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Ameliorative effect of L-Glutamic acid against CCl4- induced oxidative stress in rat's brain and spleen

Year 2022, Volume: 26 Issue: 5, 1323 - 1330, 28.06.2025

Nataliya Salyha

Abstract

Carbon tetrachloride (CCl4) causes tissues damage by inducing a state of oxidative stress. This research
was arranged to evaluate the role of L-glutamic acid (L-Glu) against oxidative stress induced by CCl4 in brain and spleen
tissues of rats. Antioxidant profiles were evaluated by estimating the activities of antioxidant enzymes; superoxide
dismutase (SOD), catalase (CAT), glutathione-S-transferase (GST), glutathione peroxidase (GPx), glutathione reductase
(GR) and reduced glutathione (GSH). In addition to this, the lipid peroxidation products content (TBARS and LOOH)
was monitored. Rats were divided into three groups: two experimental (CCl4, CCl4/L-Glu) and Control. The rats of CCl4
group were treated with CCl4 only, CCl4/L-Glu group was treated with CCl4 and L-Glu. Administration of CCl4
reduced the antioxidant enzymes activity in the spleen and brain tissues of rats. Co-treatment of L-Glu restored the
activities of antioxidant enzymes GPx (brain), GST (spleen), GR (spleen, brain) compared to control and CCl4
experimental group of animals. Increased spleen TBARS content was observed in rats treated with CCl4. But this index
didn't change in the CCl4/L-Glu group, which additionally received L-Glu. Results of the present study revealed that LGlu
could protect the brain and spleen tissues against oxidative stress induced by CCl4.

Keywords

L-glutamic acid carbon tetrachloride antioxidant system enzymes oxidative stress

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There are 62 citations in total.

Details

Primary Language English
Subjects Pharmaceutical Sciences
Journal Section Articles
Authors

Nataliya Salyha

Publication Date June 28, 2025
Published in Issue Year 2022 Volume: 26 Issue: 5

Cite

APA Salyha, N. (2025). Ameliorative effect of L-Glutamic acid against CCl4- induced oxidative stress in rat’s brain and spleen. Journal of Research in Pharmacy, 26(5), 1323-1330.
AMA Salyha N. Ameliorative effect of L-Glutamic acid against CCl4- induced oxidative stress in rat’s brain and spleen. J. Res. Pharm. June 2025;26(5):1323-1330.
Chicago Salyha, Nataliya. “Ameliorative Effect of L-Glutamic Acid Against CCl4- Induced Oxidative Stress in rat’s Brain and Spleen”. Journal of Research in Pharmacy 26, no. 5 (June 2025): 1323-30.
EndNote Salyha N (June 1, 2025) Ameliorative effect of L-Glutamic acid against CCl4- induced oxidative stress in rat’s brain and spleen. Journal of Research in Pharmacy 26 5 1323–1330.
IEEE N. Salyha, “Ameliorative effect of L-Glutamic acid against CCl4- induced oxidative stress in rat’s brain and spleen”, J. Res. Pharm., vol. 26, no. 5, pp. 1323–1330, 2025.
ISNAD Salyha, Nataliya. “Ameliorative Effect of L-Glutamic Acid Against CCl4- Induced Oxidative Stress in rat’s Brain and Spleen”. Journal of Research in Pharmacy 26/5 (June 2025), 1323-1330.
JAMA Salyha N. Ameliorative effect of L-Glutamic acid against CCl4- induced oxidative stress in rat’s brain and spleen. J. Res. Pharm. 2025;26:1323–1330.
MLA Salyha, Nataliya. “Ameliorative Effect of L-Glutamic Acid Against CCl4- Induced Oxidative Stress in rat’s Brain and Spleen”. Journal of Research in Pharmacy, vol. 26, no. 5, 2025, pp. 1323-30.
Vancouver Salyha N. Ameliorative effect of L-Glutamic acid against CCl4- induced oxidative stress in rat’s brain and spleen. J. Res. Pharm. 2025;26(5):1323-30.