Abstract
Medicinal plants are a rich source of disease-prevention medicinal chemicals, and their health advantages
are continually expanding. Traditional treatments can help with a variety of disease conditions, but they need to be
scientifically validated before they can be fully utilized. The current study was therefore conducted to evaluate the
diuretic activity of ethanolic extract of Teucrium polium L. in Wistar rats. The ground aerial parts of T. polium were
extracted with 70% ethanol in a Soxhlet apparatus. The Wistar rats were divided into four groups; one control group
and three treatment groups that were given a reference diuretic medication (furosemide at 10 mg/kg), and ethanolic
extracts of T. polium (200 and 400 mg/kg). 5 hours after the administration, the volume of urine and electrolytes (Na+,
K+, and Cl) excretion were calculated. Also, diuretic index, diuretic, and saluretic activities as well as carbonic
anhydrase inhibition were estimated. The results showed that the 200 and 400 mg/kg treatment groups had a significant
increase (P < 0.05) in urine volume and mild diuretic activity of 0.78 and 0.99, respectively. Compared to the control
group, T. polium (400 mg/kg) ethanolic extract showed a significant increase (P < 0.05) in the excretion of K+ and Cl-.
Also, there was an increase in saluretic activity in the 400 mg/kg treatment group, as measured by the Na++K+, to be
528.0, compared to the control, which had a saluretic activity of 308.0. The study supports the use of T. polium as a
diuretic in traditional folk medicine.
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Details
| Primary Language | English |
|---|---|
| Subjects | Pharmaceutical Sciences, Clinical Pharmacology and Therapeutics |
| Journal Section | Articles |
| Authors | |
| Publication Date | June 28, 2025 |
| Published in Issue | Year 2022 Volume: 26 Issue: 5 |