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Progressive Journey of Phytosomes: Preparation, Characterization, Patents, Clinical trials & Commercial products

Year 2023, Volume: 27 Issue: 5, 1687 - 1733, 28.06.2025

Jyotsana Dwivedi Pranjal Sachan Pranay Wal Sourabh Kosey Uzzaman Khan

Abstract

Phytosomes stand sophisticated herbal preparations that contain the phytoactive ingredients found in extracted from herbs and have the ability towards change the cell membrane's hydrophilic to lipophilic state. They may be produced as pills, creams, gels, suspensions, and other medicinal forms. Many illnesses now have a fantastic treatment alternative in phytosomes. Their therapeutic applicability may be limited by poor bioavailability and selectivity. A potential possibility for the delivery of insoluble phytochemicals has been introduced: nano-vesicles. The most commonly formulated substances are curcumin and silymarin. A variety of human and animal systems, including the cardiovascular, digestion, urination, immunological, muscle-skeletal and integumentary, pulmonary and respiratory systems, have been the subject of more than 100 studies looking at the effects of phytosomes. This list contains the quantity of articles on phytosomes and their biological functions, broken down by the system being studied. The existing method of delivering topically applied bioactive phytochemicals may be drastically altered by phytosome nanotechnology. The main problems are the inadequate penetration through biological barriers and the very low absorption rate (specifically, the skin). Phytosomes which are nanocarriers made up of lipids are essential for enhancing polyphenolic chemicals that come from herbs. A novel, patented method called phytosomes produces lipid-compatible molecular complexes by complexing standardized plant extracts or water-soluble phytoconstituents with phospholipids. This significantly increases absorption and bioavailability by increasing the hydrophilicity of a highly lipophilic drug, the phytosome or herbosome approach makes it ideal for drug administration.

Keywords

Phytosomes drug delivery system phyto-phospholipid complex polyphenols flavonoids clinical trial

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There are 145 citations in total.

Details

Primary Language English
Subjects Pharmacology and Pharmaceutical Sciences (Other)
Journal Section Articles
Authors

Jyotsana Dwivedi

Pranjal Sachan 0009-0004-8844-5940

Pranay Wal 0000-0002-6342-6290

Sourabh Kosey 0000-0002-3102-0069

Uzzaman Khan 0000-0002-2562-7403

Publication Date June 28, 2025
Published in Issue Year 2023 Volume: 27 Issue: 5

Cite

APA Dwivedi, J., Sachan, P., Wal, P., Kosey, S., et al. (2025). Progressive Journey of Phytosomes: Preparation, Characterization, Patents, Clinical trials & Commercial products. Journal of Research in Pharmacy, 27(5), 1687-1733.
AMA Dwivedi J, Sachan P, Wal P, Kosey S, Khan U. Progressive Journey of Phytosomes: Preparation, Characterization, Patents, Clinical trials & Commercial products. J. Res. Pharm. July 2025;27(5):1687-1733.
Chicago Dwivedi, Jyotsana, Pranjal Sachan, Pranay Wal, Sourabh Kosey, and Uzzaman Khan. “Progressive Journey of Phytosomes: Preparation, Characterization, Patents, Clinical Trials & Commercial Products”. Journal of Research in Pharmacy 27, no. 5 (July 2025): 1687-1733.
EndNote Dwivedi J, Sachan P, Wal P, Kosey S, Khan U (July 1, 2025) Progressive Journey of Phytosomes: Preparation, Characterization, Patents, Clinical trials & Commercial products. Journal of Research in Pharmacy 27 5 1687–1733.
IEEE J. Dwivedi, P. Sachan, P. Wal, S. Kosey, and U. Khan, “Progressive Journey of Phytosomes: Preparation, Characterization, Patents, Clinical trials & Commercial products”, J. Res. Pharm., vol. 27, no. 5, pp. 1687–1733, 2025.
ISNAD Dwivedi, Jyotsana et al. “Progressive Journey of Phytosomes: Preparation, Characterization, Patents, Clinical Trials & Commercial Products”. Journal of Research in Pharmacy 27/5 (July 2025), 1687-1733.
JAMA Dwivedi J, Sachan P, Wal P, Kosey S, Khan U. Progressive Journey of Phytosomes: Preparation, Characterization, Patents, Clinical trials & Commercial products. J. Res. Pharm. 2025;27:1687–1733.
MLA Dwivedi, Jyotsana et al. “Progressive Journey of Phytosomes: Preparation, Characterization, Patents, Clinical Trials & Commercial Products”. Journal of Research in Pharmacy, vol. 27, no. 5, 2025, pp. 1687-33.
Vancouver Dwivedi J, Sachan P, Wal P, Kosey S, Khan U. Progressive Journey of Phytosomes: Preparation, Characterization, Patents, Clinical trials & Commercial products. J. Res. Pharm. 2025;27(5):1687-733.