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Protective effects of olive cake against heart and kidney injury in dexamethasone-induced hypertensive rats

Year 2022, Volume: 26 Issue: 5, 1331 - 1341, 28.06.2025

Mansourou Samba Garba Sherazede Bouderbala

Abstract

In this study, we investigated the protective effects of olive cake (OC) from heart and kidney damage in dexamethasoneinduced hypertensive (HT) rats. HT rats were divided into two groups fed standard diet supplemented (HT-OC) or not (HT) with OC at 7.5% for 28 days. A control group (C) was submitted to standard diet for the same experimental period. The results showed that serum levels of lactate dehydrogenase (LDH), creatine kinase (CK), aspartate aminotransferase (AST), urea creatinine and uric acid were significantly increased in the HT group compared with the C group. The HT group was associated with increased levels of thiobarbituric acid reactive substances, lipid hydroperoxides and protein carbonyl, while reducing glutathione concentration and glutathione peroxidase, superoxide dismutase and catalase activities in heart and kidney. OC treatment reduced systolic blood pressure, creatinine, urea, uric acid, LDH, CK and AST and increased nitric oxide in serum than the HT group. OC reduced oxidative stress biomarkers and increased antioxidants enzyme activities in heart and kidney than the HT group. In the HT group compared with C, histopathological examination of renal tissues revealed glomerular necrosis, renal tubular distortion, and increased Bowman's space, and that of the heart showed cardiac cells nuclear peripheralization, pyknosis, and congestion of myocardial blood vessels. However, OC treatment attenuated cardiac and renal damage compared with the HT group. Conclusions, in dexamethasone-induced hypertensive rats, OC protects against kidney and heart damage by reducing blood pressure, oxidative stress and improving antioxidant defense. These results could be referred to their flavonoid and polyphenol content.

Keywords

Hypertension rat dexamethasone olive cake antioxidant enzymes oxidative stress

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There are 59 citations in total.

Details

Primary Language English
Subjects Clinical Pharmacy and Pharmacy Practice
Journal Section Articles
Authors

Mansourou Samba Garba

Sherazede Bouderbala

Publication Date June 28, 2025
Published in Issue Year 2022 Volume: 26 Issue: 5

Cite

APA Samba Garba, M., & Bouderbala, S. (2025). Protective effects of olive cake against heart and kidney injury in dexamethasone-induced hypertensive rats. Journal of Research in Pharmacy, 26(5), 1331-1341.
AMA Samba Garba M, Bouderbala S. Protective effects of olive cake against heart and kidney injury in dexamethasone-induced hypertensive rats. J. Res. Pharm. June 2025;26(5):1331-1341.
Chicago Samba Garba, Mansourou, and Sherazede Bouderbala. “Protective Effects of Olive Cake Against Heart and Kidney Injury in Dexamethasone-Induced Hypertensive Rats”. Journal of Research in Pharmacy 26, no. 5 (June 2025): 1331-41.
EndNote Samba Garba M, Bouderbala S (June 1, 2025) Protective effects of olive cake against heart and kidney injury in dexamethasone-induced hypertensive rats. Journal of Research in Pharmacy 26 5 1331–1341.
IEEE M. Samba Garba and S. Bouderbala, “Protective effects of olive cake against heart and kidney injury in dexamethasone-induced hypertensive rats”, J. Res. Pharm., vol. 26, no. 5, pp. 1331–1341, 2025.
ISNAD Samba Garba, Mansourou - Bouderbala, Sherazede. “Protective Effects of Olive Cake Against Heart and Kidney Injury in Dexamethasone-Induced Hypertensive Rats”. Journal of Research in Pharmacy 26/5 (June 2025), 1331-1341.
JAMA Samba Garba M, Bouderbala S. Protective effects of olive cake against heart and kidney injury in dexamethasone-induced hypertensive rats. J. Res. Pharm. 2025;26:1331–1341.
MLA Samba Garba, Mansourou and Sherazede Bouderbala. “Protective Effects of Olive Cake Against Heart and Kidney Injury in Dexamethasone-Induced Hypertensive Rats”. Journal of Research in Pharmacy, vol. 26, no. 5, 2025, pp. 1331-4.
Vancouver Samba Garba M, Bouderbala S. Protective effects of olive cake against heart and kidney injury in dexamethasone-induced hypertensive rats. J. Res. Pharm. 2025;26(5):1331-4.