [213] Zhang J, Zhu WF, Zhu WY, Yang PP, Xu J, Manosroi J, et al. Melanogenesis-Inhibitory and Cytotoxic Activities of Chemical Constituents from the Leaves of Sauropus androgynus L. Merr. (Euphorbiaceae). Chem Biodivers. 2018; 15(2): e1700486. [CrossRef]
  • [214] Kummalue T, Suntiparpluacha M, Jiratchariyakul W. Antiproliferative activity of combination of Thai herbal remedy and chemotherapeutic agents on human cancer cell lines. J Med Plant Res. 2012; 6(2): 200-205. [CrossRef]
  • [215] Jung Y, Xu W, Kim H, Ha N, Neckers L. Curcumin-induced degradation of ErbB2: A role for the E3 ubiquitin ligase CHIP and the Michael reaction acceptor activity of curcumin. Biochimica et biophysica acta. 2007; 1773(3): 383-390. [CrossRef]
  • [216] Park S, Cho DH, Andera L, Suh N, Kim I. Curcumin enhances TRAIL-induced apoptosis of breast cancer cells by regulating apoptosis-related proteins. Mol Cell Biochem. 2013; 383(1-2): 39-48. [CrossRef]
  • [217] Moongkarndi P, Kosem N, Kaslungka S, Luanratana O, Pongpan N, Neungton N. Antiproliferation, antioxidation and induction of apoptosis by Garcinia mangostana (mangosteen) on SKBR3 human breast cancer cell line. J Ethnopharmacol. 2004; 90(1): 161-166. [CrossRef]
  • [218] Moongkarndi P, Jaisupa N, Samer J, Kosem N, Konlata J, Rodpai E, et al. Comparison of the biological activity of two different isolates from mangosteen. J Pharm Pharmacol. 2014; 66(8): 1171-1179. [CrossRef]
  • [219] Fong S, Shoemaker M, Cadaoas J, Lo A, Liao W, Tagliaferri M, et al. Molecular mechanisms underlying selective cytotoxic activity of BZL101, an extract of Scutellaria barbata, towards breast cancer cells. Cancer Biol Ther. 2008; 7(4): 577-586. [CrossRef]
  • [220] Cohen I. Process of making purified extract of Scutellaria barbata D. Don. Google Patents; 2012.
  • [221] Cohen I. Scutellaria barbata extract for the treatment of cancer. Google Patents; 2010.
  • [222] Chen V, Staub RE, Baggett S, Chimmani R, Tagliaferri M, Cohen I, et al. Identification and analysis of the active phytochemicals from the anti-cancer botanical extract Bezielle. PLoS One. 2012; 7(1): e30107. [CrossRef]
  • [223] Oleaga C, Garcia M, Sole A, Ciudad CJ, Izquierdo-Pulido M, Noe V. CYP1A1 is overexpressed upon incubation of breast cancer cells with a polyphenolic cocoa extract. Eur J Nutr. 2012; 51(4): 465-476. [CrossRef]
  • [224] Pan X, Matsumoto M, Nakamura Y, Kikuchi T, Zhang J, Ukiya M, et al. Three new and other limonoids from the hexane extract of Melia azedarach fruits and their cytotoxic activities. Chem Biodivers. 2014; 11(7): 987-1000. [CrossRef]
  • [225] Manosroi A, Kitdamrongtham W, Ishii K, Shinozaki T, Tachi Y, Takagi M, et al. Limonoids from Azadirachta indica var. siamensis extracts and their cytotoxic and melanogenesis-inhibitory activities. Chem Biodivers. 2014; 11(4): 505-531. [CrossRef]
  • [226] Zhang J, Zhu W-f, Xu J, Kitdamrongtham W, Manosroi A, Manosroi J, et al. Potential cancer chemopreventive and anticancer constituents from the fruits of Ficus hispida Lf (Moraceae). J Ethnopharmacol. 2018; 214: 37-46. [CrossRef]
  • [227] Zhang L, Shamaladevi N, Lokeshwar BL. An aqueous extract of Allspice (berries of Pimenta dioica) inhibits breast cancer growth through autophagy by targeting the estrogen receptor. AACR; 2011. [CrossRef]
  • [228] Quirantes-Pine R, Zurek G, Barrajon-Catalan E, Bassmann C, Micol V, Segura-Carretero A, et al. A metaboliteprofiling approach to assess the uptake and metabolism of phenolic compounds from olive leaves in SKBR3 cells by HPLC-ESI-QTOF-MS. J Pharm Biomed Anal. 2013; 72: 121-126. [CrossRef]
  • [229] Samara P, Christoforidou N, Lemus C, Argyropoulou A, Ioannou K, Vougogiannopoulou K, et al. New semisynthetic analogs of oleuropein show improved anticancer activity in vitro and in vivo. Eur J Med Chem. 2017; 137: 11-29. [CrossRef]
  • [230] Kalkhoran MR, Kazerouni F, Omrani MD, Rahimipour A, Shanaki M, Dehghan-Nayeri N, et al. Cytotoxic Effect of Emodin on Growth of SKBR3 Breast Cancer Cells. Int J Cancer Manag. 2017; 10(4): e8094. [CrossRef]
  • [231] Ma W-l, Liang H, Liu Y. Effect of aplysin on the proliferation and apoptosis in human breast cancer SK-BR-3. Nat Prod Res Dev. 2012; 24: 1201-1205.
  • [232] Gu G, Barone I, Gelsomino L, Giordano C, Bonofiglio D, Statti G, et al. Oldenlandia diffusa extracts exert antiproliferative and apoptotic effects on human breast cancer cells through ERα/Sp1‐mediated p53 activation. J Cell Physiol. 2012; 227(10): 3363-3372. [CrossRef]
  • [233] Pradhan D, Tripathy G, Patanaik S. Anticancer activity of Limonia acidissima Linn (Rutaceae) fruit extracts on human breast cancer cell lines. Trop J Pharm Res. 2012; 11(3): 413-419. [CrossRef]
  • [234] Lanza-Jacoby S, Yan G, Wang C. Nexrutine, a phellodendron amurense extract protects against breast cancer. AACR; 2010. [CrossRef]
  • [235] Widodo N, Kaur K, Shrestha BG, Takagi Y, Ishii T, Wadhwa R, et al. Selective killing of cancer cells by leaf extract of Ashwagandha: identification of a tumor-inhibitory factor and the first molecular insights to its effect. Clin Cancer Res. 2007; 13(7): 2298-2306. [CrossRef]
  • [236] Amirghofran Z, Miri R, Javidnia K, Davoodi M. Study of cytotoxic activity of Daphne mucronata Royle grown in Iran. Iran J Med Sci. 2001; 26(3-4): 146-151.
  • [237] Pradhan D, Tripathy G. Antiproliferative activity of Trapa acornis shell extracts against human breast cancer cell lines. Int J Pharm Sci Res. 2014; 5: 2238-2243. [CrossRef]
  • [238] Kijima I, Phung S, Hur G, Kwok S-L, Chen S. Grape seed extract is an aromatase inhibitor and a suppressor of aromatase expression. Cancer Res. 2006; 66(11): 5960-5967. [CrossRef]
  • [239] Tallant EA, Holmes CH, Gallagher PE. Inhibition of cancer cell growth by muscadine grape seed and grape skin extracts. AACR; 2011; 71(8): 4220. [CrossRef]
There are 238 citations in total.

Details

Primary Language English
Subjects Pharmacology and Pharmaceutical Sciences (Other)
Journal Section Articles
Authors

Nasrin Dehghan-nayeri

Mina Darvishi

Pargol Mashati

Maryam Rezapour-kalkhoran

Morteza Rezaiefard

Samareh Younesian

Publication Date June 27, 2025
Published in Issue Year 2020 Volume: 24 Issue: 1

Cite

APA Dehghan-nayeri, N., Darvishi, M., Mashati, P., Rezapour-kalkhoran, M., et al. (2025). Comparison of cytotoxic activity of herbal extracts on the most commonly used breast cancer cell lines (MCF7 and SKBR3): A systematic review. Journal of Research in Pharmacy, 24(1), 1-22. https://doi.org/10.35333/jrp.2020.121
AMA Dehghan-nayeri N, Darvishi M, Mashati P, Rezapour-kalkhoran M, Rezaiefard M, Younesian S. Comparison of cytotoxic activity of herbal extracts on the most commonly used breast cancer cell lines (MCF7 and SKBR3): A systematic review. J. Res. Pharm. June 2025;24(1):1-22. doi:10.35333/jrp.2020.121
Chicago Dehghan-nayeri, Nasrin, Mina Darvishi, Pargol Mashati, Maryam Rezapour-kalkhoran, Morteza Rezaiefard, and Samareh Younesian. “Comparison of Cytotoxic Activity of Herbal Extracts on the Most Commonly Used Breast Cancer Cell Lines (MCF7 and SKBR3): A Systematic Review”. Journal of Research in Pharmacy 24, no. 1 (June 2025): 1-22. https://doi.org/10.35333/jrp.2020.121.
EndNote Dehghan-nayeri N, Darvishi M, Mashati P, Rezapour-kalkhoran M, Rezaiefard M, Younesian S (June 1, 2025) Comparison of cytotoxic activity of herbal extracts on the most commonly used breast cancer cell lines (MCF7 and SKBR3): A systematic review. Journal of Research in Pharmacy 24 1 1–22.
IEEE N. Dehghan-nayeri, M. Darvishi, P. Mashati, M. Rezapour-kalkhoran, M. Rezaiefard, and S. Younesian, “Comparison of cytotoxic activity of herbal extracts on the most commonly used breast cancer cell lines (MCF7 and SKBR3): A systematic review”, J. Res. Pharm., vol. 24, no. 1, pp. 1–22, 2025, doi: 10.35333/jrp.2020.121.
ISNAD Dehghan-nayeri, Nasrin et al. “Comparison of Cytotoxic Activity of Herbal Extracts on the Most Commonly Used Breast Cancer Cell Lines (MCF7 and SKBR3): A Systematic Review”. Journal of Research in Pharmacy 24/1 (June 2025), 1-22. https://doi.org/10.35333/jrp.2020.121.
JAMA Dehghan-nayeri N, Darvishi M, Mashati P, Rezapour-kalkhoran M, Rezaiefard M, Younesian S. Comparison of cytotoxic activity of herbal extracts on the most commonly used breast cancer cell lines (MCF7 and SKBR3): A systematic review. J. Res. Pharm. 2025;24:1–22.
MLA Dehghan-nayeri, Nasrin et al. “Comparison of Cytotoxic Activity of Herbal Extracts on the Most Commonly Used Breast Cancer Cell Lines (MCF7 and SKBR3): A Systematic Review”. Journal of Research in Pharmacy, vol. 24, no. 1, 2025, pp. 1-22, doi:10.35333/jrp.2020.121.
Vancouver Dehghan-nayeri N, Darvishi M, Mashati P, Rezapour-kalkhoran M, Rezaiefard M, Younesian S. Comparison of cytotoxic activity of herbal extracts on the most commonly used breast cancer cell lines (MCF7 and SKBR3): A systematic review. J. Res. Pharm. 2025;24(1):1-22.

Cited By

<i>In silico</i> and <i>in vitro</i> Characterizations of Rodent Tuber (<i>Typhonium flagelliforme</i>) Mutant Plant Isolates against FXR Receptor on MCF-7 Cells
Journal of Oleo Science
https://doi.org/10.5650/jos.ess24020
Evaluation of Cytotoxicity of normal Vero and Anticancer Activity of Human Breast Cancer Cell Lines by Aqueous Unripe Fruit Extract of Solanum torvum
Research Journal of Pharmacy and Technology
https://doi.org/10.52711/0974-360X.2021.00607