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Development and evaluation of multiple unit particulate system (MUPS) of topiramate for taste masking

Year 2024, Volume: 28 Issue: 4, 997 - 1009, 28.06.2025

Isaiah Boyapati Neerupma Dhiman Giriraj T Kulkarni

Abstract

Multiple unit particulate system (MUPS) is a more recent, challenging, effective and attractive option for the pharmaceutical industries that gives an efficient way to deliver the drug in modified pattern. MUPS are the most preferred dosage forms considering their ease of administration and consistency in manufacturing. Topiramate, indicated for schizophrenia, has a very bitter taste. The aim of this study was to develop a MUPS dosage form for taste masking of topiramate. Inert sugar spheres were coated with topiramate by fluid bed technique using povidone as binder. The drug loaded pellets were taste masked with cellulose acetate as taste masking agent. In the taste masking coating also, povidone was used as a binder and pore former. Developed taste masked MUPS were evaluated for polymorphic changes, drug content and dissolution in various media. Drug content of all batches of MUPS were within the range of 95-105%. Dissolution profile of the taste masked topiramate MUPS in 0.1N HCl, acetate buffer (pH 4.5) and phosphate buffer (pH 6.8) was found to be satisfactory.

Keywords

Taste masking MUPS Topiramate Fluid Bed processor

References

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There are 24 citations in total.

Details

Primary Language English
Subjects Pharmaceutical Delivery Technologies
Journal Section Articles
Authors

Isaiah Boyapati 0000-0001-9580-6389

Neerupma Dhiman 0000-0001-8168-1511

Giriraj T Kulkarni 0000-0002-9563-9469

Publication Date June 28, 2025
Published in Issue Year 2024 Volume: 28 Issue: 4

Cite

APA Boyapati, I., Dhiman, N., & Kulkarni, G. T. (2025). Development and evaluation of multiple unit particulate system (MUPS) of topiramate for taste masking. Journal of Research in Pharmacy, 28(4), 997-1009.
AMA Boyapati I, Dhiman N, Kulkarni GT. Development and evaluation of multiple unit particulate system (MUPS) of topiramate for taste masking. J. Res. Pharm. July 2025;28(4):997-1009.
Chicago Boyapati, Isaiah, Neerupma Dhiman, and Giriraj T Kulkarni. “Development and Evaluation of Multiple Unit Particulate System (MUPS) of Topiramate for Taste Masking”. Journal of Research in Pharmacy 28, no. 4 (July 2025): 997-1009.
EndNote Boyapati I, Dhiman N, Kulkarni GT (July 1, 2025) Development and evaluation of multiple unit particulate system (MUPS) of topiramate for taste masking. Journal of Research in Pharmacy 28 4 997–1009.
IEEE I. Boyapati, N. Dhiman, and G. T. Kulkarni, “Development and evaluation of multiple unit particulate system (MUPS) of topiramate for taste masking”, J. Res. Pharm., vol. 28, no. 4, pp. 997–1009, 2025.
ISNAD Boyapati, Isaiah et al. “Development and Evaluation of Multiple Unit Particulate System (MUPS) of Topiramate for Taste Masking”. Journal of Research in Pharmacy 28/4 (July 2025), 997-1009.
JAMA Boyapati I, Dhiman N, Kulkarni GT. Development and evaluation of multiple unit particulate system (MUPS) of topiramate for taste masking. J. Res. Pharm. 2025;28:997–1009.
MLA Boyapati, Isaiah et al. “Development and Evaluation of Multiple Unit Particulate System (MUPS) of Topiramate for Taste Masking”. Journal of Research in Pharmacy, vol. 28, no. 4, 2025, pp. 997-1009.
Vancouver Boyapati I, Dhiman N, Kulkarni GT. Development and evaluation of multiple unit particulate system (MUPS) of topiramate for taste masking. J. Res. Pharm. 2025;28(4):997-1009.