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A systematic review and meta-analysis: the effect of pharmacist-led antibiotic stewardship programs on antibiotic consumption and rational use

Year 2024, Volume: 28 Issue: 4, 912 - 922, 28.06.2025

Eda Aydin Guldur Erdem Karabulut , Gülbin Özçelikay

Abstract

Irrational use of antibiotics and antibiotic resistance are one of the major problems encountered in healthcare services. Antibiotic stewardship programs (ASPs) have been one of the most successful attempts in hospitals to control antibiotic resistance. Pharmacists are the core health professionals in ASPs. This study aimed to examine the effect of clinical pharmacist-led ASPs on antibiotic consumption with meta-analysis. ScienceDirect, PubMed, MEDLINE and Cochrane databases were searched for relevant studies. The Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guideline was used to identify studies for the review. Methodological quality was assessed using Newcastle-Ottawa scale (NOS) and National Heart, Lung and Blood Institute (NHLBI) pre-post comparison studies quality tool. The R (version 4.0.3.) and metafor packages (version 2.1-0) were used for a random-effects meta- analysis. After pharmacist intervention, the pooled rational use of antibiotics was determined as 0.28 (28% improvement, I2=98.26; 95% CI 0.15-0.41). The pooled duration of therapy data was determined as 0.41 (41% reduction, I2=96.30%; 95% CI 0.54-0.29) in favor of the group with the pharmacist’s intervention. As a result of this study, it was determined that clinical pharmacists took part in the evaluation of the patient, regulation of the treatment, follow-up of the patient after treatment, and education in ASPs. These findings can contribute to improving the role of the pharmacist in ASPs and rational antibiotic use, thereby controlling antibiotic resistance.

Keywords

Antibiotic use antibiotic resistance duration of therapy pharmacist-led antibiotic stewardship program pharmacist intervention.

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There are 53 citations in total.

Details

Primary Language English
Subjects Pharmacology and Pharmaceutical Sciences (Other)
Journal Section Reviews
Authors

Eda Aydin Guldur 0000-0001-8263-1583

Erdem Karabulut

Gülbin Özçelikay 0000-0002-1580-5050

Publication Date June 28, 2025
Published in Issue Year 2024 Volume: 28 Issue: 4

Cite

APA Aydin Guldur, E., Karabulut, E., & Özçelikay, G. (2025). A systematic review and meta-analysis: the effect of pharmacist-led antibiotic stewardship programs on antibiotic consumption and rational use. Journal of Research in Pharmacy, 28(4), 912-922.
AMA Aydin Guldur E, Karabulut E, Özçelikay G. A systematic review and meta-analysis: the effect of pharmacist-led antibiotic stewardship programs on antibiotic consumption and rational use. J. Res. Pharm. July 2025;28(4):912-922.
Chicago Aydin Guldur, Eda, Erdem Karabulut, and Gülbin Özçelikay. “A Systematic Review and Meta-Analysis: The Effect of Pharmacist-Led Antibiotic Stewardship Programs on Antibiotic Consumption and Rational Use”. Journal of Research in Pharmacy 28, no. 4 (July 2025): 912-22.
EndNote Aydin Guldur E, Karabulut E, Özçelikay G (July 1, 2025) A systematic review and meta-analysis: the effect of pharmacist-led antibiotic stewardship programs on antibiotic consumption and rational use. Journal of Research in Pharmacy 28 4 912–922.
IEEE E. Aydin Guldur, E. Karabulut, and G. Özçelikay, “A systematic review and meta-analysis: the effect of pharmacist-led antibiotic stewardship programs on antibiotic consumption and rational use”, J. Res. Pharm., vol. 28, no. 4, pp. 912–922, 2025.
ISNAD Aydin Guldur, Eda et al. “A Systematic Review and Meta-Analysis: The Effect of Pharmacist-Led Antibiotic Stewardship Programs on Antibiotic Consumption and Rational Use”. Journal of Research in Pharmacy 28/4 (July 2025), 912-922.
JAMA Aydin Guldur E, Karabulut E, Özçelikay G. A systematic review and meta-analysis: the effect of pharmacist-led antibiotic stewardship programs on antibiotic consumption and rational use. J. Res. Pharm. 2025;28:912–922.
MLA Aydin Guldur, Eda et al. “A Systematic Review and Meta-Analysis: The Effect of Pharmacist-Led Antibiotic Stewardship Programs on Antibiotic Consumption and Rational Use”. Journal of Research in Pharmacy, vol. 28, no. 4, 2025, pp. 912-2.
Vancouver Aydin Guldur E, Karabulut E, Özçelikay G. A systematic review and meta-analysis: the effect of pharmacist-led antibiotic stewardship programs on antibiotic consumption and rational use. J. Res. Pharm. 2025;28(4):912-2.