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GC-MS profiling, anti-inflammatory, antioxidant, anti enzymatic and antimicrobial activities of Algerian Cléome amblyocarpa Barr. & Murb

Year 2024, Volume: 28 Issue: 4, 1174 - 1187, 28.06.2025

Manel Srief Moustafa Bani Mouna Derdour Chawki Bensouici

Abstract

This study evaluated the antioxidant, antidiabetic, anticholinesterase, anti-inflammatory, and antimicrobial effects of Algerian Cleome amblyocarpa through its chloroform fraction. Furthermore, phenolic, flavonoids and volatile compounds have been studied. The results indicated high phenols and flavonoids contents, and the gas chromatography- mass spectrometry (GC-MS) analysis revealed the presence of various compounds, mainly 2- Tetracosane, Palmitic acid, 2- Aminothiazole, and Linolenic acid. Previous research supports the potential antidiabetic effects of palmitic acid and linolenic acid, while tetracosane has been studied for its anticholinesterase activity, validating the observed biological activities in our research. The fraction has demonstrated a substantial anti-inflammatory activity similar to the reference, antimicrobial actions against Escherichia coli, Klebsiella pneumonia, Bacillus cereus, Pseudomonas aeruginosa, and Candida albicans, as well as an antioxidant potential, and significant inhibition of key enzymes: alpha-amylase, alpha-glucosidase, acetyl, and butyrylcholinesterase (AChE and BChE), with interesting IC50 values. Our result found that Cléome amblyocarpa is a rich source of value-enhancing biocompounds, and it presents interesting antioxidant, antidiabetic, and anticholinesterase properties, as well as substantial anti-inflammatory and antimicrobial activities. These findings can be exploited in developing new formulations that may be useful in treating a variety of situations.

Keywords

anti-enzymatic anti-inflammatory antimicrobial antioxidant Cléome amblyocarpa Barr. & Murb. GC–MS

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There are 36 citations in total.

Details

Primary Language English
Subjects Pharmacognosy
Journal Section Articles
Authors

Manel Srief 0009-0007-9119-8022

Moustafa Bani 0000-0001-7301-5340

Mouna Derdour 0009-0005-7600-2154

Chawki Bensouici 0000-0003-4612-4642

Publication Date June 28, 2025
Published in Issue Year 2024 Volume: 28 Issue: 4

Cite

APA Srief, M., Bani, M., Derdour, M., Bensouici, C. (2025). GC-MS profiling, anti-inflammatory, antioxidant, anti enzymatic and antimicrobial activities of Algerian Cléome amblyocarpa Barr. & Murb. Journal of Research in Pharmacy, 28(4), 1174-1187.
AMA Srief M, Bani M, Derdour M, Bensouici C. GC-MS profiling, anti-inflammatory, antioxidant, anti enzymatic and antimicrobial activities of Algerian Cléome amblyocarpa Barr. & Murb. J. Res. Pharm. July 2025;28(4):1174-1187.
Chicago Srief, Manel, Moustafa Bani, Mouna Derdour, and Chawki Bensouici. “GC-MS Profiling, Anti-Inflammatory, Antioxidant, Anti Enzymatic and Antimicrobial Activities of Algerian Cléome Amblyocarpa Barr. & Murb”. Journal of Research in Pharmacy 28, no. 4 (July 2025): 1174-87.
EndNote Srief M, Bani M, Derdour M, Bensouici C (July 1, 2025) GC-MS profiling, anti-inflammatory, antioxidant, anti enzymatic and antimicrobial activities of Algerian Cléome amblyocarpa Barr. & Murb. Journal of Research in Pharmacy 28 4 1174–1187.
IEEE M. Srief, M. Bani, M. Derdour, and C. Bensouici, “GC-MS profiling, anti-inflammatory, antioxidant, anti enzymatic and antimicrobial activities of Algerian Cléome amblyocarpa Barr. & Murb”, J. Res. Pharm., vol. 28, no. 4, pp. 1174–1187, 2025.
ISNAD Srief, Manel et al. “GC-MS Profiling, Anti-Inflammatory, Antioxidant, Anti Enzymatic and Antimicrobial Activities of Algerian Cléome Amblyocarpa Barr. & Murb”. Journal of Research in Pharmacy 28/4 (July 2025), 1174-1187.
JAMA Srief M, Bani M, Derdour M, Bensouici C. GC-MS profiling, anti-inflammatory, antioxidant, anti enzymatic and antimicrobial activities of Algerian Cléome amblyocarpa Barr. & Murb. J. Res. Pharm. 2025;28:1174–1187.
MLA Srief, Manel et al. “GC-MS Profiling, Anti-Inflammatory, Antioxidant, Anti Enzymatic and Antimicrobial Activities of Algerian Cléome Amblyocarpa Barr. & Murb”. Journal of Research in Pharmacy, vol. 28, no. 4, 2025, pp. 1174-87.
Vancouver Srief M, Bani M, Derdour M, Bensouici C. GC-MS profiling, anti-inflammatory, antioxidant, anti enzymatic and antimicrobial activities of Algerian Cléome amblyocarpa Barr. & Murb. J. Res. Pharm. 2025;28(4):1174-87.