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LC-MS /MS characterization and biological activities of Morina persica L. (Caprifoliaceae)

Year 2024, Volume: 28 Issue: 4, 961 - 973, 28.06.2025

Sefa Gözcü , Zeynep Akşit , Samed Şimşek , Ali Kandemir , Ali Aydın , Mustafa Abdullah Yılmaz , Hüseyin Akşit

Abstract

The study aimed to comprehensively identify the phenolic fingerprint of Morina persica L. (Caprifoliaceae) and evaluate its various biological activities. LC-MS/MS analysis of 70% Morina persica methanol extract revealed the presence of 27 phytochemicals, with quinic acid, chlorogenic acid, and rutin being the major phenolics. The antioxidant, antibacterial, antiproliferative, and cytotoxic activities were evaluated for biological screening. The results showed that the methanolic extract of M. persica has a moderate DPPH radical scavenging and ferric-reducing capacity, indicating antioxidant activity. M. persica was observed to have a sufficient antiproliferative effect against cancer cells and low cytotoxicity against normal cells. Moreover, M. persica demonstrated good antibacterial activity against Clostridium perfringens, Enterococcus faecalis, and Escherichia coli. These data suggest that the methanolic extract of M. persica could be considered both an industrial source of quinic acid and a potential biologically active ingredient for developing drug formulations.

Keywords

Morina persica L. antibacterial antioxidant antiproliferative LC-MS/MS

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Details

Primary Language English
Subjects Pharmacognosy
Journal Section Articles
Authors

Sefa Gözcü 0000-0002-0735-4229

Zeynep Akşit 0000-0002-0349-0223

Samed Şimşek 0000-0001-8451-3425

Ali Kandemir 0000-0003-1902-9631

Ali Aydın

Mustafa Abdullah Yılmaz 0000-0002-4090-7227

Hüseyin Akşit 0000-0002-1509-851X

Publication Date June 28, 2025
Published in Issue Year 2024 Volume: 28 Issue: 4

Cite

APA Gözcü, S., Akşit, Z., Şimşek, S., Kandemir, A., et al. (2025). LC-MS /MS characterization and biological activities of Morina persica L. (Caprifoliaceae). Journal of Research in Pharmacy, 28(4), 961-973.
AMA Gözcü S, Akşit Z, Şimşek S, Kandemir A, Aydın A, Yılmaz MA, Akşit H. LC-MS /MS characterization and biological activities of Morina persica L. (Caprifoliaceae). J. Res. Pharm. July 2025;28(4):961-973.
Chicago Gözcü, Sefa, Zeynep Akşit, Samed Şimşek, Ali Kandemir, Ali Aydın, Mustafa Abdullah Yılmaz, and Hüseyin Akşit. “LC-MS /MS Characterization and Biological Activities of Morina Persica L. (Caprifoliaceae)”. Journal of Research in Pharmacy 28, no. 4 (July 2025): 961-73.
EndNote Gözcü S, Akşit Z, Şimşek S, Kandemir A, Aydın A, Yılmaz MA, Akşit H (July 1, 2025) LC-MS /MS characterization and biological activities of Morina persica L. (Caprifoliaceae). Journal of Research in Pharmacy 28 4 961–973.
IEEE S. Gözcü, Z. Akşit, S. Şimşek, A. Kandemir, A. Aydın, M. A. Yılmaz, and H. Akşit, “LC-MS /MS characterization and biological activities of Morina persica L. (Caprifoliaceae)”, J. Res. Pharm., vol. 28, no. 4, pp. 961–973, 2025.
ISNAD Gözcü, Sefa et al. “LC-MS /MS Characterization and Biological Activities of Morina Persica L. (Caprifoliaceae)”. Journal of Research in Pharmacy 28/4 (July 2025), 961-973.
JAMA Gözcü S, Akşit Z, Şimşek S, Kandemir A, Aydın A, Yılmaz MA, Akşit H. LC-MS /MS characterization and biological activities of Morina persica L. (Caprifoliaceae). J. Res. Pharm. 2025;28:961–973.
MLA Gözcü, Sefa et al. “LC-MS /MS Characterization and Biological Activities of Morina Persica L. (Caprifoliaceae)”. Journal of Research in Pharmacy, vol. 28, no. 4, 2025, pp. 961-73.
Vancouver Gözcü S, Akşit Z, Şimşek S, Kandemir A, Aydın A, Yılmaz MA, Akşit H. LC-MS /MS characterization and biological activities of Morina persica L. (Caprifoliaceae). J. Res. Pharm. 2025;28(4):961-73.