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Acetylcholinesterase inhibitory activities and LC-MS analysis of the antioxidant Ferula caspica M. Bieb. and F. halophila Peşmen extracts

Year 2019, Volume: 23 Issue: 3, 543 - 551, 27.06.2025

Çiğdem Kahraman , İpek Baysal İffet İrem Tatlı Çankaya , Fatih Göğer , Neşe Kırımer , Zeliha Ş. Akdemir

Abstract

The aim of the current study is to evaluate the biological activity of F. caspica M. Bieb. which is used for the treatment of diabetes in traditional Turkish medicine and to compare with F. halophila Peşmen. Antioxidant capacities and total phenolic contents of the plants’ extracts were tested by DPPH radical scavenging assay and Folin Ciocalteu assay, respectively. Acetylcholinesterase inhibitory activities of the extracts were investigated with the aim of indicating whether there was a correlation with their antioxidant capacities. Different quinic acid and flavonoid derivatives which may be responsible for the activities of the extracts were detected using LC-MS screening in the methanol extracts. The methanol extract from the aerial parts of F. caspica was found to show most antioxidant capacity and acetylcholinesterase inhibitory activity.

Keywords

Ferula antioxidant capacity acetylcholinesterase inhibition LC-MS

References

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There are 51 citations in total.

Details

Primary Language English
Subjects Pharmacognosy
Journal Section Articles
Authors

Çiğdem Kahraman

İpek Baysal

İffet İrem Tatlı Çankaya

Fatih Göğer

Neşe Kırımer

Zeliha Ş. Akdemir

Publication Date June 27, 2025
Published in Issue Year 2019 Volume: 23 Issue: 3

Cite

APA Kahraman, Ç., Baysal, İ., Tatlı Çankaya, İ. İ., Göğer, F., et al. (2025). Acetylcholinesterase inhibitory activities and LC-MS analysis of the antioxidant Ferula caspica M. Bieb. and F. halophila Peşmen extracts. Journal of Research in Pharmacy, 23(3), 543-551.
AMA Kahraman Ç, Baysal İ, Tatlı Çankaya İİ, Göğer F, Kırımer N, Akdemir ZŞ. Acetylcholinesterase inhibitory activities and LC-MS analysis of the antioxidant Ferula caspica M. Bieb. and F. halophila Peşmen extracts. J. Res. Pharm. June 2025;23(3):543-551.
Chicago Kahraman, Çiğdem, İpek Baysal, İffet İrem Tatlı Çankaya, Fatih Göğer, Neşe Kırımer, and Zeliha Ş. Akdemir. “Acetylcholinesterase Inhibitory Activities and LC-MS Analysis of the Antioxidant Ferula Caspica M. Bieb. and F. Halophila Peşmen Extracts”. Journal of Research in Pharmacy 23, no. 3 (June 2025): 543-51.
EndNote Kahraman Ç, Baysal İ, Tatlı Çankaya İİ, Göğer F, Kırımer N, Akdemir ZŞ (June 1, 2025) Acetylcholinesterase inhibitory activities and LC-MS analysis of the antioxidant Ferula caspica M. Bieb. and F. halophila Peşmen extracts. Journal of Research in Pharmacy 23 3 543–551.
IEEE Ç. Kahraman, İ. Baysal, İ. İ. Tatlı Çankaya, F. Göğer, N. Kırımer, and Z. Ş. Akdemir, “Acetylcholinesterase inhibitory activities and LC-MS analysis of the antioxidant Ferula caspica M. Bieb. and F. halophila Peşmen extracts”, J. Res. Pharm., vol. 23, no. 3, pp. 543–551, 2025.
ISNAD Kahraman, Çiğdem et al. “Acetylcholinesterase Inhibitory Activities and LC-MS Analysis of the Antioxidant Ferula Caspica M. Bieb. and F. Halophila Peşmen Extracts”. Journal of Research in Pharmacy 23/3 (June 2025), 543-551.
JAMA Kahraman Ç, Baysal İ, Tatlı Çankaya İİ, Göğer F, Kırımer N, Akdemir ZŞ. Acetylcholinesterase inhibitory activities and LC-MS analysis of the antioxidant Ferula caspica M. Bieb. and F. halophila Peşmen extracts. J. Res. Pharm. 2025;23:543–551.
MLA Kahraman, Çiğdem et al. “Acetylcholinesterase Inhibitory Activities and LC-MS Analysis of the Antioxidant Ferula Caspica M. Bieb. and F. Halophila Peşmen Extracts”. Journal of Research in Pharmacy, vol. 23, no. 3, 2025, pp. 543-51.
Vancouver Kahraman Ç, Baysal İ, Tatlı Çankaya İİ, Göğer F, Kırımer N, Akdemir ZŞ. Acetylcholinesterase inhibitory activities and LC-MS analysis of the antioxidant Ferula caspica M. Bieb. and F. halophila Peşmen extracts. J. Res. Pharm. 2025;23(3):543-51.